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  1. Article ; Online: Adolescent THC Treatment Does Not Potentiate the Behavioral Effects in Adulthood of Maternal Immune Activation.

    Stollenwerk, Todd M / Hillard, Cecilia J

    Cells

    2021  Volume 10, Issue 12

    Abstract: Both in utero exposure to maternal immune activation and cannabis use during adolescence have been associated with increased risk for the development of schizophrenia; however, whether these exposures exert synergistic effects on brain function is not ... ...

    Abstract Both in utero exposure to maternal immune activation and cannabis use during adolescence have been associated with increased risk for the development of schizophrenia; however, whether these exposures exert synergistic effects on brain function is not known. In the present study, mild maternal immune activation (MIA) was elicited in mice with prenatal exposure to polyinosinic-polycytidylic acid (poly(I:C)), and ∆
    MeSH term(s) Aging/physiology ; Amphetamine ; Animals ; Behavior, Animal/drug effects ; Conditioning, Classical ; Dronabinol/pharmacology ; Extinction, Psychological/drug effects ; Fear/drug effects ; Female ; Locomotion/drug effects ; Male ; Maze Learning/physiology ; Mice, Inbred C57BL ; Pregnancy ; Prenatal Exposure Delayed Effects/immunology ; Prepulse Inhibition/drug effects ; Rats, Sprague-Dawley ; Reflex, Startle/drug effects ; Swimming ; Mice ; Rats
    Chemical Substances Dronabinol (7J8897W37S) ; Amphetamine (CK833KGX7E)
    Language English
    Publishing date 2021-12-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10123503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Contribution of the Adenosine 2A Receptor to Behavioral Effects of Tetrahydrocannabinol, Cannabidiol and PECS-101.

    Stollenwerk, Todd M / Pollock, Samantha / Hillard, Cecilia J

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 17

    Abstract: The cannabis-derived molecules, ∆ ...

    Abstract The cannabis-derived molecules, ∆
    MeSH term(s) Animals ; Cannabidiol/analogs & derivatives ; Cannabidiol/pharmacology ; Dronabinol/administration & dosage ; Dronabinol/pharmacology ; Exploratory Behavior/drug effects ; Injections, Intraperitoneal ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Receptor, Adenosine A2A/deficiency ; Receptor, Adenosine A2A/metabolism
    Chemical Substances Receptor, Adenosine A2A ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2021-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26175354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Endocannabinoid signaling in the central nervous system.

    Martinez Ramirez, César E / Ruiz-Pérez, Gonzalo / Stollenwerk, Todd M / Behlke, Christina / Doherty, Ashley / Hillard, Cecilia J

    Glia

    2022  Volume 71, Issue 1, Page(s) 5–35

    Abstract: It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on central nervous system (CNS) function. In the 40 years since cannabinoids were found to trigger specific cell signaling cascades, studies of the ECS system continue ...

    Abstract It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on central nervous system (CNS) function. In the 40 years since cannabinoids were found to trigger specific cell signaling cascades, studies of the ECS system continue to cause amazement, surprise, and confusion! CB1 cannabinoid receptors are expressed widely in the CNS and regulate cell-cell communication via effects on the release of both neurotransmitters and gliotransmitters. CB2 cannabinoid receptors are difficult to detect in the CNS but seem to "punch above their weight" as compounds targeting these receptors have significant effects on inflammatory state and behavior. Positive and negative allosteric modulators for both receptors have been identified and examined in preclinical studies. Concentrations of the endocannabinoid ligands, N-arachidonoylethanolamine and 2-arachidonoylglycerol (2-AG), are regulated by a combination of enzymatic synthesis and degradation and inhibitors of these processes are available and making their way into clinical trials. Importantly, ECS regulates many essential brain functions, including regulation of reward, anxiety, inflammation, motor control, and cellular development. While the field is on the cusp of preclinical discoveries providing impactful clinical and therapeutic insights into many CNS disorders, there is still much to be learned about this remarkable and versatile modulatory system.
    MeSH term(s) Endocannabinoids/metabolism ; Receptors, Cannabinoid/metabolism ; Cannabinoids ; Signal Transduction ; Central Nervous System/metabolism ; Receptor, Cannabinoid, CB1
    Chemical Substances Endocannabinoids ; Receptors, Cannabinoid ; Cannabinoids ; Receptor, Cannabinoid, CB1
    Language English
    Publishing date 2022-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639414-0
    ISSN 1098-1136 ; 0894-1491
    ISSN (online) 1098-1136
    ISSN 0894-1491
    DOI 10.1002/glia.24280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2345: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Meet Your Stress Management Professionals: The Endocannabinoids.

    deRoon-Cassini, Terri A / Stollenwerk, Todd M / Beatka, Margaret / Hillard, Cecilia J

    Trends in molecular medicine

    2020  Volume 26, Issue 10, Page(s) 953–968

    Abstract: The endocannabinoid signaling system (ECSS) is altered by exposure to stress and mediates and modulates the effects of stress on the brain. Considerable preclinical data support critical roles for the endocannabinoids and their target, the CB1 ... ...

    Abstract The endocannabinoid signaling system (ECSS) is altered by exposure to stress and mediates and modulates the effects of stress on the brain. Considerable preclinical data support critical roles for the endocannabinoids and their target, the CB1 cannabinoid receptor, in the adaptation of the brain to repeated stress exposure. Chronic stress exposure increases vulnerability to mental illness, so the ECSS has attracted attention as a potential therapeutic target for the prevention and treatment of stress-related psychopathology. We discuss human genetic studies indicating that the ECSS contributes to risk for mental illness in those exposed to severe stress and trauma early in life, and we explore the potential difficulties in pharmacological manipulation of the ECSS.
    MeSH term(s) Animals ; Brain/metabolism ; Endocannabinoids/genetics ; Humans ; Mental Disorders/genetics ; Signal Transduction/genetics ; Stress, Psychological/genetics
    Chemical Substances Endocannabinoids
    Language English
    Publishing date 2020-08-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2020.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4345: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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