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  1. Article ; Online: Hemostasis System in Patients with Schizophrenia and Schizophrenia Spectrum Disorders.

    Karpova, N S / Brusov, O S / Oleichik, I V / Stolyarov, S A / Klyushnik, T P

    Bulletin of experimental biology and medicine

    2024  Volume 176, Issue 3, Page(s) 390–393

    Abstract: Hemostasis system in patients with schizophrenia and schizophrenia spectrum disorders was examined using "Fibrinodynamics" technology that allows evaluating the overal coagulation, fibrinolysis, and hemostasis potentials. All indices, except for the ... ...

    Abstract Hemostasis system in patients with schizophrenia and schizophrenia spectrum disorders was examined using "Fibrinodynamics" technology that allows evaluating the overal coagulation, fibrinolysis, and hemostasis potentials. All indices, except for the parameter characterizing the hemostasis balance, were statistically higher (p<0.0001) in patients than in healthy volunteers (control). In most patients, the hemostasis system remained balanced despite changes in individual coagulation and fibrinolysis parameters. The obtained results have a fundamental importance, expand the understanding of the pathogenesis of endogenous mental disorders, and are useful for the development of personalized approaches to the treatment of these patients.
    MeSH term(s) Humans ; Schizophrenia ; Hemostasis ; Blood Coagulation ; Fibrinolysis
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390407-6
    ISSN 1573-8221 ; 0007-4888 ; 0365-9615
    ISSN (online) 1573-8221
    ISSN 0007-4888 ; 0365-9615
    DOI 10.1007/s10517-024-06030-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [The relationship between quantitative clinical and EEG parameters in the treatment of delusional conditions in patients with attack-like schizophrenia].

    Iznak, A F / Iznak, E V / Oleichik, I V / Abramova, L I / Stolyarov, S A / Kobelkov, G M

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2016  Volume 116, Issue 2, Page(s) 80–84

    Abstract: Objective: To study neurophysiologic correlates of the severity of clinical conditions and to search for possible predictors of therapeutic response in attack-like schizophrenic patients with delusional disorders.: Material and methods: During the ... ...

    Abstract Objective: To study neurophysiologic correlates of the severity of clinical conditions and to search for possible predictors of therapeutic response in attack-like schizophrenic patients with delusional disorders.
    Material and methods: During the treatment of 40 attack-like schizophrenic patients (all females, right-handed, aged 20--50 years old) with delusional disorders, clinical symptoms were quantitatively assessed using PANSS. Resting EEG was recorded with the consequent spectral-coherent analysis. Correlation analysis was performed at the beginning of treatment and at the stage of the development of remission.
    Results: Significant (p<0.05) correlations between some initial (before treatment) resting EEG parameters and PANSS scores before treatment and at the stage of remission were revealed. The reduction in psychopathologic symptoms after treatment course was associated with the decrease in alpha-3 spectral power in occipital zones and increase of theta-1 and theta-2 spectral power in frontal-central regions. Besides, the number of statistically significant intra-hemispheric and inter-hemispheric links was increased in theta-1 and theta-2 frequency bands in frontal and central regions compared to initial levels.
    Conclusion: These EEG changes reflected the facilitation of cortical inhibitory processes as well as recovery of impaired intra-cortical links i.e. the normalization of the brain integrative activity.
    Language Russian
    Publishing date 2016
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro20161162180-84
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [No effect of the BDNF Val66Met polymorphism on cognitive deficit in patients with schizophrenia and on the risk of the disease in their relatives].

    Alfimova, M V / Golimbet, V E / Korovaitseva, G I / Lezheiko, T V / Gabaeva, M V / Oleichik, I V / Stolyarov, S A

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2015  Volume 115, Issue 1, Page(s) 75–79

    Abstract: Objective: The brain-derived neurotrophic factor (BDNF) gene is thought to be a candidate gene for schizophrenia. At the same time, many studies failed to find the association between BDNF and the disease though the contribution of the BDNF Val66Met ... ...

    Abstract Objective: The brain-derived neurotrophic factor (BDNF) gene is thought to be a candidate gene for schizophrenia. At the same time, many studies failed to find the association between BDNF and the disease though the contribution of the BDNF Val66Met polymorphism to the variance of characteristics of schizophrenia has been confirmed. Authors suggested that this contribution was the consequence of the involvement of this gene in the formation of "cognitive reserve" that had a protective effect on the different aspects of the disease. This protective effect should emerge in relatively intact cognitive function in patients with the protective Val66Met genotype as well as in the accumulation of the protective genotypes in unaffected relatives.
    Material and methods: We examined 169 patients with schizophrenia spectrum disorders, 320 their first-degree relatives and control groups using molecular-genetic and experimental psychological methods.
    Results: No effect of the Val66Met polymorphism on verbal memory, executive functions and total index of cognitive functioning was found. Besides, we did not find any differences in Val66Met genotype frequencies in first-degree relatives of patients with schizophrenia and healthy people without family history of schizophrenia.
    Conclusion: The results do not support our hypothesis that BDNF is a gene of "cognitive reserve".
    MeSH term(s) Adult ; Brain-Derived Neurotrophic Factor/genetics ; Cognition Disorders/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Methionine/genetics ; Pedigree ; Polymorphism, Genetic ; Schizophrenia/genetics ; Valine/genetics ; Young Adult
    Chemical Substances Brain-Derived Neurotrophic Factor ; Methionine (AE28F7PNPL) ; Valine (HG18B9YRS7)
    Language Russian
    Publishing date 2015
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro20151151175-79
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  4. Article: Klinicheskie i patopsikhologicheskie aspekty formirovaniya negativnykh lichnostnykh izmenenii v remissii pri pristupoobraznoi shizofrenii pri lechenii neiroleptikami raznykh pokolenii.

    Panteleyeva, G P / Oleichik, I V / Abramova, L I / Meleshko, T K / Kritskaya, V P / Bologov, P V / Stolyarov, S A

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2015  Volume 115, Issue 11 Pt 2, Page(s) 62–69

    Abstract: Objective: To determine clinical and pathopsychological parameters of negative personality changes, their diagnostic and predictive significance based on the variant of neuroleptic treatment in the dynamics of remissions in shift-like schizophrenia.: ... ...

    Title translation Clinical and pathopsychological aspects of forming negative disorders in remissions of shift-like schizophrenia treated with different generations of neuroleptics.
    Abstract Objective: To determine clinical and pathopsychological parameters of negative personality changes, their diagnostic and predictive significance based on the variant of neuroleptic treatment in the dynamics of remissions in shift-like schizophrenia.
    Material and methods: Twenty-nine female patients diagnosed with ICD-10 schizophrenia (items F20.01 and F20.02) were examined. The patients were treated with typical neuroleptics (TN) or atypical (ATN) neuroleptics in the hospital and then as outpatients. Patient's state was assessed clinically and psychometrically with the PANSS at admission, at the beginning of remission and after one and two years of remission. Mean score of positive (PS) and negative (NS) symptoms was determined differentially in the dynamics basing on the neuroleptic used. Twenty-seven patients underwent experimental/pathopsychological examination.
    Results and conclusion: In different stages of the dynamics of shift-like schizophrenia, NS had different capacity of «reversibility» and were distinctly associated with the illness-shaping influence of PS severity and activity and characteristics of psychotropic effect of the neuroleptics. The highest severity of NS was noted in the stage of active psychosis (up to 3.6 and 4.2 scores), with the following decrease in the beginning of remission (up to 2.3 and 2.8 scores). The most distinct trend towards the reduction of NS in the first and second years of remission (up to 2.0-1.0 scores), along with a trend to the complete reduction of PS, was identified in patients treated with ATN. In patients treated with TN, the severity of NS was relatively stable in all stages of remission, with a trend towards the increased severity (up to 2.8 and 3.2 scores) with the stable reduction of PS to1.6 scores. The distinct property of ATN to exert the reducing psychotropic effect on NS and the lack of antinegative effect in the antipsychotic spectrum of TN is discussed.
    Language Russian
    Publishing date 2015
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro201511511262-69
    Database MEDical Literature Analysis and Retrieval System OnLINE

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