Treffer 1 - 10 von insgesamt 800
The Dental register
2021 Band 19, Heft 2, Seite(n) 70–74
| Sprache | Englisch |
|---|---|
| Erscheinungsdatum | 2021-03-10 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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The Dental register
2021 Band 19, Heft 2, Seite(n) 65–69
| Sprache | Englisch |
|---|---|
| Erscheinungsdatum | 2021-03-10 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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The Dental register
2021 Band 20, Heft 3, Seite(n) 133–141
| Sprache | Englisch |
|---|---|
| Erscheinungsdatum | 2021-03-10 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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2024 Band 12, Heft 3, Seite(n) e0147323
Abstract: Oxacillinases (OXA)-48-like β-lactamases are one of the most common resistance determinants among carbapenem-resistant Enterobacterales reported globally. Moreover, there is no standard treatment available against organisms producing OXA-48-like enzymes, ...
| Abstract | Oxacillinases (OXA)-48-like β-lactamases are one of the most common resistance determinants among carbapenem-resistant Enterobacterales reported globally. Moreover, there is no standard treatment available against organisms producing OXA-48-like enzymes, and they are sometimes difficult to detect, making treatment challenging. The objective of this study was to evaluate the distribution and antimicrobial susceptibility of Importance: Resistance to carbapenems among Enterobacterales is often due to the production of enzymes that are members of the oxacillinases (OXA)-48-like family. These organisms can also be resistant to other classes of drugs and are difficult to identify and treat. This study evaluated the activity of the drug ceftazidime-avibactam (CAZ-AVI) and other comparator agents against a global collection of Enterobacterales that produce OXA-48-like enzymes. CAZ-AVI was active against |
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| Mesh-Begriff(e) | Colistin/pharmacology ; Tigecycline/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; beta-Lactamases ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; Ceftazidime ; Drug Combinations ; Azabicyclo Compounds |
| Chemische Substanzen | avibactam, ceftazidime drug combination ; Colistin (Z67X93HJG1) ; Tigecycline (70JE2N95KR) ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; Ceftazidime (9M416Z9QNR) ; Drug Combinations ; Azabicyclo Compounds |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-02-08 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2807133-5 |
| ISSN | 2165-0497 ; 2165-0497 |
| ISSN (online) | 2165-0497 |
| ISSN | 2165-0497 |
| DOI | 10.1128/spectrum.01473-23 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of global antimicrobial resistance
2023 Band 34, Seite(n) 113–118
Abstract: Objectives: The objective of this study was to assess the distribution and antimicrobial susceptibility of Pseudomonas aeruginosa isolates against ceftazidime-avibactam (CAZ-AVI) and a panel of comparator agents collected globally and in each region ... ...
| Abstract | Objectives: The objective of this study was to assess the distribution and antimicrobial susceptibility of Pseudomonas aeruginosa isolates against ceftazidime-avibactam (CAZ-AVI) and a panel of comparator agents collected globally and in each region from 2017-2020 from the Antimicrobial Testing Leadership and Surveillance program. Methods: Susceptibility and minimum inhibitory concentration of all P. aeruginosa isolates were determined using broth microdilution methodology according to the Clinical and Laboratory Standards Institute guidelines. Results: Of the total 29746 isolates of P. aeruginosa collected, 20.9% were multidrug resistant (MDR), 20.7% were extremely drug resistant (XDR), 8.4% were CAZ-AVI-resistant (CAZ-AVI-R), and 3.0% were MBL-positive. Amongst the MBL-positive isolates, the proportion of VIM-positive isolates was highest (77.8%). The highest proportion of MDR (25.5%), XDR (25.0%), MBL-positive (5.7%), and CAZ-AVI-R (12.3%) isolates were in Latin America. Amongst the sources, the highest proportion of isolates were from respiratory sources (43.0%), and the majority of isolates were from non-intensive care unit wards (71.2%). Overall, all P. aeruginosa isolates (90.9%) showed high susceptibility to CAZ-AVI. However, MDR and XDR isolates were less susceptible to CAZ-AVI (≤60.7). The only comparators to which all isolates of P. aeruginosa showed good overall susceptibility were colistin (99.1%) and amikacin (90.5%). However, only colistin was active (≥98.3%) against all the resistant isolates. Conclusion: CAZ-AVI presents a potential treatment option against P. aeruginosa infections. However, active monitoring and surveillance, especially of the resistant phenotypes, is warranted for effective treatment of infections caused by P. aeruginosa. |
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| Mesh-Begriff(e) | Pseudomonas aeruginosa ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Colistin/pharmacology ; Colistin/therapeutic use ; Ceftazidime/pharmacology ; Ceftazidime/therapeutic use |
| Chemische Substanzen | avibactam, ceftazidime drug combination ; Anti-Bacterial Agents ; Colistin (Z67X93HJG1) ; Ceftazidime (9M416Z9QNR) |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-07-06 |
| Erscheinungsland | Netherlands |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2710046-7 |
| ISSN | 2213-7173 ; 2213-7173 |
| ISSN (online) | 2213-7173 |
| ISSN | 2213-7173 |
| DOI | 10.1016/j.jgar.2023.06.005 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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BMC infectious diseases
2021 Band 21, Heft 1, Seite(n) 600
Abstract: Background: This antimicrobial surveillance study reports in vitro antimicrobial activity and susceptibility data for a panel of agents against respiratory isolates of Enterobacterales and Pseudomonas aeruginosa.: Methods: Isolates from respiratory ... ...
| Abstract | Background: This antimicrobial surveillance study reports in vitro antimicrobial activity and susceptibility data for a panel of agents against respiratory isolates of Enterobacterales and Pseudomonas aeruginosa. Methods: Isolates from respiratory specimens were collected in Africa/Middle East, Asia/South Pacific, Europe and Latin America between 2016 and 2018, as part of the Antimicrobial Testing Leadership and Surveillance (ATLAS) program. Broth microdilution methodology was used to quantify minimum inhibitory concentrations, from which rates of susceptibility were determined using EUCAST breakpoints (version 10). Rates of subsets with genes encoding β-lactamases (extended-spectrum β-lactamases [ESBLs], serine carbapenemases and metallo-β-lactamases [MBLs]) were also determined, as well as rates of multidrug-resistant (MDR) P. aeruginosa. Results: Among all respiratory Enterobacterales isolates, susceptibility to ceftazidime-avibactam, meropenem, colistin and amikacin was ≥94.4% in each region. For Enterobacterales isolates that were ESBL-positive or carbapenemase-positive/MBL-negative, ceftazidime-avibactam susceptibility was 93.6 and 98.9%, respectively. Fewer than 42.7% of MBL-positive Enterobacterales isolates were susceptible to any agents, except colistin (89.0% susceptible). Tigecycline susceptibility was ≥90.0% among Citrobacter koseri and Escherichia coli isolates, including all β-lactamase-positive subsets. ESBL-positive Enterobacterales were more commonly identified in each region than isolates that were ESBL/carbapenemase-positive; carbapenemase-positive/MBL-negative; or MBL-positive. Among all respiratory P. aeruginosa isolates, the combined susceptibility rates (susceptible at standard dosing regimen plus susceptible at increased exposure) were highest to ceftazidime-avibactam, colistin and amikacin (≥82.4% in each region). Susceptibility to colistin was ≥98.1% for all β-lactamase-positive subsets of P. aeruginosa. The lowest rates of antimicrobial susceptibility were observed among MBL-positive isolates of P. aeruginosa (≤56.6%), with the exception of colistin (100% susceptible). MDR P. aeruginosa were most frequently identified in each region (18.7-28.7%), compared with the subsets of ESBL-positive; carbapenemase-positive/MBL-negative; or MBL-positive isolates. Conclusions: Rates of susceptibility among the collections of respiratory Enterobacterales and P. aeruginosa isolates were highest to ceftazidime-avibactam, colistin and amikacin in each region. Tigecycline was active against all subsets of C. koseri and E. coli, and colistin was active against all subsets of P. aeruginosa. The findings of this study indicate the need for continued antimicrobial surveillance among respiratory Gram-negative pathogens, in particular those with genes encoding MBLs. |
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| Mesh-Begriff(e) | Amikacin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Azabicyclo Compounds/pharmacology ; Bacterial Proteins/genetics ; Ceftazidime/pharmacology ; Citrobacter koseri/drug effects ; Citrobacter koseri/isolation & purification ; Colistin/pharmacology ; Drug Combinations ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/isolation & purification ; Epidemiological Monitoring ; Escherichia coli/drug effects ; Escherichia coli/isolation & purification ; Humans ; Meropenem/pharmacology ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/isolation & purification ; Tigecycline/pharmacology ; beta-Lactamases/genetics |
| Chemische Substanzen | Anti-Bacterial Agents ; Azabicyclo Compounds ; Bacterial Proteins ; Drug Combinations ; avibactam, ceftazidime drug combination ; Tigecycline (70JE2N95KR) ; Amikacin (84319SGC3C) ; Ceftazidime (9M416Z9QNR) ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6) ; Meropenem (FV9J3JU8B1) ; Colistin (Z67X93HJG1) |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-06-23 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ISSN | 1471-2334 |
| ISSN (online) | 1471-2334 |
| DOI | 10.1186/s12879-021-06153-0 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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Antimicrobial agents and chemotherapy
2024 Band 68, Heft 3, Seite(n) e0164023
| Sprache | Englisch |
|---|---|
| Erscheinungsdatum | 2024-02-13 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article ; Published Erratum |
| ZDB-ID | 217602-6 |
| ISSN | 1098-6596 ; 0066-4804 |
| ISSN (online) | 1098-6596 |
| ISSN | 0066-4804 |
| DOI | 10.1128/aac.01640-23 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 809: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Einzelsignatur: Hefte anzeigen |
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The Proceedings of the Nutrition Society
2024 , Seite(n) 1–7
Abstract: Nutritional requirements of individuals vary across the lifecycle, according to activity, age and gender. To optimize human health, consideration of nutritional priorities at each stage is needed. This conference brought together multidisciplinary ... ...
| Abstract | Nutritional requirements of individuals vary across the lifecycle, according to activity, age and gender. To optimize human health, consideration of nutritional priorities at each stage is needed. This conference brought together multidisciplinary experts in maternal and child nutrition and health, cardiometabolic and plant-based nutrition and dietitians involved in the care of vulnerable populations, plus nutritional metabolism, health and ageing. The presentations highlighted the most important nutrition research in these areas, updating knowledge and suggesting how dietary advice and policy could be adapted to incorporate research findings. With the global increase in non-communicable disease (NCD) and nutrition being considered as a key modifiable risk factor for the prevention and management of NCD, this conference was much needed. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2024-01-19 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 391142-1 |
| ISSN | 1475-2719 ; 0029-6651 |
| ISSN (online) | 1475-2719 |
| ISSN | 0029-6651 |
| DOI | 10.1017/S0029665124000089 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Ue I Zs.179: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2023 Band 18, Heft 7, Seite(n) e0288628
Abstract: Despite extensive debate on the effects of COVID-19 mitigation measures in school settings, little evidence exists on trends in school children's mental health over the course of the COVID-19 pandemic. The objective of this paper was to identify factors ... ...
| Abstract | Despite extensive debate on the effects of COVID-19 mitigation measures in school settings, little evidence exists on trends in school children's mental health over the course of the COVID-19 pandemic. The objective of this paper was to identify factors affecting parent reports of school children's mental health during COVID-19 Omicron variant outbreak in a cohort of high-risk, socially vulnerable children attending public elementary schools. We analyzed four waves of cross-sectional, online-administered surveys completed by parents of children attending public elementary schools in San Diego between November 2021 and March of 2022. Children (n = 684) ranged in age from 2-17 years. We used multilevel linear mixed effects models to assess determinants of parent-reported child mental health status. The outcome was child mental health, as reported by the parent. Parents consistently rated their children's mental health as very good, though parents who experienced recent COVID-related challenges and who had older children reported lower levels of mental health in their children. Children's mental health was generally considered to be very good, as judged by their parents during a period of constant in-school masking and the Omicron variant outbreak. Structural support mechanisms aimed at mitigating COVID-related challenges for adults may offer benefit to children's mental health. |
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| Mesh-Begriff(e) | Adult ; Humans ; Child ; Adolescent ; Child, Preschool ; Cross-Sectional Studies ; COVID-19/epidemiology ; Pandemics ; SARS-CoV-2 ; Health Status |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-07-26 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2267670-3 |
| ISSN | 1932-6203 ; 1932-6203 |
| ISSN (online) | 1932-6203 |
| ISSN | 1932-6203 |
| DOI | 10.1371/journal.pone.0288628 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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2022
Abstract: The paper examines the impact of the coronavirus disease 2019 (COVID-19) pandemic on school-age children and their families. Changes to their daily lives were examined through the lens of their physical, mental, and emotional well-being. An analysis of ... ...
| Abstract | The paper examines the impact of the coronavirus disease 2019 (COVID-19) pandemic on school-age children and their families. Changes to their daily lives were examined through the lens of their physical, mental, and emotional well-being. An analysis of current literature was conducted examining the emerging research on the pandemic's effects on families. A case example is provided to offer a narrative snapshot of the many experiences faced by children and families throughout school closures and stay at home orders. The paper concludes with implications for providers and further research with special attention paid to the emergence of telehealth and implications for treatment. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2022-12-01 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2002070-3 |
| ISSN | 1520-6807 ; 0033-3085 |
| ISSN (online) | 1520-6807 |
| ISSN | 0033-3085 |
| DOI | 10.1002/pits.22831 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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