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  1. Book ; Online: Protein Quality Controlling Systems in Plant Responses to Environmental Stresses

    Stone, Sophia / Wang, Wei / Hellmann, Hanjo A / Zhou, Jie / Liu, Yule / Lu, Minghui

    2018  

    Abstract: Environmental stress factors negatively affect plant growth by inducing proteins dysfunction. As coping strategies, plant have developed a comprehensive protein quality controlling system (PQCS) to keep proteins homeostasis. In this research topic of " ... ...

    Abstract Environmental stress factors negatively affect plant growth by inducing proteins dysfunction. As coping strategies, plant have developed a comprehensive protein quality controlling system (PQCS) to keep proteins homeostasis. In this research topic of "Protein Quality Controlling Systems in Plant Responses to Environmental Stresses", some latest researches and opinions in this field, including heat shock proteins (HSPs), unfolded protein response (UPR), ubiquitin-proteasome system (UPS) and autophagy, were reported, aiming to provide novel insights for increasing crop production under environmental challenges
    Keywords Science (General) ; Botany
    Size 1 electronic resource (214 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101872
    ISBN 9782889455584 ; 2889455580
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Ubiquitin ligases at the nexus of plant responses to biotic and abiotic stresses.

    Stone, Sophia L

    Essays in biochemistry

    2022  Volume 66, Issue 2, Page(s) 123–133

    Abstract: Plants must cope with an ever-changing environment, including concurrent biotic and abiotic stresses. The ubiquitin-proteasome system (UPS) is intricately involved in regulating signaling events that facilitate cellular changes required to mitigate the ... ...

    Abstract Plants must cope with an ever-changing environment, including concurrent biotic and abiotic stresses. The ubiquitin-proteasome system (UPS) is intricately involved in regulating signaling events that facilitate cellular changes required to mitigate the detrimental effects of environmental stress. A key component of the UPS are ubiquitin ligases (or E3s) that catalyze the attachment of ubiquitin molecules to select substrate proteins, which are then recognized by the 26S proteasome for degradation. With the identification of substrate proteins, a growing number of E3s are shown to differentially regulate responses to abiotic as well as bioitic stresses. The review discusses select E3s to illustrate the role of ubiquitin ligases as negative and/or positive regulators of responses to both biotic and abiotic stresses.
    MeSH term(s) Plants/metabolism ; Signal Transduction ; Stress, Physiological ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Ubiquitin ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1744-1358 ; 0071-1365
    ISSN (online) 1744-1358
    ISSN 0071-1365
    DOI 10.1042/EBC20210070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Ubiquitin Proteasome System and Nutrient Stress Response.

    Mackinnon, Erin / Stone, Sophia L

    Frontiers in plant science

    2022  Volume 13, Page(s) 867419

    Abstract: Plants utilize different molecular mechanisms, including the Ubiquitin Proteasome System (UPS) that facilitates changes to the proteome, to mitigate the impact of abiotic stresses on growth and development. The UPS encompasses the ubiquitination of ... ...

    Abstract Plants utilize different molecular mechanisms, including the Ubiquitin Proteasome System (UPS) that facilitates changes to the proteome, to mitigate the impact of abiotic stresses on growth and development. The UPS encompasses the ubiquitination of selected substrates followed by the proteasomal degradation of the modified proteins. Ubiquitin ligases, or E3s, are central to the UPS as they govern specificity and facilitate the attachment of one or more ubiquitin molecules to the substrate protein. From recent studies, the UPS has emerged as an important regulator of the uptake and translocation of essential macronutrients and micronutrients. In this review, we discuss select E3s that are involved in regulating nutrient uptake and responses to stress conditions, including limited or excess levels of nitrogen, phosphorus, iron, and copper.
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.867419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Role of the Ubiquitin Proteasome System in Plant Response to Abiotic Stress.

    Stone, Sophia L

    International review of cell and molecular biology

    2018  Volume 343, Page(s) 65–110

    Abstract: Ubiquitination is a prevalent post-translation modification system that is involved in almost all aspects of eukaryotic biology. It involves the attachment of ubiquitin, a small, highly conserved protein to selected substrates. The most notable function ... ...

    Abstract Ubiquitination is a prevalent post-translation modification system that is involved in almost all aspects of eukaryotic biology. It involves the attachment of ubiquitin, a small, highly conserved protein to selected substrates. The most notable function of ubiquitin is the targeting of modified proteins to the multi-proteolytic 26S proteasome complex for degradation. The ubiquitin proteasome system (UPS) regulates the abundance of numerous enzymes, structural and regulatory proteins ensuring proper cellular function. Plants utilize the UPS to facilitate cellular changes required to respond to and tolerate adverse growth conditions. In this review, the regulatory role of the UPS in responses to abiotic stress is discussed, particularly the function of ubiquitin-dependent degradation in the suppression, activation and attenuation or termination of stress signaling.
    MeSH term(s) Abscisic Acid/metabolism ; Animals ; Humans ; Plants/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Signal Transduction ; Stress, Physiological
    Chemical Substances Abscisic Acid (72S9A8J5GW) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2018-06-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2018.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.317: Show issues Location:
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  5. Article ; Online: An exploration into the impact of the COVID-19 pandemic on maternal mental health in high-and middle-income countries with a case study in East Sussex

    Sabesan, Abbeishna / Ackley, Caroline / Stone, Sophia

    medRxiv

    Abstract: Background  The physical isolation that the Coronavirus pandemic enforced resulted in a decline in mental health that disproportionally affected higher risk individuals, including women in the perinatal period. The wellbeing of perinatal women was, at ... ...

    Abstract Background  The physical isolation that the Coronavirus pandemic enforced resulted in a decline in mental health that disproportionally affected higher risk individuals, including women in the perinatal period. The wellbeing of perinatal women was, at times, neglected due to hospital and governmental isolation regulations. The aim of this study was to conduct a scoping review and Key Informant Interviews (KII) to identify gaps and opportunities for further research, and to distinguish discrepancies and correlations between the two sources of information.  Methods Two methods were utilised: a scoping review and KIIs. The scoping review identified relevant articles through a database search on Google Scholar, PubMed and EBSCO. The KIIs were conducted virtually with counsellors working in a maternal mental health charity in South-East England. Both methods collected qualitative data and were thematically analysed.  Results  95 articles were eligible for the review and 5 participants were recruited for the KIIs. Thematic analysis revealed 6 themes in both sources (1) demographics; (2) support; (3) policy; (4) insecurity; (5) anxiety; and (6) milestones. Between the two datasets there were no disparities in the impacts of changing policies, fear of the virus, and the grief caused by missing perinatal milestones on mental health. Significant discrepancies were identified in the influence of demographic characteristics, which was a risk factor for adverse mental health outcomes.  Conclusion  The most prominent theme in the review is the reduced support available, whilst the KIIs indicate that changing hospital policies are the main cause of harm to perinatal mental health. Birth trauma is deemed to be of significance in the interviews but not in the literature. Further research should focus on the impact of the pandemic on recovery  following birth trauma to identify long-term implications and facilitate policy changes to reduce the risk of birth trauma/ post-traumatic stress disorder.
    Keywords covid19
    Language English
    Publishing date 2023-11-03
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.11.02.23298002
    Database COVID19

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  6. Article ; Online: Quality of life improvements after bariatric surgery in reproductive age women with and without PCOS: a cohort study.

    Lacey, Hester / Attersley-Smith, Stephanie / Stone, Sophia / Whyte, Martin / Shawe, Jill / Hart, Kathryn

    Minerva obstetrics and gynecology

    2023  Volume 75, Issue 3, Page(s) 251–259

    Abstract: Background: Obesity can negatively influence quality of life (QoL). Polycystic ovarian syndrome (PCOS), associated with obesity, presents with sub-fertility, hyperandrogenism, and/or insulin resistance. These features can also negatively influence QoL. ... ...

    Abstract Background: Obesity can negatively influence quality of life (QoL). Polycystic ovarian syndrome (PCOS), associated with obesity, presents with sub-fertility, hyperandrogenism, and/or insulin resistance. These features can also negatively influence QoL. This study aimed to determine whether bariatric surgery improves QoL in women of reproductive age, with and without PCOS. We hypothesized greater QoL improvements would be seen post-operatively in women with PCOS.
    Methods: Women undergoing bariatric surgery (N.=77) completed questionnaires exploring health-related quality of life (HR-QoL) prior to and at 3, 6 and 12 months post-surgery. Weight loss, symptoms, and association with change in QoL were assessed.
    Results: Bariatric surgery resulted in significant QoL improvements, independent of PCOS status. Oligo/amenorrhea was reported in 68% of women at baseline, decreasing to 35% by 12 months. Sixty-five percent of women whose menstrual irregularity resolved over follow-up had PCOS. Hirsutism was reported in 64% of women at baseline (all of whom had PCOS), decreasing to 19% by 12 months. Weight loss at 12-months was 45.8±20.7 kg for women without PCOS compared to 44.3±16.8 kg in women with PCOS (P=0.07). Weight loss was moderately associated with 12-month QoL improvements for both groups.
    Conclusions: Bariatric surgery provides significant physical and psychological health benefits for women with obesity both with and without PCOS. Surgery can also ameliorate the clinical syndrome of PCOS, including oligomenorrhoea, hirsutism, and subfertility, with subsequent QoL benefits. Psychological support perioperatively may aid QoL outcomes by acknowledging factors influencing QoL beside absolute weight loss.
    MeSH term(s) Female ; Humans ; Bariatric Surgery/psychology ; Cohort Studies ; Obesity/complications ; Obesity/surgery ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/surgery ; Polycystic Ovary Syndrome/psychology ; Quality of Life
    Language English
    Publishing date 2023-05-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062815-5
    ISSN 2724-6450
    ISSN (online) 2724-6450
    DOI 10.23736/S2724-606X.21.05011-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.245: Show issues Location:
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  7. Article ; Online: Expression of a Heat Shock Protein 70 from the Brown Alga Ectocarpus sp. Imparts Salinity Stress Tolerance in Arabidopsis thaliana

    Rathor, Pramod / Borza, Tudor / Bahmani, Ramin / Stone, Sophia / Tonon, Thierry / Yurgel, Svetlana / Potin, Philippe / Prithiviraj, Balakrishnan

    J Appl Phycol. 2023 Apr., v. 35, no. 2 p.803-819

    2023  

    Abstract: The brown alga Ectocarpus sp. belongs to Phaeophyceae, a class of macroalgae in the phylum Heterokonts, which is also known as the Stramenopiles lineage. Ectocarpus is a dominant seaweed in temperate regions around the globe, abundant mostly in the ... ...

    Abstract The brown alga Ectocarpus sp. belongs to Phaeophyceae, a class of macroalgae in the phylum Heterokonts, which is also known as the Stramenopiles lineage. Ectocarpus is a dominant seaweed in temperate regions around the globe, abundant mostly in the intertidal zone, a habitat with harsh environmental conditions resulting from tidal cycles. Analysis of previously generated transcriptomic data of brown alga showed the up-regulation of the Esi0379_0027 gene, encoding a HSP70 protein, in response to various abiotic stresses. Bioinformatics study demonstrated that the HSP70 protein is soluble, monomeric and well conserved compared to other organisms. Subcellular localization of EsHSP70 revealed that the protein is localized in the nucleus. To explore the role of HSP70 in stress tolerance, it was expressed in Arabidopsis under constitutive and stress inducible promoters. Transgenic Arabidopsis plants generated using both promoters exhibited higher tolerance to salinity stress compared to wild type plant. Transcript analysis of various abiotic stress-responsive genes showed that genes participating in Na⁺ efflux and sequestration, and in ABA-mediated stress tolerance were remarkably upregulated in the EsHSP70-expressing transgenic Arabidopsis. Overall, our results showed that the expression of the EsHSP70 promotes salt stress tolerance by upregulating stress responsive genes in Arabidopsis.
    Keywords Arabidopsis thaliana ; Ectocarpus ; bioinformatics ; genes ; genetically modified organisms ; habitats ; heat-shock protein 70 ; littoral zone ; macroalgae ; salt stress ; salt tolerance ; stress tolerance ; transcriptomics
    Language English
    Dates of publication 2023-04
    Size p. 803-819.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 1002324-0
    ISSN 1573-5176 ; 0921-8971
    ISSN (online) 1573-5176
    ISSN 0921-8971
    DOI 10.1007/s10811-022-02897-7
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  8. Article: The role of ubiquitin and the 26S proteasome in plant abiotic stress signaling.

    Stone, Sophia L

    Frontiers in plant science

    2014  Volume 5, Page(s) 135

    Abstract: Ubiquitin is a small, highly conserved, ubiquitously expressed eukaryotic protein with immensely important and diverse regulatory functions. A well-studied function of ubiquitin is its role in selective proteolysis by the ubiquitin-proteasome system (UPS) ...

    Abstract Ubiquitin is a small, highly conserved, ubiquitously expressed eukaryotic protein with immensely important and diverse regulatory functions. A well-studied function of ubiquitin is its role in selective proteolysis by the ubiquitin-proteasome system (UPS). The UPS has emerged as an integral player in plant response and adaptation to environmental stresses such as drought, salinity, cold and nutrient deprivation. The UPS has also been shown to influence the production and signal transduction of stress-related hormones such as abscisic acid. Understanding UPS function has centered mainly on defining the role of E3 ubiquitin ligases, which are the substrate-recruiting component of the ubiquitination pathway. The recent identification of stress signaling/regulatory proteins that are the subject of ubiquitin-dependent degradation has increased our knowledge of how the UPS facilitates responses to adverse environmental conditions. A brief overview is provided on role of the UPS in modulating protein stability during abiotic stress signaling. E3 ubiquitin ligases for which stress-related substrate proteins have been identified are discussed.
    Language English
    Publishing date 2014-04-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2014.00135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Editorial: Structure, Function, and Evolution of E3 Ligases and Targets.

    Gingerich, Derek J / Hellmann, Hanjo / Christians, Matthew J / Stone, Sophia L

    Frontiers in plant science

    2021  Volume 12, Page(s) 767281

    Language English
    Publishing date 2021-10-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.767281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Letter to the Editor.

    von Guionneau, Alexandra / Burford, Charlotte / Stone, Sophia

    Obstetric medicine

    2019  Volume 12, Issue 3, Page(s) 154

    Language English
    Publishing date 2019-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612229-7
    ISSN 1753-4968 ; 1753-495X
    ISSN (online) 1753-4968
    ISSN 1753-495X
    DOI 10.1177/1753495X19842527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7029: Show issues Location:
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