Article ; Online: Alternagin-C, an alpha2beta1 integrin ligand, attenuates collagen-based adhesion, stimulating the metastasis suppressor 1 expression in triple-negative breast tumor cells.
Toxicon : official journal of the International Society on Toxinology
2022 Volume 210, Page(s) 1–10
Abstract: Triple-negative breast cancer has an aggressive clinical course and its treatment has been challenging due to high metastatic risk. Molecular targets have been sought to provide better strategies for this type of cancer. Integrins are cell adhesion ... ...
Abstract | Triple-negative breast cancer has an aggressive clinical course and its treatment has been challenging due to high metastatic risk. Molecular targets have been sought to provide better strategies for this type of cancer. Integrins are cell adhesion receptors involved in tumor progression and α |
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MeSH term(s) | Cell Adhesion/drug effects ; Collagen/metabolism ; Disintegrins/pharmacology ; Humans ; Integrin alpha2beta1/metabolism ; Integrins/genetics ; Integrins/metabolism ; Ligands ; Microfilament Proteins/biosynthesis ; Neoplasm Proteins/biosynthesis ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Tumor Microenvironment |
Chemical Substances | Disintegrins ; Integrin alpha2beta1 ; Integrins ; Ligands ; MTSS1 protein, human ; Microfilament Proteins ; Neoplasm Proteins ; alternagin-C ; Collagen (9007-34-5) |
Language | English |
Publishing date | 2022-02-09 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 204479-1 |
ISSN | 1879-3150 ; 0041-0101 |
ISSN (online) | 1879-3150 |
ISSN | 0041-0101 |
DOI | 10.1016/j.toxicon.2022.02.001 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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