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  1. AU="Stoufflet, Julie"
  2. AU="Min Kyu Kim"
  3. AU="Kutmon, M."
  4. AU="Christofoletti, Ronaldo Adriano"
  5. AU="Greice Machado Pieszak"

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  1. Artikel ; Online: The Primary Cilium and Neuronal Migration.

    Stoufflet, Julie / Caillé, Isabelle

    Cells

    2022  Band 11, Heft 21

    Abstract: The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons. The extremely severe phenotypes of ciliopathies have suggested their ... ...

    Abstract The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons. The extremely severe phenotypes of ciliopathies have suggested their paramount importance for multiple developmental events, including brain formation. Neuronal migration is an essential step of neural development, with all neurons traveling from their site of birth to their site of integration. Neurons perform a unique type of cellular migration called cyclic saltatory migration, where their soma periodically jumps along with the stereotyped movement of their centrosome. We will review here how the role of the PC on cell motility was first described in non-neuronal cells as a guide pointing to the direction of migration. We will see then how these findings are extended to neuronal migration. In neurons, the PC appears to regulate the rhythm of cyclic saltatory neuronal migration in multiple systems. Finally, we will review recent findings starting to elucidate how extracellular cues sensed by the PC could be intracellularly transduced to regulate the machinery of neuronal migration. The PC of migrating neurons was unexpectedly discovered to display a rhythmic extracellular emergence during each cycle of migration, with this transient exposure to the external environment associated with periodic transduction of cyclic adenosine monophosphate (cAMP) signaling at the centrosome. The PC in migrating neurons thus uniquely appears as a beat maker, regulating the tempo of cyclic saltatory migration.
    Mesh-Begriff(e) Cilia/metabolism ; Cell Movement/physiology ; Neurons/metabolism ; Centrosome ; Neurogenesis
    Sprache Englisch
    Erscheinungsdatum 2022-10-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11213384
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Shaping the cerebral cortex by cellular crosstalk.

    Stoufflet, Julie / Tielens, Sylvia / Nguyen, Laurent

    Cell

    2023  Band 186, Heft 13, Seite(n) 2733–2747

    Abstract: The cerebral cortex is the brain's outermost layer. It is responsible for processing motor and sensory information that support high-level cognitive abilities and shape personality. Its development and functional organization strongly rely on cell ... ...

    Abstract The cerebral cortex is the brain's outermost layer. It is responsible for processing motor and sensory information that support high-level cognitive abilities and shape personality. Its development and functional organization strongly rely on cell communication that is established via an intricate system of diffusible signals and physical contacts during development. Interfering with this cellular crosstalk can cause neurodevelopmental disorders. Here, we review how crosstalk between migrating cells and their environment influences cerebral cortex development, ranging from neurogenesis to synaptogenesis and assembly of cortical circuits.
    Mesh-Begriff(e) Cerebral Cortex ; Neurogenesis ; Cell Communication ; Cognition
    Sprache Englisch
    Erscheinungsdatum 2023-06-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.05.040
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: FMRP regulates postnatal neuronal migration via MAP1B.

    Messaoudi, Salima / Allam, Ada / Stoufflet, Julie / Paillard, Theo / Le Ven, Anaïs / Fouquet, Coralie / Doulazmi, Mohamed / Trembleau, Alain / Caille, Isabelle

    eLife

    2024  Band 12

    Abstract: The fragile X syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is the first monogenic cause of autism spectrum disorder. FXS results from the absence of the RNA-binding protein FMRP (fragile X messenger ... ...

    Abstract The fragile X syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is the first monogenic cause of autism spectrum disorder. FXS results from the absence of the RNA-binding protein FMRP (fragile X messenger ribonucleoprotein). Neuronal migration is an essential step of brain development allowing displacement of neurons from their germinal niches to their final integration site. The precise role of FMRP in neuronal migration remains largely unexplored. Using live imaging of postnatal rostral migratory stream (RMS) neurons in
    Mesh-Begriff(e) Fragile X Mental Retardation Protein/metabolism ; Fragile X Mental Retardation Protein/genetics ; Animals ; Neurons/metabolism ; Neurons/physiology ; Microtubule-Associated Proteins/metabolism ; Microtubule-Associated Proteins/genetics ; Cell Movement ; Mice ; Mice, Knockout ; Fragile X Syndrome/metabolism ; Fragile X Syndrome/genetics ; Gene Knockdown Techniques
    Chemische Substanzen microtubule-associated protein 1B ; Fmr1 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2024-05-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88782
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Oligodendrocyte precursors guide interneuron migration by unidirectional contact repulsion.

    Lepiemme, Fanny / Stoufflet, Julie / Javier-Torrent, Míriam / Mazzucchelli, Gabriel / Silva, Carla G / Nguyen, Laurent

    Science (New York, N.Y.)

    2022  Band 376, Heft 6595, Seite(n) eabn6204

    Abstract: In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. ... ...

    Abstract In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. By coupling histological analysis of genetic models with live imaging, we show that although they are both attracted by the chemokine Cxcl12, vOPCs and cortical interneurons occupy mutually exclusive forebrain territories enriched in this chemokine. Moreover, first-wave vOPC depletion selectively disrupts the migration and distribution of cortical interneurons. At the cellular level, we found that by promoting unidirectional contact repulsion, first-wave vOPCs steered the migration of cortical interneurons away from the blood vessels to which they were both attracted, thereby allowing interneurons to reach their proper cortical territories.
    Mesh-Begriff(e) Animals ; Cell Movement/genetics ; Cerebral Cortex/cytology ; Cerebral Cortex/embryology ; Chemokine CXCL12/metabolism ; Interneurons/physiology ; Mice ; Models, Genetic ; Neurogenesis/genetics ; Oligodendrocyte Precursor Cells/cytology ; Oligodendrocyte Precursor Cells/physiology
    Chemische Substanzen Chemokine CXCL12 ; Cxcl12 protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2022-05-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abn6204
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 27: Hefte anzeigen Standort:
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  5. Artikel: FMRP regulates tangential neuronal migration via MAP1B.

    Messaoudi, Salima / Allam, Ada / Stoufflet, Julie / Paillard, Théo / Fouquet, Coralie / Doulazmi, Mohamed / Le Ven, Anaïs / Trembleau, Alain / Caillé, Isabelle

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The Fragile X Syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is the first monogenic cause of Autism Spectrum Disorder. FXS results from the absence of the RNA-binding protein FMRP (Fragile X Messenger ... ...

    Abstract The Fragile X Syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is the first monogenic cause of Autism Spectrum Disorder. FXS results from the absence of the RNA-binding protein FMRP (Fragile X Messenger Ribonucleoprotein). Neuronal migration is an essential step of brain development allowing displacement of neurons from their germinal niches to their final integration site. The precise role of FMRP in neuronal migration remains largely unexplored. Using live imaging of postnatal Rostral Migratory Stream (RMS) neurons in Fmr1-null mice, we observed that the absence of FMRP leads to delayed neuronal migration and altered trajectory, associated with defects of centrosomal movement. RNA-interference-induced knockdown of
    Sprache Englisch
    Erscheinungsdatum 2023-12-28
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.03.06.530447
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration.

    Stoufflet, Julie / Chaulet, Maxime / Doulazmi, Mohamed / Fouquet, Coralie / Dubacq, Caroline / Métin, Christine / Schneider-Maunoury, Sylvie / Trembleau, Alain / Vincent, Pierre / Caillé, Isabelle

    Science advances

    2020  Band 6, Heft 36

    Abstract: The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the surface of most eukaryotic cells. It plays a key role in cell migration, but the underlying mechanisms are unknown. Here, we show that the PC regulates neuronal ... ...

    Abstract The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the surface of most eukaryotic cells. It plays a key role in cell migration, but the underlying mechanisms are unknown. Here, we show that the PC regulates neuronal migration via cyclic adenosine 3'-5' monosphosphate (cAMP) production activating centrosomal protein kinase A (PKA). Biosensor live imaging revealed a periodic cAMP hotspot at the centrosome of embryonic, postnatal, and adult migrating neurons. Genetic ablation of the PC, or knockdown of ciliary adenylate cyclase 3, caused hotspot disappearance and migratory defects, with defective centrosome dynamics and altered nucleokinesis. Delocalization of PKA from the centrosome phenocopied the migratory defects. Our results show that the PC and centrosome form a single cAMP signaling unit dynamically regulating migration, further highlighting the centrosome as a signaling hub.
    Mesh-Begriff(e) Adenosine/metabolism ; Cell Movement ; Centrosome/metabolism ; Cilia ; Cyclic AMP-Dependent Protein Kinases/metabolism
    Chemische Substanzen Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Adenosine (K72T3FS567)
    Sprache Englisch
    Erscheinungsdatum 2020-09-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aba3992
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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