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  1. Article ; Online: Delayed hypersensitivity to the Comirnaty coronavirus disease 2019 vaccine presenting with pneumonitis and rash.

    Stoyanov, Alex / Thompson, Graeme / Lee, Monique / Katelaris, Connie

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2021  Volume 128, Issue 3, Page(s) 321–322

    MeSH term(s) Alveolitis, Extrinsic Allergic/diagnosis ; COVID-19 ; COVID-19 Vaccines/adverse effects ; Exanthema ; Humans ; Hypersensitivity, Delayed/diagnosis ; Pneumonia ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2021.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Musical hallucinations: a rare and atypical presentation of anti-IgLON5 disease responsive to immunosuppressive therapy.

    Stoyanov, Alex / McDougall, Alan / Urriola, Nicolas

    BMJ case reports

    2021  Volume 14, Issue 2

    Abstract: IgLON5 antibodies are typically associated with the insidious onset of sleep disorder, parasomnia, gait disturbance and abnormal movements, with variable response to immunosuppressive therapy. We describe a case of a 50-year-old man who presented with ... ...

    Abstract IgLON5 antibodies are typically associated with the insidious onset of sleep disorder, parasomnia, gait disturbance and abnormal movements, with variable response to immunosuppressive therapy. We describe a case of a 50-year-old man who presented with acute speech difficulties, headache and focal seizures followed by well-formed visual hallucinations, and later, musical hallucinations of mainstream popular music. MRI of the brain demonstrated right temporal lobe changes with corresponding epileptiform activity seen on electroencephalogram. Subsequently, IgLON5 antibodies were detected in the serum. The patient was treated with anticonvulsants, as well as azathioprine with a tapering oral prednisone course with a complete resolution of the symptoms. Our case demonstrates an unusual presentation of the rare but increasingly described anti-IgLON5 disease, with musical hallucinations. The case highlights the variable and evolving clinical phenotypes that can be seen in autoimmune central nervous system disorders.
    MeSH term(s) Cell Adhesion Molecules, Neuronal ; Encephalitis ; Hallucinations/drug therapy ; Hashimoto Disease ; Humans ; Male ; Middle Aged ; Music ; Parasomnias
    Chemical Substances Cell Adhesion Molecules, Neuronal ; IgLON5 protein, human
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Serum protein electrophoresis and rheumatoid factor analysis is an effective screening strategy for cryoglobulinaemia.

    Stoyanov, Alex / Toong, Catherine / Kong, Yvonne / Chen, Renfen / Urriola, Nicolás

    Pathology

    2022  Volume 55, Issue 3, Page(s) 391–396

    Abstract: Accurate serum cryoglobulin detection is important to allow prompt treatment but laboratory testing requires stringent pre-analytical conditions and has long turnaround times. Serum protein electrophoresis (EPG) for paraproteinaemia and rheumatoid factor ...

    Abstract Accurate serum cryoglobulin detection is important to allow prompt treatment but laboratory testing requires stringent pre-analytical conditions and has long turnaround times. Serum protein electrophoresis (EPG) for paraproteinaemia and rheumatoid factor (RF) analysis may offer an effective initial screening strategy for the presence of cryoglobulinaemia. We retrospectively assessed the sensitivity of ancillary EPG and RF testing for the presence of serum cryoglobulinaemia in 586 eligible cryoglobulin positive samples received at the Royal Prince Alfred and Liverpool Hospital immunopathology laboratories over an 11-year period. Ninety-one percent of all cryoglobulin positive samples had either a detectable paraprotein or RF activity, with greatest sensitivity for type I and type II cryoglobulins (97% and 98%, respectively). The sensitivity remained high irrespective of whether EPG and RF analysis was performed with the same, or different, pre-analytical collection conditions to the cryoglobulin collection (92% vs 90%, p=0.46). Only two patients with detected cryoglobulins and no associated paraprotein or RF activity had clinical features of cryoglobulinaemia and neither required treatment. This study demonstrates that serum EPG and RF analysis has high sensitivity for the detection of clinically relevant cryoglobulinaemia, even when not collected under ideal pre-analytical conditions, and potentially offers a prompt and effective screening strategy.
    MeSH term(s) Humans ; Cryoglobulinemia/diagnosis ; Cryoglobulins ; Rheumatoid Factor ; Retrospective Studies ; Electrophoresis ; Paraproteins
    Chemical Substances Cryoglobulins ; Rheumatoid Factor (9009-79-4) ; Paraproteins
    Language English
    Publishing date 2022-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2022.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Is the risk of motor neuron disease increased or decreased after cancer? An Australian case-control study.

    Stoyanov, Alex / Pamphlett, Roger

    PloS one

    2014  Volume 9, Issue 7, Page(s) e103572

    Abstract: Cancer appears to be inversely associated with both Alzheimer's and Parkinson's disease. The relationship between cancer and sporadic motor neuron disease (SMND), however, remains uncertain. Most previous cancer-SMND studies have been undertaken in ... ...

    Abstract Cancer appears to be inversely associated with both Alzheimer's and Parkinson's disease. The relationship between cancer and sporadic motor neuron disease (SMND), however, remains uncertain. Most previous cancer-SMND studies have been undertaken in northern hemisphere populations. We therefore undertook a case-control study to see if a link between cancer and SMND exists in an Australian population. A questionnaire was used to compare past cancer diagnoses in 739 SMND patients and 622 controls, recruited across Australia. Odds ratios with 95% confidence intervals were calculated to look for associations between cancer and SMND. A history of cancer was not associated either positively or negatively with a risk of subsequent SMND. This result remained when age, gender, smoking status, and the four SMND diagnostic subgroups were taken into account. No association was observed between SMND and specific tumours, including melanoma, a common malignancy in Australia. In conclusion, this Australian case-control study does not support an association between a past history of cancer and the development of SMND. This suggests that some pathogenetic mechanisms, such as apoptosis, are less relevant in SMND than in other neurodegenerative diseases where negative associations with cancer have been found.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Australia/epidemiology ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Motor Neuron Disease/epidemiology ; Neoplasms/epidemiology ; Odds Ratio ; Risk Factors ; Smoking/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2014-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0103572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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