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Artikel: Vertebral osteomyelitis with

Greminger, Simone / Strahm, Carol / Notter, Julia / Martens, Benjamin / Helfenstein, Seth Florian / Den Hollander, Jürgen / Frischknecht, Manuel

Journal of bone and joint infection

2024 Band 9, Heft 1, Seite(n) 59–65

Abstract: Infections ... ...

Abstract	Infections with
Sprache	Englisch
Erscheinungsdatum	2024-02-12
Erscheinungsland	Germany
Dokumenttyp	Case Reports
ISSN	2206-3552
ISSN	2206-3552
DOI	10.5194/jbji-9-59-2024
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evolution of symptoms compatible with post-acute sequelae of SARS-CoV-2 (PASC) after Wild-type and/or Omicron BA.1 infection: A prospective healthcare worker cohort.

Strahm, Carol / Kahlert, Christian R / Güsewell, Sabine / Vuichard-Gysin, Danielle / Stocker, Reto / Kuster, Stefan P / Kohler, Philipp

The Journal of infection

2023 Band 88, Heft 2, Seite(n) 200–202

Mesh-Begriff(e)	Humans ; COVID-19 ; Prospective Studies ; SARS-CoV-2
Sprache	Englisch
Erscheinungsdatum	2023-12-07
Erscheinungsland	England
Dokumenttyp	Letter
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2023.12.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Accuracy of Synovial Leukocyte and Polymorphonuclear Cell Count in Patients with Shoulder Prosthetic Joint Infection.

Strahm, Carol / Zdravkovic, Vilijam / Egidy, Claus / Jost, Bernhard

Journal of bone and joint infection

2018 Band 3, Heft 5, Seite(n) 245–248

Abstract: Joint aspiration in suspected infected implants is a validated diagnostic method in establishing the diagnosis of prosthetic joint infection (PJI). Cut-off values for synovial leukocyte counts and differentials are well described for patients with hip ... ...

Abstract	Joint aspiration in suspected infected implants is a validated diagnostic method in establishing the diagnosis of prosthetic joint infection (PJI). Cut-off values for synovial leukocyte counts and differentials are well described for patients with hip and knee PJI. In 19 failed shoulder implants, a leucocyte count of >12.2 G/L had a sensitivity and specificity of 92% and 100% respectively; A differential of >54% neutrophils had a sensitivity of 100 % and a specificity of 75%.
Sprache	Englisch
Erscheinungsdatum	2018-11-11
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ISSN	2206-3552
ISSN	2206-3552
DOI	10.7150/jbji.29289
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Osteoarticular and skin and soft-tissue infections caused by Streptococcus agalactiae in elderly patients are frequently associated with bacteremia.

Ruppen, Corinne / Notter, Julia / Strahm, Carol / Sonderegger, Beat / Sendi, Parham

Diagnostic microbiology and infectious disease

2018 Band 90, Heft 1, Seite(n) 55–57

Abstract: Older persons (≥65 years) are at risk for invasive group B streptococcal (GBS) infections. The most frequent clinical syndromes in 174 infection episodes were osteoarticular (40%) and skin and soft-tissue infections (30%). In 36% of episodes, a companion ...

Abstract	Older persons (≥65 years) are at risk for invasive group B streptococcal (GBS) infections. The most frequent clinical syndromes in 174 infection episodes were osteoarticular (40%) and skin and soft-tissue infections (30%). In 36% of episodes, a companion microorganism was isolated, and in 45%, blood culture results were positive. Antibiotics were streamlined after species identification in 29% of monomicrobial infections. These findings have clinical and therapeutic implications for GBS infections in the elderly.
Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Blood Culture ; Female ; Humans ; Male ; Retrospective Studies ; Skin/microbiology ; Skin Diseases, Infectious/drug therapy ; Skin Diseases, Infectious/microbiology ; Skin Diseases, Infectious/mortality ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/microbiology ; Soft Tissue Infections/mortality ; Streptococcal Infections/drug therapy ; Streptococcal Infections/microbiology ; Streptococcal Infections/mortality ; Streptococcus agalactiae/drug effects ; Streptococcus agalactiae/isolation & purification
Chemische Substanzen	Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2018-01
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Multicenter Study
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2017.09.008
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Short-interval two-stage approach to primary total knee arthroplasty for acutely septic osteoarthritic knees.

Hochreiter, Bettina / Strahm, Carol / Behrend, Henrik

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

2016 Band 24, Heft 10, Seite(n) 3115–3121

Abstract: Treatment strategies for advanced knee osteoarthritis with coexistent joint infection are not well established. While in periprosthetic joint infection the two-stage approach has been studied extensively, only few case reports on two-stage total knee ... ...

Abstract	Treatment strategies for advanced knee osteoarthritis with coexistent joint infection are not well established. While in periprosthetic joint infection the two-stage approach has been studied extensively, only few case reports on two-stage total knee arthroplasty (TKA) for knee osteoarthritis with coexistent joint infection have been published. The purpose of this paper was to report on our method of implementing a two-stage TKA with intervening antibiotic-loaded articulating cement spacers and a short interval between first- and second-stage procedures to treat two patients with Staphylococcus aureus-infected end-stage knee osteoarthritis. Consistent infection eradication was found at a 1-year follow-up with postoperative range of motion and knee scores comparing favourably with those of other case series. Level of evidence V.
Mesh-Begriff(e)	Aged ; Anti-Bacterial Agents/administration & dosage ; Arthritis, Infectious/microbiology ; Arthritis, Infectious/surgery ; Arthroplasty, Replacement, Knee/methods ; Bone Cements ; Drug Delivery Systems ; Humans ; Knee Joint/microbiology ; Knee Joint/surgery ; Knee Prosthesis ; Male ; Middle Aged ; Osteoarthritis, Knee/surgery ; Range of Motion, Articular ; Staphylococcal Infections/therapy
Chemische Substanzen	Anti-Bacterial Agents ; Bone Cements
Sprache	Englisch
Erscheinungsdatum	2016-10
Erscheinungsland	Germany
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	1159064-6
ISSN	1433-7347 ; 0942-2056
ISSN (online)	1433-7347
ISSN	0942-2056
DOI	10.1007/s00167-016-3982-8
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Factors to Consider When Assessing the Diagnostic Accuracy of Synovial Leukocyte Count in Periprosthetic Joint Infection.

Ottink, Karsten D / Strahm, Carol / Muller-Kobold, Anneke / Sendi, Parham / Wouthuyzen-Bakker, Marjan

Journal of bone and joint infection

2019 Band 4, Heft 4, Seite(n) 167–173

Abstract: Synovial white blood cell (WBC) count and the percentage of polymorphonuclear leucocytes (PMN%) is one of the diagnostic criteria to diagnose a periprosthetic joint infection (PJI). Although the test is widely available, the diagnostic accuracy of ... ...

Abstract	Synovial white blood cell (WBC) count and the percentage of polymorphonuclear leucocytes (PMN%) is one of the diagnostic criteria to diagnose a periprosthetic joint infection (PJI). Although the test is widely available, the diagnostic accuracy of proposed cut-off levels are influenced by several factors, such as: the affected joint, co-morbid conditions, the causative microorganism and the gathering and processing of samples in the laboratory. In this narrative review we provide an overview on how and to what extent these factors can affect the synovial WBC count and PMN% in synovial fluid.
Sprache	Englisch
Erscheinungsdatum	2019-08-02
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Review
ISSN	2206-3552
ISSN	2206-3552
DOI	10.7150/jbji.34854
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Septic arthritis due to streptococci and enterococci in native joints: a 13 year retrospective study.

Lotz, Helene / Strahm, Carol / Zdravkovic, Vilijam / Jost, Bernhard / Albrich, Werner C

Infection

2019 Band 47, Heft 5, Seite(n) 761–770

Abstract: Objectives: Streptococcal species are the second most common cause of native joint septic arthritis (SA). However, there are few systematic data about streptococcal SA.: Methods: The medical records of adults with SA caused by streptococci, ... ...

Abstract	Objectives: Streptococcal species are the second most common cause of native joint septic arthritis (SA). However, there are few systematic data about streptococcal SA. Methods: The medical records of adults with SA caused by streptococci, pneumococci, and enterococci at our tertiary care centre between 2003 and 2015 were reviewed. Results: 71 patients (34% female) with 83 affected joints were included. Median age was 62 years. A single joint was involved in 62 patients (87%). One or more comorbidities were present in 58 patients (82%). 16 patients (23%) had a concomitant soft-tissue infection overlying the affected joint. The hematogenous route was the dominating pathogenesis (42/71, 59%). 9 (13%) patients were diagnosed with endocarditis. The knee was the most commonly affected joint (27/83, 33%) followed by shoulder (13/83, 16%). ß-haemolytic streptococci were most commonly identified (37/71, 52%) followed by polymicrobial infections (12/71, 17%). Surgical interventions included arthroscopic irrigation and debridement in 31 (44%), arthrotomy in 23 (32%), and amputation in five patients (7%). Median duration of antimicrobial therapy was 42 days. Antibiotic treatment without any surgical intervention was performed in 5 (7%) patients. Outcome was good in 55 (89%) patients; mortality was 13% with four of nine deaths attributed to joint infection. Age and pathogen group independently predicted poor outcome in recursive partitioning analysis. Conclusions: Streptococcal SA was mostly due to ß-haemolytic streptococci in older and polymorbid patients. Old age, anginosus group streptococci, enterococci, and polymicrobial infections predicted poor outcome, while antibiotic treatment duration can likely be shortened.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/drug therapy ; Arthritis, Infectious/microbiology ; Arthritis, Infectious/mortality ; Debridement ; Endocarditis, Bacterial/etiology ; Enterococcus/drug effects ; Enterococcus/pathogenicity ; Female ; Gram-Positive Bacterial Infections/complications ; Humans ; Knee Joint/microbiology ; Male ; Medical Records ; Middle Aged ; Pneumococcal Infections/complications ; Retrospective Studies ; Streptococcal Infections/complications ; Streptococcus/drug effects ; Streptococcus/pathogenicity ; Streptococcus pneumoniae/pathogenicity ; Young Adult
Chemische Substanzen	Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2019-03-30
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-019-01301-w
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: AmpC hyperproduction in a Cedecea davisae implant-associated bone infection during treatment: a case report and therapeutic implications.

Notter, Julia / Seiffert, Salome N / Zimmermann-Kogadeeva, Maria / Bösch, Anja / Wenger, Robert / Strahm, Carol / Frischknecht, Manuel / Livermore, David M / Babouee Flury, Baharak

BMC infectious diseases

2022 Band 22, Heft 1, Seite(n) 33

Abstract: Background: Data on antimicrobial resistance mechanisms are scanty for Cedecea spp., with very variable antibiotic resistance patterns documented. Here we report the first in vivo resistance evolution of a C. davisae clinical isolate in a patient with a ...

Abstract	Background: Data on antimicrobial resistance mechanisms are scanty for Cedecea spp., with very variable antibiotic resistance patterns documented. Here we report the first in vivo resistance evolution of a C. davisae clinical isolate in a patient with a complex hand trauma and provide insight in the resistance mechanism, leading to therapeutic implications for this pathogen. Case presentation: Cedecea davisae was isolated from a patient with hand trauma during a first surgical debridement. Six days after primary surgical treatment and under antimicrobial treatment with amoxicillin-clavulanic acid and later cefepime, follow up cultures yielded C. davisae which demonstrated a resistance development. The susceptible parental isolate and its resistant derivative were characterized by whole genome sequencing, ampC, ompC and ompF by RT- PCR. The resistant derivative demonstrated an A224G SNP in ampD, the transcriptional regulator of ampC, leading to a His75Arg change in the corresponding AmpD protein. AmpC transcription of the resistant derivative was 362-times higher than the susceptible isolate. Transcription levels of ompF and ompC were 8.5-fold and 1.3-fold lower, respectively, in the resistant derivative. Downregulation of OmpF putatively resulted from a mutation in the presumed promoter region upstream of the dusB-Fis operon, a proposed regulator for ompF. Conclusions: This case demonstrates the in vivo resistance development of C. davisae within 7 days similar to that of the members of the Enterobacter cloacae complex. Our findings add valuable information for future therapeutic management of these opportunistic pathogens as they warrant the same empirical treatment as AmpC producers.
Mesh-Begriff(e)	Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins/genetics ; Enterobacteriaceae ; Humans ; Microbial Sensitivity Tests ; beta-Lactamases/genetics
Chemische Substanzen	Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6)
Sprache	Englisch
Erscheinungsdatum	2022-01-06
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-021-07000-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Clinical and Imaging Features of COVID-19-Associated Pulmonary Aspergillosis.

Fischer, Tim / El Baz, Yassir / Graf, Nicole / Wildermuth, Simon / Leschka, Sebastian / Kleger, Gian-Reto / Pietsch, Urs / Frischknecht, Manuel / Scanferla, Giulia / Strahm, Carol / Wälti, Stephan / Dietrich, Tobias Johannes / Albrich, Werner C

Diagnostics (Basel, Switzerland)

2022 Band 12, Heft 5

Abstract: Background: COVID-19 superinfection by Aspergillus (COVID-19-associated aspergillosis, CAPA) is increasingly observed due to increased awareness and use of corticosteroids. The aim of this study is to compare clinical and imaging features between COVID- ... ...

Abstract	Background: COVID-19 superinfection by Aspergillus (COVID-19-associated aspergillosis, CAPA) is increasingly observed due to increased awareness and use of corticosteroids. The aim of this study is to compare clinical and imaging features between COVID-19 patients with and without associated pulmonary aspergillosis. Material and methods: In this case-control study, hospitalized patients between March 2020 and March 2021 were evaluated. Two observers independently compared 105 chest CTs of 52 COVID-19 patients without pulmonary aspergillosis to 40 chest CTs of 13 CAPA patients. The following features were evaluated: lung involvement, predominant main pattern (ground glass opacity, crazy paving, consolidation) and additional lung and chest findings. Chronological changes in the abnormal extent upon CT and chronological changes in the main patterns were compared with mixed models. Patient-wise comparisons of additional features and demographic and clinical data were performed using Student's t-test, Chi-squared test, Fisher's exact tests and Wilcoxon rank-sum tests. Results: Compared to COVID-19 patients without pulmonary aspergillosis, CAPA patients were older (mean age (±SD): 70.3 (±7.8) versus 63.5 (±9.5) years ( Conclusions: CAPA patients showed a tendency for consolidation in early COVID-19 disease. Bronchial wall thickening and higher patient age were associated with CAPA. The overall lung involvement was similar between both groups.
Sprache	Englisch
Erscheinungsdatum	2022-05-11
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12051201
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Infection Rate after Cranial Neurosurgical Procedures: A Prospective Single-Center Study.

Strahm, Carol / Albrich, Werner C / Zdravkovic, Vilijam / Schöbi, Barbara / Hildebrandt, Gerhard / Schlegel, Matthias

World neurosurgery

2018 Band 111, Seite(n) e277–e285

Abstract: Objective: To determine infection rate (IR) and to identify modifiable risk factors (RF) in cranial neurosurgery in a neurosurgical department for tertiary referral as part of an infection control surveillance to reduce surgical site infections (SSI).!## ...

Abstract	Objective: To determine infection rate (IR) and to identify modifiable risk factors (RF) in cranial neurosurgery in a neurosurgical department for tertiary referral as part of an infection control surveillance to reduce surgical site infections (SSI). Methods: A prospective SSI incidence cohort study from February 2013 to January 2014 was performed in a tertiary-care neurosurgical teaching hospital and referral center. All consecutive adults undergoing any cranial neurosurgical procedure were included. Data were collected by a trained member of the infection control staff during the twice-weekly visits of the hospitalized patients. Follow-up was 30 days (procedures without implant) and 1 year (procedures involving permanent implants). SSI was diagnosed according to criteria of CDC. Results: A total of 317 patients undergoing 333 index procedures were included. The median age was 61 years (range, 17-91 years) and 46% were female. Survival in patients with completed follow-up was 76% (196/258). Overall, IR was 7.2% (24/333 index procedures); in 96% (23/24), a neurosurgical implant was involved. The IR of extraventricular drainage (EVD) was 12.5% (13.1/1000 EVD days). The main causative pathogens were Staphylococcus aureus followed by coagulase-negative staphylococci and Propionibacterium acnes. Independent RF for neurosurgical SSI were EVD as part of the index operation and body mass index >25 kg/m Conclusions: IR was in accordance with recent prospective single-center studies (reported IR between 1.6% and 9%). EVD placement was identified as the strongest modifiable RF for SSI in cranial neurosurgical procedures. The need for standard infection control procedures for the insertion and maintenance of EVDs to avoid their contamination is reinforced.
Mesh-Begriff(e)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Neurosurgical Procedures/adverse effects ; Prospective Studies ; Skull/surgery ; Surgical Wound Infection/epidemiology ; Young Adult
Sprache	Englisch
Erscheinungsdatum	2018-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2017.12.062
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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