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Article ; Online: Trauma-Informed Care in Pediatrics: A Developmental Perspective in Twelve Cases with Narratives.

Strait, Joshua / Meagher, Sean

2019 Volume 24

Abstract: Introduction: The dose-response relationship of adverse childhood experiences (ACEs) with chronic morbidities is recognized as prevalent. However, screening for ACEs and implementing trauma-informed care (TIC) have yet to become a standard of care in ... ...

Abstract	Introduction: The dose-response relationship of adverse childhood experiences (ACEs) with chronic morbidities is recognized as prevalent. However, screening for ACEs and implementing trauma-informed care (TIC) have yet to become a standard of care in pediatrics. Objectives: To document impactful developmental experiences of implementing TIC and universal screening of ACEs in the pediatric setting, elucidate the relationship between ACEs and their common presentation of developmental and behavioral health problems in pediatric patients, and propose feasible system changes to promote evidence-based professional expertise. Methods: During pediatric residency training, I implemented routine universal screening of pediatric patients using ACE questionnaires. Research-based trauma-informed practices, such as patient-centered communication regarding adverse health outcomes associated with prevalent ACEs, were used. Clinical vignettes describe 12 cases. Results: Most patients and their families were receptive to counsel on recognizing, preventing, and mitigating the effects of toxic stress resulting from ACEs. Behavior in a patient, and sometimes a parent, was addressed from a developmentally sensitive lens of TIC, and appropriate therapeutic interventions were discussed. Addressing ACEs opened crucial conversations with some patients, which promoted efficacious, developmentally sensitive care. Discussion: Implementing TIC in the pediatric setting, especially in training, is not only feasible but also vital to adequately understand the patient population. Equipped with clinical knowledge and experience in addressing ACEs, practitioners will more readily empower patients and their families to improve health outcomes. Conclusion: When pediatric practitioners discover, intervene, and address the adverse effects of ACEs, their care becomes more efficacious and evidence based.
MeSH term(s)	Adolescent ; Adverse Childhood Experiences/prevention & control ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Inservice Training/organization & administration ; Male ; Mass Screening/organization & administration ; Mental Disorders/diagnosis ; Mental Disorders/therapy ; Patient-Centered Care/organization & administration ; Pediatrics/organization & administration ; Stress, Psychological/epidemiology ; Stress, Psychological/prevention & control
Language	English
Publishing date	2019-12-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2062823-7
ISSN	1552-5775 ; 1552-5775
ISSN (online)	1552-5775
ISSN	1552-5775
DOI	10.7812/TPP/19.045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Automatic Detection and Uncertainty Quantification of Landmarks on Elastic Curves.

Strait, Justin / Chkrebtii, Oksana / Kurtek, Sebastian

Journal of the American Statistical Association

2019 Volume 114, Issue 527, Page(s) 1002–1017

Abstract: A population quantity of interest in statistical shape analysis is the location of landmarks, which are points that aid in reconstructing and representing shapes of objects. We provide an automated, model-based approach to inferring landmarks given a ... ...

Abstract	A population quantity of interest in statistical shape analysis is the location of landmarks, which are points that aid in reconstructing and representing shapes of objects. We provide an automated, model-based approach to inferring landmarks given a sample of shape data. The model is formulated based on a linear reconstruction of the shape, passing through the specified points, and a Bayesian inferential approach is described for estimating unknown landmark locations. The question of how many landmarks to select is addressed in two different ways: (1) by defining a criterion-based approach, and (2) joint estimation of the number of landmarks along with their locations. Efficient methods for posterior sampling are also discussed. We motivate our approach using several simulated examples, as well as data obtained from applications in computer vision, biology and medical imaging.
Language	English
Publishing date	2019-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2064981-2
ISSN	1537-274X ; 0162-1459 ; 0003-1291
ISSN (online)	1537-274X
ISSN	0162-1459 ; 0003-1291
DOI	10.1080/01621459.2018.1527224
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Parallel tempering strategies for model-based landmark detection on shapes.

Strait, Justin / Chkrebtii, Oksana / Kurtek, Sebastian

Communications in statistics: Simulation and computation

2019 Volume 51, Issue 4, Page(s) 1415–1435

Abstract: In the field of shape analysis, landmarks are defined as a low-dimensional, representative set of important features of an object's shape that can be used to identify regions of interest along its outline. An important problem is to infer the number and ... ...

Abstract	In the field of shape analysis, landmarks are defined as a low-dimensional, representative set of important features of an object's shape that can be used to identify regions of interest along its outline. An important problem is to infer the number and arrangement of landmarks, given a set of shapes drawn from a population. One proposed approach defines a posterior distribution over landmark locations by associating each landmark configuration with a linear reconstruction of the shape. In practice, sampling from the resulting posterior density is challenging using standard Markov chain Monte Carlo (MCMC) methods because multiple configurations of landmarks can describe a complex shape similarly well, manifesting in a multi-modal posterior with well-separated modes. Standard MCMC methods traverse multi-modal posteriors poorly and, even when multiple modes are identified, the relative amount of time spent in each one can be misleading. We apply new advances in the parallel tempering literature to the problem of landmark detection, providing guidance on implementation generalized to other applications within shape analysis. Proposal adaptation is used during burn-in to ensure efficient traversal of the parameter space while maintaining computational efficiency. We demonstrate this algorithm on simulated data and common shapes obtained from computer vision scenes.
Language	English
Publishing date	2019-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1476872-0
ISSN	1532-4141 ; 0361-0918
ISSN (online)	1532-4141
ISSN	0361-0918
DOI	10.1080/03610918.2019.1670843
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Automatic Detection and Uncertainty Quantification of Landmarks on Elastic Curves

Strait, Justin / Chkrebtii, Oksana / Kurtek, Sebastian

Journal of the American Statistical Association. 2019 July 3, v. 114, no. 527

2019

Abstract	A population quantity of interest in statistical shape analysis is the location of landmarks, which are points that aid in reconstructing and representing shapes of objects. We provide an automated, model-based approach to inferring landmarks given a sample of shape data. The model is formulated based on a linear reconstruction of the shape, passing through the specified points, and a Bayesian inferential approach is described for estimating unknown landmark locations. The question of how many landmarks to select is addressed in two different ways: (1) by defining a criterion-based approach and (2) joint estimation of the number of landmarks along with their locations. Efficient methods for posterior sampling are also discussed. We motivate our approach using several simulated examples, as well as data obtained from applications in computer vision, biology, and medical imaging. Supplementary materials for this article, including a standardized description of the materials available for reproducing the work, are available as an online supplement.
Keywords	Bayesian theory ; automatic detection ; computer vision ; equations ; image analysis ; models ; uncertainty
Language	English
Dates of publication	2019-0703
Size	p. 1002-1017.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2064981-2
ISSN	1537-274X ; 0003-1291 ; 0162-1459
ISSN (online)	1537-274X
ISSN	0003-1291 ; 0162-1459
DOI	10.1080/01621459.2018.1527224
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Combining Geometric and Topological Information for Boundary Estimation

Luo, Hengrui / Strait, Justin

2019

Abstract: A fundamental problem in computer vision is boundary estimation, where the goal is to delineate the boundary of objects in an image. In this paper, we propose a method which jointly incorporates geometric and topological information within an image to ... ...

Abstract	A fundamental problem in computer vision is boundary estimation, where the goal is to delineate the boundary of objects in an image. In this paper, we propose a method which jointly incorporates geometric and topological information within an image to simultaneously estimate boundaries for objects within images with more complex topologies. We use a topological clustering-based method to assist initialization of the Bayesian active contour model. This combines pixel clustering, boundary smoothness, and potential prior shape information to produce an estimated object boundary. Active contour methods are knownto be extremely sensitive to algorithm initialization, relying on the user to provide a reasonable starting curve to the algorithm. In the presence of images featuring objects with complex topological structures, such as objects with holes or multiple objects, the user must initialize separate curves for each boundary of interest. Our proposed topologically-guided method can provide an interpretable, smart initialization in these settings, freeing up the user from potential pitfalls associated with objects of complex topological structure. We provide a detailed simulation study comparing our initialization to boundary estimates obtained from standard segmentation algorithms. The method is demonstrated on artificial image datasets from computer vision, as well as real-world applications to skin lesion and neural cellular images, for which multiple topological features can be identified. Comment: 38 pages with appendices, 15 figures
Keywords	Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning ; Statistics - Machine Learning
Subject code	004 ; 006
Publishing date	2019-10-10
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Consideration of Personal Adverse Childhood Experiences during Implementation of Trauma-Informed Care Curriculum in Graduate Health Programs.

Strait, Joshua / Bolman, Tiffany

The Permanente journal

2016 Volume 21, Page(s) 16–61

Abstract: Context: Scientific findings of adverse childhood experiences (ACEs) and their lifelong graded relationship with leading causes of death are well established. Many health care practitioners, however, have yet to implement ACEs screening in clinical ... ...

Abstract	Context: Scientific findings of adverse childhood experiences (ACEs) and their lifelong graded relationship with leading causes of death are well established. Many health care practitioners, however, have yet to implement ACEs screening in clinical practice. Furthermore, ACEs screening and trauma-informed care (TIC) are not part of standard graduate-level training. Objective: To 1) implement trauma-informed curriculum for multiple graduate health programs, 2) determine student understanding of and willingness to address ACEs, and 3) assess the relationship between students voluntarily evaluating their individual ACE Score and their attitude toward ACEs and TIC. Design: Prospective study with pre- and postcurricular surveys (12-question digital survey administered before and after the curriculum) for 967 graduate students from 9 health professions programs at 2 campuses who received curriculum focused on ACEs and TIC. Main outcome measures: Students' understanding of ACEs and TIC, their awareness of personal ACEs, and their willingness to incorporate TIC in practice. Results: Among students who voluntarily completed an ACE questionnaire, there was statistical significance in familiarity with clinical and scientific findings of the ACE Study (p < 0.001) and familiarity with TIC (p < 0.02). A significant intercampus difference in the students' familiarity with the scientific and clinical findings of the ACE Study (p < 0.05) was found. Conclusion: Students and future health care practitioners who voluntarily assess their ACE Score are significantly more likely to understand scientific and clinical findings of the ACE Study as well as TIC.
MeSH term(s)	Adult ; Adult Survivors of Child Abuse/psychology ; Child ; Curriculum ; Education, Professional/methods ; Education, Professional/organization & administration ; Education, Professional/standards ; Female ; Health Personnel/education ; Humans ; Male ; Mass Screening/methods ; Mass Screening/standards ; Medical History Taking/methods ; Medical History Taking/standards ; Organizational Case Studies ; Professional-Patient Relations ; Prospective Studies ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/etiology ; Stress Disorders, Post-Traumatic/therapy ; Students, Health Occupations/psychology ; Time
Language	English
Publishing date	2016-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2062823-7
ISSN	1552-5775 ; 1552-5767
ISSN (online)	1552-5775
ISSN	1552-5767
DOI	10.7812/TPP/16-061
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Broadband Tunable Infrared Light Emission from Metal-Oxide-Semiconductor Tunnel Junctions in Silicon Photonics.

Doderer, Michael / Keller, Killian / Winiger, Joel / Baumann, Michael / Messner, Andreas / Moor, David / Chelladurai, Daniel / Fedoryshyn, Yuriy / Leuthold, Juerg / Strait, Jared / Agrawal, Amit / Lezec, Henri J / Haffner, Christian

Nano letters

2023 Volume 24, Issue 3, Page(s) 859–865

Abstract: Broadband near-infrared light emitting tunnel junctions are demonstrated with efficient coupling to a silicon photonic waveguide. The metal oxide semiconductor devices show long hybrid photonic-plasmonic mode propagation lengths of approximately 10 μm ... ...

Abstract	Broadband near-infrared light emitting tunnel junctions are demonstrated with efficient coupling to a silicon photonic waveguide. The metal oxide semiconductor devices show long hybrid photonic-plasmonic mode propagation lengths of approximately 10 μm and thus can be integrated into an overcoupled resonant cavity with quality factor
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c03684
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chiroptical Response of Aluminum Nanocrescents at Ultraviolet Wavelengths.

Davis, Matthew S / Zhu, Wenqi / Strait, Jared / Lee, Jay K / Lezec, Henri J / Blair, Steve / Agrawal, Amit

Nano letters

2020 Volume 20, Issue 5, Page(s) 3656–3662

Abstract: Manipulation of plasmon modes at ultraviolet wavelengths using engineered nanophotonic devices allows for the development of high-sensitivity chiroptical spectroscopy systems. We present here an experimental framework based on aluminum-based crescent- ... ...

Abstract	Manipulation of plasmon modes at ultraviolet wavelengths using engineered nanophotonic devices allows for the development of high-sensitivity chiroptical spectroscopy systems. We present here an experimental framework based on aluminum-based crescent-shaped nanostructures that exhibit a strong chiroptical response at ultraviolet wavelengths. Through utilization of higher-order plasmon modes in wavelength-scale nanostructures, we address the inherent fabrication challenges in scaling the response to higher frequencies. Additionally, the distinct far-field spectral response types are analyzed within a coupled-oscillator model framework. We find two competing chiroptical response types that contribute toward potential ambiguity in the interpretation of the circular dichroism spectra. The first, optical activity, originates from the interaction between hybridized eigenmodes, whereas the second manifests as a response superficially similar to optical activity but originating instead from differential near-field absorption modes. The study of the chiroptical response from nanoplasmonic devices presented here is expected to aid the development of next-generation chiroptical spectroscopy systems.
Language	English
Publishing date	2020-04-27
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.0c00586
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Age-associated changes in cardiovascular structure and function: a fertile milieu for future disease.

Fleg, Jerome L / Strait, James

Heart failure reviews

2011 Volume 17, Issue 4-5, Page(s) 545–554

Abstract: Important changes occur in the cardiovascular system with advancing age, even in apparently healthy individuals. Thickening and stiffening of the large arteries develop due to collagen and calcium deposition and loss of elastic fibers in the medial layer. ...

Abstract	Important changes occur in the cardiovascular system with advancing age, even in apparently healthy individuals. Thickening and stiffening of the large arteries develop due to collagen and calcium deposition and loss of elastic fibers in the medial layer. These arterial changes cause systolic blood pressure to rise with age, while diastolic blood pressure generally declines after the sixth decade. In the left ventricle, modest concentric wall thickening occurs due to cellular hypertrophy, but cavity size does not change. Although left ventricular systolic function is preserved across the age span, early diastolic filling rate declines 30-50% between the third and ninth decades. Conversely, an age-associated increase in late diastolic filling due to atrial contraction preserves end-diastolic volume. Aerobic exercise capacity declines approximately 10% per decade in cross-sectional studies; in longitudinal studies, however, this decline is accelerated in the elderly. Reductions in peak heart rate and peripheral oxygen utilization but not stroke volume appear to mediate the age-associated decline in aerobic capacity. Deficits in both cardiac β-adrenergic receptor density and in the efficiency of postsynaptic β-adrenergic signaling contribute significantly to the reduced cardiovascular performance during exercise in older adults. Although these cardiovascular aging changes are considered "normative", they lower the threshold for the development of cardiovascular disease, which affects the majority of older adults.
MeSH term(s)	Aged ; Aging/physiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular System/physiopathology ; Exercise/physiology ; Female ; Humans ; Male ; Receptors, Adrenergic, beta/metabolism ; Ventricular Function, Left/physiology
Chemical Substances	Receptors, Adrenergic, beta
Language	English
Publishing date	2011-08-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1336499-6
ISSN	1573-7322 ; 1382-4147
ISSN (online)	1573-7322
ISSN	1382-4147
DOI	10.1007/s10741-011-9270-2
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Article: Orientational dependence of photorefractive two-beam coupling in InP:Fe.

Strait, J / Reed, J D / Kukhtarev, N V

Optics letters

2008 Volume 15, Issue 4, Page(s) 209–211

Abstract: We present the theory for photorefractive two-beam coupling without optical activity in cubic crystals rotated around the [110] axis. We also describe two-beam coupling experiments in InP:Fe that fit the theory closely. The 15.5% gain enhancement for ... ...

Abstract	We present the theory for photorefractive two-beam coupling without optical activity in cubic crystals rotated around the [110] axis. We also describe two-beam coupling experiments in InP:Fe that fit the theory closely. The 15.5% gain enhancement for grating wave vectors aligned along the <111> directions is demonstrated explicitly.
Language	English
Publishing date	2008-09-11
Publishing country	United States
Document type	Journal Article
ISSN	0146-9592
ISSN	0146-9592
DOI	10.1364/ol.15.000209
Database	MEDical Literature Analysis and Retrieval System OnLINE

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