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  1. Article ; Online: A systematic methodology for epicardial and epiaortic echocardiography in swine research models.

    Galbas, Michelle C / Meissner, Florian / Asmussen, Alexander / Straky, Hendrik C / Schimmel, Marius / Reuter, Johanna / Grundmann, Sebastian / Czerny, Martin / Bothe, Wolfgang

    Health science reports

    2024  Volume 7, Issue 1, Page(s) e1777

    Abstract: Background: Perioperative echocardiography is of paramount importance during cardiac surgery. Nonetheless, in the experimental large-animal setting, it might be challenging obtaining optimal imaging when using conventional imaging acquisition techniques, ...

    Abstract Background: Perioperative echocardiography is of paramount importance during cardiac surgery. Nonetheless, in the experimental large-animal setting, it might be challenging obtaining optimal imaging when using conventional imaging acquisition techniques, such as transthoracic and transesophageal screenings. Open-chest surgery allows epicardial echocardiographic assessment with direct contact between probe and heart, thus providing superior quality. Standard protocols regarding the use of epicardial ultrasound in swine for research purposes are lacking.
    Methods: Epicardial echocardiography was performed in 10 female German Landrace pigs undergoing cardiac surgery. A structured and comprehensive protocol for epicardial echocardiography was elaborated including apical, ventricular long and short axis, as well as epiaortic planes. All experiments were approved by the local board for animal welfare and conducted in accordance with the German animal protection law (TierSchG) and the ARRIVE guidelines.
    Conclusions: Systematic protocols using epicardial echocardiography may serve as an additional tool to assess cardiac dimensions and function in experimental scenarios with swine models.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiac dimensions and hemodynamics in healthy juvenile Landrace swine.

    Galbas, Michelle Costa / Straky, Hendrik Cornelius / Meissner, Florian / Reuter, Johanna / Schimmel, Marius / Grundmann, Sebastian / Czerny, Martin / Bothe, Wolfgang

    Cardiovascular ultrasound

    2024  Volume 22, Issue 1, Page(s) 3

    Abstract: Background: Swine are frequently used as animal model for cardiovascular research, especially in terms of representativity of human anatomy and physiology. Reference values for the most common species used in research are important for planning and ... ...

    Abstract Background: Swine are frequently used as animal model for cardiovascular research, especially in terms of representativity of human anatomy and physiology. Reference values for the most common species used in research are important for planning and execution of animal testing. Transesophageal echocardiography is the gold standard for intraoperative imaging, but can be technically challenging in swine. Its predecessor, epicardial echocardiography (EE), is a simple and fast intraoperative imaging technique, which allows comprehensive and goal-directed assessment. However, there are few echocardiographic studies describing echocardiographic parameters in juvenile swine, none of them using EE. Therefore, in this study, we provide a comprehensive dataset on multiple geometric and functional echocardiographic parameters, as well as basic hemodynamic parameters in swine using EE.
    Methods: The data collection was performed during animal testing in ten female swine (German Landrace, 104.4 ± 13.0 kg) before left ventricular assist device implantation. Hemodynamic data was recorded continuously, before and during EE. The herein described echocardiographic measurements were acquired according to a standardized protocol, encompassing apical, left ventricular short axis and long axis as well as epiaortic windows. In total, 50 echocardiographic parameters and 10 hemodynamic parameters were assessed.
    Results: Epicardial echocardiography was successfully performed in all animals, with a median screening time of 14 min (interquartile range 11-18 min). Referring to left ventricular function, ejection fraction was 51.6 ± 5.9% and 51.2 ± 6.2% using the Teichholz and Simpson methods, respectively. Calculated ventricular mass was 301.1 ± 64.0 g, as the left ventricular end-systolic and end-diastolic diameters were 35.3 ± 2.5 mm and 48.2 ± 3.5 mm, respectively. The mean heart rate was 103 ± 28 bpm, mean arterial pressure was 101 ± 20 mmHg and mean flow at the common carotid artery was 627 ± 203 mL/min.
    Conclusion: Epicardial echocardiography allows comprehensive assessment of most common echocardiographic parameters. Compared to humans, there are important differences in swine with respect to ventricular mass, size and wall thickness, especially in the right heart. Most hemodynamic parameters were comparable between swine and humans. This data supports study planning, animal and device selection, reinforcing the three R principles in animal research.
    MeSH term(s) Humans ; Female ; Animals ; Swine ; Ventricular Function, Left/physiology ; Echocardiography/methods ; Hemodynamics ; Heart Ventricles/diagnostic imaging
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2105610-9
    ISSN 1476-7120 ; 1476-7120
    ISSN (online) 1476-7120
    ISSN 1476-7120
    DOI 10.1186/s12947-023-00321-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Conference proceedings: Intraoperative Hemolysis during Left Ventricular Assist Device Implantation in Pigs

    Meissner, F. / Reuter, J. / Büchsel, M. / Straky, HC. / Galbas, M.C. / Czerny, M. / Bothe, W.

    The Thoracic and Cardiovascular Surgeon

    2024  Volume 72, Issue S 01

    Event/congress 53rd Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery (DGTHG), Congress Center Hamburg, 2024-02-17
    Language English
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0044-1780607
    Database Thieme publisher's database

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