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  1. AU="Strandwitz, Philip"
  2. AU="Modrau, Boris"
  3. AU="Sallese, Anthony"
  4. AU="T Kennedy, Patrick"
  5. AU="Cheng, XiaoQing"
  6. AU="Onwuteaka-Philipsen, Bregje D"
  7. AU="Robert D. Welch"
  8. AU="Forget, Francois"

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Treffer 1 - 10 von insgesamt 12

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  1. Artikel ; Online: Neurotransmitter modulation by the gut microbiota.

    Strandwitz, Philip

    Brain research

    2018  Band 1693, Heft Pt B, Seite(n) 128–133

    Abstract: The gut microbiota - the trillions of bacteria that reside within the gastrointestinal tract - has been found to not only be an essential component immune and metabolic health, but also seems to influence development and diseases of the enteric and ... ...

    Abstract The gut microbiota - the trillions of bacteria that reside within the gastrointestinal tract - has been found to not only be an essential component immune and metabolic health, but also seems to influence development and diseases of the enteric and central nervous system, including motility disorders, behavioral disorders, neurodegenerative disease, cerebrovascular accidents, and neuroimmune-mediated disorders. By leveraging animal models, several different pathways of communication have been identified along the "gut-brain-axis" including those driven by the immune system, the vagus nerve, or by modulation of neuroactive compounds by the microbiota. Of the latter, bacteria have been shown to produce and/or consume a wide range of mammalian neurotransmitters, including dopamine, norepinephrine, serotonin, or gamma-aminobutyric acid (GABA). Accumulating evidence in animals suggests that manipulation of these neurotransmitters by bacteria may have an impact in host physiology, and preliminary human studies are showing that microbiota-based interventions can also alter neurotransmitter levels. Nonetheless, substantially more work is required to determine whether microbiota-mediated manipulation of human neurotransmission has any physiological implications, and if so, how it may be leveraged therapeutically. In this review this exciting route of communication along the gut-brain-axis, and accompanying data, are discussed.
    Mesh-Begriff(e) Animals ; Brain/metabolism ; Gastrointestinal Microbiome/physiology ; Humans ; Neurotransmitter Agents/metabolism
    Chemische Substanzen Neurotransmitter Agents
    Sprache Englisch
    Erscheinungsdatum 2018-07-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2018.03.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Corrigendum to "Systematic comparisons between Lyme disease and post-treatment Lyme disease syndrome in the U.S. with administrative claims data".

    Chung, Ming Kei / Caboni, Mariaelena / Strandwitz, Philip / D'Onofrio, Anthony / Lewis, Kim / Patel, Chirag J

    EBioMedicine

    2023  Band 93, Seite(n) 104652

    Sprache Englisch
    Erscheinungsdatum 2023-06-19
    Erscheinungsland Netherlands
    Dokumenttyp Published Erratum
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104652
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  3. Artikel ; Online: Microbes make metabolic mischief by targeting drugs.

    Lewis, Kim / Strandwitz, Philip

    Nature

    2019  Band 570, Heft 7762, Seite(n) 453–454

    Mesh-Begriff(e) Bacteria ; Humans ; Microbiota
    Sprache Englisch
    Erscheinungsdatum 2019-06-24
    Erscheinungsland England
    Dokumenttyp News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-01851-x
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  4. Artikel ; Online: Systematic comparisons between Lyme disease and post-treatment Lyme disease syndrome in the U.S. with administrative claims data.

    Chung, Ming Kei / Caboni, Mariaelena / Strandwitz, Philip / D'Onofrio, Anthony / Lewis, Kim / Patel, Chirag J

    EBioMedicine

    2023  Band 90, Seite(n) 104524

    Abstract: Background: Post-treatment Lyme disease syndrome (PTLDS) is used to describe Lyme disease patients who have the infection cleared by antibiotic but then experienced persisting symptoms of pain, fatigue, or cognitive impairment. Currently, little is ... ...

    Abstract Background: Post-treatment Lyme disease syndrome (PTLDS) is used to describe Lyme disease patients who have the infection cleared by antibiotic but then experienced persisting symptoms of pain, fatigue, or cognitive impairment. Currently, little is known about the cause or epidemiology of PTLDS.
    Methods: We conducted a data-driven study with a large nationwide administrative dataset, which consists of more than 98 billion billing and 1.4 billion prescription records between 2008 and 2016, to identify unique aspects of PTLDS that could have diagnostic and etiologic values. We defined PTLDS based on its symptomatology and compared the demographic, longitudinal changes of comorbidity, and antibiotic prescriptions between patients who have Lyme with absence of prolonged symptoms (APS) and PTLDS.
    Findings: The age and temporal distributions were similar between Lyme APS and PTLDS. The PTLDS-to-Lyme APS case ratio was 3.42%. The co-occurrence of 3 out of 19 chronic conditions were significantly higher in PTLDS versus Lyme APS-odds ratio and 95% CI for anemia, hyperlipidemia, and osteoarthrosis were 1.46 (1.11-1.92), 1.39 (1.15-1.68), and 1.62 (1.23-2.12) respectively. We did not find significant differences between PTLDS and Lyme APS for the number of types of antibiotics prescribed (incidence rate ratio = 1.009, p = 0.90) and for the prescription of each of the five antibiotics (FDR adjusted p values 0.72-0.95).
    Interpretation: PTLDS cases have more codes corresponding to anemia, hyperlipidemia, and osteoarthrosis compared to Lyme APS. Our finding of hyperlipidemia is consistent with a dysregulation of fat metabolism reported by other researchers, and further investigation should be conducted to understand the potential biological relationship between the two.
    Funding: Steven & Alexandra Cohen Foundation, Global Lyme Alliance, and the Pazala Foundation; National Institutes of Health R01ES032470.
    Mesh-Begriff(e) Humans ; Post-Lyme Disease Syndrome/complications ; Post-Lyme Disease Syndrome/drug therapy ; Lyme Disease/diagnosis ; Lyme Disease/drug therapy ; Lyme Disease/epidemiology ; Anti-Bacterial Agents/therapeutic use ; Chronic Disease ; Pain/drug therapy
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2023-03-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104524
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  5. Artikel ; Online: Nourishing the brain on deep space missions: nutritional psychiatry in promoting resilience.

    Pathare, Nihar N / Fayet-Moore, Flavia / Fogarty, Jennifer A / Jacka, Felice N / Strandwitz, Philip / Strangman, Gary E / Donoviel, Dorit B

    Frontiers in neural circuits

    2023  Band 17, Seite(n) 1170395

    Abstract: The grueling psychological demands of a journey into deep space coupled with ever-increasing distances away from home pose a unique problem: how can we best take advantage of the benefits of fresh foods in a place that has none? Here, we consider the ... ...

    Abstract The grueling psychological demands of a journey into deep space coupled with ever-increasing distances away from home pose a unique problem: how can we best take advantage of the benefits of fresh foods in a place that has none? Here, we consider the biggest challenges associated with our current spaceflight food system, highlight the importance of supporting optimal brain health on missions into deep space, and discuss evidence about food components that impact brain health. We propose a future food system that leverages the gut microbiota that can be individually tailored to best support the brain and mental health of crews on deep space long-duration missions. Working toward this goal, we will also be making investments in sustainable means to nourish the crew that remains here on spaceship Earth.
    Mesh-Begriff(e) Brain ; Mental Health ; Psychiatry ; Space Flight
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2452968-0
    ISSN 1662-5110 ; 1662-5110
    ISSN (online) 1662-5110
    ISSN 1662-5110
    DOI 10.3389/fncir.2023.1170395
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  6. Artikel ; Online: Microbiology: Antibiotics right under our nose.

    Lewis, Kim / Strandwitz, Philip

    Nature

    2016  Band 535, Heft 7613, Seite(n) 501–502

    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Humans ; Nose
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2016--28
    Erscheinungsland England
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/535501a
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  7. Artikel ; Online: An

    Lock, Jaclyn Y / Caboni, Mariaelena / Strandwitz, Philip / Morrissette, Madeleine / DiBona, Kevin / Joughin, Brian A / Lewis, Kim / Carrier, Rebecca L

    Gut microbes

    2022  Band 14, Heft 1, Seite(n) 2039002

    Abstract: Considerable effort has been put forth to understand mechanisms by which the microbiota modulates and responds to inflammation. Here, we explored whether oxidation metabolites produced by the host during inflammation, sodium nitrate and trimethylamine ... ...

    Abstract Considerable effort has been put forth to understand mechanisms by which the microbiota modulates and responds to inflammation. Here, we explored whether oxidation metabolites produced by the host during inflammation, sodium nitrate and trimethylamine oxide, impact the composition of a human stool bacterial population in a gut simulator. We then assessed whether an immune-competent
    Mesh-Begriff(e) Animals ; Bacteria ; Cytokines ; Gastrointestinal Microbiome ; Humans ; Inflammation ; Mammals ; Microbiota
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2022-03-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2022.2039002
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  8. Artikel ; Online: Feasibility, Acceptability, and Safety of Faecal Microbiota Transplantation in the Treatment of Major Depressive Disorder: A Pilot Randomized Controlled Trial.

    Green, Jessica Emily / Berk, Michael / Mohebbi, Mohammadreza / Loughman, Amy / McGuinness, Amelia J / Castle, David / Chatterton, Mary Lou / Perez, Joahna / Strandwitz, Philip / Athan, Eugene / Hair, Christopher / Nierenberg, Andrew A / Cryan, John F / Jacka, Felice

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2023  Band 68, Heft 5, Seite(n) 315–326

    Abstract: Objectives: Perturbations of the intestinal microbiota have been associated with mental health disorders, including major depressive disorder (MDD). Therefore, faecal microbiota transplantation (FMT) holds promise as a microbiota-modulating treatment ... ...

    Abstract Objectives: Perturbations of the intestinal microbiota have been associated with mental health disorders, including major depressive disorder (MDD). Therefore, faecal microbiota transplantation (FMT) holds promise as a microbiota-modulating treatment for MDD. Yet, to date, there are no published controlled studies evaluating the use of FMT for MDD. This study aimed to address this gap by evaluating the feasibility, acceptability, and safety of FMT for MDD.
    Methods: The study was an 8-week, double-blind, 2:1 parallel group, randomized controlled pilot trial (
    Results: Recruitment was completed within 2 months, with 0% attrition and 100% attendance at key study appointments. There were no major protocol deviations. The placebo and blinding strategies were considered successful; nurses and participants correctly guessing their treatment allocation at a rate similar to that anticipated by chance. No serious or severe adverse events were reported in either group, and there were no significant differences in mild-to-moderate adverse events between groups (median of 2 adverse events per participant reported in both groups). Furthermore, the 12/15 participants who completed the Week 2 participant satisfaction survey agreed or strongly agreed that the enema delivery was tolerable and that they would have the treatment again if required. Whilst the study was not designed to measure clinical outcomes, exploratory data also suggested that the active FMT treatment may lead to improvements in gastrointestinal symptoms and quality of life in this population, noting that irritable bowel syndrome is commonly comorbid with MDD.
    Conclusions: All feasibility targets were met or exceeded. This study found that enema-delivered FMT is feasible, acceptable, well-tolerated, and safe in patients with MDD. The findings of this study support further research to evaluate clinical efficacy, and the use of this protocol is supported.
    Mesh-Begriff(e) Adult ; Humans ; Fecal Microbiota Transplantation/adverse effects ; Fecal Microbiota Transplantation/methods ; Depressive Disorder, Major/therapy ; Pilot Projects ; Feasibility Studies ; Quality of Life ; Treatment Outcome ; Double-Blind Method
    Sprache Englisch
    Erscheinungsdatum 2023-01-13
    Erscheinungsland United States
    Dokumenttyp Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0008-4824 ; 0706-7437
    ISSN (online) 1497-0015
    ISSN 0008-4824 ; 0706-7437
    DOI 10.1177/07067437221150508
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  9. Artikel ; Online: Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model.

    O'Connor, Kathleen / Morrissette, Madeleine / Strandwitz, Philip / Ghiglieri, Meghan / Caboni, Mariaelena / Liu, Haiyan / Khoo, Christina / D'Onofrio, Anthony / Lewis, Kim

    PloS one

    2019  Band 14, Heft 11, Seite(n) e0224836

    Abstract: The opportunistic pathogen Escherichia coli, a common member of the human gut microbiota belonging to the Enterobacteriaceae family, is the causative agent of the majority of urinary tract infections (UTIs). The gut microbiota serves as a reservoir for ... ...

    Abstract The opportunistic pathogen Escherichia coli, a common member of the human gut microbiota belonging to the Enterobacteriaceae family, is the causative agent of the majority of urinary tract infections (UTIs). The gut microbiota serves as a reservoir for uropathogenic E. coli where they are shed in feces, colonize the periurethral area, and infect the urinary tract. Currently, front line treatment for UTIs consists of oral antibiotics, but the rise of antibiotic resistance is leading to higher rates of recurrence, and antibiotics cause collateral damage to other members of the gut microbiota. It is commonly believed that incorporation of the American cranberry, Vaccinium macrocarpon, into the diet is useful for reducing recurrence of UTIs. We hypothesized such a benefit might be explained by a prebiotic or antimicrobial effect on the gut microbiota. As such, we tested cranberry extracts and whole cranberry powder on a human gut microbiome-derived community in a gut simulator and found that cranberry components broadly modulate the microbiota by reducing the abundance of Enterobacteriaceae and increasing the abundance of Bacteroidaceae. To identify the specific compounds responsible for this, we tested a panel of compounds isolated from cranberries for activity against E. coli, and found that salicylate exhibited antimicrobial activity against both laboratory E. coli and human UTI E. coli isolates. In a gut simulator, salicylate reduced levels of Enterobacteriaceae and elevated Bacteroidaceae in a dose dependent manner.
    Mesh-Begriff(e) Bacteroidaceae/drug effects ; Bacteroidaceae/growth & development ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/growth & development ; Escherichia coli/drug effects ; Escherichia coli/isolation & purification ; Gastrointestinal Microbiome/drug effects ; Humans ; Hydroxybenzoates/pharmacology ; Microbial Sensitivity Tests ; Models, Biological ; Plant Extracts/pharmacology ; Powders ; Salicylic Acid/pharmacology ; Urinary Tract Infections/microbiology ; Vaccinium macrocarpon/chemistry
    Chemische Substanzen Hydroxybenzoates ; Plant Extracts ; Powders ; beta-resorcylic acid (LU39SC9JYL) ; Salicylic Acid (O414PZ4LPZ)
    Sprache Englisch
    Erscheinungsdatum 2019-11-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0224836
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  10. Artikel ; Online: A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients.

    Morrissette, Madeleine / Pitt, Norman / González, Antonio / Strandwitz, Philip / Caboni, Mariaelena / Rebman, Alison W / Knight, Rob / D'Onofrio, Anthony / Aucott, John N / Soloski, Mark J / Lewis, Kim

    mBio

    2020  Band 11, Heft 5

    Abstract: Lyme disease is the most common vector-borne disease in the United States, with an estimated incidence of 300,000 infections annually. Antibiotic intervention cures Lyme disease in the majority of cases; however, 10 to 20% of patients develop ... ...

    Abstract Lyme disease is the most common vector-borne disease in the United States, with an estimated incidence of 300,000 infections annually. Antibiotic intervention cures Lyme disease in the majority of cases; however, 10 to 20% of patients develop posttreatment Lyme disease syndrome (PTLDS), a debilitating condition characterized by chronic fatigue, pain, and cognitive difficulties. The underlying mechanism responsible for PTLDS symptoms, as well as a reliable diagnostic tool, has remained elusive. We reasoned that the gut microbiome may play an important role in PTLDS given that the symptoms overlap considerably with conditions in which a dysbiotic microbiome has been observed, including mood, cognition, and autoimmune disorders. Analysis of sequencing data from a rigorously curated cohort of patients with PTLDS revealed a gut microbiome signature distinct from that of healthy control subjects, as well as from that of intensive care unit (ICU) patients. Notably, microbiome sequencing data alone were indicative of PTLDS, which presents a potential, novel diagnostic tool for PTLDS.
    Mesh-Begriff(e) Adult ; Anti-Bacterial Agents/therapeutic use ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Cohort Studies ; Dysbiosis/etiology ; Feces/microbiology ; Female ; Humans ; Lyme Disease/drug therapy ; Male ; Microbiota/drug effects ; Middle Aged ; Post-Lyme Disease Syndrome/diagnosis ; Post-Lyme Disease Syndrome/microbiology ; Transcriptome
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2020-09-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02310-20
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