Result 1 - 10 of total 440
2017
| Keywords | Text ; ddc:630 |
|---|---|
| Language | German |
| Publishing date | 2017-04-20 |
| Publishing country | de |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2017
| Keywords | Text ; ddc:630 |
|---|---|
| Language | German |
| Publishing date | 2017-02-20 |
| Publishing country | de |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2020 Volume 10, Issue 1, Page(s) 7054
Abstract: Our existence in the Universe resulted from a rare combination of circumstances. The same must hold for any highly developed extraterrestrial civilisation, and if they have ever existed in the Milky Way, they would likely be scattered over large ... ...
| Abstract | Our existence in the Universe resulted from a rare combination of circumstances. The same must hold for any highly developed extraterrestrial civilisation, and if they have ever existed in the Milky Way, they would likely be scattered over large distances in space and time. However, all technologically advanced species must be aware of the unique property of the galactic centre: it hosts Sagittarius A* (Sgr A*), the closest supermassive black hole to anyone in the Galaxy. A civilisation with sufficient technical know-how may have placed material in orbit around Sgr A* for research, energy extraction, and communication purposes. In either case, its orbital motion will necessarily be a source of gravitational waves. We show that a Jupiter-mass probe on the retrograde innermost stable circular orbit around Sgr A* emits, depending on the black hole spin, at a frequency of f |
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| Language | English |
| Publishing date | 2020-04-27 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-020-63206-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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PloS one
2021 Volume 16, Issue 11, Page(s) e0259093
Abstract: The objective was to determine the prognostic utility of a new biomarker combination in prostate cancer (PCa) patients undergoing Radical Prostatectomy (RP). Serum samples and clinical data of 557 men who underwent RP for PCa with pathological stage (pT) ...
| Abstract | The objective was to determine the prognostic utility of a new biomarker combination in prostate cancer (PCa) patients undergoing Radical Prostatectomy (RP). Serum samples and clinical data of 557 men who underwent RP for PCa with pathological stage (pT) <3 at Martini Clinic (Hamburg, Germany) were used for analysis. Clinical Grade Group and clinical stage was determined using biopsy samples while tumor marker concentrations were measured in serum using immunoassays. The prognostic utility of the proposed marker combination was assessed using Cox proportional hazard regression and Kaplan-Meier analysis. The performance was compared to the Cancer of the Prostate Risk Assessment (CAPRA) score in the overall cohort and in a low-risk patient subset. A multivariable model comprising fibronectin 1, galectin-3-binding protein, lumican, matrix metalloprotease 9, thrombospondin-1 and PSA together with clinical Grade Group (GG) and clinical stage (cT) was created. The proposed model was a significant predictor of biochemical recurrence (BCR) (HR 1.29 per 5 units score, 95%CI 1.20-1.38, p<0.001). The Kaplan-Meier analysis showed that the proposed model had a better prediction for low-risk disease after RP compared to CAPRA (respectively 5.0% vs. 9.1% chance of BCR). In a pre-defined low risk population subset, the risk of BCR using the proposed model was below 5.2% and thus lower when compared to CAPRA = 0-2 (9%), GG<2 (7%) and NCCN = low-risk (6%) subsets. Additionally, the proposed model could significantly (p<0.001) discriminate patients with adverse pathology (AP) events at RP from those without. In conclusion, the proposed model is superior to CAPRA for the prediction of BCR after RP in the overall cohort as well as a in a pre-defined low risk patient population subset. It is also significantly associated with AP at RP. |
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| MeSH term(s) | Adult ; Aged ; Antigens, Neoplasm/blood ; Biomarkers, Tumor/blood ; Germany/epidemiology ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Staging ; Prognosis ; Prostate-Specific Antigen/blood ; Prostatectomy/methods ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Risk Assessment ; Treatment Outcome |
| Chemical Substances | Antigens, Neoplasm ; Biomarkers, Tumor ; LGALS3BP protein, human ; Prostate-Specific Antigen (EC 3.4.21.77) |
| Language | English |
| Publishing date | 2021-11-12 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 1932-6203 |
| ISSN (online) | 1932-6203 |
| DOI | 10.1371/journal.pone.0259093 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2019
Abstract: Context. The properties of the accretion flow surrounding the supermassive central black hole of the Galaxy, Sgr A*, will be scrutinized by the new-generation instrument GRAVITY and the Event Horizon Telescope (EHT). Developing fast, robust, and simple ... ...
| Abstract | Context. The properties of the accretion flow surrounding the supermassive central black hole of the Galaxy, Sgr A*, will be scrutinized by the new-generation instrument GRAVITY and the Event Horizon Telescope (EHT). Developing fast, robust, and simple models of such flows is thus important and very timely. Aims. We want to model the quiescent emission of Sgr A* from radio to mid-infrared by considering a magnetized compact torus and an extended jet. Results. We find perfect spectral fit both for face-on and edge-on views. These best fits give parameters values very close to that found by the most recent numerical simulations, which are much more complex than our model. The intrinsic radio size of Sgr A* is found to be in reasonable agreement with the centimetric observed constraints. Our best-fit infrared spectral index is in perfect agreement with the latest constraints. Our emission region at 1.3 mm, although larger than the Doeleman et al. (2008) Gaussian best-fit, does contain bright features at the 40 microarcsec scale. EHT-reconstructed images show that torus/jet-specific features persist after the reconstruction procedure, and that these features are sensitive to inclination. Conclusions. The main interest of our model is to give a simple and fast model of the quiescent state of Sgr A*, which gives extremely similar results as compared to state-of-the-art numerical simulations. Our model is easy to use and we publish all the material necessary to reproduce our spectra and images, so that anyone interested can use our results rather straightforwardly. We hope that such a public tool can be useful in the context of the recent and near-future GRAVITY and EHT results. Our model can in particular be easily used to test alternative compact objects models, or alternative gravity theories. The main limitation of our model is that we do not yet treat the X-ray emission. Comment: 12 pages, 8 figures, accepted by A&A |
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| Keywords | Astrophysics - High Energy Astrophysical Phenomena ; General Relativity and Quantum Cosmology |
| Subject code | 612 ; 520 |
| Publishing date | 2019-02-04 |
| Publishing country | us |
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
veterinär spiegel
2008 Volume 18, Issue 02, Page(s) 100–104
| Language | German |
|---|---|
| Publishing date | 2008-02-01 |
| Publisher | Georg Thieme Verlag, Stuttgart |
| Publishing place | Stuttgart ; New York |
| Document type | Article |
| ISSN | 1868-0437 ; 0940-8711 |
| ISSN (online) | 1868-0437 |
| ISSN | 0940-8711 |
| DOI | 10.1055/s-0029-1225499 |
| Database | Thieme publisher's database |
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2004
Abstract: Briefly the history of maedi–visna and the major clinical symptoms are described. Examples are presented to demonstrate that the genetic composition of a breed determines whether or not sheep become sick after an infection with maedi–visna virus (mvv) or ...
| Abstract | Briefly the history of maedi–visna and the major clinical symptoms are described. Examples are presented to demonstrate that the genetic composition of a breed determines whether or not sheep become sick after an infection with maedi–visna virus (mvv) or develop solely specific antibodies. The major pathway of transmission is not colostrum and milk, but a cell containing increased nasal discharge in cases of respiratory distress. The role of the environment and prophylactic measures against parasites is stressed, because even sheep of highly susceptible breeds can survive an infection under optimal conditions. The virus and subsequently the disease simply die out. The cooperation between clinicians and laboratories is necessary. |
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| Keywords | ddc:630 ; Sheep; Maedi–visna virus; Infection; Breed; Immunity; Clinical symptoms; Tests |
| Language | English |
| Publishing country | de |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2004
Abstract: Briefly the history of maedi–visna and the major clinical symptoms are described. Examples are presented to demonstrate that the genetic composition of a breed determines whether or not sheep become sick after an infection with maedi–visna virus (mvv) or ...
| Abstract | Briefly the history of maedi–visna and the major clinical symptoms are described. Examples are presented to demonstrate that the genetic composition of a breed determines whether or not sheep become sick after an infection with maedi–visna virus (mvv) or develop solely specific antibodies. The major pathway of transmission is not colostrum and milk, but a cell containing increased nasal discharge in cases of respiratory distress. The role of the environment and prophylactic measures against parasites is stressed, because even sheep of highly susceptible breeds can survive an infection under optimal conditions. The virus and subsequently the disease simply die out. The cooperation between clinicians and laboratories is necessary. |
|---|---|
| Keywords | Text ; ddc:630 ; Sheep ; Maedi–visna virus ; Infection ; Breed ; Immunity ; Clinical symptoms ; Tests |
| Language | English |
| Publishing country | de |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
DTW. Deutsche tierarztliche Wochenschrift
2001 Volume 108, Issue 10, Page(s) 419–422
Abstract: Bovine Herpesvirus Type 1 (BHV1) is the aetiological agent of a number of diseases and not only of IBR, namely infectious pustular vulvovaginitis (IPV), infectious balanoposthitis (IBP), conjunctivitis, encephalomyelitis, mastitis, abortion, enteritis, ... ...
| Abstract | Bovine Herpesvirus Type 1 (BHV1) is the aetiological agent of a number of diseases and not only of IBR, namely infectious pustular vulvovaginitis (IPV), infectious balanoposthitis (IBP), conjunctivitis, encephalomyelitis, mastitis, abortion, enteritis, and lesions in the interdigital space. The serological identical strains differ, however, in some aspects. Typical genital strains usually cause a mild illness, sometimes not even detected clinically, but serologically. They hamper eradication programmes and do not cause IBR when inoculated intranasally. The other--modern--strains are, however, always able to induce a severe disease in the genital tracts. But infection of field or vaccine virus leads to the development of humoral and cell-mediated immunity. The latter is, however, not transmitted to neonates via colostrum. BHV1 antibodies can be found in bovines in all continents, and in many wild species. Prevalences vary greatly depending on herd size and management. Because seronegative cattle play a role in international trade a number of European countries have eradicated BHV1, with very high costs involved. Marker and conventional vaccines can prevent disease but not infection followed by the state of latency. The genomes of several strains, including the marker strains can remain latent in the same animal and be reactivated after stress or injection of corticosteroids. For the detection of humoral antibodies the ELISA is widely used. It is useful for testing bulk milk samples for antibodies derived from field virus and conventional vaccines but not from gE-deleted marker vaccines. Importing countries should consider only vaccinated animals for import. They should require that the animals are seronegative prior to vaccination. |
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| MeSH term(s) | Animals ; Antibodies, Viral/blood ; Cattle ; Cattle Diseases/epidemiology ; Cattle Diseases/immunology ; Cattle Diseases/prevention & control ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/prevention & control ; Herpesviridae Infections/veterinary ; Herpesvirus 1, Bovine/classification ; Herpesvirus 1, Bovine/immunology ; Immunity, Cellular ; Infectious Bovine Rhinotracheitis/epidemiology ; Infectious Bovine Rhinotracheitis/immunology ; Infectious Bovine Rhinotracheitis/prevention & control ; Prevalence ; Viral Vaccines ; Virus Latency |
| Chemical Substances | Antibodies, Viral ; Viral Vaccines |
| Language | English |
| Publishing date | 2001-10 |
| Publishing country | Germany |
| Document type | Journal Article ; Review |
| ZDB-ID | 6803-2 |
| ISSN | 0341-6593 ; 0012-0847 ; 0366-9904 |
| ISSN | 0341-6593 ; 0012-0847 ; 0366-9904 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 649: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Fleischmehl-Industrie (Germany)
1990
| Institution | Hohenheim Universität Stuttgart (Germany, F.R.) |
|---|---|
| Keywords | Volksgesundheit ; Abfallbeseitigung ; Hygiene |
| Language | German |
| Edition | v. 42(12) p. 222-237 |
| Document type | Article |
| Database | ELFIS - Nutrition, agriculture and forestry information system |
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