Article: A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis.
bioRxiv : the preprint server for biology
2024
Abstract: T cell receptor (TCR) recognition followed by clonal expansion is a fundamental feature of adaptive immune responses. Here, we developed a mass cytometric (CyTOF) approach combining antibodies specific for different TCR Vα- and Vβ-chains with antibodies ... ...
| Abstract | T cell receptor (TCR) recognition followed by clonal expansion is a fundamental feature of adaptive immune responses. Here, we developed a mass cytometric (CyTOF) approach combining antibodies specific for different TCR Vα- and Vβ-chains with antibodies against T cell activation and differentiation proteins to identify antigen-specific expansions of T cell subsets and assess aspects of cellular function. This strategy allowed for the identification of expansions of specific Vβ and Vα chain expressing CD8 |
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| Language | English |
| Publishing date | 2024-01-12 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2024.01.11.575237 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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