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  1. Book ; Thesis: Bortezomib significantly impairs the immunostimulatory capacity of human myeloid blood dendritic cells

    Straube, Christoph

    2007  

    Author's details vorgelegt von Christoph Straube
    Language English
    Size V, 35 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Med. Fak., Diss., 2007
    HBZ-ID HT016307113
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Strahlentherapie spinaler Tumoren

    Straube, Christoph / Combs, Stephanie E.

    Die Wirbelsäule

    2020  Volume 04, Issue 02, Page(s) 113–119

    Abstract: Die Behandlung maligner Erkrankungen der Wirbelsäule ist grundsätzlich multidiziplinär angelegt. In vielen Fällen wird daher nach einer Operation, in Einzelfällen auch neoadjuvant oder als Alternative zur Operation, eine Strahlentherapie diskutiert. Die ... ...

    Abstract Die Behandlung maligner Erkrankungen der Wirbelsäule ist grundsätzlich multidiziplinär angelegt. In vielen Fällen wird daher nach einer Operation, in Einzelfällen auch neoadjuvant oder als Alternative zur Operation, eine Strahlentherapie diskutiert. Die vorliegende Arbeit soll die Möglichkeiten, die Wirksamkeit und auch die Grenzen der modernen Radioonkologie aufzeigen. Dabei werden die typischen Indikationen zur Strahlentherapie besprochen und die zu erwartende Prognose und evtl. auftretende Nebenwirkungen besprochen. Weiterhin wird auf die Wechselwirkungen zwischen der operativen Versorgung inklusive der verwendeten Implantate und der sich anschließenden Bestrahlung eingegangen.
    Keywords Spinale Metastasen ; Strahlentherapie ; Körperstereotaxie ; PEEK ; Carbonfaser ; Spinal metastases ; Radiotherapy ; SBRT; PEEK ; Carbonfibre
    Language German
    Publishing date 2020-04-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2509-825X ; 2509-8241
    ISSN (online) 2509-825X
    ISSN 2509-8241
    DOI 10.1055/a-0968-8820
    Database Thieme publisher's database

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  3. Article ; Online: Überdenken der Radiochirurgie von Resektionshöhlen nach kompletter Resektion von 1–3 Hirnmetastasen.

    Straube, Christoph / Combs, Stephanie E

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2017  Volume 193, Issue 12, Page(s) 1074–1076

    Title translation Reconsideration of radiosurgery for resection cavities following complete resection of 1-3 brain metastases.
    MeSH term(s) Brain Neoplasms/surgery ; Humans ; Radiosurgery ; Radiotherapy, Adjuvant ; Retrospective Studies
    Language German
    Publishing date 2017-09-08
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-017-1210-1
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  4. Article ; Online: Kombination von Strahlentherapie mit Temozolomid bei über 65-jährigen Glioblastompatienten.

    Straube, Christoph / Combs, Stephanie E

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2017  Volume 193, Issue 6, Page(s) 510–512

    Title translation Combining radiation plus temozolomide in glioblastoma patients older than 65 years of age.
    MeSH term(s) Antineoplastic Agents, Alkylating ; Brain Neoplasms ; Dacarbazine ; Glioblastoma ; Humans
    Chemical Substances Antineoplastic Agents, Alkylating ; Dacarbazine (7GR28W0FJI)
    Language German
    Publishing date 2017
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-017-1134-9
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  5. Article ; Online: Adjuvant re-irradiation vs. no early re-irradiation of resected recurrent glioblastoma: pooled comparative cohort analysis from two tertiary centers.

    Straube, Christoph / Combs, Stephanie E / Bernhardt, Denise / Gempt, Jens / Meyer, Bernhard / Zimmer, Claus / Schmidt-Graf, Friederike / Vajkoczy, Peter / Grün, Arne / Ehret, Felix / Zips, Daniel / Kaul, David

    Journal of neuro-oncology

    2024  

    Abstract: Background: The optimal management strategy for recurrent glioblastoma (rGBM) remains uncertain, and the impact of re-irradiation (Re-RT) on overall survival (OS) is still a matter of debate. This study included patients who achieved gross total ... ...

    Abstract Background: The optimal management strategy for recurrent glioblastoma (rGBM) remains uncertain, and the impact of re-irradiation (Re-RT) on overall survival (OS) is still a matter of debate. This study included patients who achieved gross total resection (GTR) after a second surgery after recurrence, following the GlioCave criteria.
    Methods: Inclusion criteria include being 18 years or older, having histologically confirmed locally recurrent IDHwt or IDH unknown GBM, achieving MRI-proven GTR after the second surgery, having a Karnofsky performance status of at least 60% after the second surgery, having a minimum interval of 6 months between the first radiotherapy and the second surgery, and a maximum of 8 weeks from second surgery to the start of Re-RT.
    Results: A total of 44 patients have met the inclusion criteria. The median OS after the second surgery was 14 months. All patients underwent standard treatment after initial diagnosis, including maximum safe resection, adjuvant radiochemotherapy and adjuvant chemotherapy. Re-RT did not significantly impact OS. However, MGMT promoter methylation status and a longer interval (> 12 months) between treatments were associated with better OS. Multivariate analysis revealed the MGMT status as the only significant predictor of OS.
    Conclusion: Factors such as MGMT promoter methylation status and treatment interval play crucial roles in determining patient outcomes after second surgery. Personalized treatment strategies should consider these factors to optimize the management of rGBM. Prospective research is needed to define the value of re-RT after second surgery and to inform decision making in this situation.
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-024-04633-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: IMAGES IN CLINICAL MEDICINE. Pneumorrhachis, Pneumothorax, and Subcutaneous Emphysema.

    Straube, Christoph / Vazan, Martin

    The New England journal of medicine

    2016  Volume 375, Issue 9, Page(s) e18

    MeSH term(s) Aged ; Humans ; Male ; Pneumorrhachis/diagnostic imaging ; Pneumorrhachis/etiology ; Pneumothorax/diagnostic imaging ; Pneumothorax/etiology ; Postoperative Complications/diagnostic imaging ; Radiography ; Sarcoma, Synovial/surgery ; Spine/surgery ; Subcutaneous Emphysema/diagnostic imaging ; Subcutaneous Emphysema/etiology
    Language English
    Publishing date 2016-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm1506684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Radiochirurgie und operative neurovaskuläre Dekompression annähernd gleichwertig bei der Behandlung von Trigeminusneuralgien.

    Straube, Christoph / Shiban, Ehab / Meyer, Bernhard / Combs, Stephanie E

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2019  Volume 195, Issue 7, Page(s) 688–690

    Title translation Radiosurgery and surgical neurovascular decompression are almost equal for treatment of trigeminal neuralgia.
    MeSH term(s) Decompression, Surgical ; Humans ; Osteochondrodysplasias ; Radiosurgery ; Robotic Surgical Procedures ; Trigeminal Neuralgia
    Language German
    Publishing date 2019-04-04
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-019-01454-5
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    Ue I Zs.40: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online ; Thesis: Retrospektive Untersuchung zur prognostischen Beurteilung von älteren Glioblastompatienten

    Antoni, Stefanie Julia Verfasser] / [Schmidt-Graf, Friederike [Akademischer Betreuer] / Schmidt-Graf, Friederike [Gutachter] / Straube, Christoph [Gutachter]

    2022  

    Author's details Stefanie Julia Antoni ; Gutachter: Friederike Schmidt-Graf, Christoph Straube ; Betreuer: Friederike Schmidt-Graf
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article: Which Obstacles Prevent Us from Recruiting into Clinical Trials: A Survey about the Environment for Clinical Studies at a German University Hospital in a Comprehensive Cancer Center.

    Straube, Christoph / Herschbach, Peter / Combs, Stephanie E

    Frontiers in oncology

    2017  Volume 7, Page(s) 181

    Abstract: Background: Prospective clinical studies are the most important tool in modern medicine. The standard in good clinical practice in clinical trials has constantly improved leading to more sophisticated protocols. Moreover, translational questions are ... ...

    Abstract Background: Prospective clinical studies are the most important tool in modern medicine. The standard in good clinical practice in clinical trials has constantly improved leading to more sophisticated protocols. Moreover, translational questions are increasingly addressed in clinical trials. Such trials must follow elaborate rules and regulations. This is accompanied by a significant increase in documentation issues which require substantial manpower. Furthermore, university-based clinical centers are interested in increasing the amount of patients treated within clinical trials, and this number has evolved to be a key quality criterion. The present study was initiated to elucidate the obstacles that limit clinical scientists in screening and recruiting for clinical trials.
    Methods: A specific questionnaire with 28 questions was developed focusing on all aspects of clinical trial design as well as trial management. This included questions on organizational issues, medical topics as well as potential patients' preferences and physician's goals. The questionnaire was established to collect data anonymously on a web-based platform. The survey was conducted within the Klinikum rechts der Isar, Faculty of Medicine, Technical University of Munich; physicians of all levels (Department Chairs, attending physicians, residents, as well as study nurses, and other study-related staff) were addressed. The answers were analyzed using the Survio analyzing tool (http://www.survio.com/de/).
    Results: We collected 42 complete sets of answers; in total 28 physicians, 11 study nurses, and 3 persons with positions in administration answered our survey. The study centers reported to participate in a range of 3-160 clinical trials with a recruitment rate of 1-80%. Main obstacles were determined: 31/42 (74%) complained about limited human resources and 22/42 (52%) reported to have a lack on technical resources, too. 30/42 (71%) consented to the answer, that the documentation effort of clinical trials is too large. A possible increase of the patients' study participation rate up to over 20% was deemed to be possible if the described limitations could be overcome.
    Discussion: The increasing documentation effort in clinical trials has led to a strong increase in the work load of scientific personnel. Recruiting of patients into clinical trials therefore is not only limited by patient issues, but also by the infrastructure of the centers. Especially the lack of study nurses is likely to be a major limitation. Furthermore, technical resources for time efficient and safe documentation within clinical routine as well as in clinical trials are required. By optimization of these factors, a significant increase in the amount of patients treated in clinical trials seems to be possible.
    Language English
    Publishing date 2017-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2017.00181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hypofractionated stereotactic radiotherapy (HFSRT) versus single fraction stereotactic radiosurgery (SRS) to the resection cavity of brain metastases after surgical resection (SATURNUS): study protocol for a randomized phase III trial.

    Waltenberger, Maria / Bernhardt, Denise / Diehl, Christian / Gempt, Jens / Meyer, Bernhard / Straube, Christoph / Wiestler, Benedikt / Wilkens, Jan J / Zimmer, Claus / Combs, Stephanie E

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 709

    Abstract: Background: The brain is a common site for cancer metastases. In case of large and/or symptomatic brain metastases, neurosurgical resection is performed. Adjuvant radiotherapy is a standard procedure to minimize the risk of local recurrence and is ... ...

    Abstract Background: The brain is a common site for cancer metastases. In case of large and/or symptomatic brain metastases, neurosurgical resection is performed. Adjuvant radiotherapy is a standard procedure to minimize the risk of local recurrence and is increasingly performed as local stereotactic radiotherapy to the resection cavity. Both hypofractionated stereotactic radiotherapy (HFSRT) and single fraction stereotactic radiosurgery (SRS) can be applied in this case. Although adjuvant stereotactic radiotherapy to the resection cavity is widely used in clinical routine and recommended in international guidelines, the optimal fractionation scheme still remains unclear. The SATURNUS trial prospectively compares adjuvant HFSRT with SRS and seeks to detect the superiority of HFSRT over SRS in terms of local tumor control.
    Methods: In this single center two-armed randomized phase III trial, adjuvant radiotherapy to the resection cavity of brain metastases with HFSRT (6 - 7 × 5 Gy prescribed to the surrounding isodose) is compared to SRS (1 × 12-20 Gy prescribed to the surrounding isodose). Patients are randomized 1:1 into the two different treatment arms. The primary endpoint of the trial is local control at the resected site at 12 months. The trial is based on the hypothesis that HFSRT is superior to SRS in terms of local tumor control.
    Discussion: Although adjuvant stereotactic radiotherapy after resection of brain metastases is considered standard of care treatment, there is a need for further prospective research to determine the optimal fractionation scheme. To the best of our knowledge, the SATURNUS study is the only randomized phase III study comparing different regimes of postoperative stereotactic radiotherapy to the resection cavity adequately powered to detect the superiority of HFSRT regarding local control.
    Trial registration: The study was retrospectively registered with ClinicalTrials.gov, number NCT05160818, on December 16, 2021. The trial registry record is available on  https://clinicaltrials.gov/study/NCT05160818 . The presented protocol refers to version V1.3 from March 21, 2021.
    MeSH term(s) Humans ; Radiosurgery ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/surgery ; Radiation Dose Hypofractionation ; Brain ; Dose Fractionation, Radiation ; Adjuvants, Immunologic ; Randomized Controlled Trials as Topic ; Clinical Trials, Phase III as Topic
    Chemical Substances Adjuvants, Immunologic
    Language English
    Publishing date 2023-07-29
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11202-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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