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Artikel ; Online: Genetic analysis of probable sleep bruxism and its associations with clinical and behavioral traits.

Strausz, Tommi / Strausz, Satu / Palotie, Tuula / Ahlberg, Jari / Ollila, Hanna M

2023 Band 46, Heft 10

Abstract: Study objectives: Sleep bruxism (SB) can cause damage on teeth, headache and severe pain affecting both sleep and daily functioning. Yet despite the growing interest into bruxism, the underlying clinically relevant biological mechanisms remain ... ...

Abstract	Study objectives: Sleep bruxism (SB) can cause damage on teeth, headache and severe pain affecting both sleep and daily functioning. Yet despite the growing interest into bruxism, the underlying clinically relevant biological mechanisms remain unresolved. The aim of our study was to understand biological mechanisms and clinical correlates of SB including previously reported disease associations. Methods: We used data from the FinnGen release R9 (N = 377 277 individuals) that are linked with Finnish hospital and primary care registries. We identified 12 297 (3.26%) individuals with International Classification of Diseases (ICD)-10 codes used for SB. In addition, we used logistic regression to examine the association between probable SB and its clinically diagnosed risk factors and comorbidities using ICD-10 codes. Furthermore, we examined medication purchases using prescription registry. Finally, we performed the first genome-wide association analysis for probable SB and computed genetic correlations using questionnaire, lifestyle, and clinical traits. Results: The genome-wide association analysis revealed one significant association: rs10193179 intronic to Myosin IIIB (MYO3B) gene. In addition, we observed phenotypic associations and high genetic correlations with pain diagnoses, sleep apnea, reflux disease, upper respiratory diseases, psychiatric traits, and also their related medications such as antidepressants and sleep medication (p < 1e-4 for each trait). Conclusions: Our study provides a large-scale genetic framework to understand risk factors for SB and suggests potential biological mechanisms. Furthermore, our work strengthens the important earlier work that highlights SB as a trait that is associated with multiple axes of health. As part of this study, we provide genome-wide summary statistics that we hope will be useful for the scientific community studying SB.
Sprache	Englisch
Erscheinungsdatum	2023-05-04
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	424441-2
ISSN	1550-9109 ; 0161-8105
ISSN (online)	1550-9109
ISSN	0161-8105
DOI	10.1093/sleep/zsad107
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Genetic Analysis of Obstructive Sleep Apnea and Its Relationship with Severe COVID-19.

Strausz, Satu / Agafonova, Elizabete / Tiullinen, Varvara / Kiiskinen, Tuomo / Broberg, Martin / Ruotsalainen, Sanni E / Koskela, Jukka / Bachour, Adel / Sofer, Tamar / Gottlieb, Daniel J / Palotie, Aarno / Palotie, Tuula / Ripatti, Samuli / Ollila, Hanna M

Annals of the American Thoracic Society

2024

Abstract: Rationale: While patients with obstructive sleep apnea (OSA) have a higher risk for COVID-19 hospitalization, the causal relationship has remained unexplored.: Objectives: To understand the causal relationship between OSA and COVID-19 leveraging data ...

Abstract	Rationale: While patients with obstructive sleep apnea (OSA) have a higher risk for COVID-19 hospitalization, the causal relationship has remained unexplored. Objectives: To understand the causal relationship between OSA and COVID-19 leveraging data from vaccination and electronic health records, genetic risk factors from genome-wide association studies (GWAS) and Mendelian randomization. Methods: We elucidated genetic risk factors for OSA using FinnGen (N total = 377,277 individuals) performing genome-wide association. We used the associated variants as instruments for univariate and multivariate Mendelian randomization (MR) analyses and computed absolute risk reduction (ARR) against COVID-19 hospitalization with or without vaccination. Measurements and main results: We identified 9 novel loci for OSA and replicated our findings in the Million Veterans Program. Furthermore, MR analysis showed that OSA was a causal risk factor for severe COVID-19 (P=9.41x10-4). Probabilistic modelling showed that the strongest genetic risk factor for OSA at the FTO locus reflected a signal of higher BMI, whereas BMI independent association was seen with the earlier reported SLC9A4 locus and a MECOM locus which is a transcriptional regulator with 210-fold enrichment in the Finnish population. Similarly, Multivariate MR (MVMR) analysis showed that the causality for severe COVID-19 was driven by body mass index (BMI), (P MVMR = 5.97x10-6, beta=0.47). Finally, vaccination reduced the risk for COVID-19 hospitalization more in the OSA patients than in the non-OSA controls: ARR = 13.3% vs. ARR = 6.3% in the OSA vs. non-OSA population. Conclusions: Our analysis identified novel genetic risk factors for OSA and showed that OSA is a causal risk factor for severe COVID-19. The effect is predominantly explained by higher BMI and suggests BMI-dependent effects at the level of individual variants and at the level of comorbid causality.
Sprache	Englisch
Erscheinungsdatum	2024-02-08
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202303-215OC
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA.

Tervi, Anniina / Junna, Nella / Broberg, Martin / Jones, Samuel E / Strausz, Satu / Kreivi, Hanna-Riikka / Heckman, Caroline A / Ollila, Hanna M

Human molecular genetics

2022 Band 32, Heft 1, Seite(n) 161–171

Abstract: Tuberculosis is a significant public health concern resulting in the death of over 1 million individuals each year worldwide. While treatment options and vaccines exist, a substantial number of infections still remain untreated or are caused by treatment ...

Abstract	Tuberculosis is a significant public health concern resulting in the death of over 1 million individuals each year worldwide. While treatment options and vaccines exist, a substantial number of infections still remain untreated or are caused by treatment resistant strains. Therefore, it is important to identify mechanisms that contribute to risk and prognosis of tuberculosis as this may provide tools to understand disease mechanisms and provide novel treatment options for those with severe infection. Our goal was to identify genetic risk factors that contribute to the risk of tuberculosis and to understand biological mechanisms and causality behind the risk of tuberculosis. A total of 1895 individuals in the FinnGen study had International Classification of Diseases-based tuberculosis diagnosis. Genome-wide association study analysis identified genetic variants with statistically significant association with tuberculosis at the human leukocyte antigen (HLA) region (P < 5e-8). Fine mapping of the HLA association provided evidence for one protective haplotype tagged by HLA DQB105:01 (P = 1.82E-06, OR = 0.81 [CI 95% 0.74-0.88]), and predisposing alleles tagged by HLA DRB113:02 (P = 0.00011, OR = 1.35 [CI 95% 1.16-1.57]). Furthermore, genetic correlation analysis showed association with earlier reported risk factors including smoking (P < 0.05). Mendelian randomization supported smoking as a risk factor for tuberculosis (inverse-variance weighted P < 0.05, OR = 1.83 [CI 95% 1.15-2.93]) with no significant evidence of pleiotropy. Our findings indicate that specific HLA alleles associate with the risk of tuberculosis. In addition, lifestyle risk factors such as smoking contribute to the risk of developing tuberculosis.
Mesh-Begriff(e)	Humans ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Tuberculosis/genetics ; HLA-DQ beta-Chains/genetics ; HLA-DRB1 Chains/genetics ; Haplotypes/genetics ; Risk Factors ; Alleles ; Gene Frequency
Chemische Substanzen	HLA-DQ beta-Chains ; HLA-DRB1 Chains
Sprache	Englisch
Erscheinungsdatum	2022-08-26
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddac212
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections.

Jones, Samuel E / Maisha, Fahrisa I / Strausz, Satu J / Lammi, Vilma / Cade, Brian E / Tervi, Anniina / Helaakoski, Viola / Broberg, Martin E / Lane, Jacqueline M / Redline, Susan / Saxena, Richa / Ollila, Hanna M

EBioMedicine

2023 Band 93, Seite(n) 104630

Abstract: Background: Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. We examined if poor sleep contributes as a causal risk factor ... ...

Abstract	Background: Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. We examined if poor sleep contributes as a causal risk factor to respiratory infections. Methods: We used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000). We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and performed Mendelian randomization analyses to assess causality. Findings: Utilizing 23 years of registry data and follow-up, we discovered that insomnia diagnosis associated with increased risk for infections (FinnGen influenza Cox's proportional hazard (CPH) HR = 4.34 [3.90, 4.83], P = 4.16 × 10 Interpretation: Our findings indicate that chronic poor sleep is a causal risk factor for contracting respiratory infections, and in addition contributes to the severity of respiratory infections. These findings highlight the role of sleep in maintaining sufficient immune response against pathogens. Funding: Instrumentarium Science Foundation, Academy of Finland, Signe and Ane Gyllenberg Foundation, National Institutes of Health.
Mesh-Begriff(e)	Humans ; Influenza, Human/complications ; Influenza, Human/epidemiology ; Sleep Initiation and Maintenance Disorders ; Public Health ; COVID-19/complications ; COVID-19/epidemiology ; Respiratory Tract Infections/complications ; Respiratory Tract Infections/epidemiology ; Sleep ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide
Sprache	Englisch
Erscheinungsdatum	2023-06-08
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2023.104630
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease.

Nature communications

2024 Band 15, Heft 1, Seite(n) 2041

Abstract: Lyme disease is a tick-borne disease caused by bacteria of the genus Borrelia. The host factors that modulate susceptibility for Lyme disease have remained mostly unknown. Using epidemiological and genetic data from FinnGen and Estonian Biobank, we ... ...

Abstract	Lyme disease is a tick-borne disease caused by bacteria of the genus Borrelia. The host factors that modulate susceptibility for Lyme disease have remained mostly unknown. Using epidemiological and genetic data from FinnGen and Estonian Biobank, we identify two previously known variants and an unknown common missense variant at the gene encoding for Secretoglobin family 1D member 2 (SCGB1D2) protein that increases the susceptibility for Lyme disease. Using live Borrelia burgdorferi (Bb) we find that recombinant reference SCGB1D2 protein inhibits the growth of Bb in vitro more efficiently than the recombinant protein with SCGB1D2 P53L deleterious missense variant. Finally, using an in vivo murine infection model we show that recombinant SCGB1D2 prevents infection by Borrelia in vivo. Together, these data suggest that SCGB1D2 is a host defense factor present in the skin, sweat, and other secretions which protects against Bb infection and opens an exciting therapeutic avenue for Lyme disease.
Mesh-Begriff(e)	Mice ; Animals ; Humans ; Borrelia burgdorferi/genetics ; Lyme Disease/microbiology ; Ixodes/microbiology ; Secretoglobins
Chemische Substanzen	SCGB1D2 protein, human ; Secretoglobins
Sprache	Englisch
Erscheinungsdatum	2024-03-19
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45983-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections.

Jones, Samuel E / Maisha, Fahrisa I / Strausz, Satu J / Cade, Brian E / Tervi, Anniina M / Helaakoski, Viola / Broberg, Martin E / Lammi, Vilma / Lane, Jacqueline M / Redline, Susan / Saxena, Richa / Ollila, Hanna M

medRxiv : the preprint server for health sciences

2022

Abstract: Background: Poor sleep is associated with an increased risk of infections and all-cause mortality, and acute sleep loss and disruption have been linked with inflammation and poorer immune control. Previous studies, however, have been unable to evidence ... ...

Abstract	Background: Poor sleep is associated with an increased risk of infections and all-cause mortality, and acute sleep loss and disruption have been linked with inflammation and poorer immune control. Previous studies, however, have been unable to evidence causality between the chronic effects of poor sleep and respiratory infection risk. In light of the ongoing COVID-19 pandemic and potential future disease outbreaks, understanding the risk factors for these infections is of great importance. Aim: Our goal was to understand if chronic poor sleep could be identified as a causal risk factor for respiratory infections including influenza, upper respiratory infections and COVID-19. Methods: We used population cohorts from the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 327,000) with ICD-10 based electronic health records and obtained diagnoses of insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital settings. We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and used summary statistics from genome-wide association studies of insomnia, influenza, URI and COVID-19 to perform Mendelian randomization analyses and assess causality. Findings: Utilizing 23 years of registry data and follow-up, we saw that insomnia diagnosis associated with increased risk for infections in FinnGen and in UK Biobank (FinnGen influenza HR = 5.32 [4.09, 6.92], P = 1.02×10 Conclusions: Our findings indicate that chronic poor sleep is a causal risk factor for contracting respiratory infections, and in addition contributes to the severity of respiratory infections. These findings highlight the role of sleep in maintaining sufficient immune response against pathogens as suggested by earlier work. As the current COVID-19 pandemic has increased the number of people suffering from poor sleep, safe interventions such as sleep management and treating individuals with insomnia could be promoted to reduce infections and save lives.
Sprache	Englisch
Erscheinungsdatum	2022-02-17
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2022.02.16.22271055
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sleep apnoea is a risk factor for severe COVID-19.

Strausz, Satu / Kiiskinen, Tuomo / Broberg, Martin / Ruotsalainen, Sanni / Koskela, Jukka / Bachour, Adel / Palotie, Aarno / Palotie, Tuula / Ripatti, Samuli / Ollila, Hanna M

BMJ open respiratory research

2021 Band 8, Heft 1

Abstract: Background: Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection ...

Abstract	Background: Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19. Methods: OSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies. Results: We identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10 Conclusion: Risk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19.
Mesh-Begriff(e)	Aged ; COVID-19/epidemiology ; Comorbidity ; Female ; Finland/epidemiology ; Humans ; Male ; Middle Aged ; Registries ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Sleep Apnea, Obstructive/epidemiology
Sprache	Englisch
Erscheinungsdatum	2021-01-12
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2020-000845
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections

Jones, Samuel E. / Maisha, Fahrisa I. / Strausz, Satu J. / Cade, Brian E. / Tervi, Anniina M. / Helaakoski, Viola / Broberg, Martin E. / Lammi, Vilma / FinnGen / Lane, Jacqueline M. / Redline, Susan / Saxena, Richa / Ollila, Hanna M.

medRxiv

Abstract: ... Background ... Poor sleep is associated with an increased risk of infections and all-cause mortality, and acute sleep loss and disruption have been linked with inflammation and poorer immune control. Previous studies, however, have been unable to ... ...

Abstract	Background Poor sleep is associated with an increased risk of infections and all-cause mortality, and acute sleep loss and disruption have been linked with inflammation and poorer immune control. Previous studies, however, have been unable to evidence causality between the chronic effects of poor sleep and respiratory infection risk. In light of the ongoing COVID-19 pandemic and potential future disease outbreaks, understanding the risk factors for these infections is of great importance. Aim Our goal was to understand if chronic poor sleep could be identified as a causal risk factor for respiratory infections including influenza, upper respiratory infections and COVID-19. Methods We used population cohorts from the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 327,000) with ICD-10 based electronic health records and obtained diagnoses of insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital settings. We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and used summary statistics from genome-wide association studies of insomnia, influenza, URI and COVID-19 to perform Mendelian randomization analyses and assess causality. Findings Utilizing 23 years of registry data and follow-up, we saw that insomnia diagnosis associated with increased risk for infections in FinnGen and in UK Biobank (FinnGen influenza HR = 5.32 [4.09, 6.92], P = 1.02×10<sup>-35</sup>, UK Biobank influenza HR = 1.54 [1.37, 1.73], P = 2.49×10<sup>-13</sup>). Mendelian randomization indicated that insomnia causally predisposed to influenza (OR = 1.59, P = 6.23×10<sup>-4</sup>), upper respiratory infections (OR = 1.71, P = 7.60×10<sup>-13</sup>), COVID-19 infection (OR = 1.08, P = 0.037) and risk of hospitalization from COVID-19 (OR = 1.47, P = 4.96×10<sup>-5</sup>). Conclusions Our findings indicate that chronic poor sleep is a causal risk factor for contracting respiratory infections, and in addition contributes to the severity of respiratory infections. These findings highlight the role of sleep in maintaining sufficient immune response against pathogens as suggested by earlier work. As the current COVID-19 pandemic has increased the number of people suffering from poor sleep, safe interventions such as sleep management and treating individuals with insomnia could be promoted to reduce infections and save lives.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2022-02-17
Verlag	Cold Spring Harbor Laboratory Press
Dokumenttyp	Artikel ; Online
DOI	10.1101/2022.02.16.22271055
Datenquelle	COVID19

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Artikel ; Online: Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.

The European respiratory journal

2021 Band 57, Heft 5

Abstract: There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We conducted the ... ...

Abstract	There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients identified using nationwide health registries.We estimated 0.08 (95% CI 0.06-0.11) heritability and identified five loci associated with OSA (p<5.0×10
Mesh-Begriff(e)	Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Body Mass Index ; Diabetes Mellitus, Type 2 ; Genome-Wide Association Study ; Humans ; Hypertension ; Risk Factors ; Sleep Apnea, Obstructive
Chemische Substanzen	Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
Sprache	Englisch
Erscheinungsdatum	2021-05-06
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.03091-2020
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sleep apnoea is a risk factor for severe COVID-19

Strausz, Satu / Kiiskinen, Tuomo / Broberg, Martin / Ruotsalainen, Sanni / Koskela, Jukka / Bachour, Adel / Palotie, Aarno / Palotie, Tuula / Ripatti, Samuli / Ollila, Hanna M

medRxiv

Abstract: Objective: To investigate if obstructive sleep apnoea (OSA) is an independent risk factor for severe COVID-19. To examine whether the risk for contracting COVID-19 is elevated among OSA patients. Design and setting: Registry based retrospective case- ... ...

Abstract	Objective: To investigate if obstructive sleep apnoea (OSA) is an independent risk factor for severe COVID-19. To examine whether the risk for contracting COVID-19 is elevated among OSA patients. Design and setting: Registry based retrospective case-control study using Finnish nationwide health registries and the FinnGen Study cohort. Participants: Information regarding OSA diagnosis and COVID-19 infection was extracted from the FinnGen study (N=260,405) with a total of 305 patients who had a recorded PCR-validated COVID-19 infection including 26 (8.5%) individuals who were also OSA patients. Severe COVID-19 (N=83, 27.2%) was defined as an infection requiring hospitalization. Among the hospitalized individuals there were 16 (19.3%) with OSA diagnosis. In addition, we also included in our analysis previously reported risk factors for both severe COVID-19 or risk factors and comorbidities for OSA from FinnGen. Main outcome measures: OSA diagnosis, information concerning COVID-19 infection such as hospitalization, were derived from Finnish National Hospital Discharge Registry, Causes of Death Registry and the National Infectious Diseases Registry. Results: We show that OSA is a risk factor for COVID-19 hospitalization independent from age, sex, body mass index (BMI), hypertension, diabetes, coronary heart disease (CHD), asthma and chronic obstructive pulmonary disease (COPD), (p-unadjusted=1.04x10^-4, OR-adjusted=5.24 [95%CI 1.33 to 23.43], p-adjusted=0.022). OSA was not associated with the risk of contracting COVID-19 (p=0.49). Conclusion: While an OSA patients risk of contracting COVID-19 is the same as non-OSA individuals, the OSA patients have a five-fold risk to be hospitalized when affected by COVID-19 than non-OSA individuals. Our findings suggest that, in assessment of patients with suspected or confirmed COVID-19 infection, OSA needs to be recognized as one of the comorbidity risk factors for developing a severe form of the disease.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-09-28
Verlag	Cold Spring Harbor Laboratory Press
Dokumenttyp	Artikel ; Online
DOI	10.1101/2020.09.26.20202051
Datenquelle	COVID19

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