LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Tracheostomies for respiratory failure are associated with a high inpatient mortality: a potential trigger to reconsider goals of care.

    Colbert, Cameron / Streblow, Aaron D / Sherry, Scott P / Dobbertin, Konrad / Cook, Mackenzie

    Trauma surgery & acute care open

    2024  Volume 9, Issue 1, Page(s) e001105

    Abstract: Introduction: Acute care surgeons are frequently consulted for tracheostomy placement in the intensive care unit (ICU). Tracheostomy may facilitate ventilator weaning and improve physical comfort. Short-term outcomes after tracheostomy are not well ... ...

    Abstract Introduction: Acute care surgeons are frequently consulted for tracheostomy placement in the intensive care unit (ICU). Tracheostomy may facilitate ventilator weaning and improve physical comfort. Short-term outcomes after tracheostomy are not well studied. We hypothesize that a high proportion of ICU patients who underwent tracheostomy died prior to discharge. These data will help guide clinical decision-making at a key pivot point in care.
    Methods: We identified 177 mixed ICU patients who received a tracheostomy for respiratory failure between January 2013 and December 2018. We excluded patients with trauma. Patient information was collected and comparisons made with univariable and multivariable statistics.
    Results: Of the 177 patients who underwent a tracheostomy for respiratory failure, 45% were women, median age was 63 (51-71) years. Of this group 18% died prior to discharge, 63% were discharged to a care facility and only 16% discharged home. Compared with survivors, patients with tracheostomies who died during their admission were older, age 69 (64-76) versus 61 (49-71) years (p<0.01) on univariable analysis. In this model, no single comorbid condition or length of stay (LOS) variable was predictive of death before discharge. A multivariable model controlling for covariation similarly identified age, as well as a longer ICU LOS of 34 (20-49) versus 23 (16-31) days (p=0.003) as factors associated with increased likelihood of death before discharge.
    Conclusions: Tracheostomy placement in a mixed ICU population is associated with a nearly 20% inpatient mortality and the vast majority of surviving patients were discharged to a care facility. This suggests that the need for tracheostomy could be considered a trigger for re-evaluation of patient goals. The high risk of death due to underlying illness and high intensity care after their hospitalization emphasize the need for clear advanced care planning discussions around the time of tracheostomy placement.
    Level of evidence: Level IV, Retrospective cohort study.
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ISSN 2397-5776
    ISSN (online) 2397-5776
    DOI 10.1136/tsaco-2023-001105
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Placental Glucose Uptake in a Nonhuman Primate Model of Western-Style Diet Consumption and Chronic Hyperandrogenemia Exposure.

    Roberts, Victoria H J / Streblow, Aaron D / Gaffney, Jessica E / Rettke, Samantha P / Frias, Antonio E / Slayden, Ov D

    Reproductive sciences (Thousand Oaks, Calif.)

    2021  Volume 28, Issue 9, Page(s) 2574–2581

    Abstract: We reported that consumption of a western-style diet (WSD) with and without hyperandrogenemia perturbed placental perfusion and altered levels of glucose transporter proteins in rhesus macaques. Based on that result, we hypothesized that placental ... ...

    Abstract We reported that consumption of a western-style diet (WSD) with and without hyperandrogenemia perturbed placental perfusion and altered levels of glucose transporter proteins in rhesus macaques. Based on that result, we hypothesized that placental glucose uptake would be dysregulated in this model. In this study, female rhesus macaques were assigned at puberty to one of four groups: subcutaneous cholesterol implants + standard chow diet (controls, C); testosterone implants + chow (T); cholesterol implants + a high-fat, WSD; and T+WSD. After ~6 years of treatment, animals were mated, and pregnancies were delivered by cesarean section at gestational day (G) 130 (the term is G168). Placental villous explants were immediately prepared for radiolabeled glucose assay. Linear glucose uptake was observed between 0 and 30 s. At 20 s, glucose uptake in placental villous explants did not differ across the four treatment groups with values as follows: C: 25.5 ± 6.33, T: 22.9 ± 0.404, WSD: 26.9.0 ± 3.71, and T+WSD: 33.0 ± 3.12 (mean ± SD expressed in pmol/mg). Unlike our prior experiment, glucose transporter expression was reduced in WSD placentas, and our in vitro functional assay did not demonstrate a difference in glucose uptake across the transporting epithelium of the placenta. Notably, maternal blood glucose levels were significantly elevated in animals chronically fed a WSD. This disparity may indicate differences in glucose utilization and metabolism by the placenta itself, as glucose transporter expression and circulating fetal glucose concentrations were comparable across all four groups in this pregnancy cohort.
    MeSH term(s) Animal Feed ; Animals ; Blood Glucose/metabolism ; Diet, Western/adverse effects ; Disease Models, Animal ; Female ; Glucose Transport Proteins, Facilitative/genetics ; Glucose Transport Proteins, Facilitative/metabolism ; Hyperandrogenism/blood ; Hyperandrogenism/microbiology ; Hyperandrogenism/physiopathology ; Macaca mulatta ; Maternal Nutritional Physiological Phenomena ; Nutritive Value ; Placenta/blood supply ; Placenta/metabolism ; Placental Circulation ; Pregnancy ; Time Factors
    Chemical Substances Blood Glucose ; Glucose Transport Proteins, Facilitative
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-021-00526-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Quantitative longitudinal T2* mapping for assessing placental function and association with adverse pregnancy outcomes across gestation.

    Schabel, Matthias C / Roberts, Victoria H J / Gibbins, Karen J / Rincon, Monica / Gaffney, Jessica E / Streblow, Aaron D / Wright, Adam M / Lo, Jamie O / Park, Byung / Kroenke, Christopher D / Szczotka, Kathryn / Blue, Nathan R / Page, Jessica M / Harvey, Kathy / Varner, Michael W / Silver, Robert M / Frias, Antonio E

    PloS one

    2022  Volume 17, Issue 7, Page(s) e0270360

    Abstract: Existing methods for evaluating in vivo placental function fail to reliably detect pregnancies at-risk for adverse outcomes prior to maternal and/or fetal morbidity. Here we report the results of a prospective dual-site longitudinal clinical study of ... ...

    Abstract Existing methods for evaluating in vivo placental function fail to reliably detect pregnancies at-risk for adverse outcomes prior to maternal and/or fetal morbidity. Here we report the results of a prospective dual-site longitudinal clinical study of quantitative placental T2* as measured by blood oxygen-level dependent magnetic resonance imaging (BOLD-MRI). The objectives of this study were: 1) to quantify placental T2* at multiple time points across gestation, and its consistency across sites, and 2) to investigate the association between placental T2* and adverse outcomes. 797 successful imaging studies, at up to three time points between 11 and 38 weeks of gestation, were completed in 316 pregnancies. Outcomes were stratified into three groups: (UN) uncomplicated/normal pregnancy, (PA) primary adverse pregnancy, which included hypertensive disorders of pregnancy, birthweight <5th percentile, and/or stillbirth or fetal death, and (SA) secondary abnormal pregnancy, which included abnormal prenatal conditions not included in the PA group such as spontaneous preterm birth or fetal anomalies. Of the 316 pregnancies, 198 (62.6%) were UN, 70 (22.2%) PA, and 48 (15.2%) SA outcomes. We found that the evolution of placental T2* across gestation was well described by a sigmoid model, with T2* decreasing continuously from a high plateau level early in gestation, through an inflection point around 30 weeks, and finally approaching a second, lower plateau in late gestation. Model regression revealed significantly lower T2* in the PA group than in UN pregnancies starting at 15 weeks and continuing through 33 weeks. T2* percentiles were computed for individual scans relative to UN group regression, and z-scores and receiver operating characteristic (ROC) curves calculated for association of T2* with pregnancy outcome. Overall, differences between UN and PA groups were statistically significant across gestation, with large effect sizes in mid- and late- pregnancy. The area under the curve (AUC) for placental T2* percentile and PA pregnancy outcome was 0.71, with the strongest predictive power (AUC of 0.76) at the mid-gestation time period (20-30 weeks). Our data demonstrate that placental T2* measurements are strongly associated with pregnancy outcomes often attributed to placental insufficiency. Trial registration: ClinicalTrials.gov: NCT02749851.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Placenta/diagnostic imaging ; Pregnancy ; Pregnancy Outcome ; Pregnancy Trimester, Third ; Premature Birth/diagnostic imaging ; Prospective Studies
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0270360
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus.

    Haese, Nicole N / May, Nicholas A / Taft-Benz, Sharon / Moukha-Chafiq, Omar / Madadi, Nikhil / Zhang, Sixue / Karyakarte, Shuklendu D / Rodzinak, Kevin J / Nguyen, Theresa H / Denton, Michael / Streblow, Aaron D / Towers, Nichole A / Rasmussen, Lynn / Bostwick, Robert J / Maddry, Joseph A / Ananthan, Subramaniam / Augelli-Szafran, Corinne E / Suto, Mark J / Sanders, Wes /
    Moorman, Nathaniel / DeFilippis, Victor / Heise, Mark T / Pathak, Ashish K / Streblow, Daniel N / Morrison, Thomas E

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 9, Page(s) e0024421

    Abstract: Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound that protected against ... ...

    Abstract Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound that protected against VEEV-induced cytopathic effects. Analysis of viral replication in cells identified several quinolinone compounds with potent inhibitory activity against vaccine and virulent strains of VEEV. These quinolinones also displayed inhibitory activity against additional alphaviruses, such as Mayaro virus and Ross River virus, although the potency was greatly reduced. Time-of-addition studies indicated that these compounds inhibit the early-to-mid stage of viral replication. Deep sequencing and reverse genetics studies identified two unique resistance mutations in the nsP2 gene (Y102S/C; stalk domain) that conferred VEEV resistance on this chemical series. Moreover, introduction of a K102Y mutation into the nsP2 gene enhanced the sensitivity of chikungunya virus (CHIKV) to this chemical series. Computational modeling of CHIKV and VEEV nsP2 identified a highly probable docking alignment for the quinolinone compounds that require a tyrosine residue at position 102 within the helicase stalk domain. These studies identified a class of compounds with antiviral activity against VEEV and other alphaviruses and provide further evidence that therapeutics targeting nsP2 may be useful against alphavirus infection.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Chikungunya virus ; Encephalitis Virus, Venezuelan Equine/genetics ; Horses ; Humans ; Quinolones/pharmacology ; Virus Replication
    Chemical Substances Antiviral Agents ; Quinolones
    Language English
    Publishing date 2021-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00244-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors.

    Ahmed, S Kaleem / Haese, Nicole N / Cowan, Jaden T / Pathak, Vibha / Moukha-Chafiq, Omar / Smith, Valerie J / Rodzinak, Kevin J / Ahmad, Fahim / Zhang, Sixue / Bonin, Kiley M / Streblow, Aaron D / Streblow, Cassilyn E / Kreklywich, Craig N / Morrison, Clayton / Sarkar, Sanjay / Moorman, Nathaniel / Sander, Wes / Allen, Robbie / DeFilippis, Victor /
    Tekwani, Babu L / Wu, Mousheng / Hirsch, Alec J / Smith, Jessica L / Tower, Nichole A / Rasmussen, Lynn / Bostwick, Robert / Maddry, Joseph A / Ananthan, Subramaniam / Gerdes, John M / Augelli-Szafran, Corinne E / Suto, Mark J / Morrison, Thomas E / Heise, Mark T / Streblow, Daniel N / Pathak, Ashish K

    Journal of medicinal chemistry

    2021  Volume 64, Issue 8, Page(s) 4762–4786

    Abstract: A benzo[6]annulene, 4-( ...

    Abstract A benzo[6]annulene, 4-(
    MeSH term(s) Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Benzene Derivatives/chemistry ; Benzene Derivatives/metabolism ; Benzene Derivatives/pharmacology ; Benzene Derivatives/therapeutic use ; Binding Sites ; Cell Line ; Cell Survival/drug effects ; Chikungunya Fever/drug therapy ; Chikungunya virus/physiology ; Dihydroorotate Dehydrogenase ; Disease Models, Animal ; Female ; Half-Life ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Microsomes, Liver/metabolism ; Molecular Docking Simulation ; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Structure-Activity Relationship ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Benzene Derivatives ; Dihydroorotate Dehydrogenase ; Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-)
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.0c02183
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top