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  1. Book ; Online ; Thesis: Die Rolle des Stopcodons im ERV3- Hüllprotein im Bezug zur Infertilität

    Münz, Lisa Annika [Verfasser] / Strick, Reiner [Akademischer Betreuer] / Rübner, Matthias [Gutachter]

    2023  

    Author's details Lisa Annika Münz ; Gutachter:  Matthias Rübner ; Betreuer:  Reiner Strick
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article: Editorial: Unravelling the Role of HERVs in Cancer: Insights and New Targets for Therapy.

    Matteucci, Claudia / Balestrieri, Emanuela / Hurst, Tara Patricia / Magiorkinis, Gkikas / Strick, Reiner

    Frontiers in oncology

    2022  Volume 12, Page(s) 874245

    Language English
    Publishing date 2022-03-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.874245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Human Leukocyte Antigen G as an Immune Escape Mechanism and Novel Therapeutic Target in Urological Tumors.

    Jasinski-Bergner, Simon / Eckstein, Markus / Taubert, Helge / Wach, Sven / Fiebig, Christian / Strick, Reiner / Hartmann, Arndt / Seliger, Barbara

    Frontiers in immunology

    2022  Volume 13, Page(s) 811200

    Abstract: The non-classical human leukocyte antigen G (HLA-G) is a potent regulatory protein involved in the induction of immunological tolerance. This is based on the binding of membrane-bound as well as soluble HLA-G to inhibitory receptors expressed on various ... ...

    Abstract The non-classical human leukocyte antigen G (HLA-G) is a potent regulatory protein involved in the induction of immunological tolerance. This is based on the binding of membrane-bound as well as soluble HLA-G to inhibitory receptors expressed on various immune effector cells, in particular NK cells and T cells, leading to their attenuated functions. Despite its restricted expression on immune-privileged tissues under physiological conditions, HLA-G expression has been frequently detected in solid and hematopoietic malignancies including urological cancers, such as renal cell and urothelial bladder carcinoma and has been associated with progression of urological cancers and poor outcome of patients: HLA-G expression protects tumor cells from anti-tumor immunity upon interaction with its inhibitory receptors by modulating both the phenotype and function of immune cells leading to immune evasion. This review will discuss the expression, regulation, functional and clinical relevance of HLA-G expression in urological tumors as well as its use as a putative biomarker and/or potential therapeutic target for the treatment of renal cell carcinoma as well as urothelial bladder cancer.
    MeSH term(s) HLA-G Antigens ; Humans ; Immune Tolerance ; Immunotherapy ; Urologic Neoplasms/diagnosis ; Urologic Neoplasms/therapy
    Chemical Substances HLA-G Antigens
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.811200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.

    Bahlinger, Veronika / Branz, Annalena / Strissel, Pamela L / Strick, Reiner / Lange, Fabienne / Geppert, Carol I / Klümper, Niklas / Hölzel, Michael / Wach, Sven / Taubert, Helge / Sikic, Danijel / Wullich, Bernd / Angeloni, Miriam / Ferrazzi, Fulvia / Diehl, Lauri / Kovalenko, Maria / Elboudwarej, Emon / Jürgensmeier, Juliane M / Hartmann, Arndt /
    Eckstein, Markus

    Histopathology

    2024  Volume 84, Issue 5, Page(s) 863–876

    Abstract: Aims: Treatment options for advanced urothelial carcinoma (aUC) rapidly evolved: besides immunomodulative therapeutic options and inhibitors targeting Fibroblast growth factor receptor (FGFR) alterations, two new antibody-drug conjugates (ADC), ... ...

    Abstract Aims: Treatment options for advanced urothelial carcinoma (aUC) rapidly evolved: besides immunomodulative therapeutic options and inhibitors targeting Fibroblast growth factor receptor (FGFR) alterations, two new antibody-drug conjugates (ADC), sacituzumab govitecan (SG) and enfortumab vedotin (EV), have been approved. However, little is known about the associations of specific aUC properties and the surface target expression of TROP2 and NECTIN-4. Our aim was to characterize associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 protein and gene expression with morphomolecular and clinicopathological characteristics of aUC in two large independent cohorts.
    Methods and results: The TCGA BLCA (n = 405) and the CCC-EMN (n = 247) cohorts were retrospectively analysed. TROP2/TACSTD2 and NECTIN-4/NECTIN-4 are highly expressed at the protein and transcript level in aUC, and their expression status did not correlate with patient survival in both cohorts. NECTIN-4/NECTIN-4 expression was higher in luminal tumours and reduced in squamous aUCs. NECTIN-4 was negative in 10.6% of samples, and 18.4% of samples had low expression (H-score <15). The TROP2 negativity rate amounted to 6.5%. TACSTD2 and NECTIN-4 expression was reduced in neuroendocrine-like and/or protein-based double-negative tumours. TROP2- and NECTIN-4-negative tumours included one sarcomatoid and four neuroendocrine aUC. FGFR3 alterations and PD-L1 expression on tumour and immune cells did not associate with TROP2 or NECTIN-4 expression.
    Conclusions: TACSTD2/TROP2 and NECTIN-4/NECTIN-4 are widely expressed in aUC, independent of FGFR3 alterations or PD-L1 expression, thus representing a suitable target for ADC treatment in the majority of aUC. The expression loss was associated with aggressive morphomolecular aUC subtypes, i.e. neuroendocrine(-like) and sarcomatoid aUC.
    MeSH term(s) Humans ; Urinary Bladder Neoplasms/genetics ; Carcinoma, Transitional Cell ; Nectins/genetics ; B7-H1 Antigen ; Retrospective Studies ; Cell Adhesion Molecules/metabolism ; Antigens, Neoplasm/metabolism ; Receptor, Fibroblast Growth Factor, Type 3/genetics
    Chemical Substances Nectins ; B7-H1 Antigen ; Cell Adhesion Molecules ; TACSTD2 protein, human ; Antigens, Neoplasm ; FGFR3 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.15130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online ; Thesis: Fetale Wachstumsrestriktion – Einfluss von Proteinmangel auf die neuroplazentare Glucocorticoid-Achse im Modell der Ratte

    Schmidt, Marius [Verfasser] / Fahlbusch, Fabian [Akademischer Betreuer] / Fahlbusch, Fabian [Gutachter] / Hartner, Andrea [Gutachter] / Strick, Reiner [Gutachter] / Markert, Udo [Gutachter]

    2023  

    Author's details Marius Schmidt ; Gutachter: Fabian Fahlbusch, Andrea Hartner, Reiner Strick, Udo Markert ; Betreuer: Fabian Fahlbusch
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts.

    Wieland, Annalena / Strissel, Pamela L / Schorle, Hannah / Bakirci, Ezgi / Janzen, Dieter / Beckmann, Matthias W / Eckstein, Markus / Dalton, Paul D / Strick, Reiner

    Cancers

    2021  Volume 13, Issue 20

    Abstract: Background: Glioblastoma multiforme (GBM) and metastatic triple-negative breast cancer (TNBC) with : Methods: 3D microfibers and scaffolds were printed using melt electrowriting. GBM and TNBC cell lines with opposing PTEN genotypes were analyzed with ...

    Abstract Background: Glioblastoma multiforme (GBM) and metastatic triple-negative breast cancer (TNBC) with
    Methods: 3D microfibers and scaffolds were printed using melt electrowriting. GBM and TNBC cell lines with opposing PTEN genotypes were analyzed with RHO-ROCK-PTEN inhibitors and PTEN rescue using live-cell imaging. RNA-sequencing and qPCR of tumor cells in 3D with microfibers were performed, while scanning electron microscopy and confocal microscopy addressed cell morphology.
    Results: In contrast to the PTEN wildtype, GBM and TNBC cells with PTEN loss of function yielded enhanced durotaxis, topotaxis, adhesion, amoeboid migration on 3D microfibers and significant high RHOB expression. Functional studies concerning RHOB-ROCK-PTEN signaling confirmed the essential role for the above cellular processes.
    Conclusions: This study demonstrates a significant role of the
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13205144
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  7. Book ; Online ; Thesis: PTEN als Modulator von Östrogenrezeptor- und Tyrosinkinase-Signalwegen in Brust- und Endometriumkarzinomzellen unter Tamoxifenbehandlung

    Ellmann, Stephan / Strick, Reiner

    2013  

    Title variant PTEN as a Modulator of Estrogen Receptor and Tyrosine-Kinase-Signalling Pathways in Breast- and Endometrial Cancer Cells under Tamoxifen Treatment
    Author's details Stephan Ellmann. Betreuer: Reiner Strick
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek der Universität Erlangen-Nürnberg
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Erlangen, Universität Erlangen-Nürnberg, Diss., 2013
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility.

    Böhringer, David / Bauer, Andreas / Moravec, Ivana / Bischof, Lars / Kah, Delf / Mark, Christoph / Grundy, Thomas J / Görlach, Ekkehard / O'Neill, Geraldine M / Budday, Silvia / Strissel, Pamela L / Strick, Reiner / Malandrino, Andrea / Gerum, Richard / Mak, Michael / Rausch, Martin / Fabry, Ben

    Matrix biology : journal of the International Society for Matrix Biology

    2023  Volume 124, Page(s) 39–48

    Abstract: Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment that induce deformations and remodeling of the fiber network. By measuring these deformations, the traction forces can be reconstructed if the mechanical ... ...

    Abstract Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment that induce deformations and remodeling of the fiber network. By measuring these deformations, the traction forces can be reconstructed if the mechanical properties of the matrix and the force-free matrix configuration are known. These requirements limit the applicability of traction force reconstruction in practice. In this study, we test whether force-induced matrix remodeling can instead be used as a proxy for cellular traction forces. We measure the traction forces of hepatic stellate cells and different glioblastoma cell lines and quantify matrix remodeling by measuring the fiber orientation and fiber density around these cells. In agreement with simulated fiber networks, we demonstrate that changes in local fiber orientation and density are directly related to cell forces. By resolving Rho-kinase (ROCK) inhibitor-induced changes of traction forces, fiber alignment, and fiber density in hepatic stellate cells, we show that the method is suitable for drug screening assays. We conclude that differences in local fiber orientation and density, which are easily measurable, can be used as a qualitative proxy for changes in traction forces. The method is available as an open-source Python package with a graphical user interface.
    MeSH term(s) Extracellular Matrix/metabolism ; Cell Line ; Collagen/metabolism
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2023-11-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2023.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1694: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Improved Bladder Tumor RNA Isolation from Archived Tissues Using Methylene Blue for Normalization, Multiplex RNA Hybridization, Sequencing and Subtyping.

    Köhler, Stefanie A / Brandl, Lisa / Strissel, Pamela L / Gloßner, Laura / Ekici, Arif B / Angeloni, Miriam / Ferrazzi, Fulvia / Bahlinger, Veronika / Hartmann, Arndt / Beckmann, Matthias W / Eckstein, Markus / Strick, Reiner

    International journal of molecular sciences

    2022  Volume 23, Issue 18

    Abstract: Methylene blue (MB) is a dye used for histology with clinical importance and intercalates into nucleic acids. After MB staining of formalin fixed paraffin embedded (FFPE) muscle invasive bladder cancer (MIBC) and normal urothelium, specific regions could ...

    Abstract Methylene blue (MB) is a dye used for histology with clinical importance and intercalates into nucleic acids. After MB staining of formalin fixed paraffin embedded (FFPE) muscle invasive bladder cancer (MIBC) and normal urothelium, specific regions could be microdissected. It is not known if MB influences RNA used for gene expression studies. Therefore, we analyzed MIBC using five different RNA isolation methods comparing patient matched FFPE and fresh frozen (FF) tissues pre-stained with or without MB. We demonstrate a positive impact of MB on RNA integrity with FF tissues using real time PCR with no interference of its chemical properties. FFPE tissues showed no improvement of RNA integrity, which we propose is due to formalin induced nucleotide crosslinks. Using direct multiplex RNA hybridization the best genes for normalization of MIBC and control tissues were identified from 34 reference genes. In addition, 5SrRNA and 5.8SrRNA were distinctive reference genes detecting <200 bp fragments important for mRNA analyses. Using these normalized RNAs from MB stained MIBC and applying multiplex RNA hybridization and mRNA sequencing, a minimal gene expression panel precisely identified luminal and basal MIBC tumor subtypes, important for diagnosis, prognosis and chemotherapy response.
    MeSH term(s) Formaldehyde/chemistry ; Gene Expression Profiling/methods ; Humans ; Methylene Blue/pharmacology ; Nucleotides ; Paraffin Embedding/methods ; RNA/analysis ; RNA/genetics ; RNA, Messenger/genetics ; Tissue Fixation/methods ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/genetics
    Chemical Substances Nucleotides ; RNA, Messenger ; Formaldehyde (1HG84L3525) ; RNA (63231-63-0) ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2022-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231810267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The human leukocyte antigen G as an immune escape mechanism and novel therapeutic target in urological tumors

    Jasinski-Bergner, Simon / Eckstein, Markus Christian / Taubert, Helge / Wach, Sven / Fiebig, Christian / Strick, Reiner / Hartmann, Arndt / Seliger, Barbara

    2022  

    Abstract: The non-classical human leukocyte antigen G (HLA-G) is a potent regulatory protein involved in the induction of immunological tolerance. This is based on the binding of membrane-bound as well as soluble HLA-G to inhibitory receptors expressed on various ... ...

    Abstract The non-classical human leukocyte antigen G (HLA-G) is a potent regulatory protein involved in the induction of immunological tolerance. This is based on the binding of membrane-bound as well as soluble HLA-G to inhibitory receptors expressed on various immune effector cells, in particular NK cells and T cells, leading to their attenuated functions. Despite its restricted expression on immune-privileged tissues under physiological conditions, HLA-G expression has been frequently detected in solid and hematopoietic malignancies including urological cancers, such as renal cell and urothelial bladder carcinoma and has been associated with progression of urological cancers and poor outcome of patients: HLA-G expression protects tumor cells from anti-tumor immunity upon interaction with its inhibitory receptors by modulating both the phenotype and function of immune cells leading to immune evasion. This review will discuss the expression, regulation, functional and clinical relevance of HLA-G expression in urological tumors as well as its use as a putative biomarker and/or potential therapeutic target for the treatment of renal cell carcinoma as well as urothelial bladder cancer.

    13
    Keywords HLA-G ; Renal cell carcinoma ; Epithelial bladder cancer ; Immune evasion ; Immunotherapy ; Immune cell infiltration
    Subject code 570 ; 616
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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