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Article ; Online: Time for a botulinum toxin passport?

Stroman, Luke / Robinson, Dudley / Malde, Sachin / Sahai, Arun

2020 Volume 39, Issue 8, Page(s) 2546–2549

Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.24514
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Article ; Online: A cross-section of UK prostate cancer diagnostics during the COVID-19 era - a shifting paradigm?

Stroman, L / Cathcart, P / Lamb, A / Challacombe, B / Popert, R

BJU International ; ISSN 1464-4096

2020

Keywords	Urology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/bju.15259
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A cross-section of UK prostate cancer diagnostics during the coronavirus disease 2019 (COVID-19) era - a shifting paradigm?

Stroman, Luke / Cathcart, Paul / Lamb, Alastair / Challacombe, Ben / Popert, Rick

BJU international

2020 Volume 127, Issue 1, Page(s) 30–34

MeSH term(s)	COVID-19/epidemiology ; Comorbidity ; Humans ; Incidence ; Male ; Neoplasm Staging/methods ; Prostate/pathology ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; SARS-CoV-2 ; United Kingdom/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-10-28
Publishing country	England
Document type	Letter ; Review
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.15259
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Article ; Online: Editorial Comment on: Trends and Perioperative Outcomes Across Major Benign Prostatic Hyperplasia Procedures from the ACS-NSQIP 2011-2015 by Anderson et al. (From: Anderson BB, Heiman J, Large T, et al. J Endourol 2019;33:62-68; DOI: 10.1089/end.2018.0266).

Mehan, Nicholas / Stroman, Luke / Challacombe, Ben

Journal of endourology

2018 Volume 33, Issue 1, Page(s) 69–70

MeSH term(s)	Humans ; Male ; Postoperative Complications ; Prostatic Hyperplasia
Language	English
Publishing date	2018-10-25
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2018.0682
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Predictors of Poor Response and Adverse Events Following Botulinum Toxin-A for Refractory Idiopathic Overactive Bladder.

Abrar, Mohammad / Stroman, Luke / Malde, Sachin / Solomon, Eskinder / Sahai, Arun

Urology

2019 Volume 135, Page(s) 32–37

Abstract: Objective: To ascertain whether a poor response and adverse events (voiding dysfunction and urinary tract infection) were predictable for first time botulinum toxin-A (BTX-A) injections in a patient cohort of refractory idiopathic overactive bladder ... ...

Abstract	Objective: To ascertain whether a poor response and adverse events (voiding dysfunction and urinary tract infection) were predictable for first time botulinum toxin-A (BTX-A) injections in a patient cohort of refractory idiopathic overactive bladder with detrusor overactivity. Methods: Patients who received BTX-A injections for the first time between the dates of March 2004-August 2017 were analyzed in this single center study. Urogenital Distress Inventory short form (UDI-6) questionnaires were collected both preinjection and postinjection prospectively. A poor response was defined as a decrease of less than 16.7 on the UDI-6 questionnaire. Additional information was gathered from patient records in a retrospective fashion. Predictors of poor response, voiding dysfunction, and UTI were analyzed with multivariate logistic regression analysis. Results: Seventy-four patients were analyzed. The only predictor of poor response was male gender (OR, 5.45; 95% CI 1.83-16.47; P = .002). Lower maximum urinary flow rates (OR, 0.91; 95% CI, 0.83-0.99; P = .023), male gender (OR, 5.14; 95% CI 1.41-18.72; P = .013), and hysterectomy in females (OR, 4.55; 95% CI, 1.09-18.87; P = .038) were predictors of clean intermittent self catheterisation (CISC). There was an increased risk of UTIs in patients who performed CISC (OR, 5.26; 95% CI 1.38-20.0; P = .015). Conclusion: Male gender was associated with a poor response to BTX-A injections and increased risk of CISC. Lower maximum urinary flow rates and women with hysterectomies were at increased risk of requiring CISC postinjection. Performing CISC was associated with increased risk of UTI. These factors could be helpful when counselling or selecting patients.
MeSH term(s)	Administration, Intravesical ; Botulinum Toxins, Type A/administration & dosage ; Botulinum Toxins, Type A/adverse effects ; Female ; Humans ; Injections, Intramuscular/methods ; Intermittent Urethral Catheterization/adverse effects ; Intermittent Urethral Catheterization/methods ; Intermittent Urethral Catheterization/statistics & numerical data ; Male ; Middle Aged ; Neuromuscular Agents/administration & dosage ; Neuromuscular Agents/adverse effects ; Prognosis ; Retrospective Studies ; Self Care/methods ; Self Care/statistics & numerical data ; Sex Factors ; Surveys and Questionnaires ; Treatment Outcome ; Urinary Bladder/drug effects ; Urinary Bladder/physiopathology ; Urinary Bladder, Overactive/diagnosis ; Urinary Bladder, Overactive/physiopathology ; Urinary Bladder, Overactive/therapy ; Urinary Tract Infections/epidemiology ; Urinary Tract Infections/etiology ; Urination Disorders/diagnosis ; Urination Disorders/epidemiology ; Urination Disorders/etiology
Chemical Substances	Neuromuscular Agents ; Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2019-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2019.08.054
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: A cross-section of UK prostate cancer diagnostics during the coronavirus disease 2019 (COVID-19) era - a shifting paradigm?

Stroman, Luke / Cathcart, Paul / Lamb, Alastair / Challacombe, Ben / Popert, Rick

BJU int

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #796090
Database	COVID19

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Article ; Online: Patient Perception and Emotional Disturbance in Out-of-Hour Ophthalmic Emergency Care.

Luk, Sheila / Stroman, Luke / Kang, Swan / Natkunarajah, Mythili / Duguid, Graham

Seminars in ophthalmology

2017 Volume 32, Issue 5, Page(s) 559–563

Abstract: Purpose: To investigate patient's perception of the severity of their symptoms, reasons for attending an ophthalmic emergency department (ED) out of hours, and to review the prevalence of anxiety and depression.: Methods: We carried out a prospective ...

Abstract	Purpose: To investigate patient's perception of the severity of their symptoms, reasons for attending an ophthalmic emergency department (ED) out of hours, and to review the prevalence of anxiety and depression. Methods: We carried out a prospective analysis of the cases presenting out of hours (8:30 PM to 8:30 AM) over a four-month period. We also conducted two questionnaire studies. First, patient's perception of the severity of their symptoms (graded from 1-10). A score of 7 or above was defined as significant. A second questionnaire study used the Hospital Anxiety and Depression Scale (HADS), with a maximum score of 21. Patients who scored between 7-10 points on either anxiety or depression scales are defined as borderline; above 10 as pathological. Results: A total of 1,531 patients attended the out-of-hours service. The most common diagnoses were trauma (22.8%), infective conjunctivitis (10.2%), and contact-lens-related problems (6.6%). Of 175 completed questionnaires, worry about sight impairment and pain were the most common concerns for attendance. A total of 91% of patients believed their conditions were emergencies that require medical review within 24 hours. 127 HADS questionnaires were completed, showing that 18.9% and 15.0% of patients were suffering from borderline and pathological anxiety, respectively, with a mean HADS-A score of 6.5, SD=3.9. The prevalence of possible and pathological depression was 14.2% and 6.3%, mean=4.9 (SD=3.6). There was no statistical significance difference of score with the time of patient presentation. Conclusion: The prevalence of anxiety and depression is relatively high in patients who attended the ophthalmic ED and awareness of psychological impact should be raised amongst healthcare professionals.
Language	English
Publishing date	2017
Publishing country	England
Document type	Journal Article
ZDB-ID	632820-9
ISSN	1744-5205 ; 0882-0538
ISSN (online)	1744-5205
ISSN	0882-0538
DOI	10.3109/08820538.2015.1131834
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Article ; Online: Our first month of delivering the prostate cancer diagnostic pathway within the limitations of COVID-19 using local anaesthesia transperineal biopsy.

Popert, Rick / Kum, Francesca / MacAskill, Findlay / Stroman, Luke / Zisengwe, Grace / Rusere, Jonah / Haire, Kate / Challacombe, Ben / Cathcart, Paul

BJU international

2020 Volume 126, Issue 3, Page(s) 329–332

MeSH term(s)	Anesthesia, Local ; Betacoronavirus ; Biopsy ; COVID-19 ; Clinical Protocols ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Humans ; Infection Control/organization & administration ; Male ; Pandemics/prevention & control ; Patient Selection ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Prostatic Neoplasms/pathology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-08-05
Publishing country	England
Document type	Letter
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.15120
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Article ; Online: The rapid assessment for prostate imaging and diagnosis (RAPID) prostate cancer diagnostic pathway.

Eldred-Evans, David / Connor, Martin J / Bertoncelli Tanaka, Mariana / Bass, Edward / Reddy, Deepika / Walters, Uma / Stroman, Luke / Espinosa, Easter / Das, Raj / Khosla, Nalin / Tam, Henry / Pegers, Elizabeth / Qazi, Hasan / Gordon, Stephen / Winkler, Mathias / Ahmed, Hashim U

BJU international

2022 Volume 131, Issue 4, Page(s) 461–470

Abstract: Objective: To report outcomes within the Rapid Assessment for Prostate Imaging and Diagnosis (RAPID) diagnostic pathway, introduced to reduce patient and healthcare burdens and standardize delivery of pre-biopsy multiparametric magnetic resonance ... ...

Abstract	Objective: To report outcomes within the Rapid Assessment for Prostate Imaging and Diagnosis (RAPID) diagnostic pathway, introduced to reduce patient and healthcare burdens and standardize delivery of pre-biopsy multiparametric magnetic resonance imaging (MRI) and transperineal biopsy. Patients and methods: A total of 2130 patients from three centres who completed the RAPID pathway (3 April 2017 to 31 March 2020) were consecutively entered as a prospective registry. These patients were also compared to a pre-RAPID cohort of 2435 patients. Patients on the RAPID pathway with an MRI score 4 or 5 and those with PSA density ≥0.12 and an MRI score 3 were advised to undergo a biopsy. Primary outcomes were rates of biopsy and cancer detection. Secondary outcomes included comparison of transperineal biopsy techniques, patient acceptability and changes in time to diagnosis before and after the introduction of RAPID. Results: The median patient age and PSA level were 66 years and 6.6 ng/mL, respectively. Biopsy could be omitted in 43% of patients (920/2130). A further 7.9% of patients (168/2130) declined a recommendation for biopsy. The percentage of biopsies avoided among sites varied (45% vs 36% vs 51%; P < 0.001). In all, 30% (221/742) had a local anaesthetic (grid and stepper) transperineal biopsy. Clinically significant cancer detection (any Gleason score ≥3 + 4) was 26% (560/2130) and detection of Gleason score 3 + 3 alone constituted 5.8% (124/2130); detection of Gleason score 3 + 3 did not significantly vary among sites (P = 0.7). Among participants who received a transperineal targeted biopsy, there was no difference in cancer detection rates among local anaesthetic, sedation and general anaesthetic groups. In the 2435 patients from the pre-RAPID cohor, time to diagnosis was 32.1 days (95% confidence interval [CI] 29.3-34.9) compared to 15.9 days (95% CI 12.9-34.9) in the RAPID group. A total of 141 consecutive patient satisfaction surveys indicated a high satisfaction rate with the pathway; 50% indicated a preference for having all tests on a single day. Conclusions: The RAPID prostate cancer diagnostic pathway allows 43% of men to avoid a biopsy while preserving good detection of clinically significant cancers and low detection of insignificant cancers, although there were some centre-level variations.
MeSH term(s)	Male ; Humans ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostate-Specific Antigen ; Anesthetics, Local ; Image-Guided Biopsy/methods ; Magnetic Resonance Imaging/methods
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77) ; Anesthetics, Local
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.15899
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Article ; Online: EXIT from TRansrectal prostate biopsies (TREXIT): sepsis rates of transrectal biopsy with rectal swab culture guided antimicrobials versus freehand transperineal biopsy.

Newman, Thomas Hedley / Stroman, Luke / Hadjipavlou, Marios / Haque, Arman / Rusere, Jonah / Chan, Kimberley / Ioannides, Demetris / Di Benedetto, Antonina / Pinczes, Tibor / Popert, Rick / Hammadeh, Mohamed Y

Prostate cancer and prostatic diseases

2021 Volume 25, Issue 2, Page(s) 283–287

Abstract: Background: Transrectal prostate biopsy (TRUSBx) holds a risk of prostate biopsy related sepsis. We discuss our step-wise strategies aiming to reduce this risk, including targeted antimicrobials and switching to a freehand transperineal approach (FHTPBx) ...

Abstract	Background: Transrectal prostate biopsy (TRUSBx) holds a risk of prostate biopsy related sepsis. We discuss our step-wise strategies aiming to reduce this risk, including targeted antimicrobials and switching to a freehand transperineal approach (FHTPBx). Subjects and methods: This longitudinal cohort study included three groups. Group A underwent TRUSBx with empirical augmented antimicrobial prophylaxis; Group B underwent TRUSBx with targeted antimicrobial prophylaxis, based on rectal-swab cultures/sensitivity; Group C underwent FHTPBx with empirical antimicrobial prophylaxis. Post biopsy sepsis, defined according to the surviving sepsis campaign and confirmed with blood or urinary cultures, were determined and rates between groups were analysed using fisher's exact test. Results: Of all 1501 patients, 23 developed post biopsy sepsis; Group A (12/609, 2.0%), B (9/403, 2.2%), C (2/489, 0.4%). Targeted antimicrobials did not reduce the risk of post biopsy sepsis following TRUSBx (A vs B, 2.0% vs 2.2%; p = 0.82). Patients with antimicrobial-resistant rectal flora had an increased post biopsy sepsis rate following TRUSBx despite targeted antimicrobials (9.1% vs 1.1%, p = 0.003). Switching to FHTPBx reduced the risk of developing post biopsy sepsis (A vs C, 2% vs 0.4%, p = 0.03; B vs C, 2.2% vs 0.4%, p = 0.03). Conclusions: Targeted antimicrobials based on rectal swab culture failed to reduce the overall risk of post biopsy sepsis, while FHTPBx nearly eliminated this risk. We recommend the use of transperineal prostate biopsies for all patients as the most effective method to reduce the risk of sepsis.
MeSH term(s)	Anti-Infective Agents/therapeutic use ; Antibiotic Prophylaxis/methods ; Biopsy/adverse effects ; Biopsy/methods ; Humans ; Image-Guided Biopsy/adverse effects ; Longitudinal Studies ; Male ; Prostate/pathology ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/pathology ; Rectum/pathology ; Rectum/surgery ; Sepsis/diagnosis ; Sepsis/epidemiology ; Sepsis/etiology
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2021-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-021-00438-w
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