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  1. Article ; Online: Persistence of Pneumococcal Carriage among Older Adults in the Community despite COVID-19 Mitigation Measures.

    Wyllie, Anne L / Mbodj, Sidiya / Thammavongsa, Darani A / Hislop, Maikel S / Yolda-Carr, Devyn / Waghela, Pari / Nakahata, Maura / Stahlfeld, Anne E / Vega, Noel J / York, Anna / Allicock, Orchid M / Wilkins, Geisa / Ouyang, Andrea / Siqueiros, Laura / Strong, Yvette / Anastasio, Kelly / Alexander-Parrish, Ronika / Arguedas, Adriano / Gessner, Bradford D /
    Weinberger, Daniel M

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0487922

    Abstract: Reported rates of invasive pneumococcal disease were markedly lower than normal during the 2020/2021 winter in the Northern Hemisphere, the first year after the start of the COVID-19 pandemic. However, little is known about rates of carriage of ... ...

    Abstract Reported rates of invasive pneumococcal disease were markedly lower than normal during the 2020/2021 winter in the Northern Hemisphere, the first year after the start of the COVID-19 pandemic. However, little is known about rates of carriage of pneumococcus among adults during this period. Between October 2020-August 2021, couples in the Greater New Haven Area, USA, were enrolled if both individuals were aged 60 years and above and did not have any individuals under the age of 60 years living in the household. Saliva samples and questionnaires regarding social activities and contacts and medical history were obtained every 2 weeks for a period of 10 weeks. Following culture-enrichment, extracted DNA was tested using qPCR for pneumococcus-specific sequences
    MeSH term(s) Child ; Humans ; Child, Preschool ; Infant ; Aged ; Streptococcus pneumoniae/genetics ; Pandemics ; Nasopharynx ; Carrier State/epidemiology ; COVID-19/epidemiology ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04879-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recruitment, Consent and DNA Sample Acquisition in a U.S. Precision Health Cohort During the COVID-19 Pandemic

    Derry, Allyson M. / Strong, Yvette / Schioppo, Davia / Cotter, Joni / Wilkins, Geisa M. / Siquieros, Laura I. / Ouyang, Andrea / Hulseman, Kathleen / Petrosino, Joseph / Liang, Lorrin / Stevenson, Megan / Aguilera, Tiffany Elianne / Soto, Alexandria L. / Meurer, Katherin / Herman, Alison L. / Cohen, Inessa / Falcone, Guido J. / Longbrake, Erin E. / Ochoa Chaar, Cassius I. /
    Anastasio, Kelly M. / Murray, Michael F.

    medRxiv

    Abstract: Aim: The Yale Generations Project (YGP) is a precision health cohort initiative that began enrollment in New Haven Connecticut USA in July 2019. In March 2020, after nine months of operation, pandemic restrictions prompted abrupt changes to staff ... ...

    Abstract Aim: The Yale Generations Project (YGP) is a precision health cohort initiative that began enrollment in New Haven Connecticut USA in July 2019. In March 2020, after nine months of operation, pandemic restrictions prompted abrupt changes to staff availability as well as changes to the projects recruitment, consenting, and sample acquisition. This manuscript describes the successful addition of remote recruitment, consenting, and DNA sampling to YGP workflows during the initial 27-months of pandemic restrictions ending June 30, 2022. Methods: The initial YGP protocol established face-to-face workflow for recruiting, consenting and peripheral blood collection. A telemedicine consent protocol was initiated in April of 2020, and a remote saliva collection was established in October of 2020. De-identified data was extracted from YGP dataset and reported here. Results: At the completion of YGPs initial 36 months (9-months pre-pandemic and 27-months pandemic) YGP enrolled N=4949 volunteers. There were N=1,950 (216.7 per month) volunteers consented pre-pandemic and N=2,999 (111.1 per month) during pandemic. The peak consenting month was February 2020 with N=428. DNA sample acquisition peaked in the pre-pandemic month of February 2020 with N=291 peripheral blood draws, and in the pandemic period the peak DNA acquisition month was November 2020 with N=176 (N=68 peripheral blood draws and N=108 saliva samples). Conclusion: The YGP successfully transitioned from pre-pandemic recruiting, consenting and sample acquisition model that was exclusively face-to-face, to pandemic model that was predominantly remote. The added value of remote recruiting, consenting, and sampling has led to plans for an optimized hybrid model post-pandemic. Keywords: genomics, precision health, COVID-19, cohort
    Keywords covid19
    Language English
    Publishing date 2023-09-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.09.25.23289158
    Database COVID19

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  3. Article ; Online: Persistence of pneumococcal carriage among older adults in the community despite COVID-19 mitigation measures

    Wyllie, Anne L. / Mbodj, Sidiya / Thammavongsa, Darani A. / Hislop, Maikel S. / Yolda-Carr, Devyn / Waghela, Pari / Nakahata, Maura / Watkins, Anne E. / Vega, Noel J. / York, Anna / Allicock, Orchid M. / Wilkins, Geisa / Ouyang, Andrea / Siqueiros, Laura / Strong, Yvette / Anastasio, Kelly / Alexander-Parrish, Ronika / Arguedas, Adriano / Gessner, Bradford D. /
    Weinberger, Daniel M.

    medRxiv

    Abstract: Background. Reported rates of invasive pneumococcal disease were markedly lower than normal during the 2020/2021 winter in the Northern Hemisphere, the first year after the start of the COVID-19 pandemic. However, little is known about rates of carriage ... ...

    Abstract Background. Reported rates of invasive pneumococcal disease were markedly lower than normal during the 2020/2021 winter in the Northern Hemisphere, the first year after the start of the COVID-19 pandemic. However, little is known about rates of carriage of pneumococcus among adults during this period. Methods. Between October 2020-August 2021, couples living in the Greater New Haven Area were enrolled if both individuals were aged 60 years and above and did not have any individuals under the age of 60 years living in the household. Saliva samples and questionnaires regarding social activities and contacts and medical history were obtained every 2 weeks for a period of 10 weeks. Following culture-enrichment, extracted DNA was tested using qPCR for pneumococcus-specific sequences piaB and lytA. Individuals were considered positive for pneumococcal carriage when Ct-values for piaB were less than 40. Results. We collected 567 saliva samples from 95 individuals aged 60 years and above (47 household pairs and one singleton). Of those, 7.1% of samples tested positive for pneumococcus by either piaB only (n=6) or both piaB and lytA (n=34), representing 22/95 (23.2%) individuals and 16/48 (33.3%) households over the course of the 10-week study period. Study participants attended few social events during this period. However, many participants continued to have regular contact with children. Individuals who had regular contact with preschool and school aged children (i.e., 2-9 year olds) had a higher prevalence of carriage (15.9% vs 5.4%). Conclusions. Despite COVID-19-related disruptions, a large proportion of older adults carried pneumococcus at least once during the 10-week study period. Prevalence was particularly high among those who had contact with school-aged children, but carriage was not limited to this group.
    Keywords covid19
    Language English
    Publishing date 2022-06-29
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.06.28.22276654
    Database COVID19

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  4. Article: Non-detriment findings for international trade in wild orchids from developing countries; A case study for Broughtonia sanguínea in Jamaica

    Cohen, Jane E. / Williams, Hubert N. / Strong, Yvette E. / Fisher, H. C. Elaine

    Journal for nature conservation

    2020  Volume 56, Issue -, Page(s) 125840

    Language English
    Document type Article
    ZDB-ID 2077553-2
    ISSN 1617-1381
    Database Current Contents Nutrition, Environment, Agriculture

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