LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 165

Search options

  1. Article: Spatiotemporal Kernel Reconstruction for Linear Parametric Neurotransmitter PET Kinetic Modeling in Motion Correction Brain PET of Awake Rats.

    Miranda, Alan / Bertoglio, Daniele / Stroobants, Sigrid / Staelens, Steven / Verhaeghe, Jeroen

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 901091

    Abstract: The linear parametric neurotransmitter positron emission tomography (lp-ntPET) kinetic model can be used to detect transient changes (activation) in endogenous neurotransmitter levels. Preclinical PET scans in awake animals can be performed to ... ...

    Abstract The linear parametric neurotransmitter positron emission tomography (lp-ntPET) kinetic model can be used to detect transient changes (activation) in endogenous neurotransmitter levels. Preclinical PET scans in awake animals can be performed to investigate neurotransmitter transient changes. Here we use the spatiotemporal kernel reconstruction (Kernel) for noise reduction in dynamic PET, and lp-ntPET kinetic modeling. Kernel is adapted for motion correction reconstruction, applied in awake rat PET scans. We performed 2D rat brain phantom simulation using the ntPET model at 3 different noise levels. Data was reconstructed with independent frame reconstruction (IFR), IFR with HYPR denoising, and Kernel, and lp-ntPET kinetic parameters (
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.901091
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Motion Dependent and Spatially Variant Resolution Modeling for PET Rigid Motion Correction.

    Miranda, Alan / Staelens, Steven / Stroobants, Sigrid / Verhaeghe, Jeroen

    IEEE transactions on medical imaging

    2020  Volume 39, Issue 7, Page(s) 2518–2530

    Abstract: Recent advances in positron emission tomography (PET) have allowed to perform brain scans of freely moving animals by using rigid motion correction. One of the current challenges in these scans is that, due to the PET scanner spatially variant point ... ...

    Abstract Recent advances in positron emission tomography (PET) have allowed to perform brain scans of freely moving animals by using rigid motion correction. One of the current challenges in these scans is that, due to the PET scanner spatially variant point spread function (SVPSF), motion corrected images have a motion dependent blurring since animals can move throughout the entire field of view (FOV). We developed a method to calculate the image-based resolution kernels of the motion dependent and spatially variant PSF (MD-SVPSF) to correct the loss of spatial resolution in motion corrected reconstructions. The resolution kernels are calculated for each voxel by sampling and averaging the SVPSF at all positions in the scanner FOV where the moving object was measured. In resolution phantom scans, the use of the MD-SVPSF resolution model improved the spatial resolution in motion corrected reconstructions and corrected the image deformation caused by the parallax effect consistently for all motion patterns, outperforming the use of a motion independent SVPSF or Gaussian kernels. Compared to motion correction in which the SVPSF is applied independently for every pose, our method performed similarly, but with more than two orders of magnitude faster computation time. Importantly, in scans of freely moving mice, brain regional quantification in motion-free and motion corrected images was better correlated when using the MD-SVPSF in comparison with motion independent SVPSF and a Gaussian kernel. The method developed here allows to obtain consistent spatial resolution and quantification in motion corrected images, independently of the motion pattern of the subject.
    MeSH term(s) Algorithms ; Animals ; Image Processing, Computer-Assisted ; Mice ; Motion ; Neuroimaging ; Phantoms, Imaging ; Positron-Emission Tomography
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 622531-7
    ISSN 1558-254X ; 0278-0062
    ISSN (online) 1558-254X
    ISSN 0278-0062
    DOI 10.1109/TMI.2019.2962237
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2546: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Low activity [

    Miranda, Alan / Bertoglio, Daniele / Stroobants, Sigrid / Staelens, Steven / Verhaeghe, Jeroen

    Physics in medicine and biology

    2021  Volume 66, Issue 11

    Abstract: Depending on the molar activity of the tracer, the maximal allowable injected activity in mouse brain PET studies can be extremely low in order to avoid receptor saturation. Therefore, a high level of noise can be present in the image. We investigate ... ...

    Abstract Depending on the molar activity of the tracer, the maximal allowable injected activity in mouse brain PET studies can be extremely low in order to avoid receptor saturation. Therefore, a high level of noise can be present in the image. We investigate several dynamic PET reconstruction methods in reduced counts, or equivalently in reduced injected activity, data exemplified in [
    MeSH term(s) Algorithms ; Animals ; Brain/diagnostic imaging ; Image Processing, Computer-Assisted ; Kinetics ; Mice ; Positron-Emission Tomography ; Raclopride
    Chemical Substances Raclopride (430K3SOZ7G)
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/abfbf0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Translation of Preclinical PET Imaging Findings: Challenges and Motion Correction to Overcome the Confounding Effect of Anesthetics.

    Miranda, Alan / Bertoglio, Daniele / Stroobants, Sigrid / Staelens, Steven / Verhaeghe, Jeroen

    Frontiers in medicine

    2021  Volume 8, Page(s) 753977

    Abstract: Preclinical brain positron emission tomography (PET) in animals is performed using anesthesia to avoid movement during the PET scan. In contrast, brain PET scans in humans are typically performed in the awake subject. Anesthesia is therefore one of the ... ...

    Abstract Preclinical brain positron emission tomography (PET) in animals is performed using anesthesia to avoid movement during the PET scan. In contrast, brain PET scans in humans are typically performed in the awake subject. Anesthesia is therefore one of the principal limitations in the translation of preclinical brain PET to the clinic. This review summarizes the available literature supporting the confounding effect of anesthesia on several PET tracers for neuroscience in preclinical small animal scans. In a second part, we present the state-of-the-art methodologies to circumvent this limitation to increase the translational significance of preclinical research, with an emphasis on motion correction methods. Several motion tracking systems compatible with preclinical scanners have been developed, each one with its advantages and limitations. These systems and the novel experimental setups they can bring to preclinical brain PET research are reviewed here. While technical advances have been made in this field, and practical implementations have been demonstrated, the technique should become more readily available to research centers to allow for a wider adoption of the motion correction technique for brain research.
    Language English
    Publishing date 2021-10-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.753977
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Characterization of Structurally Diverse

    Adhikari, Karuna / Dewulf, Jonatan / Vangestel, Christel / Van der Veken, Pieter / Stroobants, Sigrid / Elvas, Filipe / Augustyns, Koen

    ACS omega

    2023  Volume 8, Issue 41, Page(s) 38252–38262

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-10-08
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c04597
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Neuroreceptor kinetics in rats repeatedly exposed to quinpirole as a model for OCD.

    Servaes, Stijn / Glorie, Dorien / Stroobants, Sigrid / Staelens, Steven

    PloS one

    2019  Volume 14, Issue 3, Page(s) e0213313

    Abstract: Background: Obsessive-compulsive disorder (OCD) is a chronic, incapacitating, early onset psychiatric disorder that is characterized by obsessions and compulsions originating from a disturbance in the cortico-striato-thalamico-cortical circuit. We ... ...

    Abstract Background: Obsessive-compulsive disorder (OCD) is a chronic, incapacitating, early onset psychiatric disorder that is characterized by obsessions and compulsions originating from a disturbance in the cortico-striato-thalamico-cortical circuit. We implemented the preclinical quinpirole (QP) rat model for compulsive checking in OCD to analyse the behaviour and visualize the D2R, mGluR5 and GLT1 density in order to contribute to the understanding of the neuroreceptor kinetics.
    Methods: Animals (n = 14) were exposed to either saline (1 mL/kg) or QP (dopamine D2-agonist, 0.5 mg/kg) twice-weekly during 7 weeks. After each injection animals were placed on an open field test. After model setup, animals were placed in a behavioural cage equipped with tracking software and hardware in order to analyse the behaviour. Subsequently, sagittal slides were made of the CP in the right hemisphere and a staining was done with the D2R, mGluR5 and GLT-1 antibody to visualize the corresponding receptor.
    Results: The QP animals displayed a strong increase in travelled distance (+596.70%) and in the number of homebase visits (+1222.90%) compared to the control animals. After chronic exposure to QP, animals had a significantly (p < 0.05) higher percentage of D2R density in the CP (7.92% ± 0.48%) versus 6.66% ± 0.28% in animals treated with saline. There were no differences for mGluR5 and GLT1 receptor density.
    Conclusions: Chronic exposure to QP leads to hyperlocomotion and an increase in D2R density. Furthermore, as mGluR5 and GLT1 density did not seem to be directly affected, decreased levels of glutamate might have influenced the binding potential in earlier reports.
    MeSH term(s) Animals ; Disease Models, Animal ; Dopamine Agonists/toxicity ; Gene Expression Regulation/drug effects ; Glutamate Plasma Membrane Transport Proteins/metabolism ; Kinetics ; Male ; Obsessive-Compulsive Disorder/chemically induced ; Obsessive-Compulsive Disorder/metabolism ; Obsessive-Compulsive Disorder/pathology ; Quinpirole/toxicity ; Rats ; Rats, Sprague-Dawley ; Receptor, Metabotropic Glutamate 5/metabolism ; Receptors, Dopamine D2/metabolism
    Chemical Substances Dopamine Agonists ; Glutamate Plasma Membrane Transport Proteins ; Grm5 protein, rat ; Receptor, Metabotropic Glutamate 5 ; Receptors, Dopamine D2 ; Quinpirole (20OP60125T)
    Language English
    Publishing date 2019-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0213313
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers.

    Beroske, Lucas / Van den Wyngaert, Tim / Stroobants, Sigrid / Van der Veken, Pieter / Elvas, Filipe

    International journal of molecular sciences

    2021  Volume 22, Issue 8

    Abstract: The molecular imaging of apoptosis remains an important method for the diagnosis and monitoring of the progression of certain diseases and the evaluation of the efficacy of anticancer apoptosis-inducing therapies. Among the multiple biomarkers involved ... ...

    Abstract The molecular imaging of apoptosis remains an important method for the diagnosis and monitoring of the progression of certain diseases and the evaluation of the efficacy of anticancer apoptosis-inducing therapies. Among the multiple biomarkers involved in apoptosis, activated caspase-3 is an attractive target, as it is the most abundant of the executioner caspases. Nuclear imaging is a good candidate, as it combines a high depth of tissue penetration and high sensitivity, features necessary to detect small changes in levels of apoptosis. However, designing a caspase-3 radiotracer comes with challenges, such as selectivity, cell permeability and transient caspase-3 activation. In this review, we discuss the different caspase-3 radiotracers for the imaging of apoptosis together with the challenges of the translation of various apoptosis-imaging strategies in clinical trials.
    MeSH term(s) Apoptosis ; Caspase 3/metabolism ; Humans ; Molecular Imaging ; Positron-Emission Tomography ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/therapeutic use
    Chemical Substances Radiopharmaceuticals ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2021-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22083948
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Quantification of Metabotropic Glutamate Receptor 5 Availability With Both [

    Glorie, Dorien / Verhaeghe, Jeroen / Miranda, Alan / De Lombaerde, Stef / Stroobants, Sigrid / Staelens, Steven

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2021  Volume 7, Issue 6, Page(s) 607–615

    Abstract: Background: This study provides a first direct comparison between positron emission tomography radioligands targeting the allosteric site of the metabotropic glutamate receptor 5 (mGluR5): [: Methods: First, wild-type mice (n = 7) received four ... ...

    Abstract Background: This study provides a first direct comparison between positron emission tomography radioligands targeting the allosteric site of the metabotropic glutamate receptor 5 (mGluR5): [
    Methods: First, wild-type mice (n = 7) received four position emission tomography/computed tomography scans: a [
    Results: Using cold FPEB as a blocking compound for [
    Conclusions: The current findings substantiate a common binding site and suggest a strong relationship between mGluR5 availability levels measured with both radioligands. In Sapap3 KO mice, a reduced mGluR5 availability could therefore be demonstrated with both radioligands. With [
    MeSH term(s) Animals ; Mice ; Mice, Knockout ; Nerve Tissue Proteins ; Obsessive-Compulsive Disorder ; Oximes ; Positron-Emission Tomography/methods ; Pyridines ; Receptor, Metabotropic Glutamate 5/metabolism
    Chemical Substances 3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime ; Grm5 protein, mouse ; Nerve Tissue Proteins ; Oximes ; Pyridines ; Receptor, Metabotropic Glutamate 5 ; Sapap3 protein, mouse
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2021.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Estimation of the net influx rate K

    Bertoglio, Daniele / Deleye, Steven / Miranda, Alan / Stroobants, Sigrid / Staelens, Steven / Verhaeghe, Jeroen

    NeuroImage

    2021  Volume 233, Page(s) 117961

    Abstract: Since accurate quantification of 2-deoxy-2- ...

    Abstract Since accurate quantification of 2-deoxy-2-
    MeSH term(s) Animals ; Body Weight/physiology ; Brain/diagnostic imaging ; Brain/metabolism ; Fluorodeoxyglucose F18/metabolism ; Glucose/metabolism ; Male ; Positron-Emission Tomography/methods ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2021.117961
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3664: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 7: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: 18

    Dockx, Yanina / Vangestel, Christel / De Bruycker, Sven / Van den Wyngaert, Tim / Huizing, Manon / Staelens, Steven / Stroobants, Sigrid

    Cancer biotherapy & radiopharmaceuticals

    2022  Volume 38, Issue 1, Page(s) 51–61

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Humans ; Female ; Fluorodeoxyglucose F18 ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Everolimus/pharmacology ; Everolimus/therapeutic use ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; TOR Serine-Threonine Kinases ; Trastuzumab ; Positron-Emission Tomography/methods ; Cell Line ; Cell Line, Tumor ; Mammals/metabolism
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Everolimus (9HW64Q8G6G) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Trastuzumab (P188ANX8CK) ; MTOR protein, human (EC 2.7.1.1)
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1315649-4
    ISSN 1557-8852 ; 1084-9785
    ISSN (online) 1557-8852
    ISSN 1084-9785
    DOI 10.1089/cbr.2022.0061
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1896: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top