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  1. Article ; Online: Head-to-Head Comparison of Dual-Source and Split-Beam Filter Multi-Energy CT versus SPECT/CT for Assessing Lobar Lung Perfusion in Emphysema.

    Strotzer, Quirin D / Heidemanns, Stefanie / Mayr, Vinzenz / Stuerzl, Roman / Meiler, Stefanie / Schmidt, Daniel / Blaas, Stefan / Grosse, Jirka / Hellwig, Dirk / Stroszczynski, Christian / Hamer, Okka W

    Radiology. Cardiothoracic imaging

    2023  Volume 5, Issue 4, Page(s) e220273

    Abstract: Purpose: To evaluate dual-source and split-beam filter multi-energy chest CT in assessing pulmonary perfusion on a lobar level in patients with lung emphysema, using perfusion SPECT as the reference standard.: Materials and methods: Patients with ... ...

    Abstract Purpose: To evaluate dual-source and split-beam filter multi-energy chest CT in assessing pulmonary perfusion on a lobar level in patients with lung emphysema, using perfusion SPECT as the reference standard.
    Materials and methods: Patients with emphysema evaluated for lung volume reduction therapy between May 2016 and February 2021 were retrospectively included. All patients underwent SPECT and either dual-source or split-beam filter (SBF) multi-energy CT. To calculate the fractional lobar lung perfusion (FLLP), SPECT acquisitions were co-registered with chest CT scans (hereafter, SPECT/CT) and semi-manually segmented. For multi-energy CT scans, lung lobes were automatically segmented using a U-Net model. Segmentations were manually verified. The FLLP was derived from iodine maps computed from the multi-energy data. Statistical analysis included Pearson and intraclass correlation coefficients and Bland-Altman analysis.
    Results: Fifty-nine patients (30 male, 29 female; 31 underwent dual-source CT, 28 underwent SBF CT; mean age for all patients, 67 years ± 8 [SD]) were included. Both multi-energy methods significantly correlated with the SPECT/CT acquisitions for all individual lobes (
    Conclusion: Dual-source and SBF multi-energy CT accurately assessed lung perfusion on a lobar level in patients with emphysema compared with SPECT/CT. The overall correlation was higher for dual-source multi-energy CT.
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2638-6135
    ISSN (online) 2638-6135
    DOI 10.1148/ryct.220273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structural Connectivity Patterns of Side Effects Induced by Subthalamic Deep Brain Stimulation for Parkinson's Disease.

    Strotzer, Quirin D / Kohl, Zacharias / Anthofer, Judith M / Faltermeier, Rupert / Schmidt, Nils O / Torka, Elisabeth / Greenlee, Mark W / Fellner, Claudia / Schlaier, Juergen R / Beer, Anton L

    Brain connectivity

    2021  Volume 12, Issue 4, Page(s) 374–384

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Brain/diagnostic imaging ; Deep Brain Stimulation/adverse effects ; Deep Brain Stimulation/methods ; Dysarthria/therapy ; Humans ; Hyperkinesis/therapy ; Motor Cortex ; Paresthesia/therapy ; Parkinson Disease/therapy
    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2609017-X
    ISSN 2158-0022 ; 2158-0014
    ISSN (online) 2158-0022
    ISSN 2158-0014
    DOI 10.1089/brain.2021.0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Structural connectivity patterns of side effects induced by subthalamic deep brain stimulation for Parkinson's disease

    Strotzer, Quirin D. / Kohl, Zacharias / Anthofer, Judith M. / Faltermeier, Rupert / Schmidt, Nils O. / Torka, Elisabeth / Greenlee, Mark W. / Fellner, Claudia / Schlaier, Juergen R. / Beer, Anton L.

    Brain Connectivity

    2022  Volume 12, Issue 4, Page(s) 374–384

    Abstract: Background: Tractography based on diffusion-weighted magnetic resonance imaging (DWI) models the structural connectivity of the human brain. Deep brain stimulation (DBS) targeting the subthalamic nucleus is an effective treatment for advanced Parkinson's ...

    Title translation Strukturelle Konnektivitätsmuster von Nebenwirkungen der subthalamischen tiefen Hirnstimulation bei der Parkinson-Krankheit
    Abstract Background: Tractography based on diffusion-weighted magnetic resonance imaging (DWI) models the structural connectivity of the human brain. Deep brain stimulation (DBS) targeting the subthalamic nucleus is an effective treatment for advanced Parkinson's disease, but may induce adverse effects. This study investigated the relationship between structural connectivity patterns of DBS electrodes and stimulation-induced side effects. Materials and Methods: Twenty-one patients with Parkinson's disease treated with bilateral subthalamic DBS were examined. Overall, 168 electrode contacts were categorized as inducing or noninducing depending on their capability for inducing side effects such as motor effects, paresthesia, dysarthria, oculomotor effects, hyperkinesia, and other complications as assessed during the initial programming session. Furthermore, the connectivity of each contact with target regions was evaluated by probabilistic tractography based on DWI. Finally, stimulation sites and structural connectivity patterns of inducing and noninducing contacts were compared. Results: Inducing contacts differed across the various side effects and from those mitigating Parkinson's symptoms. Although contacts showed a largely overlapping spatial distribution within the subthalamic region, they could be distinguished by their connectivity patterns. In particular, inducing contacts were more likely connected with supplementary motor areas (hyperkinesia, dysarthria), frontal cortex (oculomotor), fibers of the internal capsule (paresthesia), and the basal ganglia-thalamo-cortical circuitry (dysarthria). Discussion: Side effects induced by DBS seem to be associated with distinct connectivity patterns. Cerebellar connections are hardly associated with side effects, although they seem relevant for mitigating motor symptoms in Parkinson's disease. A symptom-specific, connectivity-based approach for target planning in DBS may enhance treatment outcomes and reduce adverse effects.
    Keywords Brain ; Brain Connectivity ; Deep Brain Stimulation ; Dysarthria ; Dysarthrie ; Gehirn ; Konnektivität (Gehirn) ; Nebenwirkungen (Behandlung) ; Parkinson's Disease ; Parkinson-Krankheit ; Side Effects (Treatment) ; Subthalamic Nucleus ; Subthalamischer Nukleus ; Tiefe Hirnstimulation
    Language English
    Document type Article
    ZDB-ID 2609017-X
    ISSN 2158-0022 ; 2158-0014
    ISSN (online) 2158-0022
    ISSN 2158-0014
    DOI 10.1089/brain.2021.0051
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  4. Article ; Online: Deep brain stimulation: Connectivity profile for bradykinesia alleviation.

    Strotzer, Quirin D / Anthofer, Judith M / Faltermeier, Rupert / Brawanski, Alexander T / Torka, Elisabeth / Waldthaler, Josefine A / Kohl, Zacharias / Fellner, Claudia / Beer, Anton L / Schlaier, Juergen R

    Annals of neurology

    2019  Volume 85, Issue 6, Page(s) 852–864

    Abstract: Objective: Subthalamic deep brain stimulation may alleviate bradykinesia in Parkinson patients. Research suggests that this stimulation effect may be mediated by brain networks like the corticocerebellar loop. This study investigated the connectivity ... ...

    Abstract Objective: Subthalamic deep brain stimulation may alleviate bradykinesia in Parkinson patients. Research suggests that this stimulation effect may be mediated by brain networks like the corticocerebellar loop. This study investigated the connectivity between stimulation sites and cortical and subcortical structures to identify connections for effective stimulation.
    Methods: We retrospectively investigated 21 patients with Parkinson disease with bilateral subthalamic deep brain stimulation. Stimulation effectiveness in reducing bradykinesia, tremor, and rigidity was evaluated for each electrode contact in brain hemispheres contralateral to the affected hemibody. Dysarthric side effects were also examined. Probabilistic tractography based on diffusion-weighted imaging was performed in individual patient-specific brains using electrode contacts as seeds. Connectivity profiles of contacts with effective and noneffective stimulation were compared.
    Results: Connectivity profiles of effective and noneffective contacts differed. Moreover, the connectivity profile for bradykinesia differed from that for rigidity, tremor, or dysarthria. Regarding bradykinesia, effective contacts were significantly more often connected with the ipsilateral superior cerebellar peduncle and the ipsilateral dentate nucleus, which correspond to the ipsilateral portion of the cerebellothalamocortical pathway. Rigidity was mitigated by stimulation of ascending brainstem and intralaminar thalamic connections. Tremor alleviation was related to connections with the internal capsule (anterior limb) and the pallidum. Dysarthric side effects were associated with connections to the supplementary motor area and the decussating cerebellothalamocortical pathway.
    Interpretation: Whereas bradykinesia seems to be mitigated by stimulation of the ascending, ipsilateral cerebellothalamocortical pathway, stimulation of the descending corticopontocerebellar pathway may be ineffective. Rigidity, tremor, and dysarthric side effects seem to be influenced by different neural networks. ANN NEUROL 2019;85:852-864.
    MeSH term(s) Aged ; Deep Brain Stimulation/methods ; Diffusion Tensor Imaging/methods ; Female ; Humans ; Hypokinesia/diagnostic imaging ; Hypokinesia/therapy ; Male ; Middle Aged ; Nerve Net/diagnostic imaging ; Nerve Net/physiology ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/therapy ; Retrospective Studies ; Subthalamic Nucleus/diagnostic imaging ; Subthalamic Nucleus/physiology
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.25475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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