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  1. Article ; Online: Pharmacogenomic implications of the differential distribution of CYP3A5 metabolic phenotypes among Latin American populations.

    Suarez-Kurtz, Guilherme / Struchiner, Claudio José

    Pharmacogenomics

    2024  Volume 25, Issue 4, Page(s) 187–195

    Abstract: This study shows that the distribution ... ...

    Abstract This study shows that the distribution of
    MeSH term(s) Humans ; Tacrolimus/adverse effects ; Pharmacogenetics ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Latin America ; Immunosuppressive Agents/adverse effects ; Phenotype ; Genotype ; Graft Rejection/genetics ; Polymorphism, Single Nucleotide/genetics ; South American People
    Chemical Substances Tacrolimus (WM0HAQ4WNM) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Immunosuppressive Agents ; CYP3A5 protein, human (EC 1.14.14.1)
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2024-0009
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  2. Article ; Online: Robust evidence of Bolsa Família Programme's benefits.

    Luz, Paula M / Struchiner, Claudio J

    The lancet. HIV

    2022  Volume 9, Issue 10, Page(s) e669–e670

    MeSH term(s) Brazil ; Government Programs ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Socioeconomic Factors
    Language English
    Publishing date 2022-09-27
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(22)00245-4
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  3. Article ; Online: Backdrop to the development of Brazil's national COVID-19 immunization plan.

    Macedo, Laylla Ribeiro / Struchiner, Claudio Jose / Maciel, Ethel Leonor Noia

    Ciencia & saude coletiva

    2021  Volume 26, Issue 7, Page(s) 2859–2862

    Abstract: The process of developing Brazil's COVID-19 immunization plan began belatedly and involved a number of experts, including a technical group responsible for defining priority groups for vaccination. This process was permeated by contradictions between the ...

    Title translation Contexto de elaboração do Plano de Imunização contra COVID-19 no Brasil.
    Abstract The process of developing Brazil's COVID-19 immunization plan began belatedly and involved a number of experts, including a technical group responsible for defining priority groups for vaccination. This process was permeated by contradictions between the government and researchers. Finally, on 20 January 2021, the government published an updated version of the plan, which remains limited in scope.
    MeSH term(s) Brazil ; COVID-19 ; Humans ; Immunization ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2021-04-15
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2078799-6
    ISSN 1678-4561 ; 1678-4561
    ISSN (online) 1678-4561
    ISSN 1678-4561
    DOI 10.1590/1413-81232021267.04302021
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  4. Article ; Online: Theoretical report: reflections and considerations for authors, reviewers, and editors.

    Souza Filho, Breno Augusto Bormann de / Tritany, Érika Fernandes / Struchiner, Cláudio José

    Revista de saude publica

    2022  Volume 56, Page(s) 30

    Abstract: Epidemiological studies focused on public health have currently shown significant limitations regarding in-depth theoretical reports, overvaluing methodological aspects. The lack of theoretical explanation affects both the quality and reproducibility of ... ...

    Abstract Epidemiological studies focused on public health have currently shown significant limitations regarding in-depth theoretical reports, overvaluing methodological aspects. The lack of theoretical explanation affects both the quality and reproducibility of studies. This study therefore reflected on the importance of in-depth theoretical reports considering the theoretical foundation used by researchers in the main sections of the manuscript (title, abstract, introduction, methodology, results, discussion, and conclusion) based on a review of the scientific literature on the subject. We believe that this article can help understand the importance and the development of in-depth theoretical reports in scientific articles, contributing to assessments, interpretations, and criticisms of reviewers and editors regarding the explanation and reporting of theoretical foundation in manuscripts submitted to scientific journals.
    MeSH term(s) Brazil ; Humans ; Publishing ; Reproducibility of Results ; Research Report
    Language Portuguese
    Publishing date 2022-04-22
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 732179-x
    ISSN 1518-8787 ; 0034-8910
    ISSN (online) 1518-8787
    ISSN 0034-8910
    DOI 10.11606/s1518-8787.2022056003766
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  5. Article ; Online: THE OPTIMUM LEVEL OF MELD TO MINIMIZE THE MORTALITY ON LIVER TRANSPLANTATION WAITING LIST, AND LIVER TRANSPLANTED PATIENT IN SÃO PAULO STATE, BRAZIL.

    Chaib, Eleazar / Pessoa, João Luiz Erbs / Struchiner, Claudio José / D'Albuquerque, Luiz Augusto Carneiro / Massad, Eduardo

    Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

    2023  Volume 36, Page(s) e1746

    Abstract: Background: After validation in multiple types of liver disease patients, the MELD score was adopted as a standard by which liver transplant candidates with end-stage liver disease were prioritized for organ allocation in the United States since 2002, ... ...

    Abstract Background: After validation in multiple types of liver disease patients, the MELD score was adopted as a standard by which liver transplant candidates with end-stage liver disease were prioritized for organ allocation in the United States since 2002, and in Brazil, since 2006.
    Aims: To analyze the mortality profile of patients on the liver transplant waiting list correlated to MELD score at the moment of transplantation.
    Methods: This study used the data from the Secretary of Health of the São Paulo State, Brazil, which listed 22,522 patients, from 2006 (when MELD score was introduced in Brazil) until June 2009. Patients with acute hepatic failure and tumors were included as well. We also considered the mortality of both non-transplanted and transplanted patients as a function of the MELD score at presentation.
    Results: Our model showed that the best MELD score for patients on the liver transplant waiting list associated to better results after liver transplantation was 26.
    Conclusions: We found that the best score for applying to liver transplant waiting list in the State of São Paulo was 26. This is the score that minimizes the mortality in both non-transplanted and liver transplanted patients.
    MeSH term(s) Humans ; Liver Transplantation ; Brazil ; Waiting Lists ; End Stage Liver Disease/surgery
    Language English
    Publishing date 2023-09-15
    Publishing country Brazil
    Document type Journal Article
    ISSN 2317-6326
    ISSN (online) 2317-6326
    DOI 10.1590/0102-672020230028e1746
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  6. Article ; Online: Theoretical models: necessary reflections.

    de Souza Filho, Breno Augusto Bormann / Tritany, Érika Fernandes / Arana, Gustavo Alonso Cabrera / Struchiner, Cláudio José

    Revista brasileira de epidemiologia = Brazilian journal of epidemiology

    2023  Volume 26, Page(s) e230038

    Abstract: Objective: To present theoretical-methodological reflections on the elaboration, types, and functions of theoretical models as well as their conceptual and analytic frameworks.: Methods: This is an essay, whose material collection was carried out in ... ...

    Title translation Modelos teóricos: reflexões necessárias.
    Abstract Objective: To present theoretical-methodological reflections on the elaboration, types, and functions of theoretical models as well as their conceptual and analytic frameworks.
    Methods: This is an essay, whose material collection was carried out in a non-systematic way, by electing studies exclusively based on the line of argument and reflection that the authors intend to submit to appreciation and public debate.
    Results: We present reflections on the types and functions of theoretical models, theoretical foundations in research, and reflections on the importance of theoretical models for public health research and their relation with the process of elaboration, development, and reporting in scientific studies. In addition, we describe types of theoretical models referring to the conceptual and empirical levels and the important elaboration and description of their combination for scientific practice.
    Conclusion: With this article, our intention is to stimulate discussions and reflections on current methods that permeate scientific practice and encourage the use of Theoretical Models as a basis for scientific research in its elaboration, development, and reporting process.
    MeSH term(s) Humans ; Brazil ; Public Health
    Language English
    Publishing date 2023-09-18
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2183366-7
    ISSN 1980-5497 ; 1980-5497
    ISSN (online) 1980-5497
    ISSN 1980-5497
    DOI 10.1590/1980-549720230038.2
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  7. Article ; Online: Vulnerable populations and tuberculosis treatment outcomes in Brazil.

    Macedo, Laylla Ribeiro / Maciel, Ethel Leonor Noia / Struchiner, Claudio Jose

    Ciencia & saude coletiva

    2020  Volume 26, Issue 10, Page(s) 4749–4759

    Abstract: This article aims to assess the association between being a prisoner or homeless and treatment failure in cases of tuberculosis diagnosed in Brazil in 2015. We examined cases of tuberculosis in prisoners and the homeless in Brazil in 2015 reported to the ...

    Title translation Populações vulneráveis e o desfecho dos casos de tuberculose no Brasil.
    Abstract This article aims to assess the association between being a prisoner or homeless and treatment failure in cases of tuberculosis diagnosed in Brazil in 2015. We examined cases of tuberculosis in prisoners and the homeless in Brazil in 2015 reported to the national notifiable diseases information system using descriptive analysis and logistic regression. There were 82,056 cases of tuberculosis in 2015. Of these, 7,462 (10.3%) were prisoners and 2,782 (3.9%) were homeless. The rate of treatment success in prisoners was 78.6%, while the rate of failure in the homeless was 63.2%. Being a prisoner was a protective factor against treatment failure (adjusted odds ratio 0.68, 95%CI 0.63-0.73), while being homeless was a risk factor for treatment failure (adjusted odds ratio 2.38, 95%CI 2.17-2.61). Treatment success and failure rates differed between prisoners and the homeless. Our findings reinforce the need for public health policies tailored to the specific needs of these groups implemented in conjunction with social services and public security agencies in order to have a significant impact on TB incidence.
    MeSH term(s) Brazil/epidemiology ; Homeless Persons ; Humans ; Prisoners ; Treatment Outcome ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Vulnerable Populations
    Language English
    Publishing date 2020-08-15
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2078799-6
    ISSN 1678-4561 ; 1678-4561
    ISSN (online) 1678-4561
    ISSN 1678-4561
    DOI 10.1590/1413-812320212610.24132020
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  8. Article ; Online: Factors associated with tuberculosis in persons deprived of liberty in Espírito Santo.

    Macedo, Laylla Ribeiro / Maciel, Ethel Leonor Noia / Struchiner, Claudio Jose

    Revista de saude publica

    2020  Volume 54, Page(s) 67

    Abstract: OBJECTIVES To calculate the rate of tuberculosis cases per prison unit in Espírito Santo; present the individual, clinical, and institutional characteristics of the cases in persons deprived of liberty (PPL); and analyze the association between these ... ...

    Abstract OBJECTIVES To calculate the rate of tuberculosis cases per prison unit in Espírito Santo; present the individual, clinical, and institutional characteristics of the cases in persons deprived of liberty (PPL); and analyze the association between these characteristics and treatment outcome in this population. METHODS The study included cases of tuberculosis in the PPL of Espírito Santo from 2014 to 2016. Rate calculation, descriptive analysis and hierarchical logistic regression were performed considering the individual, clinical and institutional levels. RESULTS The rate of diagnosed cases per prison unit in the state ranged from 0 to 17.3 cases per 1,000 inmates. Of all reported cases, 218 (72.6%) healed, 21 (7.0%) dropped out, 1 (0.3%) died of tuberculosis, 2 (0.7%) died from other causes, 56 (18.7%) transferred the treatment site and 2 (0.7%) developed drug-resistant tuberculosis. The adjusted analysis showed that supervised treatment ensures success (CR = 0.29; 95%CI 0.01-0.76). CONCLUSIONS The study highlighted the importance of knowing the TB treatment outcome in the PPL to implement measures to reduce failure, and the contribution of supervised treatment in this process.
    MeSH term(s) Adult ; Antitubercular Agents/therapeutic use ; Brazil ; Female ; Freedom ; Health Services Accessibility ; Humans ; Male ; Prisoners/statistics & numerical data ; Prisons ; Treatment Outcome ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Tuberculosis, Multidrug-Resistant
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2020-07-03
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 732179-x
    ISSN 1518-8787 ; 0034-8910
    ISSN (online) 1518-8787
    ISSN 0034-8910
    DOI 10.11606/s1518-8787.2020054001818
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  9. Article ; Online: Lives on the line: the impact of the Olympics and Paralympics on global public health.

    Souza Filho, Breno Augusto Bormann de / Tritany, Érika Fernandes / Struchiner, Cláudio José

    Cadernos de saude publica

    2021  Volume 37, Issue 11, Page(s) e00209321

    Title translation Vidas em jogo: reflexões sobre o impacto das Olimpíadas e Paralimpíadas para a saúde pública mundial.
    MeSH term(s) Brazil ; Humans ; Public Health ; Sports
    Language Portuguese
    Publishing date 2021-11-22
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1115730-6
    ISSN 1678-4464 ; 0102-311X
    ISSN (online) 1678-4464
    ISSN 0102-311X
    DOI 10.1590/0102-311X00209321
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  10. Article ; Online: Avaliação da qualidade da produção científica e suas consequências imprevistas e indesejadas: um conceito autoevidente?

    Struchiner, Claudio José

    Cadernos de saude publica

    2013  Volume 29, Issue 9, Page(s) 1716–1717

    Title translation Evaluation of the quality of the scientific output and its unforeseen and undesirable consequences: a self-evident concept?.
    MeSH term(s) Bibliometrics ; Humans ; Publishing/standards
    Language Portuguese
    Publishing date 2013-06-02
    Publishing country Brazil
    Document type Journal Article ; Comment
    ZDB-ID 1115730-6
    ISSN 1678-4464 ; 0102-311X
    ISSN (online) 1678-4464
    ISSN 0102-311X
    DOI 10.1590/0102-311xco040913
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