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  1. Article ; Online: Recurrent thrombotic events after disappearance of antiphospholipid autoantibodies: A long-term longitudinal study in patients with antiphospholipid syndrome.

    Ballul, Thomas / Mageau, Arthur / Roland Nicaise, Pascale / Ajzenberg, Nadine / Strukov, Andrey / Dossier, Antoine / Rouzaud, Diane / Papo, Thomas / Sacré, Karim

    Thrombosis research

    2023  Volume 224, Page(s) 1–3

    MeSH term(s) Humans ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/complications ; Longitudinal Studies ; Thrombosis/etiology ; Autoantibodies
    Chemical Substances Antibodies, Antiphospholipid ; Autoantibodies
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2023.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: High incidence of immune-mediated inflammatory diseases in sepsis survivors: A nationwide exposed-nonexposed epidemiological study.

    Mageau, Arthur / Helary, Aloïs / Ruckly, Stephane / Strukov, Andrey / Papo, Thomas / Timsit, Jean-François / Sacre, Karim

    Journal of internal medicine

    2023  Volume 295, Issue 2, Page(s) 242–252

    Abstract: Objective: Sepsis is characterized by an excessive release of inflammatory cytokines. Cytokine dysregulation is pivotal to the pathophysiology of immune-mediated inflammatory diseases (IMIDs). We aimed to analyze the incidence of IMIDs in patients who ... ...

    Abstract Objective: Sepsis is characterized by an excessive release of inflammatory cytokines. Cytokine dysregulation is pivotal to the pathophysiology of immune-mediated inflammatory diseases (IMIDs). We aimed to analyze the incidence of IMIDs in patients who survived sepsis.
    Methods: We performed a matched-cohort study using the National Medico-Administrative Hospital database in order to analyze the association between sepsis and incident IMIDs in 2020 in France. Sepsis was defined by the combination of at least one infection diagnosis code and one organ failure code. Patients with a first sepsis diagnosed in 2020 were randomly matched with patients admitted during the same period for acute myocardial infarction (AMI) with an exact matching procedure using age, gender, and comorbidities as matching variables. The main outcome was an IMID diagnosis in a 9-month follow-up period starting the first day of hospitalization for sepsis or AMI.
    Results: In France, the incidence rate of IMIDs after a sepsis in 2020-analyzed in 62,257 patients-was of 7956 (95% confidence interval [95% CI] 7392-8520) per 100,000 patient-years. As compared to the AMI population, we observed an increased risk for IMIDs of 2.80 (hazard ratio [HR]; 95% CI [2.22-3.54]) starting from day 16 after admission in the sepsis population. The risk of IMIDs onset in sepsis survivors depended on the type of IMIDs and was higher for immune thrombocytopenia (5.51 [1.97-15.4]), autoimmune hemolytic anemia (HR 4.83 [1.45-16.1]), and antineutrophil cytoplasmic antibody-associated vasculitis (4.66 [2.05-10.6]). Association between sepsis and IMIDs onset appeared well balanced across pathogen categories.
    Conclusion: Our study shows a high incidence of IMIDs among sepsis survivors.
    MeSH term(s) Humans ; Cohort Studies ; Incidence ; Sepsis/epidemiology ; Myocardial Infarction/epidemiology ; Survivors ; Immunomodulating Agents
    Chemical Substances Immunomodulating Agents
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.44: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article: Impact of direct ICU admission of pneumococcal meningitis in France: a retrospective analysis of a French medico-administrative (PMSI) database.

    Thy, Michael / Dupuis, Claire / Mageau, Arthur / Mourvillier, Bruno / Bouadma, Lila / Ruckly, Stéphane / Perozziello, Anne / Strukov, Andrey / Van-Gysel, Damien / de Montmollin, Etienne / Sonneville, Romain / Timsit, Jean-François

    Annals of intensive care

    2024  Volume 14, Issue 1, Page(s) 15

    Abstract: Background: Current guidelines for adult patients with pneumococcal meningitis (PM) recommend initial management in intermediate or intensive care units (ICU), but evidence to support these recommendations is limited. We aimed to describe ICU admission ... ...

    Abstract Background: Current guidelines for adult patients with pneumococcal meningitis (PM) recommend initial management in intermediate or intensive care units (ICU), but evidence to support these recommendations is limited. We aimed to describe ICU admission practices of patients with PM.
    Methods: We conducted a retrospective analysis of the French medico administrative database of consecutive adult patients with PM and sepsis criteria hospitalized between 2011 and 2020. We defined two groups, "Direct ICU" corresponding to a direct ICU admission and "Delayed ICU" corresponding to a secondary ICU admission.
    Results: We identified 4052 patients hospitalized for a first episode of PM, including 2006 "Direct ICU" patients (50%) and 2046 "delayed ICU" patients (50%). The patients were mainly males [n = 2260 (56%)] with median age of 61 years [IQR 50-71] and a median Charlson index of 1 [0-3]. Among them, median SAPS II on admission was 46 [33-62], 2173 (54%) had a neurological failure on admission with 2133 (53%) in coma, 654 (16%) with brainstem failure, 488 (12%) with seizures and 779 (19%) with focal signs without coma. PM was frequently associated with pneumonia [n = 1411 (35%)], and less frequently with endocarditis [n = 317 (8%)]. The median ICU length of stay and hospital length of stay were 6 days [2-14] and 21 days [13-38], respectively. In-hospital mortality was 27% (n = 1100) and 640 (16%) patients were secondarily transferred to rehabilitation care unit. Direct ICU group was significantly more severe but after adjustment for age, sex, comorbidities, organ failures on admission and admission from home, direct ICU admission was significantly associated with a lower mortality (Odds ratio 0.67 [0.56-0.80], p < 0.01). This corresponded to one death avoided for 11 PM directly admitted in ICU.
    Conclusions: Among patients with PM and sepsis, direct ICU admission was associated with lower mortality rates when compared to delayed admission.
    Language English
    Publishing date 2024-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01239-1
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  4. Article ; Online: Limb arteries involvement assessed by FDG/PET CT at diagnosis of giant cell arteritis and risk of relapse: An observational study.

    Peyrac, Geoffroy / Mageau, Arthur / Gaudemer, Augustin / Benali, Khadija / Rohmer, Julien / Alexandra, Jean-Francois / Strukov, Andrey / Ottaviani, Sebastien / Papo, Thomas / Sacre, Karim

    Joint bone spine

    2024  Volume 91, Issue 5, Page(s) 105734

    Abstract: Introduction: Steroids and anti-IL6 biotherapy are highly effective in obtaining remission in patients with giant cell arteritis (GCA) but the risk of relapses remains high. We aimed to identify predictors of relapse in GCA.: Methods: All consecutive ...

    Abstract Introduction: Steroids and anti-IL6 biotherapy are highly effective in obtaining remission in patients with giant cell arteritis (GCA) but the risk of relapses remains high. We aimed to identify predictors of relapse in GCA.
    Methods: All consecutive patients admitted with a new diagnosis of GCA - according to the 2022 American College of Rheumatology/EULAR (ACR/EULAR) classification criteria - between May 2011 and May 2022 were eligible for this study. The primary outcome was the GCA relapse rate over the 36-months follow up. Factors associated with the primary outcome and time to first relapse were analyzed.
    Results: One hundred and eight patients (74 [69-81] years, 64.8% women) with a new diagnosis of GCA were studied. GCA was biopsy-proven in 65 (60.2%) cases. Ninety-eight (90.7%) FDG/PET CT scans performed at diagnosis were available for review. All patients received steroids given for 21.0 [18.0-28.5] months, associated with methotrexate (n=1, 0.9%) or tocilizumab (n=2, 1.9%). During a median follow-up of 27.5 [11.4-35.0] months, relapse occurred in 40 (37%) patients. Multivariable Cox regression model, including general signs, gender, aortic wall thickness, FDG uptake in arterial wall and IV steroid pulse as covariates, showed that both general signs (HR 2.0 [1.0-4.0, P<0.05) and FDG uptake in limb arteries (HR 2.7 [1.3-5.5], P<0.01) at diagnosis were associated with GCA relapse.
    Conclusion: FDG uptake in limb arteries at diagnosis is a predictor of relapse in newly diagnosed GCA.
    Language English
    Publishing date 2024-04-15
    Publishing country France
    Document type Journal Article
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2024.105734
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4590: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Survival after COVID-19-associated organ failure among inpatients with systemic lupus erythematosus in France: a nationwide study.

    Mageau, Arthur / Papo, Thomas / Ruckly, Stephane / Strukov, Andrey / van Gysel, Damien / Sacre, Karim / Timsit, Jean-François

    Annals of the rheumatic diseases

    2021  Volume 81, Issue 4, Page(s) 569–574

    Abstract: Objective: We analysed the incidence of, the specific outcomes and factors associated with COVID-19-associated organ failure (AOF) in patients with systemic lupus erythematosus (SLE) in France.: Methods: We performed a cohort study using the French ... ...

    Abstract Objective: We analysed the incidence of, the specific outcomes and factors associated with COVID-19-associated organ failure (AOF) in patients with systemic lupus erythematosus (SLE) in France.
    Methods: We performed a cohort study using the French national medical/administrative hospital database for the January 2011-November 2020 period. Each patient with SLE diagnosed in a French hospital with a COVID-19-AOF until November 2020 was randomly matched with five non-SLE patients with COVID-19-AOF. We performed an exact matching procedure taking age ±2 years, gender and comorbidities as matching variables. COVID-19-AOF was defined as the combination of at least one code of COVID-19 diagnosis with one code referring to an organ failure diagnosis.
    Results: From March to November 2020, 127 380 hospital stays in France matched the definition of COVID-19-AOF, out of which 196 corresponded with patients diagnosed with SLE. Based on the presence of comorbidities, we matched 908 non-SLE patients with COVID-19-AOF with 190 SLE patients with COVID-19-AOF. On day 30, 43 in-hospital deaths (22.6%) occurred in SLE patients with COVID-19-AOF vs 198 (21.8%) in matched non-SLE patients with COVID-19-AOF: HR 0.98 (0.71-1.34). Seventy-five patients in the SLE COVID-19-AOF group and 299 in the matched control group were followed up from day 30 to day 90. During this period, 19 in-hospital deaths occurred in the SLE group (25.3%) vs 46 (15.4%) in the matched control group; the HR associated with death occurring after COVID-19-AOF among patients with SLE was 1.83 (1.05-3.20).
    Conclusions: COVID-19-AOF is associated with a poor late-onset prognosis among patients with SLE.
    MeSH term(s) Aged ; COVID-19/complications ; COVID-19/mortality ; Cohort Studies ; Databases, Factual ; Female ; France/epidemiology ; Humans ; Incidence ; Inpatients/statistics & numerical data ; Lupus Erythematosus, Systemic/mortality ; Lupus Erythematosus, Systemic/virology ; Male ; Middle Aged ; Multiple Organ Failure/mortality ; Multiple Organ Failure/virology ; SARS-CoV-2
    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2021-221599
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    Uh III Zs.114: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 167: Show issues

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  6. Article ; Online: Management of Undocumented Immigrants With End-Stage Kidney Disease in 2 Academic Hospitals in Paris.

    Le Flécher, Arnaud / Doreille, Alice / Michel, Pierre-Antoine / Hanouna, Guillaume / Daugas, Eric / Fessi, Hafedh / Claude, Pierre-Abel / Esteve, Emmanuel / Boffa, Jean-Jacques / Strukov, Andrey / Retbi, Aurelia / Petit-Hoang, Camille / François, Hélène / Ouali, Nacera / Jamme, Matthieu / Verney, Charles / Rondeau, Eric / Mesnard, Laurent / Rafat, Cédric /
    Luque, Yosu

    Kidney international reports

    2021  Volume 7, Issue 3, Page(s) 610–613

    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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