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  1. Article ; Online: Hepatitis B Virus

    Philippa C Matthews / Tongai Maponga / Indrajit Ghosh / Maud Lemoine / Ponsiano Ocama / Ibrahim Abubakar / Alistair Story / Stuart Flanagan

    PLOS Global Public Health, Vol 2, Iss 12, p e

    Infection, liver disease, carcinogen or syndemic threat? Remodelling the clinical and public health response.

    2022  Volume 0001359

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The forgotten people

    Emily Martyn / Sarah Eisen / Nicky Longley / Philippa Harris / Julian Surey / James Norman / Michael Brown / Binta Sultan / Tongai G Maponga / Collins Iwuji / Stuart Flanagan / Indrajit Ghosh / Alistair Story / Philippa C Matthews

    eLife, Vol

    Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

    2023  Volume 12

    Abstract: Hepatitis B virus (HBV) infection represents a significant global health threat, accounting for 300 million chronic infections and up to 1 million deaths each year. HBV disproportionately affects people who are under-served by health systems due to ... ...

    Abstract Hepatitis B virus (HBV) infection represents a significant global health threat, accounting for 300 million chronic infections and up to 1 million deaths each year. HBV disproportionately affects people who are under-served by health systems due to social exclusion, and can further amplify inequities through its impact on physical and mental health, relationship with stigma and discrimination, and economic costs. The ‘inclusion health’ agenda focuses on excluded and vulnerable populations, who often experience barriers to accessing healthcare, and are under-represented by research, resources, interventions, advocacy, and policy. In this article, we assimilate evidence to establish HBV on the inclusion health agenda, and consider how this view can inform provision of better approaches to diagnosis, treatment, and prevention. We suggest approaches to redress the unmet need for HBV interventions among excluded populations as an imperative to progress the global goal for the elimination of viral hepatitis as a public health threat.
    Keywords hepatitis b virus ; inclusion health ; sustainable development goals ; refugee health ; health inequality ; homelessness ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 360
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: The effect of tenofovir on renal function in HIV-positive pregnant women

    Stuart Flanagan / Lynne Barnes / Jane Anderson / Tristan Barber

    Journal of the International AIDS Society , Vol 17, Iss 4(Suppl 3), Pp 1-

    2014  Volume 1

    Abstract: Introduction: Tenofovir is a commonly used component of antiretroviral therapy (ART) to reduce vertical transmission of HIV. Although systematic review of tenofovir use in pregnancy concluded it to be low risk for foetal abnormalities (1), data is ... ...

    Abstract Introduction: Tenofovir is a commonly used component of antiretroviral therapy (ART) to reduce vertical transmission of HIV. Although systematic review of tenofovir use in pregnancy concluded it to be low risk for foetal abnormalities (1), data is limited on its impact on renal function in pregnant women. A recent South African study (2) concluded that renal dysfunction in HIV-infected pregnant women is significantly less common than in other HIV-infected adults, however there is currently no UK data. We aimed to investigate the effect of tenofovir on renal function in HIV-1 positive pregnant women in a UK clinic. Methods: We retrospectively analyzed data on renal function in pregnancy from a cohort of women attending a busy inner city London antenatal clinic. All women were screened for renal function throughout pregnancy via serum creatinine and estimated glomerular filtration rate (eGFR) calculated using modification of diet in renal disease (MDRD) and corrected for ethnicity. Results: Ninety-seven HIV-1 positive women were registered at Homerton Hospital antenatal service of a total of 105 pregnancies between January 2010 and September 2013. Tenofovir was prescribed in 71/105 pregnancies (67.6%). Of the 71 pregnancies, 41 were prescribed tenofovir pre-conception (57.7%). Of the pregnant women who started tenofovir in pregnancy, 21/31 (67.7%) were initiated before week 24 of pregnancy, in line with British HIV association (BHIVA) guidelines (3). There was no deterioration in median serum creatinine or decline in eGFR in women prescribed tenofovir during pregnancy. At six weeks after delivery, in the 42 women who continued tenofovir therapy and had eGFR measured, one woman had eGFR=60, all others eGFR >90 (Table 1). Conclusions: Consistent with current guidelines and experience, this study shows tenofovir did not cause decline in renal function in pregnancy in our cohort of HIV-1 positive women, whether started during pre-conception or during pregnancy. More evidence should be prospectively collected looking at effects of tenofovir on other measures of tubular renal function in pregnancy such as proteinuria and protein-creatinine ratio.
    Keywords General Works ; A ; Medicine ; R ; Political science ; J ; Social Sciences ; H ; Immunologic diseases. Allergy ; RC581-607
    Language English
    Publishing date 2014-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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