LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Stuart G. Tangye"
  2. AU="Yao-Zhong Zhao"
  3. AU="Chern, Chang-Ming"
  4. AU="Floeter, Jens"
  5. AU="Wijnen, Petal"
  6. AU="Saravanamuthu, Pira"
  7. AU="Kalpana Deepa Priya Dorayappan"
  8. AU="Xiao, Hongkui"
  9. AU="Lali, Arvind M"
  10. AU="Kim, Hyojeong"
  11. AU="Nasseri, Saeed"
  12. AU="Kluge"
  13. AU="Bierbaumer, Lisa"
  14. AU="Rashid, Muhammad"
  15. AU="Huang, Chiun-Sheng"
  16. AU="Shevchuk, O O"
  17. AU="Mulvihill, Emily"
  18. AU="Gandhi, Adarsh"
  19. AU="Zhao, Chuanrui"
  20. AU="Shelley Wiart"
  21. AU="Lydia E. Wroblewski" AU="Lydia E. Wroblewski"
  22. AU="Paterson, Ross"
  23. AU="Alexander Marx"
  24. AU="Robinson, Jill"
  25. AU="Mitchell, Adam W M"
  26. AU="Ingham, Jesse R"

Suchergebnis

Treffer 1 - 9 von insgesamt 9

Suchoptionen

  1. Artikel ; Online: Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

    Simona Infantino / Amanda Light / Kristy O’Donnell / Vanessa Bryant / Danielle T. Avery / Michael Elliott / Stuart G. Tangye / Gabrielle Belz / Fabienne Mackay / Stephane Richard / David Tarlinton

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Band 12

    Abstract: PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and ... ...

    Abstract PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2017-10-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

    Imogen Moran / Akira Nguyen / Weng Hua Khoo / Danyal Butt / Katherine Bourne / Clara Young / Jana R. Hermes / Maté Biro / Gary Gracie / Cindy S. Ma / C. Mee Ling Munier / Fabio Luciani / John Zaunders / Andrew Parker / Anthony D. Kelleher / Stuart G. Tangye / Peter I. Croucher / Robert Brink / Mark N. Read /
    Tri Giang Phan

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 14

    Abstract: Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from ...

    Abstract Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from the germinal centre, for rapid expansion and the induction of B memory responses.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-08-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles

    Jalila Alshekaili / Rochna Chand / Cindy Eunhee Lee / Susan Corley / Kristy Kwong / Ilenia Papa / David A. Fulcher / Katrina L. Randall / Jennifer W. Leiding / Cindy S. Ma / Marc R. Wilkins / Gulbu Uzel / Chris C. Goodnow / Carola G. Vinuesa / Stuart G. Tangye / Matthew C. Cook

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Band 11

    Abstract: Abstract A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1hi, but compared to their CD57− PD-1hi counterparts, express little IL-21 ...

    Abstract Abstract A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1hi, but compared to their CD57− PD-1hi counterparts, express little IL-21 or IL-10 among others. Instead, CD57 expression on TFH cells marks cytotoxicity transcriptional signatures that translate into only a weak cytotoxic phenotype. Similarly, circulating PD-1+ CD57+ CD4+ T cells make less cytokine than their CD57− PD-1+ counterparts, but have a prominent cytotoxic phenotype. By analysis of responses to STAT3-dependent cytokines and cells from patients with gain- or loss-of-function STAT3 mutations, we show that CD4+ T cell cytotoxicity is STAT3-dependent. TFH formation also requires STAT3, but paradoxically, once formed, PD-1hi cells become unresponsive to STAT3. These findings suggest that changes in blood and germinal center cytotoxicity might be affected by changes in STAT3 signaling, or modulation of PD-1 by therapy.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2018-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

    Imogen Moran / Akira Nguyen / Weng Hua Khoo / Danyal Butt / Katherine Bourne / Clara Young / Jana R. Hermes / Maté Biro / Gary Gracie / Cindy S. Ma / C. Mee Ling Munier / Fabio Luciani / John Zaunders / Andrew Parker / Anthony D. Kelleher / Stuart G. Tangye / Peter I. Croucher / Robert Brink / Mark N. Read /
    Tri Giang Phan

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 14

    Abstract: Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from ...

    Abstract Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from the germinal centre, for rapid expansion and the induction of B memory responses.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  5. Artikel ; Online: Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs.

    Heng Giap Woon / Asolina Braun / Jane Li / Corey Smith / Jarem Edwards / Frederic Sierro / Carl G Feng / Rajiv Khanna / Michael Elliot / Andrew Bell / Andrew D Hislop / Stuart G Tangye / Alan B Rickinson / Thomas Gebhardt / Warwick J Britton / Umaimainthan Palendira

    PLoS Pathogens, Vol 12, Iss 8, p e

    2016  Band 1005799

    Abstract: Disruption of T cell memory during severe immune suppression results in reactivation of chronic viral infections, such as Epstein Barr virus (EBV) and Cytomegalovirus (CMV). How different subsets of memory T cells contribute to the protective immunity ... ...

    Abstract Disruption of T cell memory during severe immune suppression results in reactivation of chronic viral infections, such as Epstein Barr virus (EBV) and Cytomegalovirus (CMV). How different subsets of memory T cells contribute to the protective immunity against these viruses remains poorly defined. In this study we examined the compartmentalization of virus-specific, tissue resident memory CD8+ T cells in human lymphoid organs. This revealed two distinct populations of memory CD8+ T cells, that were CD69+CD103+ and CD69+CD103-, and were retained within the spleen and tonsils in the absence of recent T cell stimulation. These two types of memory cells were distinct not only in their phenotype and transcriptional profile, but also in their anatomical localization within tonsils and spleen. The EBV-specific, but not CMV-specific, CD8+ memory T cells preferentially accumulated in the tonsils and acquired a phenotype that ensured their retention at the epithelial sites where EBV replicates. In vitro studies revealed that the cytokine IL-15 can potentiate the retention of circulating effector memory CD8+ T cells by down-regulating the expression of sphingosine-1-phosphate receptor, required for T cell exit from tissues, and its transcriptional activator, Kruppel-like factor 2 (KLF2). Within the tonsils the expression of IL-15 was detected in regions where CD8+ T cells localized, further supporting a role for this cytokine in T cell retention. Together this study provides evidence for the compartmentalization of distinct types of resident memory T cells that could contribute to the long-term protection against persisting viral infections.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-08-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel ; Online: CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

    Luca Hensen / Patricia T. Illing / E. Bridie Clemens / Thi H. O. Nguyen / Marios Koutsakos / Carolien E. van de Sandt / Nicole A. Mifsud / Andrea T. Nguyen / Christopher Szeto / Brendon Y. Chua / Hanim Halim / Simone Rizzetto / Fabio Luciani / Liyen Loh / Emma J. Grant / Phillipa M. Saunders / Andrew G. Brooks / Steve Rockman / Tom C. Kotsimbos /
    Allen C. Cheng / Michael Richards / Glen P. Westall / Linda M. Wakim / Thomas Loudovaris / Stuart I. Mannering / Michael Elliott / Stuart G. Tangye / David C. Jackson / Katie L. Flanagan / Jamie Rossjohn / Stephanie Gras / Jane Davies / Adrian Miller / Steven Y. C. Tong / Anthony W. Purcell / Katherine Kedzierska

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 20

    Abstract: The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population ... ...

    Abstract The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population expressing the susceptibility allomorph HLA A*24:02 and validate immunodominance of some of these epitopes in mice.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  7. Artikel ; Online: IRF4 haploinsufficiency in a family with Whipple’s disease

    Antoine Guérin / Gaspard Kerner / Nico Marr / Janet G Markle / Florence Fenollar / Natalie Wong / Sabri Boughorbel / Danielle T Avery / Cindy S Ma / Salim Bougarn / Matthieu Bouaziz / Vivien Béziat / Erika Della Mina / Carmen Oleaga-Quintas / Tomi Lazarov / Lisa Worley / Tina Nguyen / Etienne Patin / Caroline Deswarte /
    Rubén Martinez-Barricarte / Soraya Boucherit / Xavier Ayral / Sophie Edouard / Stéphanie Boisson-Dupuis / Vimel Rattina / Benedetta Bigio / Guillaume Vogt / Frédéric Geissmann / Lluis Quintana-Murci / Damien Chaussabel / Stuart G Tangye / Didier Raoult / Laurent Abel / Jacinta Bustamante / Jean-Laurent Casanova

    eLife, Vol

    2018  Band 7

    Abstract: Most humans are exposed to Tropheryma whipplei (Tw). Whipple’s disease (WD) strikes only a small minority of individuals infected with Tw (<0.01%), whereas asymptomatic chronic carriage is more common (<25%). We studied a multiplex kindred, containing ... ...

    Abstract Most humans are exposed to Tropheryma whipplei (Tw). Whipple’s disease (WD) strikes only a small minority of individuals infected with Tw (<0.01%), whereas asymptomatic chronic carriage is more common (<25%). We studied a multiplex kindred, containing four WD patients and five healthy Tw chronic carriers. We hypothesized that WD displays autosomal dominant (AD) inheritance, with age-dependent incomplete penetrance. We identified a single very rare non-synonymous mutation in the four patients: the private R98W variant of IRF4, a transcription factor involved in immunity. The five Tw carriers were younger, and also heterozygous for R98W. We found that R98W was loss-of-function, modified the transcriptome of heterozygous leukocytes following Tw stimulation, and was not dominant-negative. We also found that only six of the other 153 known non-synonymous IRF4 variants were loss-of-function. Finally, we found that IRF4 had evolved under purifying selection. AD IRF4 deficiency can underlie WD by haploinsufficiency, with age-dependent incomplete penetrance.
    Schlagwörter Whipple's disease ; primary immunodeficiency ; IRF4 ; haploinsufficiency ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-03-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.

    Umaimainthan Palendira / Carol Low / Anna Chan / Andrew D Hislop / Edwin Ho / Tri Giang Phan / Elissa Deenick / Matthew C Cook / D Sean Riminton / Sharon Choo / Richard Loh / Frank Alvaro / Claire Booth / H Bobby Gaspar / Alessandro Moretta / Rajiv Khanna / Alan B Rickinson / Stuart G Tangye

    PLoS Biology, Vol 9, Iss 11, p e

    2011  Band 1001187

    Abstract: X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite ... ...

    Abstract X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotropic virus, but not other viruses. Although previous studies have identified defects in lymphocytes from XLP patients, the unique role of SAP in controlling EBV infection remains unresolved. We describe a novel approach to this question using female XLP carriers who, due to random X-inactivation, contain both SAP(+) and SAP(-) cells. This represents the human equivalent of a mixed bone marrow chimera in mice. While memory CD8(+) T cells specific for CMV and influenza were distributed across SAP(+) and SAP(-) populations, EBV-specific cells were exclusively SAP(+). The preferential recruitment of SAP(+) cells by EBV reflected the tropism of EBV for B cells, and the requirement for SAP expression in CD8(+) T cells for them to respond to Ag-presentation by B cells, but not other cell types. The inability of SAP(-) clones to respond to Ag-presenting B cells was overcome by blocking the SLAM receptors NTB-A and 2B4, while ectopic expression of NTB-A on fibroblasts inhibited cytotoxicity of SAP(-) CD8(+) T cells, thereby demonstrating that SLAM receptors acquire inhibitory function in the absence of SAP. The innovative XLP carrier model allowed us to unravel the mechanisms underlying the unique susceptibility of XLP patients to EBV infection in the absence of a relevant animal model. We found that this reflected the nature of the Ag-presenting cell, rather than EBV itself. Our data also identified a pathological signalling pathway that could be targeted to treat patients with severe EBV infection. This system may allow the study of other human diseases where heterozygous gene expression from random X-chromosome inactivation can be exploited.
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2011-11-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel: Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

    Kuehn, Hye Sun / Anna Huttenlocher / Bernice Lo / Bogdan Dumitriu / Cathleen A. Frein / Christine M. Seroogy / Christopher Koh / Danielle T. Avery / Dat Q. Tran / David Kleiner / David M. Frucht / Elissa K. Deenick / Eric Meffre / Gulbu Uzel / Helen C. Su / Jason Hughes / Jean-Nicolas Schickel / Jennifer Stoddard / Joao B. Oliveira /
    Joshua McElwee / Julie E. Niemela / Kenneth N. Olivier / Les R. Folio / Luigi D. Notarangelo / Michael J. Lenardo / Phillip Scheinberg / Stefania Pittaluga / Steven M. Holland / Stuart G. Tangye / Susan Price / Theo Heller / Thomas A. Fleisher / V. Koneti Rao / Weiming Ouyang / Yajesh Rampertaap / Yu Zhang

    Science. 2014 Sept. 26, v. 345, no. 6204

    2014  

    Abstract: Beware of T cells that don't know how to stop During an infection, T cells divide extensively and secrete proteins that can severely damage tissues. But T cells know when to stop—they express proteins on their surface such as CTLA4, which put on the ... ...

    Abstract Beware of T cells that don't know how to stop During an infection, T cells divide extensively and secrete proteins that can severely damage tissues. But T cells know when to stop—they express proteins on their surface such as CTLA4, which put on the brakes. Kuehn et al. now report genetic evidence of the importance of CTLA4 in humans (see the Perspective by Rieux-Laucat and Casanova). They identified six patients with mutations in one copy of CTLA4 . Patients presented with symptoms of an overzealous immune response, with immune cells infiltrating their organs. The findings support the idea that CTLA4 tells the immune system when enough is enough. Science , this issue p. 1623; see also p. 1560
    Schlagwörter germ cells ; heterozygosity ; humans ; immune response ; mutation ; patients ; proteins ; tissues ; T-lymphocytes
    Sprache Englisch
    Erscheinungsverlauf 2014-0926
    Umfang p. 1623-1627.
    Erscheinungsort American Association for the Advancement of Science
    Dokumenttyp Artikel
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1255904
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 4' 46/137: Hefte anzeigen
    + C 27: Hefte anzeigen
    Z50.00 SC01: Hefte anzeigen
    Z 8.9: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang