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  1. Article ; Online: CD164 is a host factor for lymphocytic choriomeningitis virus entry.

    Bakkers, Mark J G / Moon-Walker, Alex / Herlo, Rasmus / Brusic, Vesna / Stubbs, Sarah Hulsey / Hastie, Kathryn M / Saphire, Erica Ollmann / Kirchhausen, Tomas L / Whelan, Sean P J

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 10, Page(s) e2119676119

    Abstract: Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne zoonotic arenavirus that causes congenital abnormalities and can be fatal for transplant recipients. Using a genome-wide loss-of-function screen, we identify host factors required for LCMV entry ...

    Abstract Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne zoonotic arenavirus that causes congenital abnormalities and can be fatal for transplant recipients. Using a genome-wide loss-of-function screen, we identify host factors required for LCMV entry into cells. We identify the lysosomal mucin CD164, glycosylation factors, the heparan sulfate biosynthesis machinery, and the known receptor alpha-dystroglycan (α-DG). Biochemical analysis revealed that the LCMV glycoprotein binds CD164 at acidic pH and requires a sialylated glycan at residue N104. We demonstrate that LCMV entry proceeds by the virus switching binding from heparan sulfate or α-DG at the plasma membrane to CD164 prior to membrane fusion, thus identifying additional potential targets for therapeutic intervention.
    MeSH term(s) A549 Cells ; CRISPR-Cas Systems ; Endolyn/physiology ; Gene Editing ; HEK293 Cells ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Hydrogen-Ion Concentration ; Lymphocytic choriomeningitis virus/pathogenicity ; Lymphocytic choriomeningitis virus/physiology ; Membrane Fusion ; Virulence Factors ; Virus Internalization
    Chemical Substances CD164 protein, human ; Endolyn ; Virulence Factors
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2119676119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vesicular Stomatitis Virus Chimeras Expressing the Oropouche Virus Glycoproteins Elicit Protective Immune Responses in Mice.

    Stubbs, Sarah Hulsey / Cornejo Pontelli, Marjorie / Mishra, Nischay / Zhou, Changhong / de Paula Souza, Juliano / Mendes Viana, Rosa Maria / Lipkin, W Ian / Knipe, David M / Arruda, Eurico / Whelan, Sean P J

    mBio

    2021  Volume 12, Issue 4, Page(s) e0046321

    Abstract: Oropouche virus (OROV) infection of humans is associated with a debilitating febrile illness that can progress to meningitis or encephalitis. First isolated from a forest worker in Trinidad and Tobago in 1955, the arbovirus OROV has since been detected ... ...

    Abstract Oropouche virus (OROV) infection of humans is associated with a debilitating febrile illness that can progress to meningitis or encephalitis. First isolated from a forest worker in Trinidad and Tobago in 1955, the arbovirus OROV has since been detected throughout the Amazon basin with an estimated 500,000 human infections over 60 years. Like other members of the family
    MeSH term(s) Animals ; Antibodies, Neutralizing ; Bunyaviridae Infections/immunology ; Bunyaviridae Infections/prevention & control ; Genome, Viral ; Male ; Mice ; Mice, Inbred C57BL ; Orthobunyavirus/genetics ; Vesicular Stomatitis/virology ; Vesiculovirus/genetics ; Vesiculovirus/immunology ; Viral Envelope Proteins/genetics ; Virus Replication
    Chemical Substances Antibodies, Neutralizing ; Viral Envelope Proteins
    Language English
    Publishing date 2021-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00463-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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