LIVIVO - Search results -

Search results

Result 1 - 10 of total 30

Search options

Book ; Online ; Thesis: Identification of apoptosis-inducing natural products and derivatives for the elimination of tumor cells

Stuhldreier, Fabian [Verfasser] / Wesselborg, Sebastian [Gutachter] / Proksch, Peter [Gutachter]

2021

Author's details	Fabian Stuhldreier ; Gutachter: Sebastian Wesselborg, Peter Proksch
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Language	English
Publisher	Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
Publishing place	Düsseldorf
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum

Harwoko, Harwoko / Daletos, Georgios / Stuhldreier, Fabian / Lee, Jungho / Wesselborg, Sebastian / Feldbrügge, Michael / Müller, Werner E. G / Kalscheuer, Rainer / Ancheeva, Elena / Proksch, Peter

Natural product research. 2021 Jan. 17, v. 35, no. 2

2021

Abstract: A new epidithiodiketopiperazine (ETP), pretrichodermamide G (1), along with three known (epi)dithiodiketopiparazines (2-4) were isolated from cultures of Trichoderma harzianum and Epicoccum nigrum, endophytic fungi associated with medicinal plants ... ...

Abstract	A new epidithiodiketopiperazine (ETP), pretrichodermamide G (1), along with three known (epi)dithiodiketopiparazines (2-4) were isolated from cultures of Trichoderma harzianum and Epicoccum nigrum, endophytic fungi associated with medicinal plants Zingiber officinale and Salix sp., respectively. The structure of the new compound (1) was established on the basis of spectroscopic data, including 1D/2D NMR and HRESIMS. The isolated compounds were investigated for their antifungal, antibacterial and cytotoxic potential against a panel of microorganisms and cell lines. Pretrichodermamide A (2) displayed antimicrobial activity towards the plant pathogenic fungus Ustilago maydis and the human pathogenic bacterium Mycobacterium tuberculosis with MIC values of 1 mg/mL (2 mM) and 25 µg/mL (50 µM), respectively. Meanwhile, epicorazine A (3) exhibited strong to moderate cytotoxicity against L5178Y, Ramos, and Jurkat J16 cell lines with IC₅₀ values ranging from 1.3 to 28 µM. Further mechanistic studies indicated that 3 induces apoptotic cell death.
Keywords	Epicoccum nigrum ; Mycobacterium tuberculosis ; Salix ; Trichoderma harzianum ; Ustilago zeae ; Zingiber officinale ; animal pathogenic bacteria ; antimicrobial properties ; apoptosis ; cell lines ; cytotoxicity ; endophytes ; medicinal plants ; minimum inhibitory concentration ; plant pathogenic fungi ; research ; spectral analysis
Language	English
Dates of publication	2021-0117
Size	p. 257-265.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-light
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2019.1627348
Database	NAL-Catalogue (AGRICOLA)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell.

Erenburg, Isabelle N / Hänsch, Sebastian / Chacko, Feby M / Hamacher, Anna / Wintgens, Sebastian / Stuhldreier, Fabian / Poschmann, Gereon / Spitz, Olivia / Stühler, Kai / Wesselborg, Sebastian / Hegemann, Johannes H / Smits, Sander H J / Weidtkamp-Peters, Stefanie / Schmitt, Lutz

Scientific reports

2022 Volume 12, Issue 1, Page(s) 17825

Abstract: Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native conformation in ... ...

Abstract	Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native conformation in the Ca
MeSH term(s)	Humans ; Acyltransferases ; Bacterial Proteins/metabolism ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Hemolysin Proteins/metabolism ; Moraxella bovis/metabolism ; Type I Secretion Systems
Chemical Substances	Acyltransferases (EC 2.3.-) ; Bacterial Proteins ; Escherichia coli Proteins ; Hemolysin Proteins ; Type I Secretion Systems
Language	English
Publishing date	2022-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-22480-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Natural Products Impacting DNA Methyltransferases and Histone Deacetylases.

Akone, Sergi Herve / Ntie-Kang, Fidele / Stuhldreier, Fabian / Ewonkem, Monique Bassomo / Noah, Alexandre Mboene / Mouelle, Simon Eitel Misse / Müller, Rolf

Frontiers in pharmacology

2020 Volume 11, Page(s) 992

Abstract: Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and respective regulators have been reported. These include DNA methylation, chromatin remodeling, ... ...

Abstract	Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and respective regulators have been reported. These include DNA methylation, chromatin remodeling, histone post-translational modifications, and non-coding RNAs. Emerging evidence has revealed that epigenetic dysregulations are involved in a wide range of diseases including cancers. Therefore, the reversible nature of epigenetic modifications concerning activation or inhibition of enzymes involved could be promising targets and useful tools for the elucidation of cellular and biological phenomena. In this review, emphasis is laid on natural products that inhibit DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) making them promising candidates for the development of lead structures for anticancer-drugs targeting epigenetic modifications. However, most of the natural products targeting HDAC and/or DNMT lack isoform selectivity, which is important for determining their potential use as therapeutic agents. Nevertheless, the structures presented in this review offer the well-founded basis that screening and chemical modifications of natural products will in future provide not only leads to the identification of more specific inhibitors with fewer side effects, but also important features for the elucidation of HDAC and DNMT function with respect to cancer treatment.
Language	English
Publishing date	2020-08-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00992
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Induction of New Lactam Derivatives From the Endophytic Fungus

Gao, Ying / Stuhldreier, Fabian / Schmitt, Laura / Wesselborg, Sebastian / Guo, Zhiyong / Zou, Kun / Mándi, Attila / Kurtán, Tibor / Liu, Zhen / Proksch, Peter

Frontiers in microbiology

2020 Volume 11, Page(s) 600983

Abstract: Fermentation of the endophytic ... ...

Abstract	Fermentation of the endophytic fungus
Language	English
Publishing date	2020-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2020.600983
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense

Ariantari, Ni Putu / Frank, Marian / Gao, Ying / Stuhldreier, Fabian / Kiffe-Delf, Anna-Lene / Hartmann, Rudolf / Höfert, Simon-Patrick / Janiak, Christoph / Wesselborg, Sebastian / Müller, Werner E.G. / Kalscheuer, Rainer / Liu, Zhen / Proksch, Peter

Tetrahedron. 2021 Apr. 09, v. 85

2021

Abstract: Three new lipodepsipeptides, fusaristatins D–F (1–3) and a new α-pyrone derivative, (7S,8R)-(−)-chlamydospordiol (5), together with eight known compounds (4, 6–12) were obtained from solid rice cultures of Fusarium sp. BZCB-CA, an endophyte of the ... ...

Abstract	Three new lipodepsipeptides, fusaristatins D–F (1–3) and a new α-pyrone derivative, (7S,8R)-(−)-chlamydospordiol (5), together with eight known compounds (4, 6–12) were obtained from solid rice cultures of Fusarium sp. BZCB-CA, an endophyte of the Chinese medicinal plant, Bothriospermum chinense. The planar structures of the new metabolites (1–3, 5) were established by spectroscopic techniques (1D/2D NMR and HRESIMS). Marfey’s method was applied to determine the absolute configuration of 1, while the absolute configuration of 5 was determined by single-crystal X-ray crystallography analysis in addition to Mosher’s method. Crystallographic data of inflatin C (7) are also supplied here for the first time. In cytotoxicity assays, rubrofusarin (8) showed a moderate effect on the lymphoma cell lines L5178Y, Ramos and Jurkat, with IC₅₀ values of 7.7, 6.2 and 6.3 μM, respectively, while the remaining compounds were inactive. When subjected to antibacterial assay, only lateropyrone (9) exhibited good to weak activity against a panel of Gram-positive bacteria including drug-resistant strains with MICs ranging from 3.1 to 25 μM.
Keywords	Bothriospermum ; Fusarium ; X-ray diffraction ; cytotoxicity ; drug resistance ; endophytes ; medicinal plants ; metabolites ; neoplasm cells ; rice
Language	English
Dates of publication	2021-0409
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2021.132065
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 1076: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.

Sun, Yadong / Berleth, Niklas / Wu, Wenxian / Schlütermann, David / Deitersen, Jana / Stuhldreier, Fabian / Berning, Lena / Friedrich, Annabelle / Akgün, Seda / Mendiburo, María José / Wesselborg, Sebastian / Conrad, Marcus / Berndt, Carsten / Stork, Björn

Cell death & disease

2021 Volume 12, Issue 11, Page(s) 1028

Abstract: Ferroptosis is a form of regulated cell death that emerges to be relevant for therapy-resistant and dedifferentiating cancers. Although several lines of evidence suggest that ferroptosis is a type of autophagy-dependent cell death, the underlying ... ...

Abstract	Ferroptosis is a form of regulated cell death that emerges to be relevant for therapy-resistant and dedifferentiating cancers. Although several lines of evidence suggest that ferroptosis is a type of autophagy-dependent cell death, the underlying molecular mechanisms remain unclear. Fin56, a type 3 ferroptosis inducer, triggers ferroptosis by promoting glutathione peroxidase 4 (GPX4) protein degradation via a not fully understood pathway. Here, we determined that Fin56 induces ferroptosis and autophagy in bladder cancer cells and that Fin56-triggered ferroptosis mechanistically depends on the autophagic machinery. Furthermore, we found that autophagy inhibition at different stages attenuates Fin56-induced oxidative stress and GPX4 degradation. Moreover, we investigated the effects of Fin56 in combination with Torin 2, a potent mTOR inhibitor used to activate autophagy, on cell viability. We found that Fin56 synergizes with Torin 2 in cytotoxicity against bladder cancer cells. Collectively, our findings not only support the concept that ferroptosis is a type of autophagy-dependent cell death but imply that the combined application of ferroptosis inducers and mTOR inhibitors is a promising approach to improve therapeutic options in the treatment of bladder cancer.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Autophagy/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Synergism ; Ferroptosis/drug effects ; Humans ; MTOR Inhibitors/pharmacology ; Naphthyridines/pharmacology ; Oxidative Stress/drug effects ; Oximes/pharmacology ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Proteolysis/drug effects ; Signal Transduction/drug effects ; Sulfonamides/pharmacology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology
Chemical Substances	9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one ; Antineoplastic Agents ; FIN56 compound ; MTOR Inhibitors ; Naphthyridines ; Oximes ; Sulfonamides ; Phospholipid Hydroperoxide Glutathione Peroxidase (EC 1.11.1.12) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-021-04306-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.

Cell death & disease

2022 Volume 13, Issue 11, Page(s) 938

Abstract: Inhibition of the mitochondrial metabolism offers a promising therapeutic approach for the treatment of cancer. Here, we identify the mycotoxin viriditoxin (VDT), derived from the endophytic fungus Cladosporium cladosporioides, as an interesting ... ...

Abstract	Inhibition of the mitochondrial metabolism offers a promising therapeutic approach for the treatment of cancer. Here, we identify the mycotoxin viriditoxin (VDT), derived from the endophytic fungus Cladosporium cladosporioides, as an interesting candidate for leukemia and lymphoma treatment. VDT displayed a high cytotoxic potential and rapid kinetics of caspase activation in Jurkat leukemia and Ramos lymphoma cells in contrast to solid tumor cells that were affected to a much lesser extent. Most remarkably, human hematopoietic stem and progenitor cells and peripheral blood mononuclear cells derived from healthy donors were profoundly resilient to VDT-induced cytotoxicity. Likewise, the colony-forming capacity was affected only at very high concentrations, which provides a therapeutic window for cancer treatment. Intriguingly, VDT could directly activate the mitochondrial apoptosis pathway in leukemia cells in the presence of antiapoptotic Bcl-2 proteins. The mitochondrial toxicity of VDT was further confirmed by inhibition of mitochondrial respiration, breakdown of the mitochondrial membrane potential (ΔΨm), the release of mitochondrial cytochrome c, generation of reactive oxygen species (ROS), processing of the dynamin-like GTPase OPA1 and subsequent fission of mitochondria. Thus, VDT-mediated targeting of mitochondrial oxidative phosphorylation (OXPHOS) might represent a promising therapeutic approach for the treatment of leukemia and lymphoma without affecting hematopoietic stem and progenitor cells.
MeSH term(s)	Humans ; Mycotoxins/metabolism ; Leukocytes, Mononuclear/metabolism ; Apoptosis ; Mitochondria/metabolism ; Reactive Oxygen Species/metabolism ; Leukemia/drug therapy ; Leukemia/metabolism ; Lymphoma/drug therapy ; Lymphoma/metabolism ; Membrane Potential, Mitochondrial
Chemical Substances	viriditoxin (35483-50-2) ; Mycotoxins ; Reactive Oxygen Species
Language	English
Publishing date	2022-11-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-022-05356-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.

Wu, Wenxian / Wang, Xiaojing / Sun, Yadong / Berleth, Niklas / Deitersen, Jana / Schlütermann, David / Stuhldreier, Fabian / Wallot-Hieke, Nora / José Mendiburo, María / Cox, Jan / Peter, Christoph / Bergmann, Ann Kathrin / Stork, Björn

Autophagy

2021 Volume 17, Issue 12, Page(s) 3992–4009

Abstract: Macroautophagy/autophagy and necroptosis represent two opposing cellular s tress responses. Whereas autophagy primarily fulfills a cyto-protective function, necroptosis is a form of regulated cell death induced via death receptors. Here, we aimed at ... ...

Abstract	Macroautophagy/autophagy and necroptosis represent two opposing cellular s tress responses. Whereas autophagy primarily fulfills a cyto-protective function, necroptosis is a form of regulated cell death induced via death receptors. Here, we aimed at investigating the molecular crosstalk between these two pathways. We observed that RIPK3 directly associates with AMPK and phosphorylates its catalytic subunit PRKAA1/2 at T183/T172. Activated AMPK then phosphorylates the autophagy-regulating proteins ULK1 and BECN1. However, the lysosomal degradation of autophagosomes is blocked by TNF-induced necroptosis. Specifically, we observed dysregulated SNARE complexes upon TNF treatment; e.g., reduced levels of full-length STX17. In summary, we identified RIPK3 as an AMPK-activating kinase and thus a direct link between autophagy- and necroptosis-regulating kinases.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Animals ; Autophagy/physiology ; Class III Phosphatidylinositol 3-Kinases/metabolism ; Fibroblasts/metabolism ; Mice ; Necroptosis ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism
Chemical Substances	Class III Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Ripk3 protein, mouse (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2021-03-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2021.1899667
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6741: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Novel meriolin derivatives as rapid apoptosis inducers.

Drießen, Daniel / Stuhldreier, Fabian / Frank, Annika / Stark, Holger / Wesselborg, Sebastian / Stork, Björn / Müller, Thomas J J

Bioorganic & medicinal chemistry

2019 Volume 27, Issue 15, Page(s) 3463–3468

Abstract: 3-(Hetero)aryl substituted 7-azaindoles possessing multikinase inhibitor activity are readily accessed in a one-pot Masuda borylation-Suzuki coupling sequence. Several promising derivatives were identified as apoptosis inducers and, emphasizing the ... ...

Abstract	3-(Hetero)aryl substituted 7-azaindoles possessing multikinase inhibitor activity are readily accessed in a one-pot Masuda borylation-Suzuki coupling sequence. Several promising derivatives were identified as apoptosis inducers and, emphasizing the multikinase inhibition potential, as sphingosine kinase 2 inhibitors. Our measurements provide additional insights into the structure-activity relationship of meriolin derivatives, suggesting derivatives bearing a pyridine moiety with amino groups in 2-position as most active anticancer compounds and thus as highly promising candidates for future in vivo studies.
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Jurkat Cells ; Molecular Structure ; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Structure-Activity Relationship
Chemical Substances	Antineoplastic Agents ; Bridged Bicyclo Compounds, Heterocyclic ; Protein Kinase Inhibitors ; Pyrimidines ; meriolin 3 ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase 2, human (EC 2.7.1.91)
Language	English
Publishing date	2019-06-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2019.06.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3815: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito