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  1. Article ; Online: Comment on 'Validation of the diagnosis of mesothelioma and BAP1 protein expression in a cohort of asbestos textile workers from Northern Italy'.

    Brentisci, C / Gangemi, M / Migliore, E / Mirabelli, D / Stura, A

    Annals of oncology : official journal of the European Society for Medical Oncology

    2018  Volume 29, Issue 12, Page(s) 2395–2396

    MeSH term(s) Asbestos ; Humans ; Italy ; Lung Neoplasms ; Mesothelioma ; Textiles ; Tumor Suppressor Proteins ; Ubiquitin Thiolesterase
    Chemical Substances BAP1 protein, human ; Tumor Suppressor Proteins ; Asbestos (1332-21-4) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2018-10-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdy463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pleural mesothelioma risk in the construction industry: a case-control study in Italy, 2000-2018.

    Stella, Simona / Consonni, Dario / Migliore, Enrica / Stura, Antonella / Cavone, Domenica / Vimercati, Luigi / Miligi, Lucia / Piro, Sara / Landi, Maria Teresa / Caporaso, Neil E / Curti, Stefania / Mattioli, Stefano / Brandi, Giovanni / Gioscia, Carmela / Eccher, Silvia / Murano, Stefano / Casotto, Veronica / Comiati, Vera / Negro, Corrado /
    D'Agostin, Flavia / Genova, Carlo / Benfatto, Lucia / Romanelli, Antonio / Grappasonni, Iolanda / Madeo, Gabriella / Cozzi, Ilaria / Romeo, Elisa / Tommaso, Staniscia / Carrozza, Francesco / Labianca, Michele / Tallarigo, Federico / Cascone, Giuseppe / Melis, Massimo / Marinaccio, Alessandro / Binazzi, Alessandra / Mensi, Carolina

    BMJ open

    2023  Volume 13, Issue 8, Page(s) e073480

    Abstract: Objectives: Workers in the construction industry have been exposed to asbestos in various occupations. In Italy, a National Mesothelioma Registry has been implemented more than 20 years ago. Using cases selected from this registry and exploiting ... ...

    Abstract Objectives: Workers in the construction industry have been exposed to asbestos in various occupations. In Italy, a National Mesothelioma Registry has been implemented more than 20 years ago. Using cases selected from this registry and exploiting existing control data sets, we estimated relative risks for pleural mesothelioma (PM) among construction workers.
    Design: Case-control study.
    Setting: Cases from the National Mesothelioma Registry (2000-2018), controls from three previous case-control studies.
    Methods: We selected male PM incident cases diagnosed in 2000-2018. Population controls were taken from three studies performed in six Italian regions within two periods (2002-2004 and 2012-2016). Age-adjusted and period-adjusted unconditional logistic regression models were fitted to estimate odds ratios (OR) for occupations in the construction industry. We followed two approaches, one (primary) excluding and the other (secondary) including subjects employed in other non-construction blue collar occupations for >5 years. For both approaches, we performed an overall analysis including all cases and, given the incomplete temporal and geographic overlap of cases and controls, three time or/and space restricted sensitivity analyses.
    Results: The whole data set included 15 592 cases and 2210 controls. With the primary approach (4797 cases and 1085 controls), OR was 3.64 (2181 cases) for subjects ever employed in construction. We found elevated risks for blue-collar occupations (1993 cases, OR 4.52), including bricklayers (988 cases, OR 7.05), general construction workers (320 cases, OR 4.66), plumbers and pipe fitters (305 cases, OR 9.13), painters (104 cases, OR 2.17) and several others. Sensitivity analyses yielded very similar findings. Using the secondary approach, we observed similar patterns, but ORs were remarkably lower.
    Conclusions: We found markedly increased PM risks for most occupations in the construction industry. These findings are relevant for compensation of subjects affected with mesothelioma in the construction industry.
    MeSH term(s) Humans ; Male ; Construction Industry ; Case-Control Studies ; Occupational Exposure/adverse effects ; Occupational Diseases/epidemiology ; Mesothelioma/epidemiology ; Mesothelioma/etiology ; Mesothelioma, Malignant ; Asbestos/adverse effects ; Pleural Neoplasms/epidemiology ; Pleural Neoplasms/etiology ; Logistic Models ; Italy/epidemiology
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073480
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  3. Article: Clinical and epidemiological characteristics associated with pneumonia at disease onset in patients admitted for COVID-19 to the Emergency Department of a large Hospital in Piedmont (North-Western Italy).

    Sacerdote, Carlotta / Castiglione, Anna / Pagano, Eva / Migliore, Enrica / Pivetta, Emanuele / Auzzas, Grazia Maria / Brenstisci, Carol / Brunetti, Francesco / Dafilé, Corina / Gangemi, Manuela / Giacometti, Lisa / Gilardetti, Marco / Martinis, Vitor Hugo / Saccona, Fabio / Stura, Antonella / Turco, Danila / Balestro, Cristina / Zozzoli, Susanna / Filandra, Umberto /
    Roggero, Stefano / Silvestre, Carlo / Scozzari, Gitana / Scaramozzino, Antonio / Ciccone, Giovannino

    Epidemiologia e prevenzione

    2021  Volume 44, Issue 5-6 Suppl 2, Page(s) 216–225

    Abstract: Objectives: to explore clinical and epidemiological characteristics associated with an imaging feature of COVID-19 pneumonia at disease onset, in order to identify factors that may be evaluable by general practitioners at patient's home, and which may ... ...

    Title translation Caratteristiche cliniche ed epidemiologiche associate alla polmonite all’esordio di pazienti con un accesso per COVID-19 al Pronto Soccorso di un grande ospedale del Piemonte.
    Abstract Objectives: to explore clinical and epidemiological characteristics associated with an imaging feature of COVID-19 pneumonia at disease onset, in order to identify factors that may be evaluable by general practitioners at patient's home, and which may lead to identify a more severe disease, needing hospitalization.
    Design: this is a retrospective/prospective observational hospital cohort.
    Setting and participants: the study population includes all patients consecutively admitted to the emergency department of Città della salute e della scienza University Hospital from 01.03 to 31.05.2020 with a confirmed diagnosis of SARS-CoV-2 infection.
    Main outcome measures: patients were classified in two groups according to the findings of X-ray imaging, lung ultrasound and chest computer tomography, as pneumonia or not pneumonia patients.
    Results: in multivariable analysis, factors most strongly associated with emergency department admission with pneumonia were age, oxygen saturation <90% (adj OR 4.16 ;95%CI 1.44-12.07), respiratory rate >24 breaths/min (adj OR 6.50; 95%CI 2.36-17.87), fever ≥38° (adj OR 3.05; 95%CI 1.53-6.08) and the presence of gastroenteric symptoms (vomiting and diarrhea). A delay (> 7 days) between the appearance of the initial lung symptoms (cough and dyspnea) and the admission to the emergency department was also related to a higher probability of receiving a positive imaging report (OR 4.99; 95%CI 2,02-12,34).
    Conclusions: in order to reorganize the management of COVID-19 patients in Italy, in view of the risk of a second wave of epidemic or of local outbreaks, it would be desirable to relocate the triage, and possibly the patient's care, from hospital to home. In this scenario it is important to identify all symptoms and signs associated with COVID-19 pneumonia that would facilitate the decision-making process of GPs leading to patients hospitalization.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/epidemiology ; Comorbidity ; Diarrhea/epidemiology ; Diarrhea/etiology ; Dyspnea/epidemiology ; Dyspnea/etiology ; Emergency Service, Hospital/statistics & numerical data ; Female ; Hospitals, University/statistics & numerical data ; Humans ; Italy/epidemiology ; Leukocyte Count ; Male ; Middle Aged ; Nervous System Diseases/epidemiology ; Nervous System Diseases/etiology ; Oxygen/blood ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Prospective Studies ; Respiratory Rate ; Retrospective Studies ; Symptom Assessment ; Time Factors ; Vomiting/epidemiology ; Vomiting/etiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-01-04
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
    DOI 10.19191/EP20.5-6.S2.121
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    Zs.A 2748: Show issues Location:
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  4. Article: Uso delle schede di dimissione ospedaliera per la stima dell'incidenza dei mesoteliomi maligni.

    Stura, Antonella / Gangemi, Manuela / Mirabelli, Dario

    Epidemiologia e prevenzione

    2007  Volume 31, Issue 2-3, Page(s) 127–131

    Abstract: Setting: cancer registries usually adopt strategies for active case finding. Interest in using administrative sources of data is rising: Objective: to assess the usefullness of Hospital discharge records (HDR) to supplement the traditional methods of ...

    Title translation Use of hospital discharge records to estimate the incidence of malignant mesotheliomas.
    Abstract Setting: cancer registries usually adopt strategies for active case finding. Interest in using administrative sources of data is rising
    Objective: to assess the usefullness of Hospital discharge records (HDR) to supplement the traditional methods of case finding of the malignant mesothelioma (MM) Registry of the Piedmont Region.
    Methods: HDRs have been used since 1996. We assessed the number of cases identified only through HDRs and their influence on MM incidence.
    Results: cases identified through HDRs were about 10% of those with histologic confirmation of the diagnosis, 34% of those with cytologic confirmation, and 72% of those without morphologic examination. Cases diagnosed in hospitals located outside the region would have been easily (50%) missed. The age-standardised (standard: Italian pop. at the 1981 census) incidence rate of pleural MM increases from 2.2 to 2.7 per 100,000 per year among men, and from 1.1 to 1.2 among women, when including all cases identified from HDRs, irrespective of their diagnostic confirmation. Peritoneal MM incidence estimates are unaffected. Overall without access to the hospital discharge files, 179 cases out of 954 would not have been registered between 1996 and 2001. In the same calendar period 59 cases identified by means of active search by the Registry have not been found in the hospital discharge files.
    Conclusions: HDRs are useful in addition, but not in substitution, to active search of MM cases.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Catchment Area (Health) ; Female ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Italy/epidemiology ; Male ; Medical Records ; Mesothelioma/epidemiology ; Middle Aged ; Patient Discharge/statistics & numerical data ; Prevalence
    Language Italian
    Publishing date 2007-03
    Publishing country Italy
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
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  5. Article: The fluoride cleavable 2-(cyanoethoxy)methyl (CEM) group as reversible 3'-O-terminator for DNA sequencing-by-synthesis - synthesis, incorporation, and cleavage.

    Földesi, A / Keller, A / Stura, A / Zigmantas, S / Kwiatkowski, M / Knapp, D / Engels, J W

    Nucleosides, nucleotides & nucleic acids

    2007  Volume 26, Issue 3, Page(s) 271–275

    Abstract: A new and promising sequencing technology called sequencing-by-synthesis (SBS) enables fast determination of DNA sequences. 2'-Deoxynucleotides containing the (2-cyanoethoxy)methyl (CEM) group at the 3'-O-position are potential reversible terminators for ...

    Abstract A new and promising sequencing technology called sequencing-by-synthesis (SBS) enables fast determination of DNA sequences. 2'-Deoxynucleotides containing the (2-cyanoethoxy)methyl (CEM) group at the 3'-O-position are potential reversible terminators for the SBS technology. Herein we describe the synthesis, the incorporation by several polymerases, and the cleavage of this 3'-O-blocking group using 3'-O-CEM-thymidinyl-5'-O-triphosphate 7 as an example.
    MeSH term(s) Alkylation ; Base Sequence ; Chemistry/methods ; Chromatography, High Pressure Liquid ; DNA/chemistry ; Fluorescent Dyes/pharmacology ; Models, Chemical ; Molecular Sequence Data ; Nucleotides/chemistry ; Phosphates/chemical synthesis ; Phosphates/chemistry ; Sequence Analysis, DNA/instrumentation ; Sequence Analysis, DNA/methods ; Templates, Genetic
    Chemical Substances Fluorescent Dyes ; Nucleotides ; Phosphates ; DNA (9007-49-2)
    Language English
    Publishing date 2007
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2008956-9
    ISSN 1525-7770
    ISSN 1525-7770
    DOI 10.1080/15257770701257301
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  6. Article: Incidenza del mesotelioma maligno in Piemonte, 1990-2001.

    Mirabelli, Dario / Stura, Antonella / Gangemi, Manuela / Bertolotti, Marinella / Maule, Milena Maria / Magnani, Corrado

    Epidemiologia e prevenzione

    2007  Volume 31, Issue 2-3, Page(s) 132–138

    Abstract: Setting: age-, period-, and cohort-models allowed the prediction ofan increase in mortality from malignant mesotheliomas (MM) in Western Europe, expected to peak between 2015 and 2025 in different Countries, and around 2020 in Italy. Recently, however, ... ...

    Title translation Incidence of malignant mesothelioma in Piedmont, 1990-2001.
    Abstract Setting: age-, period-, and cohort-models allowed the prediction ofan increase in mortality from malignant mesotheliomas (MM) in Western Europe, expected to peak between 2015 and 2025 in different Countries, and around 2020 in Italy. Recently, however, a deceleration in the increase has been reported.
    Objective: we updated to 31 december 2001 previous estimates ofMM incidence among residents in the Piedmont region (Italy) and assessed time-trends in incidence.
    Design: the Registry of Malignant Mesotheliomas actively searches cases in hospital wards and pathology units' records since 1990; since 1996 the database of hospital admissions and discharges is also used. Cases are registered when eligible for inclusion in the National Mesothelioma Registry.
    Results: the average yearly incidence of pleural MM, computed across four consecutive three-year calendar periods, from 1990-1992 to 1999-2001, increased in both sexes, for histologically confirmed as well as for all cases. No changes were observed in peritoneal MM incidence.
    Conclusions: the rise in incidence might be due to increased diagnostic awareness for MM. An analysis by birth-cohort, however, revealed a cohort-effect, therefore it is unlikely that diagnostic bias alone could explain the observed trend. Among men residing at diagnosis in the province of Turin, but not among women nor in both sexes outside Turin province, the increase in incidence has levelled off in the most recent calendar period; for them exposures stopped on average seven years earlier than those of residents in other areas of Piedmont.
    MeSH term(s) Adult ; Aged ; Catchment Area (Health) ; Female ; Humans ; Incidence ; Italy/epidemiology ; Male ; Mesothelioma/epidemiology ; Middle Aged ; Prevalence
    Language Italian
    Publishing date 2007-03
    Publishing country Italy
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
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  7. Article ; Online: STIM1 gates the store-operated calcium channel ORAI1 in vitro.

    Zhou, Yubin / Meraner, Paul / Kwon, Hyoung T / Machnes, Danya / Oh-hora, Masatsugu / Zimmer, Jochen / Huang, Yun / Stura, Antonio / Rao, Anjana / Hogan, Patrick G

    Nature structural & molecular biology

    2009  Volume 17, Issue 1, Page(s) 112–116

    Abstract: Store-operated Ca(2+) entry through the plasma membrane Ca(2+) release-activated Ca(2+) (CRAC) channel in mammalian T cells and mast cells depends on the sensor protein stromal interaction molecule 1 (STIM1) and the channel subunit ORAI1. To study STIM1- ... ...

    Abstract Store-operated Ca(2+) entry through the plasma membrane Ca(2+) release-activated Ca(2+) (CRAC) channel in mammalian T cells and mast cells depends on the sensor protein stromal interaction molecule 1 (STIM1) and the channel subunit ORAI1. To study STIM1-ORAI1 signaling in vitro, we have expressed human ORAI1 in a sec6-4 strain of the yeast Saccharomyces cerevisiae and isolated sealed membrane vesicles carrying ORAI1 from the Golgi compartment to the plasma membrane. We show by in vitro Ca(2+) flux assays that bacterially expressed recombinant STIM1 opens wild-type ORAI1 channels but not channels assembled from the ORAI1 pore mutant E106Q or the ORAI1 severe combined immunodeficiency (SCID) mutant R91W. These experiments show that the STIM1-ORAI1 interaction is sufficient to gate recombinant human ORAI1 channels in the absence of other proteins of the human ORAI1 channel complex, and they set the stage for further biochemical and biophysical dissection of ORAI1 channel gating.
    MeSH term(s) Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Chromatography, Gel ; Humans ; Ion Channel Gating/genetics ; Ion Channel Gating/physiology ; Membrane Proteins/metabolism ; Mutation/genetics ; Neoplasm Proteins/metabolism ; ORAI1 Protein ; Recombinant Proteins/metabolism ; Saccharomyces cerevisiae ; Secretory Vesicles/metabolism ; Stromal Interaction Molecule 1
    Chemical Substances Calcium Channels ; Membrane Proteins ; Neoplasm Proteins ; ORAI1 Protein ; ORAI1 protein, human ; Recombinant Proteins ; STIM1 protein, human ; Stromal Interaction Molecule 1 ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2009-12-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/nsmb.1724
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