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Article ; Online: An empirical study on the key success factors of ppp-based PCA in the big data environment -- a case study of China

Su Bowen / Hu Qiliang

E3S Web of Conferences, Vol 214, p

2020 Volume 01010

Abstract: Public-private partnerships (PPPS) are increasingly being used in the construction of public services such as infrastructure in China. In the process of PPP project implementation, there are successes and failures, and the key factors of success are not ... ...

Abstract	Public-private partnerships (PPPS) are increasingly being used in the construction of public services such as infrastructure in China. In the process of PPP project implementation, there are successes and failures, and the key factors of success are not completely clear. In order to identify the key factors for the success of PPP projects in the big data environment, PCA analysis is used to solve the problem of how to identify the key factors for the success of PPP projects in the big data environment. By studying the big data of PPP project and relevant literature at home and abroad, 32 potential key factors for success were constructed. The key success factors of PPP project were analyzed by questionnaire survey and principal component analysis. The results show that the 32 key factors for success can be summarized into five categories: political and economic environment, project development and operation management, government support and participation, government credit and commitment, strength of stakeholders, and factors of project bidding and procurement. Among the five factors, the key factors for the success of PPP projects are the continuous optimization of PPP policies, the rational project risk sharing mechanism, the guarantee and commitment of the government, the integrity and stability of government personnel, the satisfaction of public interests, and the complete financial analysis. This PCA method effectively solves the key factors for the success of PPP projects in the big data environment, ensures the smooth implementation of PPP projects, and promotes the long-term development of PPP projects.
Keywords	Environmental sciences ; GE1-350
Subject code	330 ; 690
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: A role of ROS-dependent defects in mitochondrial dynamic and autophagy in carbon black nanoparticle-mediated myocardial cell damage.

Xu, Zehua / Li, Jing / Su, Bowen / Gao, Hongying / Ren, Miaomiao / Lin, Yi / Shen, Heqing

Free radical biology & medicine

2024 Volume 220, Page(s) 249–261

Abstract: Carbon black nanoparticles (CBNPs) are widely distributed in the environment and are increasingly recognized as a contributor in the development of cardiovascular disease. A variety of cardiac injuries and diseases result from structural and functional ... ...

Abstract	Carbon black nanoparticles (CBNPs) are widely distributed in the environment and are increasingly recognized as a contributor in the development of cardiovascular disease. A variety of cardiac injuries and diseases result from structural and functional damage to cardiomyocytes. This study explored the mechanisms of CBNPs-mediated myocardial toxicity. CBNPs were given to mice through intra-tracheal instillation and it was demonstrated that the particles can be taken up into the cardiac tissue. Exposure to CBNPs induced cardiomyocyte inflammation and apoptosis. In combination with in vitro experiments, we showed that CBNPs increased the ROS and induced mitochondria fragmentation. Functionally, CBNPs-exposed cardiomyocyte exhibited depolarization of the mitochondrial membrane potential, release of cytochrome c, and activation of pro-apoptotic BAX, thereby initiating programmed cell death. On the other hand, CBNPs impaired autophagy, leading to the inadequate removal of dysfunctional mitochondria. The excess accumulation of damaged mitochondria further stimulated NF-κB activation and triggered the NLRP3 inflammasome pathway. Both the antioxidant N-acetylcysteine and the autophagy activator rapamycin were effective to attenuate the damage of CBNPs on cardiomyocytes. Taken together, this study elucidated the potential mechanism underlying CBNPs-induced myocardial injury and provided a scientific reference for the evaluation and prevention of the CBNPs-related heart risk.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2024.04.241
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Book ; Online: On the Robustness of Cross-Concentrated Sampling for Matrix Completion

Cai, HanQin / Huang, Longxiu / Kundu, Chandra / Su, Bowen

2024

Abstract: Matrix completion is one of the crucial tools in modern data science research. Recently, a novel sampling model for matrix completion coined cross-concentrated sampling (CCS) has caught much attention. However, the robustness of the CCS model against ... ...

Abstract	Matrix completion is one of the crucial tools in modern data science research. Recently, a novel sampling model for matrix completion coined cross-concentrated sampling (CCS) has caught much attention. However, the robustness of the CCS model against sparse outliers remains unclear in the existing studies. In this paper, we aim to answer this question by exploring a novel Robust CCS Completion problem. A highly efficient non-convex iterative algorithm, dubbed Robust CUR Completion (RCURC), is proposed. The empirical performance of the proposed algorithm, in terms of both efficiency and robustness, is verified in synthetic and real datasets. Comment: 58th Annual Conference of Information Sciences and Systems
Keywords	Statistics - Machine Learning ; Computer Science - Information Theory ; Computer Science - Machine Learning ; Mathematics - Optimization and Control
Publishing date	2024-01-27
Publishing country	us
Document type	Book ; Online
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Article ; Online: Research on Improving the Quality of Online Teaching Based on Big Data under the COVID-19 Coronavirus Epidemic

Su, Bowen / Hu, Qiliang

Journal of Physics: Conference Series

2020 Volume 1616, Page(s) 12018

Keywords	General Physics and Astronomy ; covid19
Publisher	IOP Publishing
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2166409-2
ISSN	1742-6596 ; 1742-6588
ISSN (online)	1742-6596
ISSN	1742-6588
DOI	10.1088/1742-6596/1616/1/012018
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Article ; Online: Preparation, characterization, and catalytic performance of Pd–Ni/AC bimetallic nano-catalysts

Zhang Yu / Liao Yalong / Shi Gongchu / Wang Wei / Su Bowen

Green Processing and Synthesis, Vol 9, Iss 1, Pp 760-

2020 Volume 769

Abstract: Palladium–nickel (Pd–Ni) bimetallic nano-catalysts supported on activated carbon (Pd–Ni/AC) have been successfully prepared by impregnation method enhanced with ultrasonic. The prepared Pd–Ni/AC catalysts were used for the catalytic hydrodechlorination ... ...

Abstract	Palladium–nickel (Pd–Ni) bimetallic nano-catalysts supported on activated carbon (Pd–Ni/AC) have been successfully prepared by impregnation method enhanced with ultrasonic. The prepared Pd–Ni/AC catalysts were used for the catalytic hydrodechlorination reaction of bleached shellac and characterized by Fourier-transform infrared spectroscopy, nitrogen adsorption, X-ray diffraction, X-ray photoelectron spectroscopy, field-emission scanning electron microscope, and high-resolution transmission electron microscopy. The results show that Pd–Ni bimetallic structures in catalytic particles with the diameter of 4 and 14 nm were distributed uniformly on AC support, and the lattice fringe spacing in catalytic particles was measured as 0.213 nm which is lying in the region between monometallic Pd (111; 0.225 nm) and Ni (111; 0.203 nm), and that Pd1–Ni1/AC catalyst exhibits the best catalytic hydrodechlorination performance with the dechlorination efficiency of 92.58 wt% while it is used for the hydrodechlorination of bleached shellac, and the optimum catalytic performance is related to the synergistic electronic effect and bimetallic structure of the Pd1–Ni1/AC sample.
Keywords	bimetallic catalysts ; ultrasonic-enhanced impregnation method ; bleached shellac ; hydrodechlorination ; synergetic electronic effect ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dementia risk in patients with type 2 diabetes: Comparing metformin with no pharmacological treatment.

Zheng, Bang / Su, Bowen / Ahmadi-Abhari, Sara / Kapogiannis, Dimitrios / Tzoulaki, Ioanna / Riboli, Elio / Middleton, Lefkos

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 19, Issue 12, Page(s) 5681–5689

Abstract: Introduction: Metformin has been suggested as a therapeutic agent for dementia, but the relevant evidence has been partial and inconsistent.: Methods: We established a national cohort of 210,237 type 2 diabetes patients in the UK Clinical Practice ... ...

Abstract	Introduction: Metformin has been suggested as a therapeutic agent for dementia, but the relevant evidence has been partial and inconsistent. Methods: We established a national cohort of 210,237 type 2 diabetes patients in the UK Clinical Practice Research Datalink. Risks of incident dementia were compared between metformin initiators and those who were not prescribed any anti-diabetes medication during follow-up. Results: Compared with metformin initiators (n = 114,628), patients who received no anti-diabetes medication (n = 95,609) had lower HbA1c and better cardiovascular health at baseline. Both Cox regression and propensity score weighting analysis showed metformin initiators had lower risk of dementia compared to those non-users (adjusted hazard ratio = 0.88 [95% confidence interval: 0.84-0.92] and 0.90 [0.84-0.96]). Patients on long-term metformin treatment had an even lower risk of dementia. Discussion: Metformin may act beyond its glycemic effect and reduce dementia risk to an even lower level than that of patients with milder diabetes and better health profiles. Highlights: Metformin initiators had a significantly lower risk of dementia compared with patients not receiving anti-diabetes medication. Compared with metformin initiators, diabetes patients not receiving pharmacological treatment had better glycemic profiles at baseline and during follow-up. Patients on long-term metformin treatment had an even lower risk of subsequent dementia incidence. Metformin may act beyond its effect on hyperglycemia and has the potential of being repurposed for dementia prevention.
MeSH term(s)	Humans ; Metformin/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Hypoglycemic Agents/therapeutic use ; Incidence ; Dementia/drug therapy ; Dementia/epidemiology ; Dementia/chemically induced ; Retrospective Studies
Chemical Substances	Metformin (9100L32L2N) ; Hypoglycemic Agents
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13349
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Article ; Online: Prevalence of and factors associated with burnout in midwifery: A scoping review.

Sidhu, Rawel / Su, Bowen / Shapiro, Kate R / Stoll, Kathrin

European journal of midwifery

2020 Volume 4, Page(s) 4

Abstract: Introduction: Midwifery care meets the triple aims of health system improvement, i.e. good health outcomes, high client satisfaction, and low per capita costs. Scaling up access to midwifery care is a global priority yet the growth and sustainability of ...

Abstract	Introduction: Midwifery care meets the triple aims of health system improvement, i.e. good health outcomes, high client satisfaction, and low per capita costs. Scaling up access to midwifery care is a global priority yet the growth and sustainability of the profession is threatened by high levels of burnout and attrition. This scoping review provides a comprehensive review of the existing literature on burnout in midwifery, with a focus on prevalence, associated factors and potential solutions. Methods: Four electronic databases were searched to locate relevant literature up to July 2019. A total of 1034 articles were identified and reduced to 27 articles that met inclusion criteria. We summarize sample sizes, settings, study designs, burnout measures, prevalence of burnout, associated factors and potential solutions, and recommendations. Results: Prevalence of burnout was highest among Australian, Western Canadian and Senegalese midwives and lowest among Dutch and Norwegian midwives. Midwives working in caseload/continuity models reported significantly lower burnout compared to midwives working in other models. We identified 26 organizational and personal factors that were significantly associated with burnout, such as high workload, exposure to traumatic events, and fewer years in practices. Organizational support to improve work-life balance and emotional well-being, as well as more continuing education to raise awareness about burnout and how to cope with it, emerged as common strategies to prevent and address burnout. Conclusions: Burnout is a serious and complex occupational phenomenon. More qualitative research is needed in this area, to better understand the lived experience of burnout.
Language	English
Publishing date	2020-02-11
Document type	Journal Article
ISSN	2585-2906
ISSN (online)	2585-2906
DOI	10.18332/ejm/115983
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Article ; Online: Glycemic Control, Diabetic Complications, and Risk of Dementia in Patients With Diabetes: Results From a Large U.K. Cohort Study.

Zheng, Bang / Su, Bowen / Price, Geraint / Tzoulaki, Ioanna / Ahmadi-Abhari, Sara / Middleton, Lefkos

Diabetes care

2021 Volume 44, Issue 7, Page(s) 1556–1563

Abstract: Objective: Type 2 diabetes is an established risk factor for dementia. However, the roles of glycemic control and diabetic complications in the development of dementia have been less well substantiated. This large-scale cohort study aims to examine ... ...

Abstract	Objective: Type 2 diabetes is an established risk factor for dementia. However, the roles of glycemic control and diabetic complications in the development of dementia have been less well substantiated. This large-scale cohort study aims to examine associations of longitudinal HbA Research design and methods: Data of eligible patients with diabetes, aged ≥50 years in the U.K. Clinical Practice Research Datalink from 1987 to 2018, were analyzed. Time-varying Cox regressions were used to estimate adjusted hazard ratios (HRs) and 95% CIs for dementia risk. Results: Among 457,902 patients with diabetes, 28,627 (6.3%) incident dementia cases were observed during a median of 6 years' follow-up. Patients with recorded hypoglycemic events or microvascular complications were at higher risk of dementia incidence compared with those without such complications (HR 1.30 [95% CI 1.22-1.39] and 1.10 [1.06-1.14], respectively). The HbA Conclusions: Higher or unstable HbA
MeSH term(s)	Aged ; Cohort Studies ; Dementia/epidemiology ; Dementia/etiology ; Diabetes Complications/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Glycemic Control ; Humans
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc20-2850
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Article ; Online: Associations between post-operative rehabilitation of hip fracture and outcomes: national database analysis (90 characters).

Su, Bowen / Newson, Roger / Soljak, Harry / Soljak, Michael

BMC musculoskeletal disorders

2018 Volume 19, Issue 1, Page(s) 211

Abstract: Background: Rehabilitation programmes are used to improve hip fracture outcomes. There is little published trial clinical trial or population-based data on the effects of the type or provider of rehabilitation treatments on hip fracture outcomes. We ... ...

Abstract	Background: Rehabilitation programmes are used to improve hip fracture outcomes. There is little published trial clinical trial or population-based data on the effects of the type or provider of rehabilitation treatments on hip fracture outcomes. We evaluated the associations of rehabilitation interventions with post-operative hip fracture outcomes. Methods: Cross-sectional (2013-2015) analysis of data from the English National Hip Fracture Database (NHFD) from all 191 English hospitals treating hip fractures. Of 62,844 NHFD patients, we included 17,708 patients with rehabilitation treatment and 30-day mobility data, and 34,142 patients with rehabilitation treatment and discharge destination data. The intervention was early mobilisation rehabilitation treatments delivered by a physiotherapist (PT, physical therapist in North America) or other clinical staff as identifiable in NHFD. We used ordinal logistic and propensity scoring regression models to adjust for confounding variables including age, sex, pre-fracture mobility, operative delay, and cognitive function and peri-operative risk scores. Results: In both the adjusted multivariate and propensity-weighted analyses, mobilisation on the day or the day following surgery is associated with better mobility function 30 days after discharge. However patients mobilised by a PT did not have better mobility compared to mobilisation by other professionals. Patients who received a PT assessment were not protected from poorer mobility 30 days after discharge, compared with those who did not receive an assessment. The discharge destination outcome is also better in mobilised than unmobilised patients, whether done by a PT or another health professional, and the difference persists, slightly attenuated, after propensity weighting. Conclusions: In addition to the type of health professional initiating mobilisation, data on rehabilitation treatment activity and post-operative gait speed is needed to determine optimum rehabilitation dosage and functional outcome. After adjustment patients mobilised by non-PTs did as well as patients mobilised by PTs, suggesting that PTs' current roles in very early rehabilitation should be reconsidered, with a view to redeploying them to more specialised later rehabilitation activity.
MeSH term(s)	Aged ; Aged, 80 and over ; Clinical Audit/methods ; Clinical Audit/trends ; Data Analysis ; Databases, Factual/trends ; Early Medical Intervention/methods ; Early Medical Intervention/trends ; Female ; Hip Fractures/diagnosis ; Hip Fractures/epidemiology ; Hip Fractures/rehabilitation ; Humans ; Male ; Middle Aged ; Postoperative Care/methods ; Postoperative Care/trends ; Treatment Outcome ; United Kingdom/epidemiology
Language	English
Publishing date	2018-07-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-018-2093-8
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Article ; Online: Correction to: Associations between post-operative rehabilitation of hip fracture and outcomes: national database analysis.

Su, Bowen / Newson, Roger / Soljak, Harry / Soljak, Michael

BMC musculoskeletal disorders

2018 Volume 19, Issue 1, Page(s) 340

Abstract: Following publication of the original article [1], the author reported an error in the Title. The original article has been corrected. ...

Abstract	Following publication of the original article [1], the author reported an error in the Title. The original article has been corrected.
Language	English
Publishing date	2018-09-19
Publishing country	England
Document type	Journal Article ; Published Erratum
ISSN	1471-2474
ISSN (online)	1471-2474
DOI	10.1186/s12891-018-2194-4
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