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Article ; Online: The transcatheter arterial chemoembolization combined with targeted nanoparticle delivering sorafenib system for the treatment of microvascular invasion of hepatocellular carcinoma.

Su, Dongna

2021 Volume 12, Issue 2, Page(s) 11124–11135

Abstract: to explore the value of transcatheter arterial chemoembolization (TACE) combined with targeted nanoparticle delivery system for sorafenib (SFB) to treat hepatocellular carcinoma (HCC) with microvascular invasion. 42 HCC patients with microvascular ... ...

Abstract	to explore the value of transcatheter arterial chemoembolization (TACE) combined with targeted nanoparticle delivery system for sorafenib (SFB) to treat hepatocellular carcinoma (HCC) with microvascular invasion. 42 HCC patients with microvascular invasion after liver cancer surgery were selected from our hospital from December 2020 and February 2021. Patients were divided into experimental group and control group based on their willingness. Patients in experimental group (18 cases) were treated with combination therapy of TACE and Ab-SFB-NP system; while patients in control group (24 cases) took TACE and non-nano drug delivery system. There was no obvious difference in liver function and blood test results between two groups of patients before treatment and one month after treatment (
MeSH term(s)	Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/blood supply ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/physiopathology ; Catheterization ; Chemoembolization, Therapeutic/adverse effects ; Female ; Humans ; Liver/pathology ; Liver/physiopathology ; Liver Neoplasms/blood ; Liver Neoplasms/blood supply ; Liver Neoplasms/drug therapy ; Liver Neoplasms/physiopathology ; Male ; Microvessels/pathology ; Middle Aged ; Nanoparticles/chemistry ; Neoplasm Invasiveness ; Sorafenib/adverse effects ; Sorafenib/therapeutic use
Chemical Substances	Sorafenib (9ZOQ3TZI87)
Language	English
Publishing date	2021-12-20
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2737830-5
ISSN	2165-5987 ; 2165-5979
ISSN (online)	2165-5987
ISSN	2165-5979
DOI	10.1080/21655979.2021.2001239
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Article ; Online: MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway.

Su, Dongna

Immunopharmacology and immunotoxicology

2021 Volume 44, Issue 1, Page(s) 17–27

Abstract: Objective: Aberrant DNA replication is regarded as a component of cancer development. Minichromosome maintenance protein 7 (MCM7), which is critical for the initiation of DNA replication, is overexpressed in multiple malignancies. The effect of MCM7 on ... ...

Abstract	Objective: Aberrant DNA replication is regarded as a component of cancer development. Minichromosome maintenance protein 7 (MCM7), which is critical for the initiation of DNA replication, is overexpressed in multiple malignancies. The effect of MCM7 on cell proliferation, apoptosis, and drug resistance of liver cancer and its mechanism were investigated in this study. Methods: MCM7 expression in normal liver cells, liver cancer cell lines, and tissues, as well as adjacent tissues, was determined by qRT-PCR. CCK-8 and flow cytometry was performed to detect cell viability, apoptosis, and cell cycle, respectively. The related mRNA and protein expressions were detected by qRT-PCR and western blot. Results: High expression of MCM7 was found in liver cancer tissues and cells, which results in notably lower survival time of patients. Cisplatin (DDP) could inhibit cell proliferation and affect MCM7 expression. Silencing of MCM7 inhibited cell viability, promoted cell apoptosis, arrested cell cycle at G1 phase, and enhanced the effect of DDP on cancer cells, while overexpression of MCM7 did the opposite. Moreover, silencing of MCM7 inhibited cyclinD1 and Ki-67 expressions. The overexpression of MCM7 increased phosphorylation levels of PI3K and AKT, activated the PI3K/AKT pathway, and weakened the inhibitory effect of DDP on the PI3K/AKT pathway. Conclusion: Silencing of MCM7 may inhibit cell proliferation and promote apoptosis by regulating the PI3K/AKT pathway to affect the cell cycle, thus affecting the development of liver cancer, and improving the sensitivity of liver cancer cells to DDP.
MeSH term(s)	Apoptosis ; Cell Line ; Cell Line, Tumor ; Cell Proliferation ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/drug therapy ; Minichromosome Maintenance Complex Component 7/genetics ; Minichromosome Maintenance Complex Component 7/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; MCM7 protein, human (EC 3.6.4.12) ; Minichromosome Maintenance Complex Component 7 (EC 3.6.4.12) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.1080/08923973.2021.1991372
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Article: [Advancements in corneal sensory reconstruction for the treatment of neurotrophic keratopathy].

Su, D / Zhang, J Y / Li, J

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2023 Volume 59, Issue 4, Page(s) 313–320

Abstract: Neurotrophic corneal disease is a degenerative eye condition that occurs due to damage to the trigeminal nerve. This condition presents as a persistent corneal epithelial defect, corneal ulceration, or even perforation, and the main cause is a loss of ... ...

Abstract	Neurotrophic corneal disease is a degenerative eye condition that occurs due to damage to the trigeminal nerve. This condition presents as a persistent corneal epithelial defect, corneal ulceration, or even perforation, and the main cause is a loss of corneal nerve function. While traditional treatments mainly focus on supportive measures to repair corneal damage, they cannot cure the condition completely. A new surgical treatment option called corneal sensory reconstruction surgery can rebuild the corneal nerve, slow down the progression of the corneal disease, promote corneal epithelial repair, and improve vision. This article reviews the surgical techniques used in corneal sensory reconstruction, including direct nerve repositioning and indirect nerve transplantation, and discusses their treatment outcomes and future prospects.
MeSH term(s)	Humans ; Epithelium, Corneal ; Keratitis ; Cornea ; Corneal Dystrophies, Hereditary ; Corneal Diseases/therapy ; Trigeminal Nerve Diseases/therapy
Language	Chinese
Publishing date	2023-04-03
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.cn112142-20220818-00410
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Zs.B 2482: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 267: Show issues

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Article: Comprehensive thermodynamic and exergoeconomic analyses and multi-objective optimization of a compressed air energy storage hybridized with a parabolic trough solar collectors

Su, Dawei

Energy. 2022 Apr. 01, v. 244

2022

Abstract: This paper designs a novel power plant consisting of a medium-temperature solar field based on parabolic trough solar collectors, an organic Rankine cycle, and a compressed air energy storage unit. The solar field supplies the energy required by the ... ...

Abstract	This paper designs a novel power plant consisting of a medium-temperature solar field based on parabolic trough solar collectors, an organic Rankine cycle, and a compressed air energy storage unit. The solar field supplies the energy required by the organic Rankine cycle at the charging period, providing the power for the compressors and high-temperature energy storage. Also, for the performance improvement of the system, zeotropic mixtures are employed as the working fluids in the Rankine cycle. The system was assessed from energy, exergy, and exergoeconomic viewpoints. A comprehensive parametric study was performed to examine the effects of some key parameters on the performance of the devised system. And, the MOPSO optimization algorithm is selected to optimize the calculations, wherein the TOPSIS decision-making method identifies the optimal solutions. According to the results, Isopentane/R142b mixture was selected as the efficient zeotropic working fluid of the Rankine cycle. Hence, the optimum energy efficiency and exergy efficiency were computed to be 5.08% and 5.04%, respectively. Besides, the optimum round trip efficiency and exergetic round trip efficiency were obtained by 57.06% and 66.20%, respectively. Moreover, considering electricity cost of 0.36 $.GJ⁻¹, the lowest payback period of 4.39 years, and the highest profitability were obtained.
Keywords	air ; algorithms ; decision making ; electricity costs ; energy efficiency ; exergy ; power plants ; profitability ; solar collectors
Language	English
Dates of publication	2022-0401
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2021.122568
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Up-regulation of MiR-145-5p promotes the growth and migration in LPS-treated HUVECs through inducing macrophage polarization to M2.

Su, Dongna

Journal of receptor and signal transduction research

2020 Volume 41, Issue 5, Page(s) 434–441

Abstract: MiR-145-5p is high-expressed in human vascular endothelial cells (HUVECs) and alternatively activated macrophages (M2). However, whether miR-145-5p can reduce HUVEC damage by regulating macrophage immunophenotype is less reported. THP-1 was stimulated by ...

Abstract	MiR-145-5p is high-expressed in human vascular endothelial cells (HUVECs) and alternatively activated macrophages (M2). However, whether miR-145-5p can reduce HUVEC damage by regulating macrophage immunophenotype is less reported. THP-1 was stimulated by Phorbolate-12-myristate-13-acetate, LPS and IFN-γ, and IL-4 to differentiate into macrophages (M0, M1 and M2). The expressions of macrophage markers were detected by Western blotting, and the expressions of miR-145-5p and kruppel-like factor-14 (KLF14) were detected by qRT-PCR. Dual-luciferase reporter assay was used to analyze the targeted relationship of miR-145-5p and KLF14. HUVEC injury was induced by LPS and then co-cultured with M1 transfected by miR-145-5p mimic. The effect of miR-145-3p on proliferation and metastasis of LPS-induced HUVECs was detected by MTT, clone formation, scratch assay and Transwell. We found that the expression of miR-145-5p was higher in M2 than that in M1. MiR-145-5p expression was down-regulated during M2-to-M1, but up-regulated during M1-to-M2. The expressions of IL-1β and iNOS were down-regulated, while the protein expressions of CCL17 and Arg-1 were up-regulated by miR-145-5p mimic in M0. The viability, proliferation, migration and invasion of HUVECs were promoted, however, LDH activity of the HUVECs was inhibited by mimics. In addition, KLF14 was predicted as the target gene for miR-145-5p in HUVECs. Collectively, our results demonstrate that miR-145-5p inhibited cell proliferation of LPS-treated HUVECs possibly through regulating macrophage polarization to M2.
MeSH term(s)	Apoptosis ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Endothelial Cells/cytology ; Endothelial Cells/pathology ; Endothelial Cells/physiology ; Gene Expression Regulation ; Humans ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Lipopolysaccharides/adverse effects ; Macrophage Activation ; MicroRNAs/genetics
Chemical Substances	KLF14 protein, human ; Kruppel-Like Transcription Factors ; Lipopolysaccharides ; MIRN145 microRNA, human ; MicroRNAs
Language	English
Publishing date	2020-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1230969-2
ISSN	1532-4281 ; 1079-9893
ISSN (online)	1532-4281
ISSN	1079-9893
DOI	10.1080/10799893.2020.1818095
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Zs.A 1643: Show issues

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Article: [Driver variations in tumor classical signaling pathways and treatment response of immune checkpoint inhibitors].

Jin, J Y / Su, D

Zhonghua bing li xue za zhi = Chinese journal of pathology

2021 Volume 50, Issue 7, Page(s) 840–844

MeSH term(s)	Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Neoplasms/drug therapy ; Signal Transduction
Chemical Substances	Immune Checkpoint Inhibitors
Language	Chinese
Publishing date	2021-08-17
Publishing country	China
Document type	Journal Article
ZDB-ID	784533-9
ISSN	0529-5807
ISSN	0529-5807
DOI	10.3760/cma.j.cn112151-20210120-00063
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Zs.B 2958: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 360: Show issues

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Article ; Online: Interaction effects between sleep disorders and depression on heart failure.

Fan, Tianshu / Su, Dechun

BMC cardiovascular disorders

2023 Volume 23, Issue 1, Page(s) 132

Abstract: Background: Sleep disorders and depression were recognized as independent risk factors for heart failure, whether their interaction effects also correlated with the risk of heart failure remains elusive. This study was to explore the interaction effects ...

Abstract	Background: Sleep disorders and depression were recognized as independent risk factors for heart failure, whether their interaction effects also correlated with the risk of heart failure remains elusive. This study was to explore the interaction effects between sleep disorders and depression on the risk of heart failure. Methods: This was a cross-sectional study that included data from 39,636 participants in the National Health and Nutritional Examination Survey (NHANES) database. Poisson regression model was applied to evaluate the associations of depression or sleep disorders with heart failure. The relative excess risk of interaction (RERI), attributable proportion of interaction (API) and synergy index (SI) were used to measure whether the interaction effects between depression and sleep disorders on heart failure was statistically significant. Results: The risk of heart failure was increased in people with sleep disorders [risk ratio (RR) = 1.92, 95% confidence interval (CI): 1.68-2.19) after adjusting for confounders including age, gender, body mass index (BMI), race, marital status, education level, annual family income, drinking history, smoking history, diabetes, hypertension and stroke. The risk of heart failure was elevated in patients with depression after adjusting for confounders (RR = 1.96, 95%CI: 1.65-2.33). Patients with depression and sleep disorders were associated with increased risk of heart failure after adjusting for confounders (RR = 2.76, 95%CI: 2.23-3.42). The CIs of interactive indexes RERI was -0.42 (95%CI: -1.23-0.39), and API was -0.15 (95%CI: -0.46-0.16), which included 0. The CI of interactive indexes SI was 0.81 (95%CI: 0.54-1.21), which contained 1. Conclusion: Depression and sleep disorders were independent risk factors for heart failure but the interaction effects between depression and sleep disorders on the occurrence of heart failure were not statistically different.
MeSH term(s)	Humans ; Nutrition Surveys ; Depression/diagnosis ; Depression/epidemiology ; Cross-Sectional Studies ; Risk Factors ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Sleep
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-023-03147-5
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Article ; Online: Screening key genes and biomarkers in gastrointestinal metaplasia that progress to gastric cancer by integrated bioinformatics analysis.

Pang, L / Yan, X / Su, D

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

2022 Volume 72, Issue 6

Abstract: This study aimed to screen the potential candidate genes and relevant biological markers associated with gastrointestinal metaplasia that progresses to gastric cancer (GIM-GC). Microarray datasets (GSE78523) were downloaded from the GEO database. ... ...

Abstract	This study aimed to screen the potential candidate genes and relevant biological markers associated with gastrointestinal metaplasia that progresses to gastric cancer (GIM-GC). Microarray datasets (GSE78523) were downloaded from the GEO database. Differentially expressed genes (DEGs) between GIM-GC samples and healthy controls were identified. GO and KEGG pathway enrichment analyses were performed. STRING and Cytoscape were used to identify significant module and hub genes. Survival analysis was applied to identify key genes. A Venn diagram was built to find hub DEGs that differed in all three relevant comparisons (GIM-GC vs. healthy controls vs. GIM-NoGC). The clinical characteristics of the hub DEGs were evaluated using the Cancer Genome Atlas dataset. The study found 257 DEGs (217 upregulated and 40 downregulated). The upregulated DEGs were enriched in regulation of microvillus length and phospholipid binding and were components of the apical plasma membrane. Downregulated DEGs were involved in digestion and hormone activity and were found in the extracellular space. Fat digestion and absorption as well as gastric acid secretion were the pathways enrichment. The most important gene modules related mainly to O-glycan processing, extracellular exosome, hormone activity, and vitamin and fat digestion and absorption. Eleven hub genes were identified, of which APOB, FABP1, CDX2, GCG, HNF4A, SLC26A3, CFTR, MUC5AC, OLFM4, and SI were related to the prognosis. Olfactomedin-4 (OLFM4) was the most relevant DEG to identify GIM-GC. In conclusion: DEGs and hub genes are helpful to understand the molecular mechanisms of GIM-GC. OLFM4 may be a biological marker for GIM-GC.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Computational Biology ; Early Detection of Cancer ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; Hormones ; Humans ; Metaplasia/genetics ; Stomach Neoplasms/genetics
Chemical Substances	Biomarkers, Tumor ; Hormones
Language	English
Publishing date	2022-04-24
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1125221-2
ISSN	1899-1505 ; 0867-5910 ; 0044-6033
ISSN (online)	1899-1505
ISSN	0867-5910 ; 0044-6033
DOI	10.26402/jpp.2021.6.09
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Zs.B 1358: Show issues

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Article ; Online: Poly-

Su, Diya / Niu, Huanyun / Wang, Shiwei / Wang, Jieqing

Aesthetic surgery journal. Open forum

2024 Volume 6, Page(s) ojae004

Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ISSN	2631-4797
ISSN (online)	2631-4797
DOI	10.1093/asjof/ojae004
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Article ; Online: Caroli's disease misdiagnosed as bile duct cystadenoma: A case report.

Su, Dai / Lan, Yuxia / Wang, Baibing / Ma, Qiang

Journal of clinical ultrasound : JCU

2024

Abstract: Caroli's disease is also known as Congenital intrahepatic bile duct dilatation, and previously known as a congenital intrahepatic bile duct cyst; it is characterized by single or multiple intrahepatic cystic dilatations. In this article, we report a case ...

Abstract	Caroli's disease is also known as Congenital intrahepatic bile duct dilatation, and previously known as a congenital intrahepatic bile duct cyst; it is characterized by single or multiple intrahepatic cystic dilatations. In this article, we report a case of Caroli's disease (CT size 21.2 × 16.9 × 19.8 cm). Preoperative abdominal ultrasound and enhanced CT were misdiagnosed as biliary cystadenoma or hepatic echinococcosis, and finally diagnosed as Caroli's disease by postoperative histopathological examinations. Most of the disease is single or multiple cystic dilatation of small bile duct. Giant Caroli disease, cystic dilations with diameter >20 cm is very rarely seen in the clinic. The lack of experience of diagnosing giant cystic dilatation makes it difficult to make accurate diagnosis. Therefore, we analyze the causes of imaging misdiagnosis through this case report, and summarize the imaging diagnostic skills of the disease combined with relevant imaging diagnosis experience. The purpose of this study is to deepen the understanding of giant Caroli disease among imaging doctors so as to reduce the misdiagnosis of the disease in the future.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23683
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