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  1. Book ; Thesis: The PNPLA3-I148M polymorphism exacerbates metabolic liver disease under a long-term high fat diet

    Su, Huan

    2023  

    Author's details vorgelegt von Huan Su
    Language English
    Size 71 Blätter, Illustrationen, Diagramme
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2023
    HBZ-ID HT030334813
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2024 D 54 order for loan Magazin

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  2. Book ; Online: Software in P2P way

    Su, Hong

    a software model without central software and enabling any software to join or leave freely

    2023  

    Abstract: The P2P model encompasses a network of equal peers, whether in hardware or software, operating autonomously without central control, allowing individual peer failure while ensuring high availability. Nevertheless, current P2P technologies primarily focus ...

    Abstract The P2P model encompasses a network of equal peers, whether in hardware or software, operating autonomously without central control, allowing individual peer failure while ensuring high availability. Nevertheless, current P2P technologies primarily focus on hardware-level resilience, often referred to as P2P networks, which do not safeguard against software failures. This paper introduces a pioneering Peer-to-Peer (P2P) software model aimed at enhancing software-level high availability. Diverging from prevalent hardware-centric P2P technologies, this model accentuates the decentralized nature of various software components, or "software peers," which function independently, enabling seamless network entry and exit without relying on central software. The model's collaborative approach cultivates a network topology with multiple autonomous processing paths, ensuring continuous operation through dynamic task allocation in a distributed manner. By surpassing the limitations of traditional redundancy methods, this P2P model provides an adaptive and scalable solution for achieving robust availability. Validation results underscore the model's effectiveness in enhancing the probabilities of successful task processing while ensuring high availability.
    Keywords Computer Science - Distributed ; Parallel ; and Cluster Computing ; Computer Science - Cryptography and Security
    Subject code 303
    Publishing date 2023-11-04
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: Quantifying Independence Redundancy in Systems

    Su, Hong

    Measurement, Factors, and Impact Analysis

    2023  

    Abstract: Redundancy represents a strategy for achieving high availability. However, various factors, known as singleness factors, necessitate corresponding redundancy measures. The absence of a systematic approach for identifying these singleness factors and the ... ...

    Abstract Redundancy represents a strategy for achieving high availability. However, various factors, known as singleness factors, necessitate corresponding redundancy measures. The absence of a systematic approach for identifying these singleness factors and the lack of a quantifiable method to assess system redundancy degrees are notable challenges. In this paper, we initially present methodologies to evaluate system redundancy, specifically quantifying independent redundancy in complex systems. This approach considers the interactions among various factors that influence redundancy, treating different factors as distinct dimensions to comprehensively account for all potential impact factors. Additionally, we propose methodologies to calculate the Independent Redundancy Degree (IRD) when combining or removing system components, offering insights into system resilience during integration or separation. Furthermore, we broaden the scope of known singleness factors by exploring time and space dimensions, aiming to identify additional related singleness factors. This process helps us pinpoint critical system aspects that necessitate redundancy for enhanced fault-tolerance and reliability. The verification results underscore the influence of different dimensions and reveal the significance of addressing weak dimensions for enhancing system reliability.
    Keywords Computer Science - Distributed ; Parallel ; and Cluster Computing ; Electrical Engineering and Systems Science - Systems and Control
    Subject code 006
    Publishing date 2023-10-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Thermo-photo catalytic anode process for carbonate-superstructured solid fuel cells.

    Su, Hanrui / Hu, Yun Hang

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 2, Page(s) e2314996121

    Abstract: Converting hydrocarbons and greenhouse gases (i.e., carbon dioxide, ... ...

    Abstract Converting hydrocarbons and greenhouse gases (i.e., carbon dioxide, CO
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2314996121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  5. Article ; Online: Exploration of the shared gene signatures and biological mechanisms between ischemia-reperfusion injury and antibody-mediated rejection in renal transplantation.

    Jiang, Shan / Su, Hua

    Transplant immunology

    2024  Volume 83, Page(s) 102001

    Abstract: Background: Antibody-mediated rejection (ABMR) plays a crucial role in graft loss during allogeneic renal transplantation. In renal transplantation, ischemia-reperfusion injury (IRI) is unavoidable, serves as a major contributor to acute rejection, and ... ...

    Abstract Background: Antibody-mediated rejection (ABMR) plays a crucial role in graft loss during allogeneic renal transplantation. In renal transplantation, ischemia-reperfusion injury (IRI) is unavoidable, serves as a major contributor to acute rejection, and is linked to graft loss. However, the mechanisms underlying IRI and ABMR are unclear. Therefore, this study aimed to investigate the shared genetic characteristics and biological mechanisms between IRI and ABMR.
    Methods: Gene expressions for IRI (GSE43974) and ABMR (GSE129166 and GSE36059) were retrieved from the Gene Expression Omnibus database. The shared differentially expressed genes (DEGs) of IRI and ABMR were identified, and subsequent functional enrichment analysis was performed. Immune cell infiltration in ABMR and its relationship with the shared DEGs were investigated using the CIBERSORT method. Random forest analysis, a protein-protein interaction network, and Cytoscape were used to screen hub genes, which were subsequently subjected to gene set enrichment analysis, miRNA prediction, and transcription factors analysis. The survival analysis was performed through Kaplan-Meier curves. Finally, drug compound prediction was performed on the shared DEGs using the Drug Signature Database.
    Results: Overall, 27 shared DEGs were identified between the renal IRI and ABMR groups. Among these, 24 genes exhibited increased co-expression, whereas none showed decreased co-expression. The shared DEGs were primarily enriched in the inflammation signaling pathways. Notably, CD4 memory T cells were identified as potential critical mediators of IRI, leading to ABMR. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), interferon regulatory factor 1 (IRF1), and early growth response 2 (EGR2) were identified as key components in the potential mechanism that link IRI and ABMR. Patients undergoing renal transplantation with higher expression levels of TNFAIP3, IRF1, and EGR2 exhibited decreased survival rates compared to those with lower expression levels.
    Conclusion: Inflammation is a key mechanism that links IRI and ABMR, with a potential role played by CD4 memory T cells. Furthermore, TNFAIP3, IRF1, and EGR2 are implicated in the underlying mechanism between IRI and ABMR.
    MeSH term(s) Humans ; Kidney Transplantation ; Kidney/pathology ; Antibodies/metabolism ; Reperfusion Injury/metabolism ; Inflammation/metabolism
    Chemical Substances Antibodies
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2024.102001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3784: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Gradient Functional Layer Anode for Carbonate-Superstructured Solid Fuel Cells with Ethane Fuel.

    Su, Hanrui / Hu, Yun Hang

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2311684

    Abstract: Carbonate-superstructured solid fuel cells (CSSFCs) are an emerging type of fuel cells with high flexibility of fuels. However, using ethane fuel for solid fuel cells is a great challenge due to serious degradation of their anodes. Herein, this critical ... ...

    Abstract Carbonate-superstructured solid fuel cells (CSSFCs) are an emerging type of fuel cells with high flexibility of fuels. However, using ethane fuel for solid fuel cells is a great challenge due to serious degradation of their anodes. Herein, this critical issue is solved by creating a novel gradient functional layer anode for CSSFCs. First, a finer-scale anode with a larger surface area is demonstrated to provide more active sites for the internal reforming reaction of ethane, achieving a 60% higher ethane conversion rate and 40% lower polarization resistance than conventional anodes. Second, incorporating a gradient functional layer into the anode results in an additional 50% enhancement in the peak power density of CSSFCs to a record high value (up to 241 mW cm
    Language English
    Publishing date 2024-03-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202311684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transmission-Constrained Consensus Over Random Graphs.

    Wang, Xiaotian / Su, Housheng

    IEEE transactions on cybernetics

    2024  Volume 54, Issue 5, Page(s) 3265–3274

    Abstract: The exchange of information is a crucial factor in achieving consensus among agents. However, in real-world scenarios, nonideal information sharing is prevalent due to complex environmental conditions. Consider the information distortions (data) and ... ...

    Abstract The exchange of information is a crucial factor in achieving consensus among agents. However, in real-world scenarios, nonideal information sharing is prevalent due to complex environmental conditions. Consider the information distortions (data) and stochastic information flow (media) during state transmission both caused by physical constraints, a novel model of transmission-constrained consensus over random networks is proposed in this work. The transmission constraints are represented by heterogeneous functions that reflect the impact of environmental interference in multiagent systems or social networks. A directed random graph is applied to model the stochastic information flow where every edge is connected probabilistically. Using stochastic stability theory and the martingale convergence theorem, it is demonstrated that the agent states will converge to a consensus value with probability 1, despite information distortions and randomness in information flow. Numerical simulations are presented to validate the effectiveness of the proposed model.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2023.3252800
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  8. Article ; Online: Factors related to parenting styles of Chinese mothers of children with and without intellectual disability.

    Su, H / Cuskelly, M / Gilmore, L

    Journal of intellectual disability research : JIDR

    2023  Volume 67, Issue 6, Page(s) 573–587

    Abstract: Background: Parenting styles play a crucial role in children's development. However, approaches to parenting children with intellectual disability (ID) beyond Western cultures have been underexamined. This study compared the self-reported parenting ... ...

    Abstract Background: Parenting styles play a crucial role in children's development. However, approaches to parenting children with intellectual disability (ID) beyond Western cultures have been underexamined. This study compared the self-reported parenting styles of Chinese mothers of children with and without ID and examined some factors that might be related.
    Methods: Chinese mothers of children with ID (n = 173) and mothers of typically developing children (n = 119) completed measures of their parenting style, parenting stress, parenting sense of competence and family support.
    Results: Both groups endorsed similar levels of authoritative parenting, but mothers of children with ID were more likely to report adopting strategies aligned with authoritarian parenting. For mothers in the ID group, family support moderated the effects of parenting stress and parenting sense of competence on authoritative parenting. Parenting stress and parenting sense of competence, respectively, predicted authoritarian parenting for mothers of children with and without ID.
    Conclusions: This study highlights the importance of reducing parenting stress, strengthening parenting sense of competence and providing family support in order to promote optimal parenting styles for Chinese mothers of children with ID.
    MeSH term(s) Child ; Female ; Humans ; Child Behavior ; East Asian People ; Intellectual Disability ; Mothers ; Parenting ; Disabled Children
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1103832-9
    ISSN 1365-2788 ; 0964-2633
    ISSN (online) 1365-2788
    ISSN 0964-2633
    DOI 10.1111/jir.13029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Convergence of dissolving and melting at the nanoscale.

    Chen, C / Wang, X / Binder, K / Pöschl, U / Su, H / Cheng, Y

    Faraday discussions

    2024  Volume 249, Page(s) 229–242

    Abstract: Phase transitions of water and its mixtures are of fundamental importance in physical chemistry, the pharmaceutical industry, materials sciences, and atmospheric sciences. However, current understanding remains elusive to explain relevant observations, ... ...

    Abstract Phase transitions of water and its mixtures are of fundamental importance in physical chemistry, the pharmaceutical industry, materials sciences, and atmospheric sciences. However, current understanding remains elusive to explain relevant observations, especially at the nanoscale. Here, by using molecular dynamics simulations, we investigate the dissolution of sodium chloride (NaCl) nanocrystals with volume-equivalent diameters from 0.51 to 1.75 nm. Our results show that the dissolution of NaCl in aqueous nanodroplets show a strong size dependence, and its solubility can be predicted by the Ostwald-Freundlich equation and Gibbs-Duhem equation after considering a size-dependent solid-liquid surface tension. We find that the structure of dissolved ions in the saturated aqueous nanodropplet resembles the structure of a molten NaCl nanoparticle. With decreasing nanodroplet size, this similarity grows and the average potential energy of NaCl in solution, the molten phase and the crystal phase converges.
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ISSN 1364-5498
    ISSN (online) 1364-5498
    DOI 10.1039/d3fd00095h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Chlorogenic acid alleviates acute kidney injury in septic mice by inhibiting NLRP3 inflammasomes and the caspase-1 canonical pyroptosis pathway].

    Fang, S / Sun, R / Su, H / Zhai, K / Xiang, Y / Gao, Y / Guo, W

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2024  Volume 44, Issue 2, Page(s) 317–323

    Abstract: Objective: To investigate the role of caspase-1-medicated canonical pyroptosis pathway in chlorogenic acid (CGA) treatment of acute kidney injury (AKI) in mice.: Method: Twenty-four C57Bl/6J mice were randomized into sham-operated group, cecal ... ...

    Abstract Objective: To investigate the role of caspase-1-medicated canonical pyroptosis pathway in chlorogenic acid (CGA) treatment of acute kidney injury (AKI) in mice.
    Method: Twenty-four C57Bl/6J mice were randomized into sham-operated group, cecal ligation and puncture (CLP) group, CLP+dexamethasone group (CLP+DXM group), and CLP+CGA group (
    Results: CGA treatment significantly improved the 7-day survival rate, reduced renal pathologies of the septic mice (
    Conclusion: CGA alleviates AKI in mice with CLP-induced sepsis by inhibiting NLRP3 inflammasomes and the caspase-1 signaling pathway.
    MeSH term(s) Mice ; Animals ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein ; Caspase 1/metabolism ; Pyroptosis ; Chlorogenic Acid/therapeutic use ; Acute Kidney Injury/metabolism ; Sepsis/drug therapy ; Sepsis/metabolism ; Dexamethasone/therapeutic use ; Mice, Inbred C57BL
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Caspase 1 (EC 3.4.22.36) ; Chlorogenic Acid (318ADP12RI) ; Dexamethasone (7S5I7G3JQL)
    Language Chinese
    Publishing date 2024-03-18
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2024.02.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6344: Show issues Location:
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