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  1. Article ; Online: Response to "Utility of electroencephalography in toxin-induced seizures".

    Gnirke, Marlis / Su, Mark K

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Letter
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4479: Show issues Location:
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  2. Article: Response to "Do Higher Doses of Naloxone Increase the Risk of Pulmonary Complications?"

    Pires, Kyle D / Su, Mark K

    The Journal of emergency medicine

    2023  Volume 64, Issue 4, Page(s) 513–514

    MeSH term(s) Humans ; Naloxone/adverse effects ; Narcotic Antagonists/adverse effects
    Chemical Substances Naloxone (36B82AMQ7N) ; Narcotic Antagonists
    Language English
    Publishing date 2023-03-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2023.02.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1895: Show issues Location:
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  3. Article: RESPONSE TO "ONDANSETRON SAFETY REGARDING PROLONG QTC FOR CHILDREN WITH HEAD TRAUMA".

    Rice, Justin K / Pires, Kyle D / Su, Mark K

    The Journal of emergency medicine

    2024  Volume 66, Issue 1, Page(s) e47–e48

    MeSH term(s) Child ; Humans ; Ondansetron ; Antiemetics/pharmacology ; Antiemetics/therapeutic use ; Long QT Syndrome ; Craniocerebral Trauma/complications
    Chemical Substances Ondansetron (4AF302ESOS) ; Antiemetics
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2023.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1895: Show issues Location:
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  4. Article ; Online: Biostatistics and Epidemiology for the Toxicologist: Rock the ROC Curve.

    Trebach, Joshua / Su, Mark K

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2022  Volume 18, Issue 2, Page(s) 163–167

    MeSH term(s) Area Under Curve ; Biostatistics ; Humans ; ROC Curve
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-022-00879-2
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    Zs.A 6682: Show issues Location:
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  5. Article ; Online: Biostatistics and Epidemiology for the Toxicologist: Measures of Central Tendency and Variability-Where Is the "Middle?" and What Is the "Spread?"

    Mohan, Sanjay / Su, Mark K

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2022  Volume 18, Issue 3, Page(s) 235–238

    MeSH term(s) Biostatistics ; Humans
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-022-00901-7
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    Zs.A 6682: Show issues Location:
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  6. Article ; Online: Massive intentional enoxaparin overdose managed with minimal protamine: A single case report.

    de Olano, Jonathan / Howland, Mary Ann / Su, Mark K

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2023  Volume 80, Issue 9, Page(s) e98–e103

    Abstract: Purpose: The case of a patient with a massive acute enoxaparin overdose managed with observation and minimal doses of protamine sulfate is reported.: Summary: Acute enoxaparin overdoses are uncommonly reported and management is widely variable. A 25- ... ...

    Abstract Purpose: The case of a patient with a massive acute enoxaparin overdose managed with observation and minimal doses of protamine sulfate is reported.
    Summary: Acute enoxaparin overdoses are uncommonly reported and management is widely variable. A 25-year-old man presented to the emergency department (ED) shortly after reporting that he had attempted suicide by injecting himself with 31 syringes of 80 mg of enoxaparin (a total of 2,480 mg) in the abdomen and other areas of his body. The patient also had self-inflicted superficial lacerations of the forearm. Due to concern over suspected compartment syndrome in the forearm, 25 mg of protamine was administered. Approximately 11 hours after reported enoxaparin self-injection, the patient's activated partial thromboplastin time (aPTT) was 206 seconds, prompting administration of an additional 50 mg of protamine. Three hours later, the aPTT had decreased to 79 seconds, then rose over several hours to 127 seconds before gradually declining to normal values. Protamine administration had no appreciable impact on anti-factor Xa activity. The patient did not require any blood products during the hospital admission. There were no further complications, and the patient was discharged to the inpatient psychiatry service on hospital day 8.
    Conclusion: The case highlights the role of protamine as a reversal agent in the management of low-molecular-weight heparin overdoses. The optimal dosing and efficacy of protamine for this indication needs further investigation.
    MeSH term(s) Male ; Humans ; Adult ; Enoxaparin ; Protamines ; Heparin, Low-Molecular-Weight ; Drug Overdose/drug therapy ; Partial Thromboplastin Time ; Anticoagulants/therapeutic use
    Chemical Substances Enoxaparin ; Protamines ; Heparin, Low-Molecular-Weight ; Anticoagulants
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxad037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 419: Show issues Location:
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  7. Article ; Online: Response to Comment on "Induction of Labor at Term for Severe Antenatal Lead Poisoning".

    Mohan, Sanjay / Koziatek, Christian / Su, Mark K

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2023  Volume 20, Issue 1, Page(s) 74

    MeSH term(s) Female ; Humans ; Pregnancy ; Labor, Induced ; Lead Poisoning
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Letter
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-023-00969-9
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  8. Article ; Online: Biostatistics and Epidemiology Principles for the Toxicologist: The "Testy" Test Characteristics Part II: Positive Predictive Value and Negative Predictive Value.

    Williams, Christy / Sahagún, Barbara Elena / Su, Mark K

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2023  Volume 19, Issue 3, Page(s) 298–302

    MeSH term(s) Humans ; Predictive Value of Tests ; Biostatistics
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-023-00953-3
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  9. Article ; Online: Comment on Treatment of carbon monoxide poisoning: high-flow nasal cannula versus non-rebreather face mask.

    Mahonski, Sarah / Su, Mark K

    Clinical toxicology (Philadelphia, Pa.)

    2021  Volume 59, Issue 8, Page(s) 768

    MeSH term(s) Cannula ; Carbon Monoxide Poisoning/therapy ; Carboxyhemoglobin ; Humans ; Masks ; Respiration, Artificial
    Chemical Substances Carboxyhemoglobin (9061-29-4)
    Language English
    Publishing date 2021-01-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2020.1862144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 419: Show issues Location:
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  10. Article ; Online: Challenges with glucagon-like peptide-1 (GLP-1) agonist initiation: a case series of semaglutide overdose administration errors.

    Wiener, Brian G / Gnirke, Marlis / Vassallo, Susi / Smith, Silas W / Su, Mark K

    Clinical toxicology (Philadelphia, Pa.)

    2024  Volume 62, Issue 2, Page(s) 131–133

    Abstract: Background: Prescriptions of semaglutide, a glucagon-like peptide-1 receptor agonist administered weekly for Type 2 diabetes mellitus and obesity, are increasing. Adverse effects from semaglutide overdose are poorly described. We report adverse effects ... ...

    Abstract Background: Prescriptions of semaglutide, a glucagon-like peptide-1 receptor agonist administered weekly for Type 2 diabetes mellitus and obesity, are increasing. Adverse effects from semaglutide overdose are poorly described. We report adverse effects from three unintentional semaglutide overdoses upon initiation.
    Case reports: Case 1
    Discussion: These unintentional semaglutide overdoses occurred due to deficits in patient and prescriber knowledge, and evasion of regulated access to pharmaceuticals. Nonspecific gastrointestinal symptoms predominated. The potential for hypoglycemia following glucagon-like peptide-1 agonist overdose is unclear, though it did not occur in our patients. It is thought that glucagon-like peptide-1 agonists are unlikely to cause hypoglycemia because their effects are glucose-dependent and diminish as serum glucose concentrations approach euglycemia. There is, however, an increase in hypoglycemia when glucagon-like peptide-1 agonists are combined with sulfonylureas.
    Conclusions: This case series highlights the critical role of patient education and training upon initiation of semaglutide therapy to minimize administration errors and adverse effects from injection of glucagon-like peptide-1 receptor agonists.
    MeSH term(s) Male ; Female ; Humans ; Middle Aged ; Adult ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/toxicity ; Glucagon-Like Peptide 1/therapeutic use ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/therapeutic use ; Hypoglycemia/chemically induced ; Hypoglycemia/drug therapy ; Glucose/therapeutic use ; Glucagon-Like Peptides
    Chemical Substances Hypoglycemic Agents ; semaglutide (53AXN4NNHX) ; Glucagon-Like Peptide 1 (89750-14-1) ; Glucagon-Like Peptide-1 Receptor ; Glucose (IY9XDZ35W2) ; Glucagon-Like Peptides (62340-29-8)
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2024.2322049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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