Article: Efficacy of metformin combined with vitamin D in the treatment of polycystic ovarian syndrome: A meta-analysis.
African journal of reproductive health
2024 Volume 28, Issue 2, Page(s) 43–54
Abstract: Polycystic ovary syndrome (PCOS), as an endocrine and metabolic disorder, affects approximately 6% -20% of women of childbearing age. This study aims to assess the therapeutic effects of Metformin combined with vitamin D in PCOS patients. Eight databases ...
Abstract | Polycystic ovary syndrome (PCOS), as an endocrine and metabolic disorder, affects approximately 6% -20% of women of childbearing age. This study aims to assess the therapeutic effects of Metformin combined with vitamin D in PCOS patients. Eight databases were searched to obtain randomized controlled trials, both domestically and internationally, on the effects of Metformin combined with vitamin D in patients with PCOS. Data analysis was performed using RevMan 5.3 software. Nine studies were ultimately included in this meta-analysis. Six studies reported the homeostatic model assessment for insulin resistance of the test group and the control group, which was significantly lower (SMD: -0.23; 95% Cl: -0.42,-0.04; P<0.05) than the control group, body mass index (BMI) (SMD: -1.86; 95% Cl: -2.77,-0.96; P<0.01), Serum 25 (OH) D (SMD: 14.28; 95% Cl: 12.26,16.29; P<0.01), testosterone (SMD: -0.11; 95% Cl: -0.15,-0.07; P<0.01) and regulated menstrual cycles (OR: 1.27; 95% Cl: 0.99,1.63; P=0.063). Our meta-analysis of nine trials demonstrates significant reductions in insulin resistance, BMI, and testosterone levels, along with increased serum vitamin D levels and improved menstrual cycle regulation after Metformin and vitamin D treatment. These findings suggest the potential of this combined therapy in managing the multifaceted aspects of PCOS. |
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MeSH term(s) | Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin Resistance/physiology ; Metformin/therapeutic use ; Polycystic Ovary Syndrome/drug therapy ; Testosterone/metabolism ; Vitamin D/therapeutic use |
Chemical Substances | Hypoglycemic Agents ; Metformin (9100L32L2N) ; Testosterone (3XMK78S47O) ; Vitamin D (1406-16-2) |
Language | English |
Publishing date | 2024-02-29 |
Publishing country | Nigeria |
Document type | Meta-Analysis ; Journal Article |
ZDB-ID | 2111906-5 |
ISSN | 1118-4841 |
ISSN | 1118-4841 |
DOI | 10.29063/ajrh2024/v28i2.4 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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