Article ; Online: Diverse SARS-CoV-2 variants preceded the initial COVID-19 outbreak in Croatia.
2021 Volume 166, Issue 6, Page(s) 1735–1739
Abstract: We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, ... ...
| Abstract | We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy. |
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| MeSH term(s) | COVID-19/epidemiology ; COVID-19/virology ; Coronavirus 3C Proteases/chemistry ; Croatia/epidemiology ; Genetic Variation ; Genome, Viral ; Humans ; Models, Molecular ; Phylogeny ; Protein Conformation ; SARS-CoV-2/genetics ; Whole Genome Sequencing |
| Chemical Substances | Coronavirus 3C Proteases (EC 3.4.22.28) |
| Language | English |
| Publishing date | 2021-03-24 |
| Publishing country | Austria |
| Document type | Journal Article |
| ZDB-ID | 7491-3 |
| ISSN | 1432-8798 ; 0304-8608 |
| ISSN (online) | 1432-8798 |
| ISSN | 0304-8608 |
| DOI | 10.1007/s00705-021-05029-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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