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  1. Article: Chronic spontaneous urticaria following ChAdOx1-S COVID-19 vaccination.

    Suan, Dan / Lee, Adrian Y S

    Allergo journal international

    2022  Volume 31, Issue 4, Page(s) 121–122

    Language English
    Publishing date 2022-03-07
    Publishing country Germany
    Document type Case Reports
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-022-00204-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of anti-NXP2 dermatomyositis following Comirnaty COVID-19 vaccination.

    Lee, Adrian Y S / Lee, Caroline / Brown, David A / Suan, Dan

    Postgraduate medical journal

    2023  Volume 99, Issue 1170, Page(s) 363–364

    MeSH term(s) Humans ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Dermatomyositis ; Vaccination
    Chemical Substances BNT162 Vaccine ; COVID-19 Vaccines ; MORC3 protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2022-141510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development of anti-NXP2 dermatomyositis following Comirnaty COVID-19 vaccination.

    Lee, Adrian Y S / Lee, Caroline / Brown, David A / Suan, Dan

    Postgraduate medical journal

    2022  

    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postmj/postgradmedj-2022-141510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences.

    Kelly, Shane / Jackson, Katherine Jl / Peters, Timothy J / Suan, Dan / Goodnow, Christopher C

    Journal of autoimmunity

    2023  Volume 142, Page(s) 103129

    Abstract: Background: PR3 autoantibodies are essential to the diagnosis and monitoring of granulomatosus with polyangiitis, but to date no PR3 autoantibody sequences have been published.: Objectives: To identify and characterise PR3-specific B cells from the ... ...

    Abstract Background: PR3 autoantibodies are essential to the diagnosis and monitoring of granulomatosus with polyangiitis, but to date no PR3 autoantibody sequences have been published.
    Objectives: To identify and characterise PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies.
    Methods: Peripheral blood mononuclear cells from seven patients with PR3 autoantibodies were stained with PR3. B cells that bound PR3 underwent single cell sorting, transcriptome sequencing, and their immunoglobulin sequences expressed as antibodies and tested for PR3-specificity by ELISA.
    Results: We identified 19 PR3-specific B cells from only one PR3-seropositive patient at a low frequency (0.0075 % of B cells) in the peripheral blood. These were polyclonal, IgG
    Conclusions: Identifying PR3-specific B cells in the peripheral blood is possible but challenging and those we did identify exhibited features suggesting that PR3-self reactivity may occur early in B-cell development.
    MeSH term(s) Humans ; Granulomatosis with Polyangiitis ; Myeloblastin ; Antibodies, Antineutrophil Cytoplasmic ; Leukocytes, Mononuclear/metabolism ; Autoantibodies
    Chemical Substances Myeloblastin (EC 3.4.21.76) ; Antibodies, Antineutrophil Cytoplasmic ; Autoantibodies
    Language English
    Publishing date 2023-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2023.103129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Granulomatous mastitis and immunosuppression: Case series at an Australian quaternary referral center.

    Liang, Ian / Berglund, Lucinda J / Brown, David A / Suan, Dan / Meybodi, Farid / Lee, Adrian Y S / Swaminathan, Sanjay

    International journal of rheumatic diseases

    2023  Volume 27, Issue 1, Page(s) e14884

    MeSH term(s) Female ; Humans ; Granulomatous Mastitis/diagnosis ; Granulomatous Mastitis/drug therapy ; Australia ; Immunosuppression Therapy ; Immune Tolerance
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Letter
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Transitioning single-cell genomics into the clinic.

    Lim, Jennifer / Chin, Venessa / Fairfax, Kirsten / Moutinho, Catia / Suan, Dan / Ji, Hanlee / Powell, Joseph E

    Nature reviews. Genetics

    2023  Volume 24, Issue 8, Page(s) 573–584

    Abstract: The use of genomics is firmly established in clinical practice, resulting in innovations across a wide range of disciplines such as genetic screening, rare disease diagnosis and molecularly guided therapy choice. This new field of genomic medicine has ... ...

    Abstract The use of genomics is firmly established in clinical practice, resulting in innovations across a wide range of disciplines such as genetic screening, rare disease diagnosis and molecularly guided therapy choice. This new field of genomic medicine has led to improvements in patient outcomes. However, most clinical applications of genomics rely on information generated from bulk approaches, which do not directly capture the genomic variation that underlies cellular heterogeneity. With the advent of single-cell technologies, research is rapidly uncovering how genomic data at cellular resolution can be used to understand disease pathology and mechanisms. Both DNA-based and RNA-based single-cell technologies have the potential to improve existing clinical applications and open new application spaces for genomics in clinical practice, with oncology, immunology and haematology poised for initial adoption. However, challenges in translating cellular genomics from research to a clinical setting must first be overcome.
    MeSH term(s) Humans ; Genomics/methods ; Genetic Testing ; Precision Medicine/methods
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/s41576-023-00613-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Coronary artery vasospasm in a patient with Churg-Strauss syndrome.

    Trivedi, Siddharth J / Tanous, David / Suan, Dan

    BMJ case reports

    2018  Volume 2018

    Abstract: Patients with Churg-Strauss syndrome often suffer from unusual cardiac manifestations and sudden cardiac death. This differs from patients with other autoimmune disorders, who typically present with premature ischaemic heart disease. We report the case ... ...

    Abstract Patients with Churg-Strauss syndrome often suffer from unusual cardiac manifestations and sudden cardiac death. This differs from patients with other autoimmune disorders, who typically present with premature ischaemic heart disease. We report the case of a 56-year-old man with recurrent coronary vasospasm, including an inferoposterior ST-elevation myocardial infarction, complicated by bradycardic arrest. There was only minor coronary artery disease on coronary angiography. An elevated eosinophil count was noted. His medical history included allergic rhinitis with polyposis, adult-onset asthma and biopsy-proven eosinophilic oesophagitis. Review of his sinus biopsies demonstrated blood vessels with marked accumulation of eosinophils in extravascular areas. The patient, therefore, met the American College of Rheumatology criteria for Churg-Strauss syndrome. The patient was commenced on immunosuppression, with the return of the eosinophil count to within normal limits, and remains free of cardiovascular events over 24 months.
    MeSH term(s) Chronic Disease ; Churg-Strauss Syndrome/complications ; Coronary Vasospasm/etiology ; Eosinophilia/complications ; Eosinophilia/drug therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Recurrence ; ST Elevation Myocardial Infarction/etiology ; Sinusitis/complications ; Sinusitis/diagnostic imaging ; Tomography, X-Ray Computed
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2018-10-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-225321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Isolated anti-Ro52 identifies a severe subset of Sjögren's syndrome patients.

    Lee, Adrian Y S / Putty, Trishni / Lin, Ming-Wei / Swaminathan, Sanjay / Suan, Dan / Chataway, Tim / Thurlings, Rogier M / Gordon, Tom P / Wang, Jing Jing / Reed, Joanne H

    Frontiers in immunology

    2023  Volume 14, Page(s) 1115548

    Abstract: Introduction: Serum autoantibodies targeting the SSA/Ro proteins are a key component of the classification criteria for the diagnosis of Sjögren's syndrome (SS). Most patients' serum reacts with both Ro60 and Ro52 proteins. Here we compare the molecular ...

    Abstract Introduction: Serum autoantibodies targeting the SSA/Ro proteins are a key component of the classification criteria for the diagnosis of Sjögren's syndrome (SS). Most patients' serum reacts with both Ro60 and Ro52 proteins. Here we compare the molecular and clinical characteristics of patients diagnosed with SS with anti-Ro52 in the presence or absence of anti-Ro60/La autoantibodies.
    Methods: A cross-sectional study was performed. Patients in the SS biobank at Westmead Hospital (Sydney, Australia) that were positive for anti-Ro52 were included and stratified based on the absence (isolated) or presence (combined) of anti-Ro60/La, measured by line immunoassay. We examined clinical associations and the serological and molecular characteristics of anti-Ro52 using ELISA and mass spectrometry in serological groups.
    Results: A total of 123 SS patients were included for study. SS patients with isolated anti-Ro52 (12%) identified a severe serological subset characterised by higher disease activity, vasculitis, pulmonary involvement, rheumatoid factor (RhF) and cryoglobulinaemia. Serum antibodies reacting with Ro52 in the isolated anti-Ro52 subset displayed less isotype switching, less immunoglobulin variable region subfamily usage and a lower degree of somatic hypermutation than the combined anti-Ro52 subset.
    Conclusions: In our cohort of SS patients, isolated anti-Ro52 represents a severe subset of SS, and is associated with the presence of cryoglobulinaemia. We therefore provide clinical relevance to the stratification of SS patients by their sero-reactivities. It is possible that the autoantibody patterns may be immunological epiphenomena of the underlying disease process, and further work is required to unearth the mechanisms of the differential clinical phenotypes.
    MeSH term(s) Humans ; Sjogren's Syndrome/diagnosis ; Cross-Sectional Studies ; Cryoglobulinemia ; Antibodies, Antinuclear ; Autoantibodies
    Chemical Substances Antibodies, Antinuclear ; Autoantibodies
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1115548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Plasma cell and memory B cell differentiation from the germinal center.

    Suan, Dan / Sundling, Christopher / Brink, Robert

    Current opinion in immunology

    2017  Volume 45, Page(s) 97–102

    Abstract: Germinal centers (GCs) form in secondary lymphoid tissues in response to antigenic challenge and are the site of somatic hypermutation, generating GC B cells with increasing affinity for the inciting agent that are positively selected over time. However, ...

    Abstract Germinal centers (GCs) form in secondary lymphoid tissues in response to antigenic challenge and are the site of somatic hypermutation, generating GC B cells with increasing affinity for the inciting agent that are positively selected over time. However, it is not until GC B cells differentiate into memory B cells and plasma cells and egress from the GC back into the circulation that effective long-lived humoral immunity is conferred upon the host. Here we review what is known about the signals that initiate the transition from a GC B cell into the memory B cell and plasma cell compartments and the downstream transcriptional regulation of these processes.
    Language English
    Publishing date 2017-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2017.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Iodide mumps.

    Chau, Anthony Minh Tien / Suan, Dan

    Clinical imaging

    2013  Volume 37, Issue 2, Page(s) 367–368

    Abstract: Iodide sialadenitis is a rare, delayed idiosyncratic reaction to iodine-containing contrast media. We present non-contrast computed tomography images of this benign but dramatic adverse reaction occurring in the submandibular glands. ...

    Abstract Iodide sialadenitis is a rare, delayed idiosyncratic reaction to iodine-containing contrast media. We present non-contrast computed tomography images of this benign but dramatic adverse reaction occurring in the submandibular glands.
    MeSH term(s) Aged ; Contrast Media/adverse effects ; Humans ; Iodides/adverse effects ; Male ; Sialadenitis/chemically induced ; Tomography, X-Ray Computed
    Chemical Substances Contrast Media ; Iodides
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1028123-x
    ISSN 1873-4499 ; 0899-7071
    ISSN (online) 1873-4499
    ISSN 0899-7071
    DOI 10.1016/j.clinimag.2012.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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