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  1. Book ; Online ; E-Book: Microbial engineering for therapeutics

    Suar, Mrutyunjay / Misra, Namrata / Dash, Chandravanu

    2022  

    Author's details Mrutyunjay Suar, Namrata Misra and Chandravanu Dash, editors
    Keywords Biomedical engineering ; Medical microbiology ; Microbial biotechnology ; Microbiologia mèdica ; Biotecnologia microbiana ; Enginyeria biomèdica
    Subject code 610.28
    Language English
    Size 1 online resource (377 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-19-3979-9 ; 9789811939785 ; 978-981-19-3979-2 ; 9811939780
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Biomedical imaging instrumentation

    Suar, Mrutyunjay / Misra, Namrata / Bhavesh, Neel Sarovar

    applications in tissue, cellular and molecular diagnostics

    2022  

    Author's details edited by Mrutyunjay Suar, Namrata Misra and Neel Sarovar Bhavesh
    MeSH term(s) Diagnostic Imaging. ; Diagnostic Imaging/instrumentation.
    Keywords Diagnostic imaging/Technique
    Language English
    Publisher Elsevier / Academic Press
    Publishing place London
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-85650-0 ; 978-0-323-85650-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Nanotechnological interventions in bacteriocin formulations - advances, and scope for challenging food spoilage bacteria and drug-resistant foodborne pathogens.

    Mohanty, Debapriya / Suar, Mrutyunjay / Panda, Sandeep Kumar

    Critical reviews in food science and nutrition

    2023  , Page(s) 1–18

    Abstract: Food spoilage bacteria (FSB) and multidrug-resistant (MDR) foodborne pathogens have emerged as one of the principal public health concerns in the twenty first century. The harmful effects of FSB lead to economic losses for the food industries. Similarly, ...

    Abstract Food spoilage bacteria (FSB) and multidrug-resistant (MDR) foodborne pathogens have emerged as one of the principal public health concerns in the twenty first century. The harmful effects of FSB lead to economic losses for the food industries. Similarly, MDR foodborne pathogens are accountable for multiple illnesses and pose a threat to consumers. Therefore, there is an urgent need to establish effective formulations for successful application against such microorganisms. In this context, the fusion of knowledge from biotechnology and nanotechnology can explore endless possibilities in the development of innovative formulations against FSB and foodborne pathogens. The current review critically examines the application of bacteriocins in the food industry and the use of nanomaterials to enhance the antimicrobial activity, stability, and precision in the target delivery of bacteriocins. This review also explores the technologies involved in the development of bacteriocin-based nanoformulations and their action against FSB and MDR foodborne pathogens, offering new possibilities in preservation technologies and addressing food safety issues in the food industry. The review highlights the challenges in the commercialization and technoeconomical feasibility of nanobacteriocin. Overall, it provides essential information and interpretation about nanotechnological advancements in bacteriocin formulation action against FSB and foodborne pathogens and future scopes.
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2023.2289184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1459: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Host-directed therapy against tuberculosis: Concept and recent developments.

    Udinia, Sonakshi / Suar, Mrutyunjay / Kumar, Dhiraj

    Journal of biosciences

    2023  Volume 48

    Abstract: Tuberculosis (TB) continues to remain at the forefront of the infectious disease burden globally, albeit with some aberrations during the COVID-19 pandemic. Among many factors, the emergence of drug resistance or antimicrobial resistance (AMR) has ... ...

    Abstract Tuberculosis (TB) continues to remain at the forefront of the infectious disease burden globally, albeit with some aberrations during the COVID-19 pandemic. Among many factors, the emergence of drug resistance or antimicrobial resistance (AMR) has necessitated a renewed focus on developing novel and repurposed drugs against TB. Host-directed therapy (HDT) has emerged as an attractive alternative and a complementary strategy to the conventional antibiotic-based therapy of tuberculosis since HDT enjoys the advantage of disarming the pathogen of its ability to develop drug resistance. Considering the imminent threat of AMR across the spectrum of bacterial pathogens, HDT promises to overcome the drug shortage against superbugs. While all these make HDT a very attractive strategy, identifying the right set of host targets to develop HDT remains a challenge, despite remarkable development in the field over the past decade. In this review, we examine the host mechanisms, that either inadvertently or through targeted perturbation by the pathogen, help TB pathogenesis, and we discuss the latest developments in the targeting of some of the key pathways to achieve newer TB therapeutics.
    MeSH term(s) Humans ; Antitubercular Agents/therapeutic use ; Mycobacterium tuberculosis/genetics ; Pandemics ; Tuberculosis/drug therapy ; Tuberculosis/genetics ; Tuberculosis/microbiology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2023-12-13
    Publishing country India
    Document type Review ; Journal Article
    ZDB-ID 756157-x
    ISSN 0973-7138 ; 0250-5991
    ISSN (online) 0973-7138
    ISSN 0250-5991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1907: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Glucose Starvation, Magnesium Ion Starvation, and Bile Stress Assays.

    Arunima, Aryashree / Suar, Mrutyunjay

    Bio-protocol

    2021  Volume 11, Issue 18, Page(s) e4157

    Abstract: Salmonella ... ...

    Abstract Salmonella enterica
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploiting AGPase genes and encoded proteins to prioritize development of optimum engineered strains in microalgae towards sustainable biofuel production.

    Sahoo, Susrita / Khuswaha, Gajraj Singh / Misra, Namrata / Suar, Mrutyunjay

    World journal of microbiology & biotechnology

    2023  Volume 39, Issue 8, Page(s) 209

    Abstract: Although ADP glucose pyrophosphorylase (AGPase), with two large subunits (ls) and two small subunits (ss), is a promising knockout target for increasing the neutral lipid content, the details regarding the sequence-structure features and their ... ...

    Abstract Although ADP glucose pyrophosphorylase (AGPase), with two large subunits (ls) and two small subunits (ss), is a promising knockout target for increasing the neutral lipid content, the details regarding the sequence-structure features and their distribution within metabolic system in microalgae is rather limited. Against this backdrop, a comprehensive genome-wide comparative analysis on 14 sequenced microalgal genomes was performed. For the first time the heterotetrameric structure of the enzyme and the interaction of the catalytic unit with the substrate was also studied. Novel findings of the present study includes: (i) at the DNA level, the genes controlling the ss are more conserved than those controlling the ls; the variation in both the gene groups is mainly due to exon number, exon length and exon phase distribution; (ii) at protein level, the ss genes are more conserved relative to those for ls; (III) three putative key consensus sequences 'LGGGAGTRLYPLTKNRAKPAV', 'WFQGTADAV' and 'ASMGIYVFRKD' were ubiquitously conserved in all the AGPases; (iv) molecular dynamics investigations revealed that the modeled AGPase heterotetrameric structure, from oleaginous algae Chlamydomonas reinharditii, was completely stable in real time environment; (v) The binding interfaces of catalytic unit, ssAGPase, from C. reinharditii with α-D-glucose 1-phosphate (αGP) was also analyzed. The results of the present study have provided system-based insights into the structure-function of the genes and encoded proteins, which provided clues for exploitation of variability in these genes that, could be further utilized to design site-specific mutagenic experiments for engineering of microalgal strains towards sustainable development of biofuel.
    MeSH term(s) Glucose-1-Phosphate Adenylyltransferase/chemistry ; Glucose-1-Phosphate Adenylyltransferase/genetics ; Glucose-1-Phosphate Adenylyltransferase/metabolism ; Amino Acid Sequence ; Biofuels ; Microalgae/genetics ; Microalgae/metabolism ; Base Sequence
    Chemical Substances Glucose-1-Phosphate Adenylyltransferase (EC 2.7.7.27) ; Biofuels
    Language English
    Publishing date 2023-05-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-023-03654-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Editorial: Green Perspective of Nano-Biotechnology: Nanotoxicity Horizon to Biomedical Applications.

    Verma, Suresh K / Suar, Mrutyunjay / Mishra, Yogendra Kumar

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 919226

    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.919226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Identification of potential flavonoid compounds as antibacterial therapeutics against Klebsiella pneumoniae infection using structure-based virtual screening and molecular dynamics simulation.

    Dey, Jyotirmayee / Mahapatra, Soumya Ranjan / Raj, T Kiran / Misra, Namrata / Suar, Mrutyunjay

    Molecular diversity

    2023  

    Abstract: Klebsiella pneumoniae, which is among the top three pathogens on WHO's priority list, is one of the gram-negative bacteria that doctors and researchers around the world have fought for decades. Capsular polysaccharide (CPS) protein is extensively ... ...

    Abstract Klebsiella pneumoniae, which is among the top three pathogens on WHO's priority list, is one of the gram-negative bacteria that doctors and researchers around the world have fought for decades. Capsular polysaccharide (CPS) protein is extensively recognized as an important K. pneumoniae virulence factor. Thus, CPS has become the most characterized target for the discovery of novel drug candidates. The ineffectiveness of currently existing antibiotics urges the search for potent antimicrobial compounds. Flavonoids are a group of plant metabolites that have antibacterial potential and can enhance the present medications to elicit improved results against diverse diseases without adverse reactions. Henceforth, the present study aims to illustrate the inhibitory potential of flavonoids with varying pharmacological properties, targeting the CPS protein of K. pneumoniae by in silico approaches. The flavonoid compounds (n = 169) were retrieved from the PubChem database and screened using the structure-based virtual screening approach. Compounds with the highest binding score were estimated through their pharmacokinetic effects by ADMET descriptors. Finally, four potential inhibitors with PubChem CID: (4301534, 5213, 5481948, and 637080) were selected after molecular docking and drug-likeness analysis. All four lead compounds were employed for the MDS analysis of a 100 ns time period. Various studies were undertaken to assess the stability of the protein-ligand complexes. The binding free energy was computed using MM-PBSA, and the outcomes indicated that the molecules are having stable interactions with the binding site of the target protein. The results revealed that all four compounds can be employed as potential therapeutics against K. pneumoniae.
    Language English
    Publishing date 2023-10-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-023-10738-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4946: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: Designing a Next-Generation Multiepitope-Based Vaccine against

    Mahapatra, Soumya Ranjan / Dey, Jyotirmayee / Raj, T Kiran / Misra, Namrata / Suar, Mrutyunjay

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Structural and Biochemical Studies on Klebsiella Pneumoniae Enoyl-ACP Reductase (FabI) Suggest Flexible Substrate Binding Site.

    Biswas, Soumya / Patra, Anupam / Paul, Prajita / Misra, Namrata / Kushwaha, Gajraj Singh / Suar, Mrutyunjay

    The protein journal

    2023  Volume 43, Issue 1, Page(s) 84–95

    Abstract: Klebsiella pneumoniae, a bacterial pathogen infamous for antibiotic resistance, is included in the priority list of pathogens by various public health organizations due to its extraordinary ability to develop multidrug resistance. Bacterial fatty acid ... ...

    Abstract Klebsiella pneumoniae, a bacterial pathogen infamous for antibiotic resistance, is included in the priority list of pathogens by various public health organizations due to its extraordinary ability to develop multidrug resistance. Bacterial fatty acid biosynthesis pathway-II (FAS-II) has been considered a therapeutic drug target for antibacterial drug discovery. Inhibition of FAS-II enzyme, enoyl-acyl carrier protein reductase, FabI, not only inhibits bacterial infections but also reverses antibiotic resistance. Here, we characterized Klebsiella pneumoniae FabI (KpFabI) using complementary experimental approaches including, biochemical, x-ray crystallography, and molecular dynamics simulation studies. Biophysical studies shows that KpFabI organizes as a tetramer molecular assembly in solution as well as in the crystal structure. Enzyme kinetics studies reveal a distinct catalytic property towards crotonyl CoA and reducing cofactor NADH. Michaelis-Menten constant (K
    MeSH term(s) Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/chemistry ; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/metabolism ; Klebsiella pneumoniae ; NAD/metabolism ; Binding Sites ; Anti-Bacterial Agents
    Chemical Substances Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) (EC 1.3.1.9) ; NAD (0U46U6E8UK) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2143071-8
    ISSN 1875-8355 ; 1572-3887
    ISSN (online) 1875-8355
    ISSN 1572-3887
    DOI 10.1007/s10930-023-10176-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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