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  1. Article ; Online: The future of immunotherapy in advanced renal cell carcinoma: beyond PD-1/PD-L1 inhibitors.

    Nuvola, Giacomo / Mollica, Veronica / Massari, Francesco / Suárez, Cristina

    Immunotherapy

    2023  Volume 15, Issue 17, Page(s) 1429–1433

    MeSH term(s) Humans ; Carcinoma, Renal Cell/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Programmed Cell Death 1 Receptor/therapeutic use ; Immunotherapy ; CTLA-4 Antigen ; Kidney Neoplasms/drug therapy ; B7-H1 Antigen
    Chemical Substances Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor ; CTLA-4 Antigen ; B7-H1 Antigen
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Selective HIF2A Inhibitors in the Management of Clear Cell Renal Cancer and Von Hippel-Lindau-Disease-Associated Tumors.

    Suárez, Cristina / Vieito, Maria / Valdivia, Augusto / González, Macarena / Carles, Joan

    Medical sciences (Basel, Switzerland)

    2023  Volume 11, Issue 3

    Abstract: Von Hippel-Lindau (VHL) loss is the hallmark event characterizing the clear cell renal cancer subtype (ccRCC). Carriers of germinal VHL mutations have an increased prevalence of kidney cysts and ccRCC as well as hemangioblastoma, pheochromocytoma and ... ...

    Abstract Von Hippel-Lindau (VHL) loss is the hallmark event characterizing the clear cell renal cancer subtype (ccRCC). Carriers of germinal VHL mutations have an increased prevalence of kidney cysts and ccRCC as well as hemangioblastoma, pheochromocytoma and pancreatic neuroendocrine tumors. In both sporadic and inherited ccRCC, the primary mechanism of VHL-mediated carcinogenesis is the abnormal stabilization of hypoxia-inducible factors (HIF1A and HIF2A). While HIF1A acts as a tumor suppressor and is frequently lost through inactivating mutations/14q chromosome deletions, HIF2A acts as an oncogene promoting the expression of its target genes (VEGF, PDGF, CAIX Oct4, among others). Selective HIF2a inhibitors block the heterodimerization between HIF2A and ARNT, stopping HIF2A-induced transcription. Several HIF2A inhibitors have entered clinical trials, where they have shown a favorable toxicity profile, characterized by anemia, fatigue and edema and promising activity in heavily pretreated ccRCC patients. Belzutifan, a second-generation HIF2a inhibitor, was the first to receive FDA approval for the treatment of unresectable ccRCC in VHL syndrome. In this review, we recapitulate the rationale for HIF2a blockade in ccRCC, summarize the development of HIF2a inhibitors from preclinical models up to its introduction to the clinic with emphasis on Belzutifan, and discuss their role in VHL disease management.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; von Hippel-Lindau Disease/complications ; von Hippel-Lindau Disease/drug therapy ; von Hippel-Lindau Disease/genetics ; Von Hippel-Lindau Tumor Suppressor Protein/genetics ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism
    Chemical Substances belzutifan (7K28NB895L) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; endothelial PAS domain-containing protein 1 (1B37H0967P)
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2754473-4
    ISSN 2076-3271 ; 2076-3271
    ISSN (online) 2076-3271
    ISSN 2076-3271
    DOI 10.3390/medsci11030046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Role of MreB, MreC and MreD in the Morphology of the Diazotrophic Filament of

    Velázquez-Suárez, Cristina / Luque, Ignacio / Herrero, Antonia

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 9

    Abstract: ... The ... ...

    Abstract The cyanobacterium
    Language English
    Publishing date 2022-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12091437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of rapid susceptibility testing on antimicrobial therapy and clinical outcomes in Gram-negative bloodstream infections.

    Anton-Vazquez, Vanesa / Suarez, Cristina / Planche, Timothy

    The Journal of antimicrobial chemotherapy

    2022  Volume 77, Issue 3, Page(s) 771–781

    Abstract: Background: Rapid antimicrobial susceptibility testing (rAST) has the potential to improve care of bloodstream infections.: Objectives: The aim of this service evaluation was to assess the impact of rAST on antimicrobial therapy and clinical outcomes ...

    Abstract Background: Rapid antimicrobial susceptibility testing (rAST) has the potential to improve care of bloodstream infections.
    Objectives: The aim of this service evaluation was to assess the impact of rAST on antimicrobial therapy and clinical outcomes in patients with Gram-negative bloodstream infection.
    Methods: A prospective service evaluation was conducted from March 2018 to December 2018. A rAST system (Alfred 60AST) was run Monday-Friday before midday and results were communicated to clinicians on the same day as positive blood culture, with subsequent conventional AST performed. Times to antibiotic therapy and clinical outcomes were compared between rAST and conventional AST.
    Results: One hundred and ninety-one patients with Gram-negative bacteraemia were included (93 in the rapid group and 98 in the conventional group). Aminoglycoside combination therapy was stopped earlier in the rapid group [32 h (0-795) versus 54 h (4-216), P = 0.002]. The median time to optimal antibiotic based on AST results was significantly shorter than that in the conventional group [50 h (10-339) versus 69.5 h (20-872), P = 0.034]. In the subgroup of patients on ineffective empirical antibiotic, time to effective antibiotic was shorter in the rapid group [39.5 h (32-97) versus 57 h (49-83), P = 0.036]. No differences were found in 28 day mortality or length of stay.
    Conclusions: Rapid susceptibility testing resulted in faster discontinuation of aminoglycosides and a shorter time to starting effective and optimal antibiotic when compared with conventional AST results. rAST has potential clinical benefits and points to the need for larger future studies in areas of high antibiotic resistance.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents ; Humans ; Microbial Sensitivity Tests ; Prospective Studies ; Sepsis/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  5. Article ; Online: The Role of Mre Factors and Cell Division in Peptidoglycan Growth in the Multicellular Cyanobacterium

    Velázquez-Suárez, Cristina / Valladares, Ana / Luque, Ignacio / Herrero, Antonia

    mBio

    2022  Volume 13, Issue 4, Page(s) e0116522

    Abstract: Bacteria in general serve two main tasks: cell growth and division. Both processes include peptidoglycan extension to allow cell expansion and to form the poles of the daughter cells, respectively. The ... ...

    Abstract Bacteria in general serve two main tasks: cell growth and division. Both processes include peptidoglycan extension to allow cell expansion and to form the poles of the daughter cells, respectively. The cyanobacterium
    MeSH term(s) Anabaena ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Division ; Cell Wall/metabolism ; Peptidoglycan/metabolism
    Chemical Substances Bacterial Proteins ; Peptidoglycan
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01165-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Tritordeum: Creating a New Crop Species-The Successful Use of Plant Genetic Resources.

    Ávila, Carmen M / Rodríguez-Suárez, Cristina / Atienza, Sergio G

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 5

    Abstract: Hexaploid tritordeum is the amphiploid derived from the cross between the wild ... ...

    Abstract Hexaploid tritordeum is the amphiploid derived from the cross between the wild barley
    Language English
    Publishing date 2021-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10051029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Lesson of the month: Late, disseminated herpes zoster reactivation in a stem cell transplant recipient: implications for post-transplant prophylaxis and immune monitoring.

    Edwards, Amy E / Suarez, Cristina / Lambourne, Jonathan

    Clinical medicine (London, England)

    2021  Volume 21, Issue 3, Page(s) e309–e312

    Abstract: Varicella zoster reactivation is a known risk following stem-cell transplantation, but has become more infrequent since universal antiviral prophylaxis. We report an unusual case of late, disseminated reactivation in a 27-year-old man with positive pre- ... ...

    Abstract Varicella zoster reactivation is a known risk following stem-cell transplantation, but has become more infrequent since universal antiviral prophylaxis. We report an unusual case of late, disseminated reactivation in a 27-year-old man with positive pre-transplant serology, and discuss implications for post-transplant prophylaxis and immune monitoring.
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Herpes Zoster/diagnosis ; Herpes Zoster/drug therapy ; Herpes Zoster/prevention & control ; Herpesvirus 3, Human ; Humans ; Male ; Monitoring, Immunologic
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-05-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2021-0064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Managing ulcerative colitis after surgery.

    Calvino-Suarez, Cristina / Ferreiro-Iglesias, Rocío / Baston Rey, Iria / Barreiro-de Acosta, Manuel

    Frontiers in medicine

    2023  Volume 9, Page(s) 1081940

    Abstract: Management of ulcerative colitis after surgery suggested by guidelines (total proctocolectomy with ileal-pouch anal anastomosis) is a big challenge for physicians because patients who believed that their disease had been cured started experiencing very ... ...

    Abstract Management of ulcerative colitis after surgery suggested by guidelines (total proctocolectomy with ileal-pouch anal anastomosis) is a big challenge for physicians because patients who believed that their disease had been cured started experiencing very uncomfortable symptoms repeatedly. A high number of patients develop episodes of pouchitis, which is a non-specific inflammation of the pouch whose etiology is unknown. Antibiotics are the elective treatment for acute pouchitis, but regarding chronic pouchitis, this condition is very complicated to treat due to the absence of well-designed specific studies for this group of patients. Antibiotics, budesonide, and biological therapies are some of the recommended drugs for these patients, but despite their use, some need a permanent ileostomy.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1081940
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  9. Article ; Online: Lutein esterification increases carotenoid retention in durum wheat grain. A step further in breeding and improving the commercial and nutritional quality during grain storage.

    Requena-Ramírez, María Dolores / Rodríguez-Suárez, Cristina / Hornero-Méndez, Dámaso / Atienza, Sergio G

    Food chemistry

    2023  Volume 435, Page(s) 137660

    Abstract: Carotenoid esterification is a common mechanism for carotenoid sequestration, accumulation and storage in plants. Carotenoids are responsible for the bright yellow colour of pasta. Therefore, carotenoid retention during storage is of great importance in ... ...

    Abstract Carotenoid esterification is a common mechanism for carotenoid sequestration, accumulation and storage in plants. Carotenoids are responsible for the bright yellow colour of pasta. Therefore, carotenoid retention during storage is of great importance in the durum wheat food chain. In this work, we investigated the role of carotenoid esterification on carotenoid retention in durum wheat using two consecutive storage experiments. Firstly, we compared two landraces and two durum wheat varieties as a preliminary work. We then compared individuals derived from the BGE047535×'Athoris' cross contrasting for esterification ability. Our results show that carotenoid esterification leads to a higher carotenoid retention during storage in durum wheat. Thus, the use of the carotenoid esterification would be useful as an extra strategy to ongoing efforts to improve carotenoid retention in the durum wheat food chain.
    MeSH term(s) Humans ; Lutein/analysis ; Triticum/metabolism ; Esterification ; Plant Breeding ; Carotenoids/analysis ; Edible Grain/chemistry ; Nutritive Value
    Chemical Substances Lutein (X72A60C9MT) ; Carotenoids (36-88-4)
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2023.137660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  10. Article ; Online: Arterial palmar arch occlusion in a woman with Raynaud's disease taking oral combined menopausal hormone therapy: A case report.

    Llaneza-Suarez, Cristina / Eiriz-Eirin, Montserrat / Llaneza, Placido

    Case reports in women's health

    2020  Volume 27, Page(s) e00206

    Abstract: Patients with surgical menopause often present to their primary care provider with menopausal symptoms. Here we present an unusual case of palmar arch artery occlusion in a 55-year-old woman with primary Raynaud's disease taking oral combined menopausal ... ...

    Abstract Patients with surgical menopause often present to their primary care provider with menopausal symptoms. Here we present an unusual case of palmar arch artery occlusion in a 55-year-old woman with primary Raynaud's disease taking oral combined menopausal hormone therapy after surgical menopause for endometriosis. She was successfully treated with intravenous infusion of prostaglandin E1 and nitroglycerin patches over two weeks. Menopausal hormone therapy was stopped and her vasomotor symptoms did not recur.
    Language English
    Publishing date 2020-04-21
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2800286-6
    ISSN 2214-9112 ; 2214-9112
    ISSN (online) 2214-9112
    ISSN 2214-9112
    DOI 10.1016/j.crwh.2020.e00206
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