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Article ; Online: Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients

Rahul Saxena / Baskar Chakrapani / M. P. Sarath Krishnan / Amit Gupta / Sweety Gupta / Jayanta Das / Subash C. Gupta / Anissa A. Mirza / Shalinee Rao / Bela Goyal

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has ...

Abstract	Abstract Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has improved our understanding of molecular pathways in cancer, sparking interest in microRNA-based gene regulation. The aim of the study is to identify dysregulated miRNAs in GBC and investigate their potential as therapeutic tools for effective and targeted treatment strategies. GBC and control tissue samples were sequenced for miRNA expression using the Illumina HiSeq platform. Biological processes and related pathways were determined using the Panther and Gene Ontology databases. 439 significantly differentially expressed miRNAs were identified; 19 of them were upregulated and 29 were downregulated. Key enriched biological processes included immune cell apoptosis, endoplasmic reticulum (ER) overload response, and negative regulation of the androgen receptor (AR) signaling pathway. Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. Kirsten rat sarcoma virus (KRAS), AR, and interferon gamma (IFN-γ) pathways were identified among the key pathways potentially amenable to targeted therapy. We concluded that a combination approach involving miRNA-based interventions could enhance therapeutic outcomes. Our research emphasizes the importance of precision medicine, targeting pathways using sense and anti-sense miRNAs as potential therapies in GBC.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Studies on solid waste generation and composition in the institutional area of Akhnoor Town, Distt. Jammu

Shalini Sharma / Subash C. Gupta

Environment Conservation Journal, Vol 14, Iss

2013 Volume 3

Abstract: The present paper deals with the analysis of solid waste generation and composition in the institutional area of Akhnoor town, within its municipal limits. For the purpose of studies, the institutional area was divided into four zones and from each zone, ...

Abstract	The present paper deals with the analysis of solid waste generation and composition in the institutional area of Akhnoor town, within its municipal limits. For the purpose of studies, the institutional area was divided into four zones and from each zone, different institutions (viz. schools, banks, colleges and government offices) were selected for the sampling and analysis of solid waste for a period of one year. Methods of disposal of Municipal Solid Waste (MSW) alongwith characterization and management of solid waste were studied to assess its impact on the environment and people inhabiting the area.
Keywords	Solid waste ; MSW ; environment ; disposal ; Environmental sciences ; GE1-350
Language	English
Publishing date	2013-12-01T00:00:00Z
Publisher	Action for Sustainable Efficacious Development and Awareness
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Studies on solid waste generation and composition in the Residential area of Akhnoor town, District Jammu

Shalini Sharma / Subash C. Gupta

Environment Conservation Journal, Vol 14, Iss 1&

2013 Volume 2

Abstract: The present paper deals with the analysis of solid waste generation and composition within the municipal limits of Akhnoor town which starts from the main bridge on the river Chenab and extends up to Sohal-Sungal turn. For purpose of studies, the ... ...

Abstract	The present paper deals with the analysis of solid waste generation and composition within the municipal limits of Akhnoor town which starts from the main bridge on the river Chenab and extends up to Sohal-Sungal turn. For purpose of studies, the residential area was divided into four zones and from each zone, five houses were selected at random for the sampling and analysis of solid waste for a period of one year. Characterization and management of solid waste alongwith methods of disposal of Municipal Solid Waste (MSW) were studied to analyze its impact on the environment and people inhabiting the area. Proper disposal methods have also been suggested so that the environment in general and the population inhabiting the area in particular is saved from the hazardous effects of fast increasing menace of the waste.
Keywords	Solid Waste ; MSW ; Disposal ; Hazardous ; Environmental sciences ; GE1-350
Language	English
Publishing date	2013-06-01T00:00:00Z
Publisher	Action for Sustainable Efficacious Development and Awareness
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Isodeoxyelephantopin, a Sesquiterpene Lactone Induces ROS Generation, Suppresses NF-κB Activation, Modulates LncRNA Expression and Exhibit Activities Against Breast Cancer

Sumit S. Verma / Vipin Rai / Nikee Awasthee / Anupam Dhasmana / Dhanya S Rajalaksmi / Mangalam S. Nair / Subash C. Gupta

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 16

Abstract: Abstract The sesquiterpene lactones, Isodeoxyelephantopin (IDET) and Deoxyelephantopin (DET) are known to exhibit activities against some cancer types. The activities of these lactones against breast cancer and the molecular bases is not known. We ... ...

Abstract	Abstract The sesquiterpene lactones, Isodeoxyelephantopin (IDET) and Deoxyelephantopin (DET) are known to exhibit activities against some cancer types. The activities of these lactones against breast cancer and the molecular bases is not known. We examined the efficacy of lactones in breast cancer preclinical model. Although both lactones exhibited drug like properties, IDET was relatively effective in comparison to DET. IDET suppressed the proliferation of both invasive and non-invasive breast cancer cell lines. IDET also suppressed the colony formation and migration of breast cancer cells. The assays for Acridine Orange (AO)/Propidium Iodide (PI) staining, cell cycle distribution, phosphatidylserine externalization and DNA laddering suggested the apoptosis inducing potential of IDET. The treatment with IDET also induced an accumulation of cells in the sub-G1 and G2/M phases. The exposure of breast cancer cells to the lactone was associated with a depolarization in mitochondrial membrane potential, and cleavage of caspase and PARP. The lactone induced reactive oxygen species (ROS) generation in breast cancer cells. Further, the use of N-acetyl cysteine (NAC) suppressed IDET induced ROS generation and apoptosis. The NF-κB-p65 nuclear translocation induced by okadaic acid (OA) was suppressed by the sesquiterpene. IDET also suppressed the expression of NF-κB regulated tumorigenic proteins, and induced the expression of proapoptotic gene (Bax) in cancer cells. While the expression of oncogenic lncRNAs was suppressed, the tumor suppressor lncRNAs were induced by the sesquiterpene. Collectively, the modulation of multiple cell signaling molecules by IDET may contribute to its activities in breast cancer cells.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Anti-cancer activities of Bharangin against breast cancer: Evidence for the role of NF-κB and lncRNAs

Awasthee, Nikee / K. Sajin Francis / Mangalam S. Nair / Subash C. Gupta / Sumit S. Verma / Vipin Rai

Biochimica et biophysica acta. 2018 Dec., v. 1862, no. 12

2018

Abstract: Breast cancer remains one of the leading causes of cancer related deaths in women worldwide. Bharangin is a diterpenoid quinonemethide that has demonstrated therapeutic potential against leukemia, lymphoma, and multiple myeloma cells. Whether this ... ...

Abstract	Breast cancer remains one of the leading causes of cancer related deaths in women worldwide. Bharangin is a diterpenoid quinonemethide that has demonstrated therapeutic potential against leukemia, lymphoma, and multiple myeloma cells. Whether this diterpenoid exhibit activities against breast cancer cells and the underlying mechanism is largely unknown. Herein, we provide evidence that bharangin suppresses the proliferation of MCF-7, MDA-MB-231, MDA-MB-453, MDA-MB-468 and T-47D breast cancer cells. As examined by AO/PI staining, DAPI staining, sub-G1 analysis, phosphatidylserine externalization, caspase activation, DNA laddering, and poly-ADP ribose polymerase cleavage, the diterpenoid induced apoptosis in breast cancer cells. The growth inhibitory effect of bharangin on breast cancer cells was further confirmed from colony-formation assay. Furthermore, the cancer cell migration was also suppressed by the diterpenoid. Mechanistically, bharangin was found to modulate multiple cancer related cell signalling pathways in breast cancer cells. Bharangin suppressed the expression of cell survival and invasive proteins, and induced Bax and mitochondrial depolarization in breast cancer cells. The diterpenoid also suppressed the activation of pro-inflammatory transcription factor, nuclear factor (NF)-κB induced by okadaic acid. Finally, the diterpenoid induced the expression of tumor suppressor lncRNAs (MEG-3, GAS-5), while down-regulating oncogenic H19 expression. Overall, these results suggest that bharangin exhibits anti-carcinogenic, anti-proliferative and anti-inflammatory activities against breast cancer cells. The modulation of lncRNA expression and inhibition of NF-κB activation by bharangin may contribute to its anti-carcinogenic activities.
Keywords	4',6-diamidino-2-phenylindole ; anticarcinogenic activity ; anti-inflammatory activity ; antineoplastic activity ; apoptosis ; breast neoplasms ; caspases ; cell movement ; cell viability ; diterpenoids ; DNA ; leukemia ; mitochondria ; myeloma ; NAD ADP-ribosyltransferase ; neoplasm cells ; okadaic acid ; phosphatidylserines ; signal transduction ; staining ; therapeutics ; transcription factor NF-kappa B ; women
Language	English
Dates of publication	2018-12
Size	p. 2738-2749.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	840755-1
ISSN	0304-4165
ISSN	0304-4165
DOI	10.1016/j.bbagen.2018.08.016
Database	NAL-Catalogue (AGRICOLA)

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Article: Dietary nutraceuticals as backbone for bone health

Pandey, Manoj K / Bharat B. Aggarwal / Deepkamal Karelia / Mehdi Shakibaei / Patrick J. Gilhooley / Subash C. Gupta

Biotechnology advances. 2018 Nov. 01, v. 36, no. 6

2018

Abstract: Bone loss or osteoporosis, is a slow-progressing disease that results from dysregulation of pro-inflammatory cytokines. The FDA has approved number of drugs for bone loss prevention, nonetheless all are expensive and have multiple side effects. The ... ...

Abstract	Bone loss or osteoporosis, is a slow-progressing disease that results from dysregulation of pro-inflammatory cytokines. The FDA has approved number of drugs for bone loss prevention, nonetheless all are expensive and have multiple side effects. The nutraceuticals identified from dietary agents such as butein, cardamonin, coronarin D curcumin, diosgenin, embelin, gambogic acid, genistein, plumbagin, quercetin, reseveratrol, zerumbone and more, can modulate cell signaling pathways and reverse/slow down osteoporosis. Most of these nutraceuticals are inexpensive; show no side effect while still possessing anti-inflammatory properties. This review provides various mechanisms of osteoporosis and how nutraceuticals can potentially prevent the bone loss.
Keywords	adverse effects ; anti-inflammatory activity ; bone health ; bone resorption ; curcumin ; cytokines ; diosgenin ; drugs ; functional foods ; genistein ; loss prevention ; osteoporosis ; plumbagin ; quercetin ; signal transduction
Language	English
Dates of publication	2018-1101
Size	p. 1633-1648.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	47165-3
ISSN	0734-9750
ISSN	0734-9750
DOI	10.1016/j.biotechadv.2018.03.014
Database	NAL-Catalogue (AGRICOLA)

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Article: Curcumin, a component of golden spice: From bedside to bench and back

Prasad, Sahdeo / Amit K. Tyagi / Bharat B. Aggarwal / Subash C. Gupta

Biotechnology Advances. 2014 Nov. 01, v. 32

2014

Abstract: Although the history of the golden spice turmeric (Curcuma longa) goes back thousands of years, it is only within the past century that we learned about the chemistry of its active component, curcumin. More than 6000 articles published within the past ... ...

Abstract	Although the history of the golden spice turmeric (Curcuma longa) goes back thousands of years, it is only within the past century that we learned about the chemistry of its active component, curcumin. More than 6000 articles published within the past two decades have discussed the molecular basis for the antioxidant, anti-inflammatory, antibacterial, antiviral, antifungal, and anticancer activities assigned to this nutraceutical. Over sixty five clinical trials conducted on this molecules, have shed light on the role of curcumin in various chronic conditions, including autoimmune, cardiovascular, neurological, and psychological diseases, as well as diabetes and cancer. The current review provides an overview of the history, chemistry, analogs, and mechanism of action of curcumin.
Keywords	antineoplastic activity ; antioxidants ; clinical trials ; Curcuma longa ; curcumin ; diabetes ; functional foods ; mechanism of action ; neoplasms ; turmeric
Language	English
Dates of publication	2014-1101
Size	p. 1053-1064.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	47165-3
ISSN	0734-9750
ISSN	0734-9750
DOI	10.1016/j.biotechadv.2014.04.004
Database	NAL-Catalogue (AGRICOLA)

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Article: Tocotrienols fight cancer by targeting multiple cell signaling pathways

Kannappan, Ramaswamy / Bharat B. Aggarwal / Ji Hye Kim / Subash C. Gupta

Genes & nutrition. 2012 Jan., v. 7, no. 1

2012

Abstract: Cancer cells are distinguished by several distinct characteristics, such as self-sufficiency in growth signal, resistance to growth inhibition, limitless replicative potential, evasion of apoptosis, sustained angiogenesis, and tissue invasion and ... ...

Abstract	Cancer cells are distinguished by several distinct characteristics, such as self-sufficiency in growth signal, resistance to growth inhibition, limitless replicative potential, evasion of apoptosis, sustained angiogenesis, and tissue invasion and metastasis. Tumor cells acquire these properties due to the dysregulation of multiple genes and associated cell signaling pathways, most of which are linked to inflammation. For that reason, rationally designed drugs that target a single gene product are unlikely to be of use in preventing or treating cancer. Moreover, targeted drugs can cause serious and even life-threatening side effects. Therefore, there is an urgent need for safe and effective promiscuous (multitargeted) drugs. âMother Natureâ produces numerous such compounds that regulate multiple cell signaling pathways, are cost effective, exhibit low toxicity, and are readily available. One among these is tocotrienol, a member of the vitamin E family, which has exhibited anticancer properties. This review summarizes data from in vitro and in vivo studies of the effects of tocotrienol on nuclear factor-ÎºB, signal transducer and activator of transcription (STAT) 3, death receptors, apoptosis, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), hypoxia-inducible factor (HIF) 1, growth factor receptor kinases, and angiogenic pathways.
Keywords	adverse effects ; angiogenesis ; antineoplastic activity ; apoptosis ; cost effectiveness ; death domain receptors ; drugs ; genes ; growth retardation ; in vivo studies ; inflammation ; metastasis ; neoplasm cells ; neoplasms ; phosphotransferases (kinases) ; signal transduction ; tocotrienols ; toxicity ; transactivators ; transcription factor NF-kappa B
Language	English
Dates of publication	2012-01
Size	p. 43-52.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2416599-2
ISSN	1865-3499 ; 1555-8932
ISSN (online)	1865-3499
ISSN	1555-8932
DOI	10.1007/s12263-011-0220-3
Database	NAL-Catalogue (AGRICOLA)

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Article: Epigenetic changes induced by curcumin and other natural compounds

Reuter, Simone / Ajay Goel / Bharat B. Aggarwal / Byoungduck Park / Subash C. Gupta

Genes & nutrition. 2011 May, v. 6, no. 2

2011

Abstract: Epigenetic regulation, which includes changes in DNA methylation, histone modifications, and alteration in microRNA (miRNA) expression without any change in the DNA sequence, constitutes an important mechanism by which dietary components can selectively ... ...

Abstract	Epigenetic regulation, which includes changes in DNA methylation, histone modifications, and alteration in microRNA (miRNA) expression without any change in the DNA sequence, constitutes an important mechanism by which dietary components can selectively activate or inactivate gene expression. Curcumin (diferuloylmethane), a component of the golden spice Curcuma longa, commonly known as turmeric, has recently been determined to induce epigenetic changes. This review summarizes current knowledge about the effect of curcumin on the regulation of histone deacetylases, histone acetyltransferases, DNA methyltransferase I, and miRNAs. How these changes lead to modulation of gene expression is also discussed. We also discuss other nutraceuticals which exhibit similar properties. The development of curcumin for clinical use as a regulator of epigenetic changes, however, needs further investigation to determine novel and effective chemopreventive strategies, either alone or in combination with other anticancer agents, for improving cancer treatment.
Keywords	acetyltransferases ; antineoplastic agents ; chemoprevention ; Curcuma longa ; curcumin ; DNA ; DNA methylation ; epigenetics ; functional foods ; gene expression ; gene expression regulation ; histone deacetylase ; histones ; methyltransferases ; microRNA ; neoplasms ; nucleotide sequences ; turmeric
Language	English
Dates of publication	2011-05
Size	p. 93-108.
Publishing place	Springer-Verlag
Document type	Article
Note	Review
ZDB-ID	2416599-2
ISSN	1865-3499 ; 1555-8932
ISSN (online)	1865-3499
ISSN	1555-8932
DOI	10.1007/s12263-011-0222-1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: RANKL signaling and osteoclastogenesis is negatively regulated by cardamonin.

Bokyung Sung / Sahdeo Prasad / Vivek R Yadav / Subash C Gupta / Simone Reuter / Norio Yamamoto / Akira Murakami / Bharat B Aggarwal

PLoS ONE, Vol 8, Iss 5, p e

2013 Volume 64118

Abstract: Bone loss/resorption or osteoporosis is a disease that is accelerated with aging and age-associated chronic diseases such as cancer. Bone loss has been linked with human multiple myeloma, breast cancer, and prostate cancer and is usually treated with ... ...

Abstract	Bone loss/resorption or osteoporosis is a disease that is accelerated with aging and age-associated chronic diseases such as cancer. Bone loss has been linked with human multiple myeloma, breast cancer, and prostate cancer and is usually treated with bisphosphonates, and recently approved denosumab, an antibody against receptor activator of NF-κB ligand (RANKL). Because of the numerous side effects of the currently available drugs, the search continues for safe and effective therapies for bone loss. RANKL, a member of the TNF superfamily, has emerged as a major mediator of bone loss via activation of osteoclastogenesis. We have identified cardamonin, a chalcone isolated from Alpinia katsumadai Hayata that can affect osteoclastogenesis through modulation of RANKL. We found that treatment of monocytes with cardamonin suppressed RANKL-induced NF-κB activation and this suppression correlated with inhibition of IκBα kinase and of phosphorylation and degradation of IκBα, an inhibitor of NF-κB. Furthermore, cardamonin also downregulated RANKL-induced phosphorylation of MAPK including ERK and p38 MAPK. Cardamonin suppressed the RANKL-induced differentiation of monocytes to osteoclasts in a dose-dependent and time-dependent manner. We also found that an inhibitor of NF-κB essential modulator (NEMO) blocked RANKL-induced osteoclastogenesis, indicating a direct link with NF-κB. Finally, osteoclastogenesis induced by human breast cancer cells or human multiple myeloma cells were completely suppressed by cardamonin. Collectively, our results indicate that cardamonin suppresses osteoclastogenesis induced by RANKL and tumor cells by suppressing activation of the NF-κB and MAPK pathway.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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