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  1. Article ; Online: Understanding the Retention of Vaping Additives in the Lungs: Model Lung Surfactant Membrane Perturbation by Vitamin E and Vitamin E Acetate.

    Taktikakis, Panagiota / Côté, Mathieu / Subramaniam, Nivetha / Kroeger, Kailen / Youssef, Hala / Badia, Antonella / DeWolf, Christine

    Langmuir : the ACS journal of surfaces and colloids

    2024  Volume 40, Issue 11, Page(s) 5651–5662

    Abstract: Deviations from the normal physicochemical and functional properties of pulmonary surfactants are associated with the incidence of lung injury and other respiratory disorders. This study aims to evaluate the alteration of the 2D molecular organization ... ...

    Abstract Deviations from the normal physicochemical and functional properties of pulmonary surfactants are associated with the incidence of lung injury and other respiratory disorders. This study aims to evaluate the alteration of the 2D molecular organization and morphology of pulmonary surfactant model membranes by the electronic cigarette additives α-tocopherol (vitamin E) and α-tocopherol acetate (vitamin E acetate), which have been associated with lung injury, termed e-cigarette or vaping-use-associated lung injury (EVALI). The model membranes used contained a 7:3 molar ratio of DPPC (1,2-dipalmitoyl-
    MeSH term(s) Humans ; alpha-Tocopherol/chemistry ; Vitamin E ; Pulmonary Surfactants/chemistry ; Electronic Nicotine Delivery Systems ; Lung Injury ; Vaping ; Microscopy, Atomic Force ; Lung ; Surface-Active Agents ; Acetates
    Chemical Substances alpha-Tocopherol (H4N855PNZ1) ; Vitamin E (1406-18-4) ; Pulmonary Surfactants ; Surface-Active Agents ; Acetates
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c02952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: E-cigarette exposure causes early pro-atherogenic changes in an inducible murine model of atherosclerosis.

    Alakhtar, Bayan / Guilbert, Cynthia / Subramaniam, Nivetha / Caruana, Vincenza / Makhani, Kiran / Baglole, Carolyn J / Mann, Koren K

    Frontiers in toxicology

    2023  Volume 5, Page(s) 1244596

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2023.1244596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In vitro and in vivo approaches to assess atherosclerosis following exposure to low-dose mixtures of arsenic and cadmium.

    Subramaniam, Nivetha K / Gagnon, Natascha / Makhani, Kiran / Kukolj, Nikola / Mouradian, Michael H / Giles, Braeden H / Srikannan, Harinee / Fruh, Victoria / Meliker, Jaymie / Wellenius, Gregory A / Mann, Koren K

    Toxicology and applied pharmacology

    2023  Volume 481, Page(s) 116763

    Abstract: Worldwide, millions of people are co-exposed to arsenic and cadmium. Environmental exposure to both metals is linked with a higher risk of atherosclerosis. While studies have characterized the pro-atherosclerotic effects of arsenic and cadmium as single ... ...

    Abstract Worldwide, millions of people are co-exposed to arsenic and cadmium. Environmental exposure to both metals is linked with a higher risk of atherosclerosis. While studies have characterized the pro-atherosclerotic effects of arsenic and cadmium as single agents, little is known about the potential effects of metal mixtures, particularly at low doses. Here, we used a combination of in vitro and in vivo models to assess the effects of low-dose metals individually and as mixtures on early events and plaque development associated with atherosclerosis. In vitro, we investigated early pro-atherogenic changes in macrophages and endothelial cells with metal treatments. The combined cytotoxic effects of both metals at low concentrations were dose interactive, specifically, synergistic in macrophages, but antagonistic in endothelial cells. Despite this differential behavior across cell types, the mixtures did not initiate early pro-atherogenic events: neither reactive oxygen species generation in macrophages nor adhesion molecule expression on endothelial cells. In vivo, we utilized the well-characterized hyperlipidemic apolipoprotein E knock-out (ApoE
    MeSH term(s) Male ; Female ; Humans ; Animals ; Mice ; Arsenic/toxicity ; Cadmium/toxicity ; Endothelial Cells/metabolism ; Atherosclerosis/metabolism ; Plaque, Atherosclerotic/chemically induced ; Metals ; Apolipoproteins E/genetics
    Chemical Substances Arsenic (N712M78A8G) ; Cadmium (00BH33GNGH) ; Metals ; Apolipoproteins E
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2023.116763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: STAT6 mutations enriched at diffuse large B-cell lymphoma relapse reshape the tumor microenvironment.

    Benoit, Alexandre / Abraham, Madelyn J / Li, Sheena / Kim, John / Estrada-Tejedor, Roger / Bakadlag, Rowa / Subramaniam, Nivetha / Makhani, Kiran / Guilbert, Cynthia / Tu, Raymond / Salaciak, Matthew / Klein, Kathleen Oros / Coyle, Krysta Mila / Hilton, Laura K / Santiago, Raoul / Dmitrienko, Svetlana / Assouline, Sarit / Morin, Ryan D / Del Rincon, Sonia V /
    Johnson, Nathalie A / Mann, Koren K

    International journal of hematology

    2024  Volume 119, Issue 3, Page(s) 275–290

    Abstract: Diffuse large B-cell lymphoma (DLBCL) relapses in approximately 40% of patients following frontline therapy. We reported that ... ...

    Abstract Diffuse large B-cell lymphoma (DLBCL) relapses in approximately 40% of patients following frontline therapy. We reported that STAT6
    MeSH term(s) Humans ; Tumor Microenvironment/genetics ; Interleukin-4/genetics ; Interleukin-4/metabolism ; Interleukin-4/pharmacology ; Neoplasm Recurrence, Local ; Lymphoma, Large B-Cell, Diffuse/pathology ; Mutation ; STAT6 Transcription Factor/genetics ; STAT6 Transcription Factor/metabolism
    Chemical Substances Interleukin-4 (207137-56-2) ; STAT6 protein, human ; STAT6 Transcription Factor
    Language English
    Publishing date 2024-01-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-023-03692-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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