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  1. Article: Facilities and services of postexposure prophylaxis in anti-rabies clinics: A national assessment in India.

    Sudarshan, Mysore Kalappa / Haradanhalli, Ravish Shankaraiah

    Indian journal of public health

    2019  Volume 63, Issue Supplement, Page(s) S26–S30

    Abstract: Background: The rabies postexposure prophylaxis (PEP) is provided through anti-rabies clinics in the country. It was considered important to assess their facilities under a nationwide multi-centric survey.: Objectives: The objective of this study is ... ...

    Abstract Background: The rabies postexposure prophylaxis (PEP) is provided through anti-rabies clinics in the country. It was considered important to assess their facilities under a nationwide multi-centric survey.
    Objectives: The objective of this study is to assess the facilities available for PEP at the anti-rabies clinics and to ascertain the PEP provided at the anti-rabies clinics.
    Methods: The cross-sectional assessment was made from May 2017 to January 2018 in selected seven states of India. Thirty-five anti-rabies clinics from both Government and private; urban and rural areas from the states were assessed by an expert team using a pretested checklist for facilities and services available for PEP.
    Results: On an average, 10 new animal bite cases were attended at each anti-rabies clinic per day. The cold chain facilities for rabies biologicals were satisfactory. The facilities for wound washing (54.3%) and the use of antiseptics to animal bite wounds were not adequate. Rabies vaccines were administered by intramuscular in 54.3% and by intradermal route in 45.7% of the cases. The vaccine stock-outs were reported only in the government sector (18.5%). The type of rabies immunoglobulin (RIG) used was equine (63.2%) and human (36.8%); given free of cost in 40% of Anti rabies clinics. The local wound infiltration of RIG was in practice at 58.6% of anti-rabies clinics. The stock-out of RIG was more in private (50%) hospitals than in Government (40.7%) hospitals.
    Conclusion: The facilities available for PEP at the anti-rabies clinics were inadequate and have to be improved across the country.
    MeSH term(s) Ambulatory Care Facilities/organization & administration ; Ambulatory Care Facilities/standards ; Bites and Stings/epidemiology ; Drug Administration Routes ; Health Behavior ; Health Knowledge, Attitudes, Practice ; Humans ; India/epidemiology ; Patient Acceptance of Health Care/statistics & numerical data ; Post-Exposure Prophylaxis/statistics & numerical data ; Rabies/epidemiology ; Rabies/prevention & control ; Rabies Vaccines/administration & dosage ; Rabies Vaccines/supply & distribution ; Residence Characteristics
    Chemical Substances Rabies Vaccines
    Language English
    Publishing date 2019-08-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.IJPH_367_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Background paper for developing a policy for the use of rabies biologicals and vaccination of humans in India.

    Sudarshan, Mysore Kalappa / Ashwath Narayana, Doddabele Hanumanthaiah

    Indian journal of public health

    2019  Volume 63, Issue Supplement, Page(s) S51–S53

    Abstract: National Rabies Control Programme, India, is in operation since 2012-2013 without much impact due to poor funding and no set policy for the rabies prevention and control. An effort was made to develop a draft policy paper which can help the Government of ...

    Abstract National Rabies Control Programme, India, is in operation since 2012-2013 without much impact due to poor funding and no set policy for the rabies prevention and control. An effort was made to develop a draft policy paper which can help the Government of India to develop a national rabies vaccination policy for humans and for achieving the goal of zero dog-mediated human rabies deaths by the year 2030. A technical stakeholders meeting was held under the chairmanship of the Drug Controller General of India at New Delhi in December 2017 to discuss the problems and solutions for providing essential rabies postexposure prophylaxis (PEP). The following problems and dilemmas were identified: frequent shortages of life-saving rabies vaccines and rabies immunoglobulin for PEP; as rabies vaccines are mostly procured by the state governments that often face resource crunch and hurdles in logistics within the states; production levels of rabies biologicals in the public sector are low; and the export of rabies biologicals from the private sector needs to be critically evaluated in the context of frequent stock-outs in the domestic market and also the national vaccine security.
    MeSH term(s) Animals ; Bacterial Proteins ; Bites and Stings/epidemiology ; Dogs/virology ; Health Policy ; Humans ; Immunoglobulins/administration & dosage ; Immunoglobulins/therapeutic use ; India ; Membrane Transport Proteins ; Post-Exposure Prophylaxis/statistics & numerical data ; Post-Exposure Prophylaxis/supply & distribution ; Rabies/epidemiology ; Rabies/prevention & control ; Rabies Vaccines/administration & dosage ; Rabies Vaccines/supply & distribution
    Chemical Substances Bacterial Proteins ; Immunoglobulins ; Membrane Transport Proteins ; PbuX protein, Bacillus subtilis ; Rabies Vaccines
    Language English
    Publishing date 2019-10-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.IJPH_378_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Providing evidence for effective prevention and control of rabies in India.

    Sudarshan, Mysore Kalappa / Ashwath Narayana, Doddabele Hanumanthaiah

    Indian journal of public health

    2019  Volume 63, Issue Suppl 1, Page(s) S1

    MeSH term(s) Health Surveys ; Humans ; India/epidemiology ; Rabies/epidemiology ; Rabies/prevention & control
    Language English
    Publishing date 2019-10-11
    Publishing country India
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.IJPH_410_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Appraisal of surveillance of human rabies and animal bites in seven states of India.

    Sudarshan, Mysore Kalappa / Ashwath Narayana, Doddabele Hanumanthaiah

    Indian journal of public health

    2019  Volume 63, Issue Supplement, Page(s) S3–S8

    Abstract: Background: The key to understanding the burden of animal bites and rabies lies in accurate and timely data with the help of proper surveillance system across the country. Such a surveillance system needs to be evaluated also for a programmatic purpose.! ...

    Abstract Background: The key to understanding the burden of animal bites and rabies lies in accurate and timely data with the help of proper surveillance system across the country. Such a surveillance system needs to be evaluated also for a programmatic purpose.
    Objectives: The present study was conducted to appraise the surveillance system of human rabies and animal bites in seven states of India and also to describe the characteristics of human rabies cases in the states.
    Methods: The record-based study was conducted from July to December 2017. The survey team collected information about the surveillance status of human rabies from the infectious diseases hospitals and animal bites from integrated disease surveillance programme (IDSP) offices of the respective states for 2012-2016. At the national level, also number of animal exposures and the human rabies cases were collected from the Central Bureau of Health Intelligence and IDSP and compared for concordance.
    Results: There was a gross underreporting of human rabies from the states to Government of India, and there was no concordance in the reports of animal bites between the IDSP offices of the states and NCDC, New Delhi, India. There was a gradual decline in the reported cases of human rabies from the states during the 5-year period of 2012-2016, attributable to improvement in the overall rabies postexposure prophylaxis services. The documentation of information of the human rabies cases was poor in the infectious disease hospitals.
    Conclusion: The surveillance system on human rabies and animal bites in India has to be improved under the national rabies control program to eliminate rabies by the year 2030.
    MeSH term(s) Adolescent ; Adult ; Bites and Stings/epidemiology ; Child ; Documentation/standards ; Documentation/statistics & numerical data ; Female ; Hospitals/standards ; Hospitals/statistics & numerical data ; Humans ; India/epidemiology ; Male ; Public Health Surveillance/methods ; Rabies/epidemiology ; Young Adult
    Language English
    Publishing date 2019-08-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.IJPH_377_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Market mapping and landscape analysis of human rabies biologicals in India.

    Sudarshan, Mysore Kalappa / Ashwath Narayana, Doddabele Hanumanthaiah / Jayakrishnappa, Mahendra Bangalore

    Indian journal of public health

    2019  Volume 63, Issue Supplement, Page(s) S37–S43

    Abstract: Background: Rabies vaccines and immunoglobulins are lifesaving in humans following animal exposures. These biologicals should continuously be available throughout the year to prevent and eliminate human rabies by 2030.: Objectives: The present study ... ...

    Abstract Background: Rabies vaccines and immunoglobulins are lifesaving in humans following animal exposures. These biologicals should continuously be available throughout the year to prevent and eliminate human rabies by 2030.
    Objectives: The present study aimed at assessing availability of different kinds of human rabies biologicals in the country and undertaking market mapping and landscape analysis of human rabies biologicals in India.
    Methods: The study comprising both quantitative and qualitative approach was conducted from May to November 2017 as a part of the Indian multicentric rabies survey by Association for Prevention and Control of Rabies in India. All stakeholders (agencies/personnel) associated with rabies biologicals were the study units/participants. Required data were generated through brainstorming sessions with key stakeholders; reviewing of databases/existing literature; conducting in-depth surveys; interviewing; focused group discussions, etc.
    Results: Two types of cell culture rabies vaccines are available in the country manufactured by different pharmaceutical companies; most of the vaccines are indigenously produced and the market size of the rabies vaccines is about INR 125 crores with highest sales in the northern region followed by South. Likewise, there are 2 types of immunoglobulin available, i.e., equine rabies immunoglobulins (RIGs), which are indigenously produced and human RIGs, which are imported. The market value of RIGs is about INR 83 crores. A novel rabies monoclonal antibody is also been marketed in the country from November 2017.
    Conclusions: There are many lacunas in the market availability of rabies biologicals in different parts of the country; therefore, a significant expansion/shift in focus must be considered, through rigorous strategic planning process.
    MeSH term(s) Biological Products/administration & dosage ; Biological Products/supply & distribution ; Biological Products/therapeutic use ; Bites and Stings/epidemiology ; Drug Administration Routes ; Geographic Mapping ; Health Services Needs and Demand ; Humans ; Immunoglobulins/therapeutic use ; India/epidemiology ; Post-Exposure Prophylaxis/statistics & numerical data ; Public Health Surveillance ; Rabies/drug therapy ; Rabies/epidemiology ; Rabies/prevention & control ; Rabies Vaccines/administration & dosage ; Rabies Vaccines/supply & distribution ; Rabies Vaccines/therapeutic use
    Chemical Substances Biological Products ; Immunoglobulins ; Rabies Vaccines
    Language English
    Publishing date 2019-08-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.IJPH_379_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Corrigendum to "Second round statewide sentinel-based population survey for estimation of the burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population of Karnataka, India, during January-February 2021" [IJID Regions Vol 1(2021) pages 107-116].

    Rajagopal Padma, M / Dinesh, Prameela / Sundaresan, Rajesh / Athreya, Siva / Shiju, Shilpa / Maroor, Parimala S / Lalitha Hande, R / Akhtar, Jawaid / Chandra, Trilok / Ravi, Deepa / Lobo, Eunice / Ana, Yamuna / Shriyan, Prafulla / Desai, Anita / Rangaiah, Ambica / Munivenkatappa, Ashok / Krishna, S / Basawarajappa, Shantala Gowdara / Sreedhara, H G /
    Siddesh, K C / Kumari, B Amrutha / Umar, Nawaz / Mythri, B A / Mythri, K M / Sudarshan, Mysore Kalappa / Vasanthapuram, Ravi / Rathnaiah Babu, Giridhara

    IJID regions

    2024  Volume 10, Page(s) 150

    Abstract: This corrects the article DOI: 10.1016/j.ijregi.2021.10.008.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.ijregi.2021.10.008.].
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Published Erratum
    ISSN 2772-7076
    ISSN (online) 2772-7076
    DOI 10.1016/j.ijregi.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Second round statewide sentinel-based population survey for estimation of the burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population of Karnataka, India, during January-February 2021.

    Padma, M Rajagopal / Dinesh, Prameela / Sundaresan, Rajesh / Athreya, Siva / Shiju, Shilpa / Maroor, Parimala S / Hande, R Lalitha / Akhtar, Jawaid / Chandra, Trilok / Ravi, Deepa / Lobo, Eunice / Ana, Yamuna / Shriyan, Prafulla / Desai, Anita / Rangaiah, Ambica / Munivenkatappa, Ashok / Krishna, S / Basawarajappa, Shantala Gowdara / Sreedhara, H G /
    Siddesh, K C / Amrutha Kumari, B / Umar, Nawaz / Mythri, B A / Mythri, K M / Sudarshan, Mysore Kalappa / Vasanthapuram, Ravi / Babu, Giridhara R

    IJID regions

    2021  Volume 1, Page(s) 107–116

    Abstract: Objective: Demonstrate the feasibility of using the existing sentinel surveillance infrastructure to conduct the second round of the serial cross-sectional sentinel-based population survey. Assess active infection, seroprevalence, and their evolution in ...

    Abstract Objective: Demonstrate the feasibility of using the existing sentinel surveillance infrastructure to conduct the second round of the serial cross-sectional sentinel-based population survey. Assess active infection, seroprevalence, and their evolution in the general population across Karnataka. Identify local variations for locally appropriate actions. Additionally, assess the clinical sensitivity of the testing kit used on account of variability of antibody levels in the population.
    Methods: The cross-sectional study of 41,228 participants across 290 healthcare facilities in all 30 districts of Karnataka was done among three groups of participants (low, moderate, and high-risk). The geographical spread was sufficient to capture local variations. Consenting participants were subjected to real-time reverse transcription-polymerase chain reaction (RT-PCR) testing, and antibody (IgG) testing. Clinical sensitivity was assessed by conducting a longitudinal study among participants identified as COVID-19 positive in the first survey round.
    Results: Overall weighted adjusted seroprevalence of IgG was 15.6% (95% CI: 14.9-16.3), crude IgG prevalence was 15.0% and crude active infection was 0.5%. Statewide infection fatality rate (IFR) was estimated as 0.11%, and COVID-19 burden estimated between 26.1 to 37.7% (at 90% confidence). Further, Cases-to-infections ratio (CIR) varied 3-35 across units and IFR varied 0.04-0.50% across units. Clinical sensitivity of the IgG ELISA test kit was estimated as ≥38.9%.
    Conclusion: We demonstrated the feasibility and simplicity of sentinel-based population survey in measuring variations in subnational and local data, useful for locally appropriate actions in different locations. The sentinel-based population survey thus helped identify districts that needed better testing, reporting, and clinical management. The state was far from attaining natural immunity during the survey and hence must step up vaccination coverage and enforce public health measures to prevent the spread of COVD-19.
    Language English
    Publishing date 2021-10-30
    Publishing country England
    Document type Journal Article
    ISSN 2772-7076
    ISSN (online) 2772-7076
    DOI 10.1016/j.ijregi.2021.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population: Results from a statewide sentinel-based population survey in Karnataka, India.

    Babu, Giridhara R / Sundaresan, Rajesh / Athreya, Siva / Akhtar, Jawaid / Pandey, Pankaj Kumar / Maroor, Parimala S / Padma, M Rajagopal / Lalitha, R / Shariff, Mohammed / Krishnappa, Lalitha / Manjunath, C N / Sudarshan, Mysore Kalappa / Gururaj, Gopalkrishna / Ranganath, Timmanahalli Sobagaiah / Vasanth, Kumar D E / Banandur, Pradeep / Ravi, Deepa / Shiju, Shilpa / Lobo, Eunice /
    Satapathy, Asish / Alahari, Lokesh / Dinesh, Prameela / Thakar, Vinitha / Desai, Anita / Rangaiah, Ambica / Munivenkatappa, Ashok / S, Krishna / Basawarajappa, Shantala Gowdara / Sreedhara, H G / Kc, Siddesh / B, Amrutha Kumari / Umar, Nawaz / Ba, Mythri / Vasanthapuram, Ravi

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 108, Page(s) 27–36

    Abstract: Objective: To estimate the burden of active infection and anti-SARS-CoV-2 IgG antibodies in Karnataka, India, and to assess variation across geographical regions and risk groups.: Methods: A cross-sectional survey of 16,416 people covering three risk ...

    Abstract Objective: To estimate the burden of active infection and anti-SARS-CoV-2 IgG antibodies in Karnataka, India, and to assess variation across geographical regions and risk groups.
    Methods: A cross-sectional survey of 16,416 people covering three risk groups was conducted between 3-16 September 2020 using the state of Karnataka's infrastructure of 290 healthcare facilities across all 30 districts. Participants were further classified into risk subgroups and sampled using stratified sampling. All participants were subjected to simultaneous detection of SARS-CoV-2 IgG using a commercial ELISA kit, SARS-CoV-2 antigen using a rapid antigen detection test (RAT) and reverse transcription-polymerase chain reaction (RT-PCR) for RNA detection. Maximum-likelihood estimation was used for joint estimation of the adjusted IgG, active and total prevalence (either IgG or active or both), while multinomial regression identified predictors.
    Results: The overall adjusted total prevalence of COVID-19 in Karnataka was 27.7% (95% CI 26.1-29.3), IgG 16.8% (15.5-18.1) and active infection fraction 12.6% (11.5-13.8). The case-to-infection ratio was 1:40 and the infection fatality rate was 0.05%. Influenza-like symptoms or contact with a COVID-19-positive patient were good predictors of active infection. RAT kits had higher sensitivity (68%) in symptomatic people compared with 47% in asymptomatic people.
    Conclusion: This sentinel-based population survey was the first comprehensive survey in India to provide accurate estimates of the COVID-19 burden. The findings provide a reasonable approximation of the population immunity threshold levels. Using existing surveillance platforms coupled with a syndromic approach and sampling framework enabled this model to be replicable.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Cross-Sectional Studies ; Humans ; Immunoglobulin G ; India/epidemiology ; Prevalence ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2021-05-21
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.05.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluation of a one week intradermal regimen for rabies post-exposure prophylaxis: results of a randomized, open label, active-controlled trial in healthy adult volunteers in India.

    Sudarshan, Mysore Kalappa / Narayana, Doddabele Hanumanthaiah Ashwath / Madhusudana, Shampur Narayan / Holla, Ramesh / Ashwin, Belludi Yajaman / Gangaboraiah, Bilagumba / Ravish, Haradanahalli S

    Human vaccines & immunotherapeutics

    2012  Volume 8, Issue 8, Page(s) 1077–1081

    Abstract: The currently recommended intradermal regimen for post-exposure prophylaxis spreads over a month period which many times lead to low compliance from the patients. There is a need to introduce and evaluate short course regimens to overcome this problem. ... ...

    Abstract The currently recommended intradermal regimen for post-exposure prophylaxis spreads over a month period which many times lead to low compliance from the patients. There is a need to introduce and evaluate short course regimens to overcome this problem. This study was conducted to evaluate the immunogenicity and safety of a "new one week intradermal regimen" for rabies post-exposure prophylaxis. A total of 80 healthy adult volunteers were enrolled and allocated randomly either to purified chick embryo cell (PCECV) rabies vaccine or purified verocell rabies vaccine (PVRV), 40 in each group. Each subject received intradermally one of the vaccines , using the one week regimen (4-4-4). Blood samples were collected on Days 0, 7, 14, 28,180 and 365 for estimation of rabies virus neutralizing antibody (RVNA) concentration. The sera samples were analyzed by rapid fluorescent focus inhibition test (RFFIT). All subjects in both the groups had adequate RVNA concentration of  0.5 IU/mL from day 14 to till day 180 and the difference of geometric mean concentrations between the two groups was not significant (P > 0.606). Further to assess the immunological memory produced by this new regimen, a "single visit four site" intradermal booster vaccination was given to those who did not have adequate RVNA concentration on day 365. This resulted in a quick and enhanced RVNA concentration in these subjects thus denoting a successful anamnestic response. The incidence of adverse events was 8.3% in PCECV group and 1.6% in PVRV group (P=0.001) and the regimen was well tolerated without any dropouts. In conclusion, the new "one week intradermal regimen" is immunogenic and safe for rabies post-exposure prophylaxis and needs to be further evaluated in persons exposed to rabies.
    MeSH term(s) Adult ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Female ; Human Experimentation ; Humans ; Immunologic Memory ; Incidence ; India ; Injections, Intradermal ; Male ; Neutralization Tests ; Post-Exposure Prophylaxis/methods ; Rabies/prevention & control ; Rabies Vaccines/administration & dosage ; Rabies Vaccines/adverse effects ; Rabies Vaccines/immunology ; Rabies virus/immunology ; Rabies virus/isolation & purification ; Time Factors ; Treatment Outcome
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Rabies Vaccines
    Language English
    Publishing date 2012-08-01
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.4161/hv.20471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Second round statewide survey for estimation of the burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population of Karnataka, India

    Padma, M Rajagopal / Dinesh, Prameela / Sundaresan, Rajesh / Athreya, Siva / Shiju, Shilpa / Maroor, Parimala S / Hande, R Lalitha / Akhtar, Jawaid / Chandra, Trilok / Ravi, Deepa / Lobo, Eunice / Ana, Yamuna / Shriyan, Prafulla / Desai, Anita / Rangaiah, Ambica / Munivenkatappa, Ashok / S, Krishna / Gowdara Basawarajappa, Shantala / Sreedhara, H.G. /
    KC, Siddhesh / Kumari B, Amrutha / Umar, Nawaz / BA, Mythri / KM, Mythri / Sudarshan, Mysore Kalappa / Vasanthapuram, Ravi / Babu, Giridhara R

    medRxiv

    Abstract: Objective: The second round of the serial cross sectional sentinel based population survey to assess active infection, seroprevalence, and their evolution in the general population across Karnataka was conducted. Additionally, a longitudinal study among ... ...

    Abstract Objective: The second round of the serial cross sectional sentinel based population survey to assess active infection, seroprevalence, and their evolution in the general population across Karnataka was conducted. Additionally, a longitudinal study among participants identified as COVID 19 positive in the first survey round was conducted to assess the clinical sensitivity of the testing kit used. Methods: The cross sectional study of 41,228 participants across 290 healthcare facilities in all 30 districts of Karnataka was done among three groups of participants (low, moderate, and high risk). Consenting participants were subjected to real time reverse transcription polymerase chain reaction (RTPCR) testing, and antibody (IgG) testing. Results: Overall weighted adjusted seroprevalence of IgG was 15.6% (95% CI: 14.9 to 16.3), crude IgG prevalence was 15.0% and crude active prevalence was 0.5%. Statewide infection fatality rate (IFR) was estimated as 0.11%, and COVID 19 burden estimated between 26.1 to 37.7% (at 90% confidence). Clinical sensitivity of the IgG ELISA test kit was estimated as equal or more than 38.9%. Conclusion: The sentinel based population survey helped identify districts that needed better testing, reporting, and clinical management. The state was far from attaining natural immunity during the survey and hence must step up vaccination coverage and enforce public health measures to prevent the spread of COVD 19.
    Keywords covid19
    Language English
    Publishing date 2021-08-11
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.08.10.21261842
    Database COVID19

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