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Article ; Online: Response.

Tashiro, Hiroki / Kuwahara, Yuki / Takahashi, Koichiro / Sueoka-Aragane, Naoko

2024 Volume 163, Issue 6, Page(s) e286

Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.02.013
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Article ; Online: A 45-Year-Old Woman With Unexplained Iron Deficiency Anemia and No Respiratory Symptoms.

Kuwahara, Yuki / Tashiro, Hiroki / Takahashi, Koichiro / Kimura, Shinya / Sueoka-Aragane, Naoko

Chest

2023 Volume 163, Issue 1, Page(s) e7–e11

Abstract: Case presentation: A 45-year-old Japanese woman was diagnosed with anemia in a work place medical check-up and came to our hospital for further investigations. She had experienced general fatigue and orthostatic dizziness for 6 months without fever or ... ...

Abstract	Case presentation: A 45-year-old Japanese woman was diagnosed with anemia in a work place medical check-up and came to our hospital for further investigations. She had experienced general fatigue and orthostatic dizziness for 6 months without fever or respiratory symptoms, including cough, sputum, hemoptysis, or dyspnea. She had undergone annual medical check-ups previously, which had shown no abnormalities, including anemia. She had no history of weight loss, epimenorrhagia, hematuria, or melena. She had no significant positive medical history and was not on any regular medication or supplements. She had no history of alcohol abuse or smoking.
MeSH term(s)	Female ; Humans ; Middle Aged ; Anemia, Iron-Deficiency/diagnosis ; Anemia, Iron-Deficiency/etiology ; Hemoptysis ; Dyspnea/diagnosis ; Dyspnea/etiology ; Cough ; Sputum ; Diagnosis, Differential
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2022.07.021
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Article ; Online: Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer.

Harada, Yohei / Sato, Akemi / Nishioka, Atsujiro / Ogusu, Shinsuke / Matsumoto, Masanori / Sueoka, Eisaburo / Kawaguchi, Atsushi / Kimura, Shinya / Sueoka-Aragane, Naoko

Oncology letters

2023 Volume 25, Issue 5, Page(s) 180

Abstract: Prospective studies on risk factors for the occurrence of venous thromboembolism (VTE) in Asian patients with cancer are limited. Therefore, the present study assessed risk factors for VTE, including multiple blood biomarkers and risk scores consisting ... ...

Abstract	Prospective studies on risk factors for the occurrence of venous thromboembolism (VTE) in Asian patients with cancer are limited. Therefore, the present study assessed risk factors for VTE, including multiple blood biomarkers and risk scores consisting of several risk factors, in Japanese patients receiving anticancer drug therapy. In this single-center, prospective, observational study, 200 patients with six types of cancer were enrolled and followed for 1 year to observe the occurrence of symptomatic or asymptomatic VTE. The present study evaluated risk factors, Khorana and Vienna cancer and thrombosis study (CATS) scores at enrollment, and longitudinal data on various blood biomarkers. A Vienna CATS score of ≥3 was significantly associated with VTE occurrence (HR, 2.8; 95% CI, 0.9-8.7; P=0.045). In multivariable analysis, there was a significant association between VTE and the presence of pancreatic cancer (HR, 3.2; 95% CI, 1.1-8.8; P=0.028) and high soluble fibrin (HR, 3.7; 95% CI, 1.1-7.8; P=0.036). Covariate analysis using the propensity score also showed a significant association with hemoglobin dichotomized at <100 g/l (HR, 3.9; 95% CI, 1.1-14.0; P=0.034). Longitudinal data indicated that VTE was associated with soluble fibrin baseline values and an increase in D-dimer levels over time. The present results suggested that blood biomarkers are beneficial for predicting the risk of VTE in Japanese patients with cancer. The present study also provided novel evidence for the importance of measuring soluble fibrin in patients with cancer.
Language	English
Publishing date	2023-03-17
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2023.13766
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Article ; Online: Thymic stromal lymphopoietin contributes to ozone-induced exacerbations of eosinophilic airway inflammation via granulocyte colony-stimulating factor in mice.

Kurihara, Yuki / Tashiro, Hiroki / Konomi, Yoshie / Sadamatsu, Hironori / Ihara, Satoshi / Takamori, Ayako / Kimura, Shinya / Sueoka-Aragane, Naoko / Takahashi, Koichiro

Allergology international : official journal of the Japanese Society of Allergology

2023 Volume 73, Issue 2, Page(s) 313–322

Abstract: Background: Ozone is one of the triggers of asthma, but its impact on the pathophysiology of asthma, such as via airway inflammation and airway hyperresponsiveness (AHR), is not fully understood. Thymic stromal lymphopoietin (TSLP) is increasingly seen ... ...

Abstract	Background: Ozone is one of the triggers of asthma, but its impact on the pathophysiology of asthma, such as via airway inflammation and airway hyperresponsiveness (AHR), is not fully understood. Thymic stromal lymphopoietin (TSLP) is increasingly seen as a crucial molecule associated with asthma severity, such as corticosteroid resistance. Methods: Female BALB/c mice sensitized and challenged with house dust mite (HDM) were exposed to ozone at 2 ppm for 3 h. Airway inflammation was assessed by the presence of inflammatory cells in bronchoalveolar lavage fluid and concentrations of cytokines including TSLP in lung. Anti-TSLP antibody was administered to mice to block the signal. Survival and adhesion of bone marrow-derived eosinophils in response to granulocyte colony-stimulating factor (G-CSF) were evaluated. Results: Ozone exposure increased eosinophilic airway inflammation and AHR in mice sensitized and challenged with HDM. In addition, TSLP, but not IL-33 and IL-25, was increased in lung by ozone exposure. To confirm whether TSLP signaling is associated with airway responses to ozone, an anti-TSLP antibody was administered, and it significantly attenuated eosinophilic airway inflammation, but not AHR. Interestingly, G-CSF, but not type 2 cytokines such as IL-4, IL-5, and IL-13, was regulated by TSLP signaling associated with eosinophilic airway inflammation, and G-CSF prolonged survival and activated eosinophil adhesion. Conclusions: The present data show that TSLP contributes to ozone-induced exacerbations of eosinophilic airway inflammation and provide greater understanding of ozone-induced severity mechanisms in the pathophysiology of asthma related to TSLP and G-CSF.
MeSH term(s)	Animals ; Female ; Mice ; Asthma ; Cytokines ; Granulocyte Colony-Stimulating Factor ; Inflammation ; Mice, Inbred BALB C ; Thymic Stromal Lymphopoietin
Chemical Substances	Cytokines ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Thymic Stromal Lymphopoietin (GT0IL38SP4) ; TSLP protein, mouse
Language	English
Publishing date	2023-12-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2023.12.002
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Article ; Online: Effect of Azithromycin on Exacerbations in Asthma Patients with Obesity: Protocol for a Multi-Center, Prospective, Single-Arm Intervention Study.

Tashiro, Hiroki / Takahashi, Koichiro / Uchida, Masaru / Kurihara, Yuki / Sadamatsu, Hironori / Takamori, Ayako / Kimura, Shinya / Sueoka-Aragane, Naoko

International journal of environmental research and public health

2023 Volume 20, Issue 3

Abstract: Introduction: Obesity is associated with severe asthma, but no specific treatment has been established. The gut microbiome is increasingly recognized as a crucial factor, but specific treatments focused on the gut microbiome have not been established. ... ...

Abstract	Introduction: Obesity is associated with severe asthma, but no specific treatment has been established. The gut microbiome is increasingly recognized as a crucial factor, but specific treatments focused on the gut microbiome have not been established. Recently, azithromycin has been found to have the capacity to attenuate exacerbations, a characteristic of severe asthma. The effect of azithromycin on obesity-induced severe asthma is not understood. Methods: The purpose of the present study is to clarify the effect of azithromycin on exacerbations in asthmatic patients with obesity. To explore the mechanism, the gut microbiome, metabolites of microbes such as short-chain fatty acids, and blood inflammatory cytokines will be analyzed to evaluate the correlation with the effect of azithromycin on exacerbations in obesity-induced severe asthma. A multi-center, prospective, single-arm intervention study is planned. Discussion: The present study will allow us to evaluate the effect of azithromycin on exacerbations, particularly in asthma patients with obesity, and explore biomarkers, targeting molecules including the gut microbiome, which are correlated with decreased exacerbations. The present results could contribute to identifying new therapeutic prospects and targeted microbes or molecules associated with severe clinical characteristics in asthmatic patients with obesity. Trial registration: This study has been registered as a prospective study with the University Hospital Medical Information Network (UMIN0000484389) and the Japan Registry of Clinical Trials (jRCTs071220023).
MeSH term(s)	Humans ; Azithromycin/therapeutic use ; Prospective Studies ; Double-Blind Method ; Asthma/drug therapy ; Obesity/complications ; Obesity/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Multicenter Studies as Topic
Chemical Substances	Azithromycin (83905-01-5) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20031861
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Article ; Online: Pleural lymphoma combined with pleural sarcoidosis.

Tashiro, Hiroki / Takahashi, Koichiro / Komiya, Natsuko / Miyahara, Naofumi / Hiratsuka, Masafumi / Okamoto, Sho / Kido, Shinichi / Kimura, Shinya / Sueoka-Aragane, Naoko

Respiratory investigation

2023 Volume 61, Issue 6, Page(s) 698–701

Abstract: A patient with sarcoidosis was found to have a massive left pleural effusion. Her chest computed tomography showed small nodules in the lung parenchyma and swelling of the hilar lymph nodes, with normal visceral and parietal pleura. Thoracoscopy showed ... ...

Abstract	A patient with sarcoidosis was found to have a massive left pleural effusion. Her chest computed tomography showed small nodules in the lung parenchyma and swelling of the hilar lymph nodes, with normal visceral and parietal pleura. Thoracoscopy showed white nodules on the visceral pleura and normal parietal pleura, which were resected. Epithelioid granulomas were seen in the visceral pleura and lung parenchyma. Surprisingly, in the parietal pleura, abnormal cells that were positive for the leukocyte common antigen, CD20, and CD79a were found, leading to the diagnosis of malignant B-cell lymphoma.
MeSH term(s)	Female ; Humans ; Pleura/diagnostic imaging ; Pleural Neoplasms/complications ; Pleural Neoplasms/diagnostic imaging ; Pleural Effusion ; Sarcoidosis/complications ; Sarcoidosis/diagnostic imaging ; Lymphoma/pathology
Language	English
Publishing date	2023-09-15
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2023.07.010
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Article ; Online: A 45-Year-Old Man With Acute Chest Pain, Fever, and Dyspnea After Tooth Extraction.

Tashiro, Hiroki / Takahashi, Koichiro / Haraguchi, Tetsuro / Jinnouchi, Kazuki / Kimura, Shinya / Sueoka-Aragane, Naoko

Chest

2021 Volume 160, Issue 6, Page(s) e623–e628

Abstract: Case presentation: A 45-year-old Japanese man underwent wisdom tooth extraction. He developed right chest pain 2 days later, followed by continuous fever with dyspnea 2 weeks after the tooth extraction, and then came to our hospital. He complained of ... ...

Abstract	Case presentation: A 45-year-old Japanese man underwent wisdom tooth extraction. He developed right chest pain 2 days later, followed by continuous fever with dyspnea 2 weeks after the tooth extraction, and then came to our hospital. He complained of cough and purulent sputum.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Bacteria, Anaerobic/isolation & purification ; Bacterial Infections/diagnosis ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Chest Pain ; Cough ; Diagnosis, Differential ; Dyspnea ; Fever ; Humans ; Lung Abscess/diagnosis ; Lung Abscess/drug therapy ; Lung Abscess/microbiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Molar, Third/surgery ; Postoperative Complications/diagnosis ; Postoperative Complications/drug therapy ; Postoperative Complications/microbiology ; Radiography, Thoracic ; Tooth Extraction
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-12-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.07.049
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Article ; Online: Absence of copy number gain of EGFR: A possible predictive marker of long-term response to afatinib.

Nakamura, Tomomi / Sato, Akemi / Nakashima, Chiho / Abe, Tomonori / Iwanaga, Kentaro / Umeguchi, Hitomi / Kawaguchi, Atsushi / Sueoka-Aragane, Naoko

Cancer science

2022 Volume 114, Issue 3, Page(s) 1045–1055

Abstract: Treatment efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is diverse even in non-small cell lung cancer (NSCLC) patients with EGFR activating mutations. Extraordinary long-term responses sustained over 3 years among ... ...

Abstract	Treatment efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is diverse even in non-small cell lung cancer (NSCLC) patients with EGFR activating mutations. Extraordinary long-term responses sustained over 3 years among NSCLC patients treated with afatinib, an EGFR-TKI, have been reported, but how to predict such long survivors has not been clarified. A multi-institutional prospective observational study, based on comprehensive genomic examination performed with next-generation sequencing of circulating tumor DNA (ctDNA), was conducted to identify potential predictive markers of long-term response to afatinib. Twenty-nine patients with advanced stage NSCLC and EGFR driver mutations detected by standard techniques were enrolled in the study. ctDNA from plasma collected before afatinib treatment was analyzed by Guardant360. ctDNA was detected in 25 of the 29 samples. Median progression-free survival was shorter in patients whose tumors had EGFR copy number gain (7.0 vs 23.0 months, p = 0.022). The impact of EGFR copy number on cell proliferation and the antitumor effect of afatinib were evaluated using genome-editing lung cancer cell lines. HCC827 with EGFR amplification was relatively resistant to afatinib at concentrations below 0.5 nM, but genome-edited derivatives of HCC827 with decreased EGFR copy number demonstrated growth inhibition with 0.1 nM afatinib. The absence of EGFR copy number gain detected in ctDNA may be a predictive marker of long-term response to afatinib. Comprehensive genomic analysis could lead to a more accurate prediction of EGFR-TKI efficacy.
MeSH term(s)	Humans ; Afatinib ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/pathology ; DNA Copy Number Variations ; Protein Kinase Inhibitors/pharmacology ; ErbB Receptors/genetics ; Mutation
Chemical Substances	Afatinib (41UD74L59M) ; Protein Kinase Inhibitors ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
Language	English
Publishing date	2022-12-16
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15655
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Article ; Online: Obesity affects pulmonary function in Japanese adult patients with asthma, but not those without asthma.

Tashiro, Hiroki / Takahashi, Koichiro / Kurihara, Yuki / Sadamatsu, Hironori / Kuwahara, Yuki / Tajiri, Ryo / Kimura, Shinya / Sueoka-Aragane, Naoko

Scientific reports

2022 Volume 12, Issue 1, Page(s) 16457

Abstract: Obesity is associated with the severity of asthma, which is characterized by airway obstruction. Pulmonary function testing is one of the important examinations for evaluating airway obstruction. However, the impact of obesity on pulmonary function in ... ...

Abstract	Obesity is associated with the severity of asthma, which is characterized by airway obstruction. Pulmonary function testing is one of the important examinations for evaluating airway obstruction. However, the impact of obesity on pulmonary function in patients with asthma is not fully understood. A total of 193 patients with asthma and 2159 patients without asthma who visited Saga University Hospital were investigated retrospectively. Obesity was defined as a body mass index (BMI) greater than 25 kg/m
MeSH term(s)	Adult ; Airway Obstruction ; Asthma/complications ; Forced Expiratory Volume ; Humans ; Japan/epidemiology ; Obesity/complications ; Retrospective Studies ; Vital Capacity
Language	English
Publishing date	2022-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20924-y
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Article: Anti-IL-5 Agents for the Treatment of Idiopathic Chronic Eosinophilic Pneumonia: A Case Series.

Tashiro, Hiroki / Takahashi, Koichiro / Kurihara, Yuki / Sadamatsu, Hironori / Kuwahara, Yuki / Kimura, Shinya / Sueoka-Aragane, Naoko

Journal of asthma and allergy

2022 Volume 15, Page(s) 169–177

Abstract: Purpose: Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare, chronic respiratory disease. Corticosteroid therapy is effective for ICEP, but relapse is frequent after its tapering, which leads to chronic use and corticosteroid-related adverse ... ...

Abstract	Purpose: Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare, chronic respiratory disease. Corticosteroid therapy is effective for ICEP, but relapse is frequent after its tapering, which leads to chronic use and corticosteroid-related adverse effects. Currently, biological agents targeting interleukin 5 (IL-5) are considered alternatives for treating ICEP patients with frequent relapse, but the detailed effects are not fully understood. Patients and methods: The clinical characteristics of 30 patients with ICEP, especially 12 patients with ICEP who experienced relapse after corticosteroid dose tapering, were evaluated retrospectively. In addition, 4 ICEP patients with frequent relapse treated by IL-5-targeted biological agents were reviewed. Results: Of the 30 patients diagnosed with ICEP, 12 patients (40.0%) recurred after corticosteroid dose tapering, and 9 (30.0%) were treated with maintenance doses of corticosteroid. Of ICEP patients who experienced recurrence, 6 (50.0%) had frequent relapses (2 or more times). All 4 patients treated with anti-IL-5 agents had their corticosteroid dose reduced without any relapses; in 3 patients, corticosteroids were withdrawn. Conclusion: Anti-IL-5 agents might be alternatives for treating ICEP patients with frequent relapses.
Language	English
Publishing date	2022-02-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494877-9
ISSN	1178-6965
ISSN	1178-6965
DOI	10.2147/JAA.S343272
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