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  1. Article ; Online: COVID-19 pandemic

    Sufia Islam / Rizwanul Islam / Fouzia Mannan / Sabera Rahman / Tahiya Islam

    Progress in Disaster Science, Vol 8, Iss , Pp 100135- (2020)

    An analysis of the healthcare, social and economic challenges in Bangladesh

    2020  

    Abstract: Bangladesh is one of the worst hit countries in South Asia for COVID-19 outbreak. The objective of this article is to analyse healthcare, social and economic challenges faced by the country. Quantitative data and qualitative information from different ... ...

    Abstract Bangladesh is one of the worst hit countries in South Asia for COVID-19 outbreak. The objective of this article is to analyse healthcare, social and economic challenges faced by the country. Quantitative data and qualitative information from different sources have been used. Our analysis indicates that limited well-equipped hospitals, inadequate testing facilities, lack of awareness, improper knowledge, attitude to and practice of rules, poverty and precarious employment are the factors dominant in spreading COVID-19. Strict enforcement measures and ensuring people's adherence to rules may help reduce spread of infections. Adequate healthcare services are essential for establishing proper medical care.
    Keywords COVID-19 ; Economic and social challenges ; Healthcare services ; Environmental sciences ; GE1-350 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Clinical features of pneumonia in severely malnourished children with diarrhoea compared to those without diarrhoea

    Sufia Islam / Nishat Nasrin / Nigar Sultana Tithi / Christian Lehmann / Mohammod Jobayer Chisti

    Frontiers in Bioscience-Landmark, Vol 26, Iss 10, Pp 717-

    2021  Volume 722

    Abstract: Introduction: Pneumonia and diarrhoea are amongst the most common causes for hospital admission for children in low- and middle-income countries such as Bangladesh. Undernourished children often have more severe infections and a higher morbidity and ... ...

    Abstract Introduction: Pneumonia and diarrhoea are amongst the most common causes for hospital admission for children in low- and middle-income countries such as Bangladesh. Undernourished children often have more severe infections and a higher morbidity and mortality. Objective: The objective of this study was to determine the clinical features and outcomes of pneumonia in severely malnourished children with and without diarrhoea. Methodology: A retrospective chart analysis was carried out on children under 5 years of age who were admitted in intensive care unit of the Dhaka hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b). A total of 245 severe acute malnourished children with pneumonia and diarrhoea (PD group) were compared with 89 children with pneumonia only (PO group). Results: A significantly higher number of children from the PD group had some/severe dehydration (16.3% vs. 1.1%; p < 0.005) when compared with children from the PO group. The PD group showed less cough (83.3% vs. 100%; p < 0.001), lower chest wall indrawing (40.4% vs. 60.7%; p = 0.001), and crackles (62.4% vs. 87.6%; p < 0.001) compared to the PO group at the time of admission. Conclusion: Early diagnosis and treatment of some/severe dehydration in addition to WHO recommended other routine treatment of diarrhoea, pneumonia and severe acute malnutrition in children may help to reduce childhood morbidity and mortality especially in low- and middle-income countries.
    Keywords pneumonia ; diarrhoea ; malnutrition ; children ; bangladesh ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
    Subject code 360
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher IMR Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis

    Sufia Islam / Ashiqur Rahman Akand / Tasnova Tasnim Nova / Christian Lehmann / Mohammod Jobayer Chisti

    Life, Vol 11, Iss 450, p

    2021  Volume 450

    Abstract: Treatment options for pneumonia and sepsis by antibiotics are limited due to the development of multidrug-resistant bacterial strains. This unmatched case-control study determined the antibiotic sensitivity against bacterial isolates obtained from septic ...

    Abstract Treatment options for pneumonia and sepsis by antibiotics are limited due to the development of multidrug-resistant bacterial strains. This unmatched case-control study determined the antibiotic sensitivity against bacterial isolates obtained from septic and nonseptic children with pneumonia. Children of either sex aged 0–59 months with a history of cough or shortness of breath and radiologically confirmed pneumonia were enrolled in this study. Cases with clinical signs of sepsis at admission ( n = 151) were compared to cases without sepsis as controls ( n = 107). A total of 205 children had a performance of blood culture, with 123 children suffering from clinical sepsis. Blood cultures showed bacterial growth in 19% of the septic samples, with 8% coagulase-negative staphylococci and 2.4% Acinetobacter species. Only 1.6% of the cases were infected by Streptococcus pneumonia , Haemophilus influenzae , Salmonella typhi and Klebsiella . In contrast, children without sepsis presented positive blood cultures with growth of Salmonella typhi in 2.4% of the cases and growth of Klebsiella in 1.2%. Bacteria were sensitive to imipenem in 100% of the cases (86% for meropenem, 83% for ceftazidime and 76% for ciprofloxacin). The mortality rate was significantly higher in children with pneumonia complicated by sepsis (odds ratio (OR) = 3.02, 95% confidence interval (CI), 1.11–8.64, p < 0.027). Knowledge about specific laboratory characteristics in children with pneumonia will facilitate an early diagnosis and treatment of sepsis and reduce mortality.
    Keywords bacterial resistance ; children ; mortality ; pneumonia ; sepsis ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: COVID-19 pandemic: An analysis of the healthcare, social and economic challenges in Bangladesh

    Islam, Sufia Islam Rizwanul Mannan Fouzia Rahman Sabera Islam Tahiya

    Progress in Disaster Science

    Abstract: Bangladesh is one of the worst hit countries in South Asia for COVID-19 outbreak The objective of this article is to analyse healthcare, social and economic challenges faced by the country Quantitative data and qualitative information from different ... ...

    Abstract Bangladesh is one of the worst hit countries in South Asia for COVID-19 outbreak The objective of this article is to analyse healthcare, social and economic challenges faced by the country Quantitative data and qualitative information from different sources have been used Our analysis indicates that limited well-equipped hospitals, inadequate testing facilities, lack of awareness, improper knowledge, attitude to and practice of rules, poverty and precarious employment are the factors dominant in spreading COVID-19 Strict enforcement measures and ensuring people's adherence to rules may help reduce spread of infections Adequate healthcare services are essential for establishing proper medical care
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #926481
    Database COVID19

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  5. Article ; Online: Bacterial Resistance in Pneumonia in Developing Countries—A Role for Iron Chelation

    Sufia Islam / Mohammod Jobayer Chisti / Muniruddin Ahmed / Nafiza Anwar / Christian Lehmann

    Tropical Medicine and Infectious Disease, Vol 4, Iss 2, p

    2019  Volume 59

    Abstract: Pneumonia represents one of the major infectious diseases in developing countries and is associated with high mortality, in particular in children under the age of five. The main causative bacterial agents are Streptococcus pneumoniae and Haemophilus ... ...

    Abstract Pneumonia represents one of the major infectious diseases in developing countries and is associated with high mortality, in particular in children under the age of five. The main causative bacterial agents are Streptococcus pneumoniae and Haemophilus influenzae type B, accounting for 33% and 16%, respectively, of the mortality in under-fives. Iron modulates the immune response in infectious diseases and increased iron levels can lead to complications such as sepsis and multiorgan failure. This review will look into the use of iron chelators in order to reduce microbial growth and attenuate a dysregulated immune response during infection. Our hypothesis is that temporary restriction of iron will lessen the incidence and complication rate of infections like pneumonia and result in a decrease of mortality and morbidity.
    Keywords pneumonia ; iron ; iron chelation ; resistance ; antibiotics ; sepsis ; Medicine ; R
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Iron Overload and Breast Cancer

    Sufia Islam / Nazia Hoque / Nishat Nasrin / Mehnaz Hossain / Farhana Rizwan / Kushal Biswas / Muhammad Asaduzzaman / Sabera Rahman / David W. Hoskin / Saki Sultana / Christian Lehmann

    Life, Vol 12, Iss 7, p

    Iron Chelation as a Potential Therapeutic Approach

    2022  Volume 963

    Abstract: Breast cancer has historically been one of the leading causes of death for women worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the most common type of cancer globally, representing an estimated 11.3% of all cancer ... ...

    Abstract Breast cancer has historically been one of the leading causes of death for women worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the most common type of cancer globally, representing an estimated 11.3% of all cancer diagnoses. A multidisciplinary approach is taken for the diagnosis and treatment of breast cancer that includes conventional and targeted treatments. However, current therapeutic approaches to treating breast cancer have limitations, necessitating the search for new treatment options. Cancer cells require adequate iron for their continuous and rapid proliferation. Excess iron saturates the iron-binding capacity of transferrin, resulting in non-transferrin-bound iron (NTBI) that can catalyze free-radical reactions and may lead to oxidant-mediated breast carcinogenesis. Moreover, excess iron and the disruption of iron metabolism by local estrogen in the breast leads to the generation of reactive oxygen species (ROS). Therefore, iron concentration reduction using an iron chelator can be a novel therapeutic strategy for countering breast cancer development and progression. This review focuses on the use of iron chelators to deplete iron levels in tumor cells, specifically in the breast, thereby preventing the generation of free radicals. The inhibition of DNA synthesis and promotion of cancer cell apoptosis are the targets of breast cancer treatment, which can be achieved by restricting the iron environment in the body. We hypothesize that the usage of iron chelators has the therapeutic potential to control intracellular iron levels and inhibit the breast tumor growth. In clinical settings, iron chelators can be used to reduce cancer cell growth and thus reduce the morbidity and mortality in breast cancer patients.
    Keywords breast cancer ; oxidative stress ; iron overload ; iron chelator ; estrogen ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: In vitro Sensitivity of Different Brands of Antiamoebic Drugs (Metronidazole Tablets) Against Clinical Isolates of Entamoeba histolytica in Bangladesh

    Md. Mehedi Aziz Sarker / Farhana Rizwan / Rashidul Haque / Abdulllah Siddique / Seheli Parveen / Sufia Islam

    Journal of Biological Sciences, Vol 8, Iss 5, Pp 925-

    2008  Volume 929

    Abstract: The aim of the study was to evaluate in vitro sensitivity of different metronidazole tablets from Bangladeshi pharmaceuticals against clinical isolates of E. histolytica. Metronidazole tablets of 12 different brands were randomized from some big and ... ...

    Abstract The aim of the study was to evaluate in vitro sensitivity of different metronidazole tablets from Bangladeshi pharmaceuticals against clinical isolates of E. histolytica. Metronidazole tablets of 12 different brands were randomized from some big and small pharmaceuticals according to their business. The parasite count was adjusted to 3x10 6 parasites mL -1 in a medium. In vitro drug sensitivity assay of the samples was carried out by using microtiter plates after treatment with different concentrations of metronidazoles. The viable parasites were counted by haemocytometer. No statistical significance was observed in terms of viable parasites with the metronidazole tablets from three big pharmaceuticals at the concentration of 2.3, 3.5 and 4.6 μM when compared with the standard metronidazole. We conclude that brands from some big pharmaceuticals showed in vitro sensitivity against E. histolytica .
    Keywords Amoebiasis ; metronidazole ; Entamoeba histolytica ; drug resistance ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2008-01-01T00:00:00Z
    Publisher Asian Network for Scientific Information
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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