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  1. Article ; Online: K

    Maslov, Leonid N / Popov, Sergey V / Naryzhnaya, Natalia V / Mukhomedzyanov, Alexandr V / Kurbatov, Boris K / Derkachev, Ivan A / Boshchenko, Alla A / Prasad, N Rajendra / Ma, Huijie / Zhang, Yi / Sufianova, Galina Z / Fu, Feng / Pei, Jian-Ming

    Fundamental & clinical pharmacology

    2023  Volume 37, Issue 6, Page(s) 1020–1049

    Abstract: Background: The use of percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5%-7%. It is clear that there is an urgent need to develop new drugs that can ... ...

    Abstract Background: The use of percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5%-7%. It is clear that there is an urgent need to develop new drugs that can effectively prevent cardiac reperfusion injury. ATP-sensitive K
    Results: KCOs prevent irreversible ischemia and reperfusion injury of the heart. K
    Conclusion: The cardioprotective effect of KCOs is mediated by the opening of mitochondrial K
    MeSH term(s) Humans ; Animals ; No-Reflow Phenomenon ; Percutaneous Coronary Intervention ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/prevention & control ; Apoptosis ; Reperfusion ; Adenosine Triphosphate ; KATP Channels
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; KATP Channels
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639134-5
    ISSN 1472-8206 ; 0767-3981
    ISSN (online) 1472-8206
    ISSN 0767-3981
    DOI 10.1111/fcp.12924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2247: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article: Apelin Is a Prototype of Novel Drugs for the Treatment of Acute Myocardial Infarction and Adverse Myocardial Remodeling.

    Popov, Sergey V / Maslov, Leonid N / Mukhomedzyanov, Alexandr V / Kurbatov, Boris K / Gorbunov, Alexandr S / Kilin, Michail / Azev, Viacheslav N / Khlestkina, Maria S / Sufianova, Galina Z

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: In-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is 5-6%. Consequently, it is necessary to develop fundamentally novel drugs capable of reducing mortality in patients with acute myocardial infarction. Apelins ... ...

    Abstract In-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is 5-6%. Consequently, it is necessary to develop fundamentally novel drugs capable of reducing mortality in patients with acute myocardial infarction. Apelins could be the prototype for such drugs. Chronic administration of apelins mitigates adverse myocardial remodeling in animals with myocardial infarction or pressure overload. The cardioprotective effect of apelins is accompanied by blockage of the MPT pore, GSK-3β, and the activation of PI3-kinase, Akt, ERK1/2, NO-synthase, superoxide dismutase, glutathione peroxidase, matrix metalloproteinase, the epidermal growth factor receptor, Src kinase, the mitoK
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15031029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pharmacological Approaches to Limit Ischemic and Reperfusion Injuries of the Heart: Analysis of Experimental and Clinical Data on P2Y

    Maslov, Leonid N / Popov, Sergey V / Mukhomedzyanov, Alexandr V / Derkachev, Ivan A / Ryabov, Vyacheslav V / Boshchenko, Alla A / Prasad, N Rajendra / Sufianova, Galina Z / Khlestkina, Maria S / Gareev, Ilgiz

    Korean circulation journal

    2022  Volume 52, Issue 10, Page(s) 737–754

    Abstract: Ischemic and reperfusion injuries of the heart underlie the pathogenesis of acute myocardial infarction (AMI) and sudden cardiac death. The mortality rate is still high and is 5-7% in patients with ST-segment elevation myocardial infarction. The review ... ...

    Abstract Ischemic and reperfusion injuries of the heart underlie the pathogenesis of acute myocardial infarction (AMI) and sudden cardiac death. The mortality rate is still high and is 5-7% in patients with ST-segment elevation myocardial infarction. The review is devoted to pharmacological approaches to limitation of ischemic and reperfusion injuries of the heart. The article analyzes experimental evidence and the clinical data on the effects of P2Y
    Language English
    Publishing date 2022-10-10
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2557464-4
    ISSN 1738-5520
    ISSN 1738-5520
    DOI 10.4070/kcj.2022.0162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6894: Show issues Location:
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  4. Article ; Online: Regulation of autophagy of the heart in ischemia and reperfusion.

    Popov, Sergey V / Mukhomedzyanov, Alexander V / Voronkov, Nikita S / Derkachev, Ivan A / Boshchenko, Alla A / Fu, Feng / Sufianova, Galina Z / Khlestkina, Maria S / Maslov, Leonid N

    Apoptosis : an international journal on programmed cell death

    2022  Volume 28, Issue 1-2, Page(s) 55–80

    Abstract: Ischemia/reperfusion (I/R) of the heart leads to increased autophagic flux. Preconditioning stimulates autophagic flux by AMPK and PI3-kinase activation and mTOR inhibition. The cardioprotective effect of postconditioning is associated with activation of ...

    Abstract Ischemia/reperfusion (I/R) of the heart leads to increased autophagic flux. Preconditioning stimulates autophagic flux by AMPK and PI3-kinase activation and mTOR inhibition. The cardioprotective effect of postconditioning is associated with activation of autophagy and increased activity of NO-synthase and AMPK. Oxidative stress stimulates autophagy in the heart during I/R. Superoxide radicals generated by NADPH-oxidase acts as a trigger for autophagy, possibly due to AMPK activation. There is reason to believe that AMPK, GSK-3β, PINK1, JNK, hexokinase II, MEK, PKCα, and ERK kinases stimulate autophagy, while mTOR, PKCδ, Akt, and PI3-kinase can inhibit autophagy in the heart during I/R. However, there is evidence that PI3-kinase could stimulate autophagy in ischemic preconditioning of the heart. It was found that transcription factors FoxO1, FoxO3, NF-κB, HIF-1α, TFEB, and Nrf-2 enhance autophagy in the heart in I/R. Transcriptional factors STAT1, STAT3, and p53 inhibit autophagy in I/R. MicroRNAs could stimulate and inhibit autophagy in the heart in I/R. Long noncoding RNAs regulate the viability and autophagy of cardiomyocytes in hypoxia/reoxygenation (H/R). Nitric oxide (NO) donors and endogenous NO could activate autophagy of cardiomyocytes. Activation of heme oxygenase-1 promotes cardiomyocyte tolerance to H/R and enhances autophagy. Hydrogen sulfide increases cardiac tolerance to I/R and inhibits apoptosis and autophagy via mTOR and PI3-kinase activation.
    MeSH term(s) Humans ; Signal Transduction ; AMP-Activated Protein Kinases/metabolism ; Glycogen Synthase Kinase 3 beta ; Apoptosis ; TOR Serine-Threonine Kinases/metabolism ; Myocytes, Cardiac/metabolism ; Myocardial Reperfusion Injury ; Ischemia ; Reperfusion ; Autophagy ; Phosphatidylinositol 3-Kinases
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2022-11-11
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-022-01786-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5178: Show issues Location:
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  5. Article ; Online: Endoscopic third ventriculostomy in patients younger than 2 years: outcome analysis of 41 hydrocephalus cases.

    Sufianov, Albert A / Sufianova, Galina Z / Iakimov, Iurii A

    Journal of neurosurgery. Pediatrics

    2010  Volume 5, Issue 4, Page(s) 392–401

    Abstract: Object: The object of this study was to analyze the outcome of endoscopic third ventriculostomy (ETV) in patients under 2 years of age and investigate factors related to ETV success or failure in this patient population.: Methods: The authors ... ...

    Abstract Object: The object of this study was to analyze the outcome of endoscopic third ventriculostomy (ETV) in patients under 2 years of age and investigate factors related to ETV success or failure in this patient population.
    Methods: The authors reviewed their experience in using endoscopic third ventriculostomy (ETV) in the treatment of 41 hydrocephalus patients younger than 2 years. The mean duration of follow-up was 45 months. The relationship between ETV efficacy and the following variables was analyzed: cause of hydrocephalus, level of CSF occlusion, primary versus secondary ETV, type of surgical procedure, head circumference, patient age at ETV, patient age at first manifestation of hydrocephalus, and anatomical features of the ventricle. Success of ETV was assessed based on the results of neurological examination and postoperative imaging during the follow-up period.
    Results: The authors performed 32 primary ETVs and 10 secondary ETVs (ETV after hydrocephalus surgery) in 41 patients (a second ETV was performed in 1 patient). The success rates of primary and secondary ETV were 75.8 and 55.6%, respectively (no significant difference, p = 0.15). The ETV was clinically and radiologically successful in 30 (71.4%) of 42 procedures during a mean (+/- SD) follow-up period of 45.0 +/- 4.8 months (range 12-127 months). A negative relationship was found between success of ETV and the thickness of the floor of the third ventricle (the most effective procedures were those in which the floor of the ventricle was thinnest [p < 0.05]). There was a highly significant correlation between ETV success and prolapse of the ventricle floor (p < 0.001). Also, there was an inverse relationship between ventricle floor thickness and the width of the third ventricle (p < 0.005). In our group of patients there was significant correlation between ETV success and patient age at onset of hydrocephalus (the most effective procedures were in patients in whom signs of hydrocephalus first occurred after 1 month of age [p = 0.02]).
    Conclusions: Endoscopic third ventriculostomy was successful in 71.4% of procedures in children younger than 2 years and in 75.0% of procedures in infants. Success of ETV in children younger than 2 years depends not on the age of the patient or cause of hydrocephalus but on the thickness of the floor of the third ventricle and the patient's age at first manifestation of hydrocephalus.
    MeSH term(s) Cerebrospinal Fluid Shunts ; Child, Preschool ; Endoscopy ; Follow-Up Studies ; Humans ; Hydrocephalus/surgery ; Infant ; Male ; Reoperation ; Retrospective Studies ; Third Ventricle/surgery ; Treatment Outcome ; Ventriculostomy
    Language English
    Publishing date 2010-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2009.11.PEDS09197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.135 -Pediatrics-: Show issues Location:
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