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  1. Article: [Elucidation of the role of the myokine IL-15 in the efficacy of exercise in conditions promoting sarcopenia].

    Sugimoto, Ken

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

    2023  Volume 60, Issue 2, Page(s) 193–195

    Language Japanese
    Publishing date 2023-05-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604107-3
    ISSN 0300-9173
    ISSN 0300-9173
    DOI 10.3143/geriatrics.60.193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Relationship between age-related changes in mandibular third molar roots and the possibility of mental nerve paresthesia after tooth extraction.

    Sakakura, H / Hayashi, Y / Sugimoto, K / Matsubara, A

    International journal of oral and maxillofacial surgery

    2024  

    Abstract: Mental nerve paresthesia is a serious postoperative complication of mandibular third molar extraction. It appears that no study has examined the relationship between the surface morphology of the mandibular third molar roots and the possibility of mental ...

    Abstract Mental nerve paresthesia is a serious postoperative complication of mandibular third molar extraction. It appears that no study has examined the relationship between the surface morphology of the mandibular third molar roots and the possibility of mental nerve paresthesia following tooth extraction. Therefore, the root morphology of the mandibular third molars was examined according to age using dental cone beam computed tomography (CBCT), and the possibility of mental nerve paresthesia following tooth extraction was evaluated. The study included 1216 patients who had undergone mandibular third molar extractions. The root morphology of 1534 teeth in 791 patients who had CBCT performed before surgery was studied. Factors evaluated were age, complete or incomplete formation of the mandibular third molar roots, periodontal ligament atrophy of the mandibular third molar roots, hypercementosis, and mandibular canal deformation. Mandibular third molar root formation was completed between the ages of 19 and 30 years. Complete formation of the mandibular third molar roots (P = 0.002) and deformation of the mandibular canal (P < 0.001) were identified as risk factors for mental nerve paresthesia. These findings suggest that the risk of mental nerve paresthesia could be reduced if the extraction of third molars is performed prior to complete root formation.
    Language English
    Publishing date 2024-01-09
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2023.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 931: Show issues Location:
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    Zs.MO 401: Show issues

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  3. Article ; Online: Development of US- and CT/MRI-based quantification of liver steatosis.

    Sugimoto, Katsutoshi

    Journal of medical ultrasonics (2001)

    2021  Volume 48, Issue 4, Page(s) 463

    MeSH term(s) Fatty Liver/diagnostic imaging ; Humans ; Liver/diagnostic imaging ; Magnetic Resonance Imaging ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-11-10
    Publishing country Japan
    Document type Editorial
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-021-01137-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2695: Show issues Location:
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  4. Article: Two Cases With Type 1 Diabetes Treated With Insulin Pump Therapy Using a Telemedicine Approach During the COVID-19 Pandemic.

    Kubo, Haremaru / Sugimoto, Kazuhiro

    Cureus

    2024  Volume 16, Issue 1, Page(s) e51607

    Abstract: Type 1 diabetes mellitus (T1D) is an autoimmune-related disease resulting in insulin dependency, treated with insulin injection via pen devices or continuous subcutaneous insulin infusion (CSII). Face-to-face instruction for managing insulin injection ... ...

    Abstract Type 1 diabetes mellitus (T1D) is an autoimmune-related disease resulting in insulin dependency, treated with insulin injection via pen devices or continuous subcutaneous insulin infusion (CSII). Face-to-face instruction for managing insulin injection and dosing and machine-to-device troubleshooting are required early to initiate CSII from insulin injections. Thus, T1D individuals may encounter significant barriers to pen devices or CSII introduction if they live in remote rural areas. In this regard, intermittently scanned continuous glucose monitoring (isCGM) can share visualized glucose profiles via a cloud-platform-based system, offering the potential as an effective tool in telemedicine. Herewith, we report two cases of subjects with T1D living in remote rural areas whose CSII was safely introduced in outpatient settings with the aid of cloud-platform-based isCGM and a video-meeting tool. They showed improved glucose profiles after CSII initiation. Even under the coronavirus disease 2019 (COVID-19) pandemic, the telemedicine system enabled healthcare providers to monitor glucose profiles and confirm device procedures of CSII. We emphasize the usefulness of online instruction with cloud-platform-based isCGM for introducing CSII in cases with barriers to healthcare access, particularly during the COVID-19 pandemic.
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Illuminating the path to shoot meristem regeneration: Molecular insights into reprogramming cells into stem cells.

    Ince, Yetkin Çaka / Sugimoto, Keiko

    Current opinion in plant biology

    2023  Volume 76, Page(s) 102452

    Abstract: Plant cells possess the ability to dedifferentiate and reprogram into stem cell-like populations, enabling the regeneration of new organs. However, the maintenance of stem cells relies on specialized microenvironments composed of distinct cell ... ...

    Abstract Plant cells possess the ability to dedifferentiate and reprogram into stem cell-like populations, enabling the regeneration of new organs. However, the maintenance of stem cells relies on specialized microenvironments composed of distinct cell populations with specific functions. Consequently, the regeneration process necessitates the orchestrated regulation of multiple pathways across diverse cellular populations. One crucial pathway involves the transcription factor WUSCHEL HOMEOBOX 5 (WOX5), which plays a pivotal role in reprogramming cells into stem cells and promoting their conversion into shoot meristems through WUSCHEL (WUS). Additionally, cell and tissue mechanics, including cell wall modifications and mechanical stress, critically contribute to de novo shoot organogenesis by regulating polar auxin transport. Furthermore, light signaling emerges as a key regulator of plant regeneration, directly influencing expression of meristem genes and potentially influencing aforementioned pathways as well.
    MeSH term(s) Meristem/genetics ; Meristem/metabolism ; Arabidopsis Proteins/metabolism ; Arabidopsis/metabolism ; Plant Shoots/genetics ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Stem Cells/metabolism ; Gene Expression Regulation, Plant
    Chemical Substances Arabidopsis Proteins ; Homeodomain Proteins
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2023.102452
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    In stock of ZB MED Bonn / Germany

    Z 2005/717: Show issues

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  6. Article ; Online: Effects of boundary conditions on magnetic friction.

    Sugimoto, Kentaro

    Physical review. E

    2019  Volume 99, Issue 5-1, Page(s) 52103

    Abstract: We consider magnetic friction between two square lattices of the ferromagnetic Ising model of finite thickness. We analyze the dependence on the boundary conditions and the sample thickness. Monte Carlo results indicate that the setup enables us to ... ...

    Abstract We consider magnetic friction between two square lattices of the ferromagnetic Ising model of finite thickness. We analyze the dependence on the boundary conditions and the sample thickness. Monte Carlo results indicate that the setup enables us to control the frictional force by magnetic fields on the boundaries. In addition, we confirm that the temperature derivative of the frictional force as well as that of the boundary energy has singularity at a velocity-dependent critical temperature.
    Language English
    Publishing date 2019-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.99.052103
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  7. Article ; Online: Comparison of clinical findings and subjective symptoms in a case of multiple evanescent white dot syndrome (MEWDS): A case report from a patient's perspective.

    Sugimoto, Kotaro / Murakami, Toshiki / Ojima, Akira / Sekiryu, Tetsuju

    Journal of general and family medicine

    2024  Volume 25, Issue 3, Page(s) 154–157

    Abstract: A 38-year-old pathologist developed multiple evanescent white dot syndrome (MEWDS). He documented his visual impairment in detail utilizing a light microscope for pathological diagnosis. Notably, the subjective defects illustrated by the patient were in ... ...

    Abstract A 38-year-old pathologist developed multiple evanescent white dot syndrome (MEWDS). He documented his visual impairment in detail utilizing a light microscope for pathological diagnosis. Notably, the subjective defects illustrated by the patient were in good spatiotemporal agreement with diagnostic outcomes. The present report enhances the understanding of visual impairment associated with MEWDS through a comparative analysis of subjective experiences and objective clinical findings.
    Language English
    Publishing date 2024-02-25
    Publishing country Japan
    Document type Case Reports
    ISSN 2189-7948
    ISSN (online) 2189-7948
    DOI 10.1002/jgf2.680
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  8. Article ; Online: [Development of Novel Preparations for Nitrogen Heterocycles Based on Cascade Reactions].

    Sugimoto, Kenji

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2018  Volume 138, Issue 9, Page(s) 1151–1161

    Abstract: Nitrogen heterocycles are important skeletons in biologically active compounds such as medicines and natural alkaloids. However, in terms of the efficiency of the synthetic process, the many synthetic steps required to achieve the target compounds with ... ...

    Abstract Nitrogen heterocycles are important skeletons in biologically active compounds such as medicines and natural alkaloids. However, in terms of the efficiency of the synthetic process, the many synthetic steps required to achieve the target compounds with complex architectures pose a significant problem. To overcome this challenge, novel approaches were developed to afford biologically active heterocycles, 1,2-diazepines, pyrroloisoquinolines, and pyrrolizidines utilizing cascade reactions that enable multiple bond formation in a one-pot process. This review discusses three one-pot reactions: 1) 1,2-diazepine synthesis from cyclobutenones and lithiodiazoesters via cascade 4π-8π electrocyclization; 2) synthesis of pyrroloisoquinolines from alkynylimino esters triggered by gold-catalyzed azomethine ylide formation; and 3) pyrrolizidine synthesis via three-component coupling reactions of iminoesters, acetylenes, and maleimides through the gold-catalyzed azomethine ylide generation/[3+2]-cycloaddition/enamine cyclization reaction.
    MeSH term(s) Azo Compounds/chemical synthesis ; Catalysis ; Cyclization ; Gold/chemistry ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Nitrogen Compounds/chemical synthesis ; Nitrogen Compounds/chemistry ; Organic Chemistry Phenomena ; Pyrroles/chemistry ; Pyrrolizidine Alkaloids/chemical synthesis ; Pyrrolizidine Alkaloids/chemistry ; Quinolines/chemistry ; Thiosemicarbazones/chemical synthesis
    Chemical Substances Azo Compounds ; Heterocyclic Compounds ; Nitrogen Compounds ; Pyrroles ; Pyrrolizidine Alkaloids ; Quinolines ; Thiosemicarbazones ; azomethine ; pyrroloquinoline ; Gold (7440-57-5)
    Language Japanese
    Publishing date 2018-09-13
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.18-00122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article: [Side Effects of Anticoagulant and Antithrombotic Therapy and their Management].

    Sugimoto, Koichi

    Masui. The Japanese journal of anesthesiology

    2018  Volume 65, Issue 7, Page(s) 724–733

    Abstract: The risk of thromboembolic event increases in patients who discontinue antithrombotic therapy, and there is no need to discontinue nonsteroidal anti- inflammatory drugs (NSAIDs), including low dose aspirin prior to interventional procedures. In contrast ... ...

    Abstract The risk of thromboembolic event increases in patients who discontinue antithrombotic therapy, and there is no need to discontinue nonsteroidal anti- inflammatory drugs (NSAIDs), including low dose aspirin prior to interventional procedures. In contrast low-molecular-weight heparin (LMWH) or unfraction- ated heparin can be discontinued 12 hours prior to interventional procedures. Warfarin should be discon- tihued and international normalized ratio (INR) should be normalized to 1.4 or less for high risk procedures and 2 or less for low risk procedures. Necessity of dis- continuation of platelet aggregation inhibitors depends on the patient's condition, the planned procedure, risk factors, and the cardiologist's opinion.
    MeSH term(s) Anticoagulants/adverse effects ; Aspirin/adverse effects ; Heparin/adverse effects ; Heparin, Low-Molecular-Weight/adverse effects ; Humans ; Platelet Aggregation Inhibitors/adverse effects ; Thromboembolism/chemically induced ; Warfarin/adverse effects
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight ; Platelet Aggregation Inhibitors ; Warfarin (5Q7ZVV76EI) ; Heparin (9005-49-6) ; Aspirin (R16CO5Y76E)
    Language Japanese
    Publishing date 2018-10-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 391878-6
    ISSN 0021-4892
    ISSN 0021-4892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 360: Show issues Location:
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  10. Article ; Online: Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases.

    Sugimoto, Katsunori

    Current genetics

    2018  Volume 64, Issue 5, Page(s) 965–970

    Abstract: Phosphatidylinositol 3-kinase-related kinases (PIKKs), are structurally related to phosphatidylinositol 3-kinase (lipid kinase), but possess protein kinase activities. PIKKs include ATM, ATR, DNA-PK, mTOR and SMG1, key regulators of cell proliferation ... ...

    Abstract Phosphatidylinositol 3-kinase-related kinases (PIKKs), are structurally related to phosphatidylinositol 3-kinase (lipid kinase), but possess protein kinase activities. PIKKs include ATM, ATR, DNA-PK, mTOR and SMG1, key regulators of cell proliferation and genome maintenance. TRRAP, which is devoid of protein kinase activity, is the sixth member of the PIKK family. PIKK family members are gigantic proteins in the range of 300-500 kDa. It has become apparent in the last decade that the stability or maturation of the PIKK family members depends on a molecular chaperone called the Tel2-Tti1-Tti2 (TTT) complex. Several lines of evidence have established a model in which TTT connects to the Hsp90 chaperone through the Rvb1-Rvb2-Tah1-Pih1 (R2TP) complex in mammalian and yeast cells. However, recent studies of yeast cells indicate that TTT is able to form different complexes. These observations raise a possibility that several different mechanisms regulate TTT-mediated protein stability of PIKKs.
    MeSH term(s) Casein Kinase II/metabolism ; Enzyme Stability ; HSP90 Heat-Shock Proteins/metabolism ; Molecular Chaperones/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Schizosaccharomyces/metabolism ; Telomere-Binding Proteins/metabolism
    Chemical Substances HSP90 Heat-Shock Proteins ; Molecular Chaperones ; Saccharomyces cerevisiae Proteins ; Tel2 protein, S cerevisiae ; Telomere-Binding Proteins ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Casein Kinase II (EC 2.7.11.1)
    Language English
    Publishing date 2018-02-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282876-5
    ISSN 1432-0983 ; 0172-8083
    ISSN (online) 1432-0983
    ISSN 0172-8083
    DOI 10.1007/s00294-018-0817-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2586: Show issues Location:
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