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  1. Article: Acute Decompensated Heart Failure in Patients with Heart Failure with Preserved Ejection Fraction.

    Sugimoto, Tadafumi

    Heart failure clinics

    2020  Volume 16, Issue 2, Page(s) 201–209

    Abstract: There are few treatment options for acute decompensated heart failure patients with preserved ejection fraction, but an increasing number of patients with heart failure with preserved ejection fraction. A deeper understanding of the cause, diagnosis, and ...

    Abstract There are few treatment options for acute decompensated heart failure patients with preserved ejection fraction, but an increasing number of patients with heart failure with preserved ejection fraction. A deeper understanding of the cause, diagnosis, and prognosis of heart failure with preserved ejection fraction may be informative for clinical practice or clinical decision making and therapeutic investigation in the acute care setting.
    MeSH term(s) Clinical Decision-Making ; Emergency Treatment/methods ; Heart Failure/physiopathology ; Heart Failure/therapy ; Hemodynamics ; Humans ; Prognosis ; Stroke Volume
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2019.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6554: Show issues Location:
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  2. Article: [112th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: Emerging Comorbidities of Diabetes Mellitus: Osteoporosis].

    Sugimoto, Toshitsugu

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2018  Volume 104, Issue 9, Page(s) 1891–1896

    MeSH term(s) Bone Density ; Diabetes Complications ; Diabetes Mellitus ; Humans ; Osteoporosis/etiology ; Osteoporosis/physiopathology ; Osteoporotic Fractures/etiology ; Risk Factors
    Language Japanese
    Publishing date 2018-09-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
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    Zs.B 594: Show issues Location:
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  3. Article ; Online: Detection of Internal Defects in Concrete and Evaluation of a Healthy Part of Concrete by Noncontact Acoustic Inspection Using Normalized Spectral Entropy and Normalized SSE.

    Sugimoto, Kazuko / Sugimoto, Tsuneyoshi

    Entropy (Basel, Switzerland)

    2022  Volume 24, Issue 2

    Abstract: Non-destructive testing, with non-contact from a remote location, to detect and visualize internal defects in composite materials such as a concrete is desired. Therefore, a noncontact acoustic inspection method has been studied. In this method, the ... ...

    Abstract Non-destructive testing, with non-contact from a remote location, to detect and visualize internal defects in composite materials such as a concrete is desired. Therefore, a noncontact acoustic inspection method has been studied. In this method, the measurement surface is forced to vibrate by powerful aerial sound waves from a remote sound source, and the vibration state is measured by a laser Doppler vibrometer. The distribution of acoustic feature quantities (spectral entropy and vibrational energy ratio) is analyzed to statistically identify and evaluate healthy parts of concrete. If healthy parts in the measuring plane can be identified, the other part is considered to be internal defects or an abnormal measurement point. As a result, internal defects are detected. Spectral entropy (SE) was used to distinguish between defective parts and healthy parts. Furthermore, in order to distinguish between the resonance of a laser head and the resonance of the defective part of the concrete, spatial spectral entropy (SSE) was also used. SSE is an extension of the concept of SE to a two-dimensional measuring space. That is, based on the concept of SE, SSE is calculated, at each frequency, for spatial distribution of vibration velocity spectrum in the measuring plane. However, these two entropy values were used in unnormalized expressions. Therefore, although relative evaluation within the same measurement surface was possible, there was the issue that changes in the entropy value could not be evaluated in a unified manner in measurements under different conditions and environments. Therefore, this study verified whether it is possible to perform a unified evaluation for different defective parts of concrete specimen by using normalized SE and normalized SSE. From the experimental results using cavity defects and peeling defects, the detection and visualization of internal defects in concrete can be effectively carried out by the following two analysis methods. The first is using both the normalized SE and the evaluation of a healthy part of concrete. The second is the normalized SSE analysis that detects resonance frequency band of internal defects.
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e24020142
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  4. Article ; Online: A Narrative Review of Sulfur Compounds in Whisk(e)y.

    Wanikawa, Akira / Sugimoto, Toshikazu

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 5

    Abstract: The production process of whisky consists of malting, mashing, fermentation, distillation and maturation. Sulfur volatile compounds generated during this process have long attracted interest because they influence quality in general. More than forty ... ...

    Abstract The production process of whisky consists of malting, mashing, fermentation, distillation and maturation. Sulfur volatile compounds generated during this process have long attracted interest because they influence quality in general. More than forty compounds have been reported: they are formed during malting, fermentation, and distillation, but some may decrease in concentration during distillation and maturation. In sensory analysis, sulfur characteristics are described as sulfury, meaty, cereal, feinty, and vegetable, among others. Their contribution to overall quality depends on their concentration, with a positive contribution at low levels, but a negative contribution at high levels. Chemical analyses of sulfur volatiles have been developed by using sulfur-selective detectors and multi-dimensional gas chromatography to overcome the numerous interferences from the matrix. Formation pathways, thresholds, and contribution have not been elucidated completely; therefore, methods for integrating diverse data and knowledge, as well as novel technical innovations, will be needed to control sulfur volatiles in the future.
    MeSH term(s) Distillation ; Fermentation ; Gas Chromatography-Mass Spectrometry/methods ; Sulfur Compounds/chemistry ; Volatile Organic Compounds/analysis
    Chemical Substances Sulfur Compounds ; Volatile Organic Compounds
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27051672
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  5. Article ; Online: Regulation of Skeletal Muscle Function by Amino Acids, Especially Non-Proteinogenic Amino Acids.

    Sugimoto, Takumi / Kamei, Yasutomi

    Journal of nutritional science and vitaminology

    2022  Volume 68, Issue Supplement, Page(s) S31–S33

    Abstract: Amino acids are compounds that contain an amino group (- ... ...

    Abstract Amino acids are compounds that contain an amino group (-NH
    MeSH term(s) Middle Aged ; Humans ; Animals ; Mice ; Aged ; Amino Acids ; Diabetes Mellitus, Type 2 ; Muscle, Skeletal ; beta-Alanine/pharmacology ; Leucine/pharmacology ; Mammals
    Chemical Substances Amino Acids ; beta-Alanine (11P2JDE17B) ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2022-09-23
    Publishing country Japan
    Document type Review ; Journal Article
    ZDB-ID 191366-9
    ISSN 1881-7742 ; 0301-4800
    ISSN (online) 1881-7742
    ISSN 0301-4800
    DOI 10.3177/jnsv.68.S31
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    Zs.B 596: Show issues Location:
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  6. Article: Safety Profile of the Concomitant Use of Atorvastatin and Cyclosporine in Renal Transplant Recipients.

    Harabayashi, R / Takahashi, M / Takahashi, K / Sugimoto, T / Uchida, J / Nakamura, Y / Nagayama, K

    Die Pharmazie

    2023  Volume 78, Issue 5, Page(s) 47–50

    Abstract: Cyclosporine (CyA) and atorvastatin (AT) are often administered concomitantly to treat dyslipidemia in renal transplant recipients. However, CyA greatly increases the plasma concentration of AT; therefore, concomitant use might increase the frequency of ... ...

    Abstract Cyclosporine (CyA) and atorvastatin (AT) are often administered concomitantly to treat dyslipidemia in renal transplant recipients. However, CyA greatly increases the plasma concentration of AT; therefore, concomitant use might increase the frequency of statin-induced adverse effects. The aim of this study was to investigate whether concomitant use of CyA and AT increases intolerance of the latter agent in Japanese renal transplantation recipients. We performed a retrospective cohort analysis of renal transplant recipients aged 18 years and older who had concomitantly received AT and CyA, or tacrolimus (Tac) therapy. We defined statin intolerance as a decrease in dose or discontinuation of AT due to adverse effects. We evaluated the incidence of statin intolerance in concomitant therapy with CyA for 100 days after the initial administration of AT in comparison with Tac. A total of 144 renal transplant recipients who received AT and CyA, or Tac between January 2013 and December 2019 were included. There was no statistical difference in the incidence of statin intolerance in both the CyA (1.8%; 1/57 patients) and Tac (3.4%; 3/87 patients) groups. Concomitant use of CyA and AT might not increase the incidence of statin intolerance in Japanese renal transplant recipients.
    MeSH term(s) Humans ; Cyclosporine/adverse effects ; Immunosuppressive Agents/pharmacology ; Atorvastatin/adverse effects ; Tacrolimus/adverse effects ; Kidney Transplantation/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Retrospective Studies
    Chemical Substances Cyclosporine (83HN0GTJ6D) ; Immunosuppressive Agents ; Atorvastatin (A0JWA85V8F) ; Tacrolimus (WM0HAQ4WNM) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-05-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208793-5
    ISSN 0031-7144
    ISSN 0031-7144
    DOI 10.1691/ph.2023.2582
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  7. Article ; Online: Quantum Chemical Study of the Cycloaddition Reaction of Tropone with 1,1-Diethoxyethene Catalyzed by B(C

    Sakata, Ken / Suzuki, Sarina / Sugimoto, Tsubasa / Yoshikawa, Takeshi

    ACS omega

    2023  Volume 8, Issue 33, Page(s) 30410–30420

    Abstract: Cycloaddition reaction of tropone with 1,1-diethoxyethene catalyzed by Lewis acid (LA), B( ... ...

    Abstract Cycloaddition reaction of tropone with 1,1-diethoxyethene catalyzed by Lewis acid (LA), B(C
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c03560
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  8. Article ; Online: Correction to "Three-Component Synthesis of Quinoline-4-carboxylic Acids Based on Doebner Hydrogen-Transfer Reaction".

    Komatsu, Hideyuki / Shigeyama, Takahide / Sugimoto, Takuya / Nishiyama, Hiroyuki

    The Journal of organic chemistry

    2023  Volume 88, Issue 19, Page(s) 14255

    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c01967
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    Zs.A 4473: Show issues Location:
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  9. Article ; Online: Broadband Tip-Enhanced Nonlinear Optical Response in a Plasmonic Nanocavity.

    Takahashi, Shota / Sakurai, Atsunori / Mochizuki, Tatsuto / Sugimoto, Toshiki

    The journal of physical chemistry letters

    2023  Volume 14, Issue 30, Page(s) 6919–6926

    Abstract: We report a significantly broad nonlinear optical response enhanced in a tip-substrate plasmonic nanocavity. Focusing on the near-field second harmonics of the wavelength-tunable femtosecond laser, we demonstrate that the tip-enhancement of nonlinear ... ...

    Abstract We report a significantly broad nonlinear optical response enhanced in a tip-substrate plasmonic nanocavity. Focusing on the near-field second harmonics of the wavelength-tunable femtosecond laser, we demonstrate that the tip-enhancement of nonlinear optical effects efficiently works over the broad wavelength range through the visible to infrared region. We also found that this broadband nonlinear optical property is directly affected not only by the nanometer-scale sharpness of the tip apexes but also by the micrometer-scale surface geometry of the tip shafts. While spatially nonlocal plasmonic modes excited throughout the micrometer-scale tip shafts enhance near-to-mid-infrared incoming light, the radiation of visible-to-near-infrared second harmonics is boosted by localized plasmons at the nanogap. These two plasmonic modes simultaneously affect the excitation and emission processes, realizing the strong and broad enhancement of second harmonic generation. Our results provide a new basis for the physical understanding and fine manipulation of nonlinear optical phenomena enhanced in plasmonic nanocavities.
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c01343
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  10. Article ; Online: Three-Component Synthesis of Quinoline-4-carboxylic Acids Based on Doebner Hydrogen-Transfer Reaction.

    Komatsu, Hideyuki / Shigeyama, Takahide / Sugimoto, Takuya / Nishiyama, Hiroyuki

    The Journal of organic chemistry

    2023  Volume 88, Issue 17, Page(s) 12816–12820

    Abstract: The Doebner hydrogen-transfer reaction has been developed for the synthesis of substituted quinolines from anilines possessing electron-withdrawing groups, which are known to give products in low yields when used in the conventional Doebner reaction. ... ...

    Abstract The Doebner hydrogen-transfer reaction has been developed for the synthesis of substituted quinolines from anilines possessing electron-withdrawing groups, which are known to give products in low yields when used in the conventional Doebner reaction. This reaction can be applied to not only anilines having electron-withdrawing groups but also those having electron-donating groups and can be used in the large-scale synthesis of bioactive molecules.
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c01123
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