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Article ; Online: Peroral cholangioscopy-guided biopsy with novel biopsy forceps in comprehensive cancer genomic profiling for cystic duct carcinoma.

Kawakami, Yujiro / Masaki, Yoshiharu / Ishigami, Keisuke / Hirano, Takehiro / Murota, Ayako / Sugita, Shintaro / Nakase, Hiroshi

Endoscopy

2024 Volume 56, Issue S 01, Page(s) E414–E415

MeSH term(s)	Humans ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/pathology ; Cystic Duct ; Endoscopy, Digestive System/methods ; Endoscopy, Digestive System/instrumentation ; Image-Guided Biopsy/methods ; Image-Guided Biopsy/instrumentation ; Male ; Aged ; Female ; Surgical Instruments
Language	English
Publishing date	2024-05-17
Publishing country	Germany
Document type	Journal Article ; Case Reports ; Video-Audio Media
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2313-9930
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Prognostic evaluation of the Ki-67 labeling system in histological grading of non-small round cell sarcoma: a supplementary analysis of a randomized controlled trial, JCOG1306.

Sugita, Shintaro / Tanaka, Kazuhiro / Oda, Yoshinao / Nojima, Takayuki / Konishi, Naomi / Machida, Ryunosuke / Kita, Ryosuke / Fukuda, Haruhiko / Ozaki, Toshifumi / Hasegawa, Tadashi

Japanese journal of clinical oncology

2024

Abstract: Background: Soft tissue sarcoma (STS) has various histological types and is rare, making it difficult to evaluate the malignancy of each histological type. Thus, comprehensive histological grading is most important in the pathological examination of STS. ...

Abstract	Background: Soft tissue sarcoma (STS) has various histological types and is rare, making it difficult to evaluate the malignancy of each histological type. Thus, comprehensive histological grading is most important in the pathological examination of STS. The Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grading system is most commonly used in daily pathological analysis of STS. Among the FNCLCC grading system parameters, mitotic count is a key morphological parameter reflecting the proliferative activity of tumor cells, although its reproducibility may be lacking. Here, we compared the prognostic utility of the conventional and modified FNCLCC grading systems in JCOG1306. Methods: We analyzed 140 patients with non-small round cell sarcoma. We performed Ki-67 immunostaining using open biopsy specimens before preoperative chemotherapy in all patients. We assessed histological grade in individual cases by conventional FNCLCC grading (tumor differentiation, mitotic count, and necrosis) and modified FNCLCC grading using the Ki-67 labeling index instead of mitotic count. We conducted univariable and multivariable Cox regression analyses to investigate the influence of grade on overall survival. Results: In univariable analysis, prognosis was worse for patients with conventional FNCLCC Grade 3 tumors compared with Grade 1 or 2 tumors (hazard ratio [HR] 4.21, 95% confidence interval [CI] 1.47-12.05, P = 0.008). Moreover, prognosis was worse in patients with modified FNCLCC Grade 3 tumors compared with Grade 1 or 2 tumors (HR 4.90, 95% CI 1.64-14.65, P = 0.004). In multivariable analysis including both conventional and modified FNCLCC grading, the modified grading more strongly affected overall survival (HR 6.70, 95% CI 1.58-28.40, P = 0.010). Conclusions: The modified FNCLCC grading system was superior to the conventional system in predicting the prognosis of patients with non-small round cell sarcoma according to this supplementary analysis of data from the randomized controlled trial JCOG1306.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyae020
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Zs.A 1298: Show issues

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Article ; Online: A case of IgG4-related cholecystitis diagnosed by transpapillary gallbladder biopsy using a novel device delivery system.

Kawakami, Yujiro / Kameyama, Naohiro / Hirobe, Yosuke / Masaki, Yoshiharu / Murota, Ayako / Sugita, Shintaro / Nakase, Hiroshi

Endoscopy

2023 Volume 55, Issue S 01, Page(s) E1108–E1110

MeSH term(s)	Humans ; Gallbladder/diagnostic imaging ; Gallbladder/surgery ; Immunoglobulin G ; Cholecystitis/diagnosis ; Abdomen ; Biopsy ; Drainage ; Cholecystitis, Acute
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2023-10-06
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2177-3793
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Complete Response to Eribulin in a Patient with Unresectable Liposarcoma: A Case Report and Implications of New Biomarkers.

Nakamura, Hajime / Takada, Kohichi / Emori, Makoto / Hayasaka, Naotaka / Sugita, Shintaro

Internal medicine (Tokyo, Japan)

2022 Volume 61, Issue 23, Page(s) 3617–3621

Abstract: We herein report a rare case of unresectable liposarcoma that showed a complete response to eribulin. Furthermore, a low expression of phosphorylated AKT (p-AKT) on an immunohistological evaluation was observed. This result is consistent with our ... ...

Abstract	We herein report a rare case of unresectable liposarcoma that showed a complete response to eribulin. Furthermore, a low expression of phosphorylated AKT (p-AKT) on an immunohistological evaluation was observed. This result is consistent with our previous preclinical study that demonstrated the significance of p-AKT signaling for eribulin resistance in multiple subtypes of soft tissue sarcoma (STS) cells. This case highlights the potential benefits of eribulin as well as the mechanism underlying resistance to eribulin in patients with unresectable or metastatic STS, especially liposarcoma.
MeSH term(s)	Humans ; Proto-Oncogene Proteins c-akt ; Furans/therapeutic use ; Ketones/therapeutic use ; Liposarcoma/drug therapy ; Biomarkers
Chemical Substances	eribulin (LR24G6354G) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Furans ; Ketones ; Biomarkers
Language	English
Publishing date	2022-05-07
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.9423-22
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Zs.A 240: Show issues

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Article ; Online: Diagnosis of prosthetic joint infection at the hip using the standard uptake value of three-phase 99mTc-hydroxymethylene diphosphonate SPECT/CT.

Yama, Naoya / Nagoya, Satoshi / Sugita, Shintaro / Koyama, Masayuki / Hatakenaka, Masamitsu

Annals of nuclear medicine

2022 Volume 36, Issue 7, Page(s) 634–642

Abstract: Purpose: To retrospectively investigate whether the standard uptake value (SUV) of 99mTc-bone single-photon emission computed tomography (SPECT)/CT could be useful for predicting prosthetic joint infection (PJI) at the hip.: Patients and methods: We ... ...

Abstract	Purpose: To retrospectively investigate whether the standard uptake value (SUV) of 99mTc-bone single-photon emission computed tomography (SPECT)/CT could be useful for predicting prosthetic joint infection (PJI) at the hip. Patients and methods: We analyzed the cases of 37 patients with a suspected PJI at the hip who underwent 99mTc-bone SPECT/CT and surgical intervention with pathological and bacterial examinations. We divided the cases into those with and those without a causative bacterium detected in a surgical specimen, i.e., the positive bacterial culture (PBC) group (n = 17) and negative bacterial culture (NBC) group (n = 20). Cases with neutrophilic infiltration of surgical specimen comprised the positive neutrophilic infiltration (PINF) group (n = 18) and those without INF comprised the non-neutrophilic infiltration (NINF) group (n = 19). Quantitative analyses were performed using maximum SUVs and peak SUVs of blood-pool (BP) phase images (SUVmaxBP and SUVpeakBP) and late (LT)-phase images (SUVmaxLT and SUVpeakLT). Results: Regarding the bacterial cultures, there were significant differences between the PBC and NBC groups in SUVmaxBP (5.26 ± 1.49 vs. 4.21 ± 1.15, respectively; p = 0.019), SUVpeakBP (4.89 ± 1.32 vs. 3.87 ± 1.06, p = 0.012), SUVmaxLT (16.10 ± 6.36 vs. 11.67 ± 4.95, p = 0.026), and SUVpeakLT (14.58 ± 5.83 vs. 10.49 ± 4.31 p = 0.036). Regarding neutrophilic infiltration, there were significant differences between the PINF and NINF groups in SUVmaxBP (5.18 ± 1.48 vs. 4.24 ± 1.19, p = 0.047) and SUVpeakBP (4.78 ± 1.32 vs. 3.92 ± 1.10, p = 0.043). Conclusion: An SUV analysis of 99mTc-bone SPECT/CT is a useful method to differentiate a PJI at the hip from non-infection.
MeSH term(s)	Bone and Bones ; Diphosphonates ; Humans ; Retrospective Studies ; Tomography, Emission-Computed, Single-Photon/methods ; Tomography, X-Ray Computed
Chemical Substances	Diphosphonates
Language	English
Publishing date	2022-04-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1146984-5
ISSN	1864-6433 ; 0914-7187
ISSN (online)	1864-6433
ISSN	0914-7187
DOI	10.1007/s12149-022-01745-5
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Zs.A 3657: Show issues

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Article: Peroral cholangioscopy-guided biopsy with novel biopsy forceps in comprehensive cancer genomic profiling for cystic duct carcinoma

Kawakami, Yujiro / Masaki, Yoshiharu / Ishigami, Keisuke / Hirano, Takehiro / Murota, Ayako / Sugita, Shintaro / Nakase, Hiroshi

Endoscopy

2024 Volume 56, Issue S 01, Page(s) E414–E415

Keywords	Pancreatobiliary (ERCP/PTCD) ; ERC topics ; Cholangioscopy ; Endoscopic ultrasonography ; Biliary tract ; Tissue diagnosis
Language	English
Publishing date	2024-05-17
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2313-9930
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Response to 'Is the case really a SMARCA4-deficient thoracic sarcoma?'

Takada, Kohichi / Sugita, Shintaro / Hasegawa, Tadashi

Thoracic cancer

2020 Volume 12, Issue 1, Page(s) 141

MeSH term(s)	Antibodies, Monoclonal, Humanized ; B7-H1 Antigen ; DNA Helicases ; Humans ; Nuclear Proteins ; Sarcoma/genetics ; Transcription Factors
Chemical Substances	Antibodies, Monoclonal, Humanized ; B7-H1 Antigen ; Nuclear Proteins ; Transcription Factors ; pembrolizumab (DPT0O3T46P) ; SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-)
Language	English
Publishing date	2020-11-18
Publishing country	Singapore
Document type	Letter ; Comment
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.13751
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Zs.A 6921: Show issues

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Article ; Online: Surgically treated gastric melanoma of unknown primary: A case report from a 10-year survivor.

Takahashi, Toshiyuki / Sugita, Shintaro / Kagaya, Hidetoshi / Morita, Takayuki

Pathology international

2020 Volume 70, Issue 10, Page(s) 786–792

Abstract: We describe an extremely rare case of simultaneous double melanoma of the stomach with no other obvious primary source. The patient has survived for more than 12 years post-complete gastrectomy. The patient was a woman in her seventies who was referred ... ...

Abstract	We describe an extremely rare case of simultaneous double melanoma of the stomach with no other obvious primary source. The patient has survived for more than 12 years post-complete gastrectomy. The patient was a woman in her seventies who was referred for anemia by another clinic. Esophagogastroscopy revealed an ulcerated gastric tumor that was diagnosed as a gastrointestinal stromal tumor (GIST) by endoscopic biopsy. She was admitted to our hospital for further examination and treatment. Gastroscopy at our institution revealed two submucosal tumors in the gastric wall. Since no metastatic lesions were detected after systemic exploration, multiple GIST of the stomach was diagnosed, and a total gastrectomy was performed. Malignant melanoma was diagnosed in both lesions by a histopathological study of the resected stomach. The patient's postoperative progress was good, and thorough examination of the skin did not result in the discovery of any systemic neoplastic lesions which could be regarded as the source for the primary tumor. No anticancer treatments were used. The patient has survived, with no recurrence for over ten years postsurgery. Strong evidence is presented in this case for the diagnosis and treatment of gastric malignant melanoma.
MeSH term(s)	Aged ; Cancer Survivors ; Female ; Gastrectomy ; Gastrointestinal Stromal Tumors/diagnosis ; Gastrointestinal Stromal Tumors/secondary ; Humans ; Melanoma/diagnosis ; Melanoma/secondary ; Melanoma/surgery ; Neoplasms, Unknown Primary ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/secondary ; Stomach Neoplasms/surgery
Language	English
Publishing date	2020-08-16
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.12991
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Ud II Zs.200: Show issues

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Article ; Online: Scattered Media Elastic Fibers from the Aortic Root to the Ascending Aorta in a 30-Year-Old Marfan Syndrome Patient.

Nakajima, Tomohiro / Iba, Yutaka / Naraoka, Syuichi / Shibata, Tsuyoshi / Sugita, Shintaro / Kawaharada, Nobuyoshi

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

2022 Volume 30, Issue 1

Abstract: We present a case report of a 30-year-old Marfan syndrome patient who underwent a David procedure for severe aortic valve insufficiency and Valsalva aneurysm. Harvested aortic walls were examined by pathologists. Although the tunica media of the ... ...

Abstract	We present a case report of a 30-year-old Marfan syndrome patient who underwent a David procedure for severe aortic valve insufficiency and Valsalva aneurysm. Harvested aortic walls were examined by pathologists. Although the tunica media of the ascending aorta contained aligned elastic fibers, the aortic root media lacked aligned elastic fibers.
MeSH term(s)	Humans ; Adult ; Marfan Syndrome/complications ; Marfan Syndrome/diagnosis ; Marfan Syndrome/surgery ; Aorta, Thoracic ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/etiology ; Aortic Aneurysm/surgery ; Elastic Tissue ; Treatment Outcome
Language	English
Publishing date	2022-05-19
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2019756-1
ISSN	2186-1005 ; 1341-1098
ISSN (online)	2186-1005
ISSN	1341-1098
DOI	10.5761/atcs.cr.22-00044
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Zs.A 5253: Show issues

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Article ; Online: Pemphigus vulgaris as an immune-related adverse event in recurrent metastatic esophageal squamous cell carcinoma treated with ipilimumab plus nivolumab: a case report and literature review.

Nakamura, Hajime / Shionoya, Aika / Arihara, Yohei / Hayasaka, Naotaka / Kubo, Tomohiro / Usami, Makoto / Sugita, Shintaro / Uhara, Hisashi / Takada, Kohichi

Frontiers in immunology

2023 Volume 14, Page(s) 1259071

Abstract: Ipilimumab plus nivolumab therapy is approved for patients with unresectable advanced esophageal squamous cell carcinoma (ESCC). Although a combination of immune checkpoint inhibitors (ICIs), compared to conventional chemotherapy, can improve overall ... ...

Abstract	Ipilimumab plus nivolumab therapy is approved for patients with unresectable advanced esophageal squamous cell carcinoma (ESCC). Although a combination of immune checkpoint inhibitors (ICIs), compared to conventional chemotherapy, can improve overall survival in patients with advanced ESCC, this increases the incidence of immune-related adverse events (irAEs). Here, we describe an ESCC case that developed pemphigus vulgaris (PV), an extremely rare cutaneous irAE, during ipilimumab plus nivolumab treatment. The patient achieved a partial response to treatment. The PV was successfully managed after the cessation of ipilimumab and the use of a topical steroid. We should thus re-treat ESCC with nivolumab monotherapy. In the era of ICIs as standard cancer therapeutics, diagnostic criteria for blistering diseases need to be established to properly manage patients with cutaneous irAEs.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/diagnosis ; Esophageal Squamous Cell Carcinoma/drug therapy ; Pemphigus/diagnosis ; Pemphigus/drug therapy ; Ipilimumab/adverse effects ; Nivolumab/adverse effects ; Esophageal Neoplasms/drug therapy
Chemical Substances	Ipilimumab ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2023-09-11
Publishing country	Switzerland
Document type	Review ; Case Reports
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1259071
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