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  1. AU="Suhlrie, Adriana"
  2. AU="Palència, Laia"
  3. AU="Crump, Michael"
  4. AU="Noyori, Osamu"
  5. AU="Atibordee Meesing"

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  1. Book ; Thesis: Renales Outcome und Komorbiditäten bei Patienten mit juveniler proliferativer Lupusnephritis

    Suhlrie, Adriana / Haffner, Dieter

    eine Auswertung des Lupusnephritis Registers der Gesellschaft für Pädiatrische Nephrologie

    2020  

    Institution Medizinische Hochschule Hannover
    Klinik für Pädiatrische Nieren-, Leber- und Stoffwechselerkrankungen und Neuropädiatrie
    Author's details vorgelegt von Adriana Suhlrie ; aus dem Zentrum für Kinderheilkunde Klinik für Pädiatrische Nieren-, Leber- und Stoffwechselerkrankungen der Medizinischen Hochschule Hannover ; Betreuer/in der Arbeit: Prof. Dr. med. Dieter Haffner
    Language German ; English
    Size 30 Blätter, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2021
    Note Text auf Deutsch, Sonderabdruck auf Englisch ; Enthält 1 Zeitschriftenaufsatz aus „Pediatric Nephrology", Jg. 35 (2020)
    HBZ-ID HT021013555
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2021 E 998 order for loan Magazin

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  2. Article ; Online: LMS-Based Pediatric Reference Values for Parameters of Phosphate Homeostasis in the HARP Cohort.

    Pott, Veronika / Tietze, Helene / Kanzelmeyer, Nele / von der Born, Jeannine / Baumann, Ulrich / Mindermann, Charlotte / Suhlrie, Adriana / Drube, Jens / Melk, Anette / Das, Anibh M / Schnabel, Dirk / Haffner, Dieter / Leifheit-Nestler, Maren

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 3, Page(s) 668–679

    Abstract: Context: The assessment of phosphate homeostasis in children is challenging due to the marked changes in laboratory parameters during growth and development, and the lack of adequate reference values.: Objective: To develop Lambda-Mu-Sigma (LMS)- ... ...

    Abstract Context: The assessment of phosphate homeostasis in children is challenging due to the marked changes in laboratory parameters during growth and development, and the lack of adequate reference values.
    Objective: To develop Lambda-Mu-Sigma (LMS)-based continuous pediatric reference percentiles for 7 key laboratory parameters of phosphate homeostasis.
    Methods: This cross-sectional, single-center study, the HAnnover Reference values for Pediatrics (HARP) study, included 455 children aged 0.1-18 years (254 boys) from outpatient hospital clinics and a secondary school program. Main outcome measures were LMS-based continuous reference percentiles for serum phosphate, plasma intact fibroblast growth factor 23 (iFGF23), and its cofactor soluble Klotho (sKlotho), tubular maximum phosphate reabsorption per glomerular filtration rate (TmP/GFR), fractional tubular reabsorption of phosphate (TRP), and urinary calcium/creatinine (Ca/Crea) and phosphate/creatinine (Pi/Crea) ratios.
    Results: LMS-based percentiles and z-scores were established for 7 key laboratory parameters of phosphate homeostasis, which were all found to be age-dependent. Serum phosphate, TmP/GFR, and sKlotho associated with sex. Serum phosphate, TmP/GFR, and urinary Ca/Crea and Pi/Crea levels were highest in infancy and declined until age 18 years, while phosphate and TmP/GFR values reached adult levels earlier in girls compared to boys. iFGF23 concentrations are highest in infancy and fall to a stable plateau by 4 years of age, while sKlotho peaks during adolescence.
    Conclusion: This is the first report of LMS-based continuous pediatric reference percentiles for key laboratory parameters of phosphate homeostasis that allow calculation of standardized patient z-scores to facilitate test result interpretation in children and adolescents.
    MeSH term(s) Male ; Adult ; Female ; Adolescent ; Humans ; Child ; Reference Values ; Cross-Sectional Studies ; Creatinine/urine ; Phosphates ; Glomerular Filtration Rate ; Fibroblast Growth Factors ; Homeostasis ; Carrier Proteins ; Cytokines
    Chemical Substances Creatinine (AYI8EX34EU) ; pleiotrophin (134034-50-7) ; Phosphates ; Fibroblast Growth Factors (62031-54-3) ; Carrier Proteins ; Cytokines
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: LMS-based continuous pediatric reference values for soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin (OPG) in the HARP cohort.

    Tietze, Helene / Pott, Veronika / Kanzelmeyer, Nele / Memaran, Nima / Baumann, Ulrich / Mindermann, Charlotte / Suhlrie, Adriana / Drube, Jens / Melk, Anette / Das, Anibh M / Schnabel, Dirk / Haffner, Dieter / Leifheit-Nestler, Maren

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2023  Volume 35, Issue 3, Page(s) 533–542

    Abstract: Soluble RANKL (sRANKL) and osteoprotegerin (OPG) are regulators of osteoclast differentiation and activation, but adequate pediatric reference values are lacking. Here we provide LMS (Lambda-Mu-Sigma)-based continuous pediatric reference percentiles for ... ...

    Abstract Soluble RANKL (sRANKL) and osteoprotegerin (OPG) are regulators of osteoclast differentiation and activation, but adequate pediatric reference values are lacking. Here we provide LMS (Lambda-Mu-Sigma)-based continuous pediatric reference percentiles for sRANKL, OPG and sRANKL/OPG ratio that will allow calculation of standardized patient z-scores to assess bone modeling in children.
    Purpose: Soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin (OPG) are regulators of osteoclast differentiation and activation and thus bone metabolic turnover in children. Adequate pediatric reference values for their serum/plasma concentrations are lacking. The development of Lambda-Mu-Sigma (LMS)-based continuous reference percentiles for laboratory parameters allow improved data interpretation in clinical practice.
    Methods: A total of 300 children aged 0.1-18 years (166 boys) were enrolled in the HAnnover Reference values for Pediatrics (HARP) study. sRANKL and OPG were assessed by ELISA. LMS-based continuous reference percentiles were generated using RefCurv software.
    Results: LMS-based percentiles were established for sRANKL, OPG and sRANKL/OPG ratio, which were all found to be age-dependent. sRANKL and sRANKL/OPG associated with sex. In boys, sRANKL percentiles were highest during infancy, followed by a continuous decline until the age of 7 years and a second peak around age 12-13 years. In girls, a continuous, slow decline of sRANKL percentiles was noticed from infancy onwards until the age of 13 years, followed by a rapid decline until adulthood. OPG percentiles continuously declined from infancy to adulthood. The percentiles for sRANKL/OPG ratio paralleled those of sRANKL. Serum concentrations of sRANKL correlated with OPG and serum phosphate z-scores, while OPG concentrations inversely associated with standardized body weight, BMI, and urinary phosphate to creatinine ratio (each p < 0.05).
    Conclusion: This is the first report of LMS-based continuous pediatric reference percentiles for sRANKL, OPG and sRANKL/OPG ratio that allows calculation of standardized patient z-scores to assess bone metabolic turnover in children.
    MeSH term(s) Child ; Female ; Humans ; Male ; Carrier Proteins ; Cytokines ; Osteoprotegerin ; Phosphates ; RANK Ligand ; Reference Values ; Adolescent
    Chemical Substances Carrier Proteins ; Cytokines ; Osteoprotegerin ; Phosphates ; pleiotrophin (134034-50-7) ; RANK Ligand
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-023-06959-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3163: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Twelve-month outcome in juvenile proliferative lupus nephritis: results of the German registry study.

    Suhlrie, Adriana / Hennies, Imke / Gellermann, Jutta / Büscher, Anja / Hoyer, Peter / Waldegger, Siegfried / Wygoda, Simone / Beetz, Rolf / Lange-Sperandio, Bärbel / Klaus, Günter / Konrad, Martin / Holder, Martin / Staude, Hagen / Rascher, Wolfgang / Oh, Jun / Pape, Lars / Tönshoff, Burkhard / Haffner, Dieter

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 35, Issue 7, Page(s) 1235–1246

    Abstract: Background: Children presenting with proliferative lupus nephritis (LN) are treated with intensified immunosuppressive protocols. Data on renal outcome and treatment toxicity is scare.: Methods: Twelve-month renal outcome and comorbidity were ... ...

    Abstract Background: Children presenting with proliferative lupus nephritis (LN) are treated with intensified immunosuppressive protocols. Data on renal outcome and treatment toxicity is scare.
    Methods: Twelve-month renal outcome and comorbidity were assessed in 79 predominantly Caucasian children with proliferative LN reported to the Lupus Nephritis Registry of the German Society of Paediatric Nephrology diagnosed between 1997 and 2015.
    Results: At the time of diagnosis, median age was 13.7 (interquartile range 11.8-15.8) years; 86% showed WHO histology class IV, nephrotic range proteinuria was noted in 55%, and median estimated glomerular filtration rate amounted to 75 ml/min/1.73 m
    Conclusions: In this cohort of juvenile proliferative LN, renal outcome at 12 months was good irrespectively if patients received induction treatment with MMF or IVCYC, but glucocorticoid toxicity was very high underscoring the need for corticoid sparing protocols. Graphical abstract.
    MeSH term(s) Adolescent ; Child ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/adverse effects ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/adverse effects ; Female ; Germany ; Glucocorticoids/adverse effects ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Lupus Nephritis/drug therapy ; Male ; Mycophenolic Acid/administration & dosage ; Mycophenolic Acid/adverse effects ; Prospective Studies ; Registries ; Remission Induction ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Enzyme Inhibitors ; Glucocorticoids ; Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P) ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2020-03-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04501-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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