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  1. Article: [Involvement of microbiota in IBD and bacteriotherapy].

    Yoshimatsu, Yusuke / Sujino, Tomohisa / Kanai, Takanori

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2023  Volume 120, Issue 7, Page(s) 554–561

    MeSH term(s) Humans ; Microbiota ; Fecal Microbiota Transplantation ; Inflammatory Bowel Diseases/therapy
    Language Japanese
    Publishing date 2023-07-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.120.554
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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.34: Show issues Location:
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    Zs.MO 477: Show issues

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  2. Article ; Online: Protocol to isolate and enrich mouse splenic naive CD4

    Harada, Yosuke / Miyamoto, Kentaro / Sujino, Tomohisa

    STAR protocols

    2022  Volume 3, Issue 4, Page(s) 101728

    Abstract: Recent studies have shown that ... ...

    Abstract Recent studies have shown that CD4
    MeSH term(s) Mice ; Animals ; CD8-Positive T-Lymphocytes ; Intestinal Mucosa ; CD4-Positive T-Lymphocytes
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101728
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  3. Article: Reviewing not Homer's Iliad, but "Kai Bao Ben Cao": indigo dye-the past, present, and future.

    Yoshimatsu, Yusuke / Sujino, Tomohisa / Kanai, Takanori

    Intestinal research

    2022  Volume 21, Issue 2, Page(s) 174–176

    Language English
    Publishing date 2022-06-14
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3018469-1
    ISSN 2288-1956 ; 1598-9100
    ISSN (online) 2288-1956
    ISSN 1598-9100
    DOI 10.5217/ir.2022.00018
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  4. Article ; Online: Video capsule endoscopy in overt and occult obscure gastrointestinal bleeding: Insights from a single-center, observational study in Japan.

    Tojo, Anna / Sujino, Tomohisa / Hayashi, Yukie / Kamiya, Kenji J L Limpias / Sato, Moe / Hinako, Sakurai / Yoshimatsu, Yusuke / Kinoshita, Satoshi / Kiyohara, Hiroki / Mikami, Yohei / Takabayashi, Kaoru / Kato, Motohiko / Ogata, Haruhiko / Kanai, Takanori / Hosoe, Naoki

    DEN open

    2024  Volume 4, Issue 1, Page(s) e354

    Abstract: Objective: This study aimed to evaluate the use of video capsule endoscopy (VCE) in patients with obscure gastrointestinal bleeding (OGIB), compare cases of overt and occult OGIB, assess the rates of balloon-assisted enteroscopy (BAE) interventions and ... ...

    Abstract Objective: This study aimed to evaluate the use of video capsule endoscopy (VCE) in patients with obscure gastrointestinal bleeding (OGIB), compare cases of overt and occult OGIB, assess the rates of balloon-assisted enteroscopy (BAE) interventions and rebleeding, and identify predictive markers of positive VCE findings.
    Methods: Medical records of 430 patients who underwent VCE for OGIB between 2004 and 2022 were analyzed. Occult OGIB was defined as IDA or positive fecal occult blood, whereas overt OGIB was defined as clinically imperceptible bleeding. We retrospectively analyzed demographics, VCE findings based on Saurin classification (P0, P1, and P2), outcome of BAE interventions, and rebleeding rates.
    Results: A total of 253 patients with overt OGIB and 177 with occult OGIB were included. P1 findings were predominant in both groups, with a similar distribution. The percentage of patients receiving conservative therapy was higher in P1 than in P2 for both overt and occult OGIB. BAE was more frequently performed in P2 than in P1 VCE (83.0% vs. 35.3% in overt OGIB, 84.4% vs. 24.4% in occult OGIB). The percentage of positive findings and intervention in total BAE performed patients were comparable in P1 and P2 of overt OGIB, whereas these percentages in P2 were more than P1 of occult OGIB.
    Conclusion: VCE effectively identified OGIB lesions requiring intervention, particularly occult OGIB lesions, potentially reducing unnecessary BAE. Rebleeding rates varied according to the VCE findings, emphasizing the importance of follow-up in high-risk patients.
    Language English
    Publishing date 2024-04-01
    Publishing country Australia
    Document type Journal Article
    ISSN 2692-4609
    ISSN (online) 2692-4609
    DOI 10.1002/deo2.354
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  5. Article: [The Relationship between Gut Microbiome, Immune System, and Cancer].

    Ichikawa, Masataka / Sujino, Tomohisa / Kanai, Takanori

    Gan to kagaku ryoho. Cancer & chemotherapy

    2019  Volume 46, Issue 12, Page(s) 1807–1813

    Abstract: Various microbes having been living in our intestine and forming the gut microbiome. When dysbiosis which is typically characterized by reduced microbial diversity occurs, many types of diseases are triggered in our bodies. Recently, relationship between ...

    Abstract Various microbes having been living in our intestine and forming the gut microbiome. When dysbiosis which is typically characterized by reduced microbial diversity occurs, many types of diseases are triggered in our bodies. Recently, relationship between gut microbiome and our immune function are discovered gradually. From this view point, the gut microbiome may have an influence on cancer medicine such as development, therapy(immune checkpoint blockade or chemotherapy), and therapeutic toxicity. In real clinical practice, this influence is reported in some cases such as colorectal cancer and other malignancies. In the near future, the approach from gut microbiome may be a clue to improve the existent cancer diagnosis and therapy. In addition, the modulation of gut microbiome in itself, for example fecal microbiota transplant(FMT), probiotics, and limited usage of antibiotics, is expected to be hints for cancer medicine, though this is not yet established and further studies are needed.
    MeSH term(s) Dysbiosis ; Fecal Microbiota Transplantation ; Gastrointestinal Microbiome ; Humans ; Immune System
    Language Japanese
    Publishing date 2019-12-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Ulcerative colitis-associated neoplasms often harbor poor prognostic histologic components with low detection by biopsy.

    Sakakibara, Ryoya / Sugimoto, Shinya / Takabayashi, Kaoru / Kiyohara, Hiroki / Wakisaka, Yusuke / Kaieda, Yuta / Kawaida, Miho / Yoshimatsu, Yusuke / Sujino, Tomohisa / Hosoe, Naoki / Kato, Motohiko / Shimoda, Masayuki / Mikami, Yohei / Iwao, Yasushi / Kanai, Takanori

    Intestinal research

    2024  

    Abstract: Background/aims: Poorly differentiated adenocarcinoma, signet-ring cell carcinoma, and mucinous adenocarcinoma (por/sig/muc), which are considered to be histologic subtypes with a poor prognosis, occur more frequently with colitis-associated cancer than ...

    Abstract Background/aims: Poorly differentiated adenocarcinoma, signet-ring cell carcinoma, and mucinous adenocarcinoma (por/sig/muc), which are considered to be histologic subtypes with a poor prognosis, occur more frequently with colitis-associated cancer than with sporadic tumors. However, their invasiveness and manifestations are unclear. This study aimed to determine the prevalence of the por/sig/muc component in ulcerative colitis-associated neoplasms (UCANs) and its association with invasiveness and to clarify its clinicohistologic and endoscopic features.
    Methods: This retrospective observational study included patients diagnosed with ulcerative colitis-associated high-grade dysplasia or adenocarcinoma from 1997 to 2022 who were divided according to the presence or absence of a por/sig/muc component.
    Results: Thirty-five patients had UCAN with a por/sig/muc component and 66 had UCAN without this component. The 5-year survival rate was significantly lower in the por/sig/muc group than in the tub group (67% vs. 96%, P= 0.001), which was attributed to disease above stage III and depth to below the subserosa. Biopsy-based diagnosis before resection detected a por/sig/muc component in only 40% of lesions (14/35). Lesions with a por/sig/muc component were prevalent even in the early stages: stage 0 (4/36, 11%), I (8/20, 40%), II (7/12, 58%), III (10/14, 71%), and IV (6/8, 75%).
    Conclusions: This is the first investigation that shows UCANs with a por/sig/muc component tended to be deeply invasive and were often not recognized preoperatively. Endoscopists should be aware that UCAN often has a por/sig/muc component that is not always recognized on biopsy, and the optimal treatment strategy needs to be carefully considered.
    Language English
    Publishing date 2024-05-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3018469-1
    ISSN 2288-1956 ; 1598-9100
    ISSN (online) 2288-1956
    ISSN 1598-9100
    DOI 10.5217/ir.2024.00006
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  7. Article ; Online: Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program.

    London, Mariya / Bilate, Angelina M / Castro, Tiago B R / Sujino, Tomohisa / Mucida, Daniel

    Nature immunology

    2021  Volume 22, Issue 4, Page(s) 449–459

    Abstract: Mesenteric lymph node (mLN) T cells undergo tissue adaptation upon migrating to intestinal lamina propria and epithelium, ensuring appropriate balance between tolerance and resistance. By combining mouse genetics with single-cell and chromatin analyses, ... ...

    Abstract Mesenteric lymph node (mLN) T cells undergo tissue adaptation upon migrating to intestinal lamina propria and epithelium, ensuring appropriate balance between tolerance and resistance. By combining mouse genetics with single-cell and chromatin analyses, we uncovered the molecular imprinting of gut epithelium on T cells. Transcriptionally, conventional and regulatory (T
    MeSH term(s) Animals ; Cell Differentiation ; Cell Lineage ; Cells, Cultured ; Chromatin Assembly and Disassembly ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Genomic Imprinting ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intraepithelial Lymphocytes/immunology ; Intraepithelial Lymphocytes/metabolism ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Mice, Knockout ; Phenotype ; RNA-Seq ; Single-Cell Analysis ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Transcriptome ; Mice
    Chemical Substances Th-POK protein, mouse ; Transcription Factors
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-00883-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 42: Show issues

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  8. Article ; Online: Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease.

    Kawaguchi, Takaaki / Fukata, Masayuki / Omori, Teppei / Kiyohara, Hiroki / Sugimoto, Shinya / Nanki, Kosaku / Sujino, Tomohisa / Mikami, Yohei / Kanai, Takanori

    Crohn's & colitis 360

    2022  Volume 4, Issue 3, Page(s) otac017

    Abstract: Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored.: Methods: A multicenter retrospective case series study of patients with active intestinal BD ... ...

    Abstract Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored.
    Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted.
    Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients.
    Conclusions: CNIs may be promising treatment options for refractory intestinal BD.
    Language English
    Publishing date 2022-06-02
    Publishing country England
    Document type Journal Article
    ISSN 2631-827X
    ISSN (online) 2631-827X
    DOI 10.1093/crocol/otac017
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  9. Article: Localization and movement of Tregs in gastrointestinal tract: a systematic review.

    Harada, Yosuke / Miyamoto, Kentaro / Chida, Akihiko / Okuzawa, Anna Tojo / Yoshimatsu, Yusuke / Kudo, Yumi / Sujino, Tomohisa

    Inflammation and regeneration

    2022  Volume 42, Issue 1, Page(s) 47

    Abstract: Background: The intestine is rich in food-derived and microbe-derived antigens. Regulatory T cells (Tregs) are an essential T-cell population that prevents systemic autoimmune diseases and inhibits inflammation by encountering antigens. Previously, it ... ...

    Abstract Background: The intestine is rich in food-derived and microbe-derived antigens. Regulatory T cells (Tregs) are an essential T-cell population that prevents systemic autoimmune diseases and inhibits inflammation by encountering antigens. Previously, it was reported that the functional loss of Tregs induces systemic inflammation, including inflammatory bowel disease and graft-versus-host disease in human and murine models. However, there is a dearth of information about how Tregs localize in different tissues and suppress effector cells.
    Main body: The development of Tregs and their molecular mechanism in the digestive tract have been elucidated earlier using murine genetic models, infectious models, and human samples. Tregs suppress immune and other nonimmune cells through direct effect and cytokine production. The recent development of in vivo imaging technology allows us to visualize how Tregs localize and move in the settings of inflammation and homeostasis. This is important because, according to a recent report, Treg characterization and function are regulated by their location. Tregs located in the proximal intestine and its draining lymph nodes induce tolerance against food antigens, and those located in the distal intestine suppress the inflammation induced by microbial antigens. Taken together, various Tregs are induced in a location-specific manner in the gastrointestinal tract and influence the homeostasis of the gut.
    Conclusion: In this review, we summarize how Tregs are induced in the digestive tract and the application of in vivo Treg imaging to elucidate immune homeostasis in the digestive tract.
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-022-00232-8
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  10. Article ; Online: Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis.

    Shimada, Fumie / Yoshimatsu, Yusuke / Sujino, Tomohisa / Fukuda, Tomohiro / Aoki, Yasuhiro / Hayashi, Yukie / Tojo, Anna / Kawaguchi, Takaaki / Kiyohara, Hiroki / Sugimoto, Shinya / Nanki, Kosaku / Mikami, Yohei / Miyamoto, Kentaro / Takabayashi, Kaoru / Hosoe, Naoki / Kato, Motohiko / Ogata, Haruhiko / Naganuma, Makoto / Kanai, Takanori

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5778

    Abstract: Indigo naturalis is an effective treatment for ulcerative colitis. However, long-term use of indigo naturalis causes adverse events, such as pulmonary hypertension. The natural history of patients with ulcerative colitis who discontinued indigo naturalis ...

    Abstract Indigo naturalis is an effective treatment for ulcerative colitis. However, long-term use of indigo naturalis causes adverse events, such as pulmonary hypertension. The natural history of patients with ulcerative colitis who discontinued indigo naturalis after induction therapy is unknown. Moreover, the clinical features of patients who relapsed within 52 weeks after the discontinuation of indigo naturalis are unclear. This study aimed to assess the clinical outcomes of patients with ulcerative colitis after discontinuation of indigo naturalis and to identify potential markers responsible for relapse. This single-center retrospective study investigated the follow-up of 72 patients who achieved a clinical response 8 weeks after indigo naturalis treatment. We observed relapse in patients with ulcerative colitis after the discontinuation of indigo naturalis. We analyzed the factors predicting long-term outcomes after discontinuation of indigo naturalis. Relapse was observed in 24%, 57%, and 71% of patients at 8, 26, and 52 weeks, respectively. There were no predictive markers in patients who relapsed within 52 weeks after the discontinuation of indigo naturalis. The ulcerative colitis relapse rate after indigo naturalis discontinuation was high. Follow-up treatment is required after the discontinuation of indigo naturalis in patients with ulcerative colitis.
    MeSH term(s) Humans ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/chemically induced ; Indigo Carmine ; Retrospective Studies ; Drugs, Chinese Herbal/pharmacology ; Recurrence
    Chemical Substances Indigo Carmine (D3741U8K7L) ; Drugs, Chinese Herbal
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56543-y
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