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  1. Article: Iron Metabolism of the Skin: Recycling versus Release.

    Surbek, Marta / Sukseree, Supawadee / Eckhart, Leopold

    Metabolites

    2023  Volume 13, Issue 9

    Abstract: The skin protects the body against exogenous stressors. Its function is partially achieved by the permanent regeneration of the epidermis, which requires high metabolic activity and the shedding of superficial cells, leading to the loss of metabolites. ... ...

    Abstract The skin protects the body against exogenous stressors. Its function is partially achieved by the permanent regeneration of the epidermis, which requires high metabolic activity and the shedding of superficial cells, leading to the loss of metabolites. Iron is involved in a plethora of important epidermal processes, including cellular respiration and detoxification of xenobiotics. Likewise, microorganisms on the surface of the skin depend on iron, which is supplied by the turnover of epithelial cells. Here, we review the metabolism of iron in the skin with a particular focus on the fate of iron in epidermal keratinocytes. The iron metabolism of the epidermis is controlled by genes that are differentially expressed in the inner and outer layers of the epidermis, establishing a system that supports the recycling of iron and counteracts the release of iron from the skin surface. Heme oxygenase-1 (HMOX1), ferroportin (SLC40A1) and hephaestin-like 1 (HEPHL1) are constitutively expressed in terminally differentiated keratinocytes and allow the recycling of iron from heme prior to the cornification of keratinocytes. We discuss the evidence for changes in the epidermal iron metabolism in diseases and explore promising topics of future studies of iron-dependent processes in the skin.
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13091005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Heme Oxygenase-1 Is Upregulated during Differentiation of Keratinocytes but Its Expression Is Dispensable for Cornification of Murine Epidermis

    Surbek, Marta / Sukseree, Supawadee / Sachslehner, Attila Placido / Copic, Dragan / Golabi, Bahar / Nagelreiter, Ionela Mariana / Tschachler, Erwin / Eckhart, Leopold

    J Dev Biol. 2023 Mar. 10, v. 11, no. 1

    2023  

    Abstract: The epidermal barrier of mammals is initially formed during embryonic development and continuously regenerated by the differentiation and cornification of keratinocytes in postnatal life. Cornification is associated with the breakdown of organelles and ... ...

    Abstract The epidermal barrier of mammals is initially formed during embryonic development and continuously regenerated by the differentiation and cornification of keratinocytes in postnatal life. Cornification is associated with the breakdown of organelles and other cell components by mechanisms which are only incompletely understood. Here, we investigated whether heme oxygenase 1 (HO-1), which converts heme into biliverdin, ferrous iron and carbon monoxide, is required for normal cornification of epidermal keratinocytes. We show that HO-1 is transcriptionally upregulated during the terminal differentiation of human keratinocytes in vitro and in vivo. Immunohistochemistry demonstrated expression of HO-1 in the granular layer of the epidermis where keratinocytes undergo cornification. Next, we deleted the Hmox1 gene, which encodes HO-1, by crossing Hmox1-floxed and K14-Cre mice. The epidermis and isolated keratinocytes of the resulting Hmox1ᶠ/ᶠ K14-Cre mice lacked HO-1 expression. The genetic inactivation of HO-1 did not impair the expression of keratinocyte differentiation markers, loricrin and filaggrin. Likewise, the transglutaminase activity and formation of the stratum corneum were not altered in Hmox1ᶠ/ᶠ K14-Cre mice, suggesting that HO-1 is dispensable for epidermal cornification. The genetically modified mice generated in this study may be useful for future investigations of the potential roles of epidermal HO-1 in iron metabolism and responses to oxidative stress.
    Keywords carbon monoxide ; embryogenesis ; genes ; heme ; heme oxygenase (biliverdin-producing) ; humans ; immunohistochemistry ; iron ; iron absorption ; keratinocytes ; mice ; organelles ; oxidative stress ; protein-glutamine gamma-glutamyltransferase ; transcription (genetics)
    Language English
    Dates of publication 2023-0310
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2720870-9
    ISSN 2221-3759
    ISSN 2221-3759
    DOI 10.3390/jdb11010012
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Heme Oxygenase-1 Is Upregulated during Differentiation of Keratinocytes but Its Expression Is Dispensable for Cornification of Murine Epidermis.

    Surbek, Marta / Sukseree, Supawadee / Sachslehner, Attila Placido / Copic, Dragan / Golabi, Bahar / Nagelreiter, Ionela Mariana / Tschachler, Erwin / Eckhart, Leopold

    Journal of developmental biology

    2023  Volume 11, Issue 1

    Abstract: The epidermal barrier of mammals is initially formed during embryonic development and continuously regenerated by the differentiation and cornification of keratinocytes in postnatal life. Cornification is associated with the breakdown of organelles and ... ...

    Abstract The epidermal barrier of mammals is initially formed during embryonic development and continuously regenerated by the differentiation and cornification of keratinocytes in postnatal life. Cornification is associated with the breakdown of organelles and other cell components by mechanisms which are only incompletely understood. Here, we investigated whether heme oxygenase 1 (HO-1), which converts heme into biliverdin, ferrous iron and carbon monoxide, is required for normal cornification of epidermal keratinocytes. We show that HO-1 is transcriptionally upregulated during the terminal differentiation of human keratinocytes in vitro and in vivo. Immunohistochemistry demonstrated expression of HO-1 in the granular layer of the epidermis where keratinocytes undergo cornification. Next, we deleted the
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720870-9
    ISSN 2221-3759 ; 2221-3759
    ISSN (online) 2221-3759
    ISSN 2221-3759
    DOI 10.3390/jdb11010012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sequestosome 1/p62 enhances chronic skin inflammation.

    Sukseree, Supawadee / Bakiri, Latifa / Palomo-Irigoyen, Marta / Uluçkan, Özge / Petzelbauer, Peter / Wagner, Erwin F

    The Journal of allergy and clinical immunology

    2021  Volume 147, Issue 6, Page(s) 2386–2393.e4

    Abstract: Background: The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of ... ...

    Abstract Background: The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of cellular homeostasis, such as proinflammatory and mechanistic target of rapamycin signaling.
    Objective: We sought to determine whether p62 plays a role in the cutaneous and systemic manifestations of an AD-like mouse model.
    Methods: AD-like skin lesions were induced by deletion of JunB/AP-1, specifically in epidermal keratinocytes (JunB
    Results: Expression of p62 was elevated in skin lesions of JunB
    Conclusions: Our results provide the first in vivo evidence for a proinflammatory role of p62 in skin and suggest that p62-dependent signaling pathways may be promising therapeutic targets to ameliorate the skin manifestations of AD and possibly psoriasis.
    MeSH term(s) Animals ; Biomarkers ; Chronic Disease ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Disease Models, Animal ; Disease Susceptibility ; Mice ; Mice, Knockout ; Phenotype ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction ; Skin/immunology ; Skin/metabolism ; Skin/pathology
    Chemical Substances Biomarkers ; Sequestosome-1 Protein
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.02.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inactivation of Autophagy in Keratinocytes Reduces Tumor Growth in Mouse Models of Epithelial Skin Cancer.

    Barresi, Caterina / Rossiter, Heidemarie / Buchberger, Maria / Pammer, Johannes / Sukseree, Supawadee / Sibilia, Maria / Tschachler, Erwin / Eckhart, Leopold

    Cells

    2022  Volume 11, Issue 22

    Abstract: Autophagy is a ubiquitous degradation mechanism, which plays a critical role in cellular homeostasis. To test whether autophagy suppresses or supports the growth of tumors in the epidermis of the skin, we inactivated the essential autophagy ... ...

    Abstract Autophagy is a ubiquitous degradation mechanism, which plays a critical role in cellular homeostasis. To test whether autophagy suppresses or supports the growth of tumors in the epidermis of the skin, we inactivated the essential autophagy gene
    MeSH term(s) Animals ; Mice ; Autophagy ; Cell Transformation, Neoplastic/metabolism ; Disease Models, Animal ; ErbB Receptors/metabolism ; Keratinocytes/metabolism ; Neoplasms, Glandular and Epithelial/metabolism ; Neoplasms, Glandular and Epithelial/pathology ; Skin Neoplasms/pathology
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11223691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Autophagy Controls the Protein Composition of Hair Shafts.

    Sukseree, Supawadee / Karim, Noreen / Jaeger, Karin / Zhong, Shaomin / Rossiter, Heidemarie / Nagelreiter, Ionela Mariana / Gruber, Florian / Tschachler, Erwin / Rice, Robert H / Eckhart, Leopold

    The Journal of investigative dermatology

    2023  Volume 144, Issue 1, Page(s) 170–173.e4

    MeSH term(s) Humans ; Hair ; Autophagy
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.06.199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Suppression of autophagy perturbs turnover of sequestosome-1/p62 in Merkel cells but not in keratinocytes.

    Sukseree, Supawadee / Bergmann, Sophie / Pajdzik, Kinga / Tschachler, Erwin / Eckhart, Leopold

    Journal of dermatological science

    2018  Volume 90, Issue 2, Page(s) 209–211

    MeSH term(s) Animals ; Autophagy ; Autophagy-Related Protein 7/deficiency ; Autophagy-Related Protein 7/genetics ; Cell Differentiation ; Cell Lineage ; Epidermis/metabolism ; Epidermis/pathology ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Merkel Cells/metabolism ; Merkel Cells/pathology ; Mice, Knockout ; Proteolysis ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction
    Chemical Substances Atg7 protein, mouse ; Sequestosome-1 Protein ; Sqstm1 protein, mouse ; Autophagy-Related Protein 7 (EC 6.2.1.45)
    Language English
    Publishing date 2018-01-31
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2018.01.008
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  8. Article ; Online: Suppression of Epithelial Autophagy Compromises the Homeostasis of Sweat Glands during Aging.

    Sukseree, Supawadee / Bergmann, Sophie / Pajdzik, Kinga / Sipos, Wolfgang / Gruber, Florian / Tschachler, Erwin / Eckhart, Leopold

    The Journal of investigative dermatology

    2018  Volume 138, Issue 9, Page(s) 2061–2063

    MeSH term(s) Aging/physiology ; Animals ; Autophagy ; Homeostasis ; Humans ; Sweat Glands/cytology ; Sweat Glands/metabolism
    Language English
    Publishing date 2018-03-20
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2018.03.1502
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  9. Article ; Online: Autophagy in epithelial homeostasis and defense.

    Sukseree, Supawadee / Eckhart, Leopold / Tschachler, Erwin / Watanapokasin, Ramida

    Frontiers in bioscience (Elite edition)

    2013  Volume 5, Issue 3, Page(s) 1000–1010

    Abstract: Autophagy delivers protein aggregates, damaged organelles and intracellular microorganisms to the lysosome for degradation. The epidermis and other epithelia show significant levels of autophagy, however, the functions of autophagy in these tissues have ... ...

    Abstract Autophagy delivers protein aggregates, damaged organelles and intracellular microorganisms to the lysosome for degradation. The epidermis and other epithelia show significant levels of autophagy, however, the functions of autophagy in these tissues have remained elusive until recently. Here we review the experimental approaches for the investigation of autophagy in epithelia and discuss the roles of autophagy in epithelial cells with a focus on epidermal keratinocytes and thymic epithelial cells.
    MeSH term(s) Animals ; Autophagy ; Epithelial Cells/immunology ; Homeostasis ; Humans
    Language English
    Publishing date 2013-06-01
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2565080-4
    ISSN 1945-0508 ; 1945-0494
    ISSN (online) 1945-0508
    ISSN 1945-0494
    DOI 10.2741/e679
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  10. Article ; Online: Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link between the Embryonic Subperiderm and Feather Barbs and Barbules.

    Alibardi, Lorenzo / Holthaus, Karin Brigit / Sukseree, Supawadee / Hermann, Marcela / Tschachler, Erwin / Eckhart, Leopold

    PloS one

    2016  Volume 11, Issue 12, Page(s) e0167789

    Abstract: The morphogenesis of feathers is a complex process that depends on a tight spatiotemporal regulation of gene expression and assembly of the protein components of mature feathers. Recent comparative genomics and gene transcription studies have indicated ... ...

    Abstract The morphogenesis of feathers is a complex process that depends on a tight spatiotemporal regulation of gene expression and assembly of the protein components of mature feathers. Recent comparative genomics and gene transcription studies have indicated that genes within the epidermal differentiation complex (EDC) encode numerous structural proteins of cornifying skin cells in amniotes including birds. Here, we determined the localization of one of these proteins, termed EDMTFH (Epidermal Differentiation Protein starting with a MTF motif and rich in Histidine), which belongs to a group of EDC-encoded proteins rich in aromatic amino acid residues. We raised an antibody against an EDMTFH-specific epitope and performed immunohistochemical investigations by light microscopy and immunogold labeling by electron microscopy of chicken embryos at days 14-18 of development. EDMTFH was specifically present in the subperiderm, a transient layer of the embryonic epidermis, and in barbs and barbules of feathers. In the latter, it partially localized to bundles of so-called feather beta-keratins (corneous beta-proteins, CBPs). Cells of the embryonic periderm, the epidermis proper, and the feather sheath were immunonegative for EDMTFH. The results of this study indicate that EDMTFH may contribute to the unique mechanical properties of feathers and define EDMTFH as a common marker of the subperiderm and the feather barbules. This expression pattern of EDMTFH resembles that of epidermal differentiation cysteine-rich protein (EDCRP) and feather CBPs and is in accordance with the hypothesis that a major part of the cyclically regenerating feather follicle is topologically, developmentally and evolutionarily related to the embryonic subperiderm.
    MeSH term(s) Amino Acid Sequence ; Animals ; Avian Proteins/analysis ; Chick Embryo ; Chickens ; Epidermis/chemistry ; Epidermis/embryology ; Feathers/chemistry ; Feathers/embryology ; Female ; Proteins/analysis ; Sequence Alignment
    Chemical Substances Avian Proteins ; Proteins ; histidine-rich proteins
    Language English
    Publishing date 2016-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0167789
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