LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Sukumar, Madhusudhanan"
  2. AU="Tomasetto, Catherine"
  3. AU="Li, Yize"
  4. AU="Barbosa, Lívia Mirelle"
  5. AU="Emanuele Dilaghi"
  6. AU="Sabetghadam, Shadi"
  7. AU="Tijssen, Henk J"
  8. AU="Hodges, Scott D"
  9. AU="Kose, Abdulkadir"
  10. AU=Matsumoto Kunio AU=Matsumoto Kunio
  11. AU="Mutus, Bulent"
  12. AU="Yu-Shan Gao"
  13. AU="Afza Gardner, Qurratulann"
  14. AU="Madan, Arina"
  15. AU="Cutshaw, Kaiyel A"
  16. AU="Al-Khazraji, Ahmed"
  17. AU="Mukherjee, Geetashree"
  18. AU="DeGraff, David J"
  19. AU="Schmoellerl, Johannes"
  20. AU="Henderson, S"
  21. AU="Carvalheiro, Tiago"
  22. AU="Bastos Soares, Taís Cristina"
  23. AU="Yin, Guo-Qing"
  24. AU="Sharber, Brian"
  25. AU="Goyaux, Nathalie"
  26. AU="Rauch, Geraldine"
  27. AU="Ekoh, Okwukwe Faith"
  28. AU="A Rahim, Haslinda"
  29. AU="Richard Stahl"
  30. AU=Vazquez-Iglesias J L
  31. AU="Amundsen, David S"
  32. AU="Konios, Dimitrios"
  33. AU="Lindh, Ingrid"
  34. AU=Zhao Chunyan
  35. AU="Scalia, Jennifer B"
  36. AU="Balint, Lajos"
  37. AU="Liang, Siping"
  38. AU="Wong, Anthony"
  39. AU="Müjdat YENİCESU"
  40. AU="Brooks, M L"
  41. AU="Garcia-Gutierrez, Ania" AU="Garcia-Gutierrez, Ania"
  42. AU="Marina Paola Gardiman"
  43. AU="Labarthe, Simon"
  44. AU="Jiahui Li"
  45. AU="Geier, Johannes"
  46. AU=Thangaraju Pugazhenthan
  47. AU="Tapio, Joona"
  48. AU="Navaratnam, Dhasakumar"
  49. AU="Blank, Marissa Cathleen"
  50. AU="Sadeghi, Yasaman"
  51. AU=Ye Keqiang
  52. AU="Huda, Walter"
  53. AU="Petrova, Polina E"
  54. AU="Pond, Gregory"
  55. AU=Krzewski Konrad
  56. AU="Feng, Yuquan"
  57. AU="Schmermund, Ben Niklas"
  58. AU="Soni, Payal D"
  59. AU="Romero-García, Carolina"
  60. AU="Petty, Lloyd"
  61. AU="James E. Posey"

Search results

Result 1 - 10 of total 33

Search options

  1. Article: The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses.

    Sukumar, Madhusudhanan / Gattinoni, Luca

    Oncoimmunology

    2014  Volume 3, Issue 1, Page(s) e27573

    Abstract: Upon antigenic stimulation, naïve ... ...

    Abstract Upon antigenic stimulation, naïve CD8
    Language English
    Publishing date 2014-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.4161/onci.27573
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy.

    Kishton, Rigel J / Sukumar, Madhusudhanan / Restifo, Nicholas P

    Cell metabolism

    2017  Volume 26, Issue 1, Page(s) 94–109

    Abstract: Cancer immunotherapy is an increasingly successful strategy for the treatment of patients who have advanced or conventional therapy-resistant cancers. T cells are key mediators of tumor destruction and their specificity for tumor-expressed antigens is of ...

    Abstract Cancer immunotherapy is an increasingly successful strategy for the treatment of patients who have advanced or conventional therapy-resistant cancers. T cells are key mediators of tumor destruction and their specificity for tumor-expressed antigens is of paramount importance, but other T cell-intrinsic qualities, such as durability, longevity, and functionality also play important roles in determining the efficacy of immunotherapy. The cellular energetic pathways that are utilized by T cells play a key role in regulating each of these qualities. Metabolic activity, which both regulates and is regulated by cellular signaling pathways and epigenetics, also profoundly influences the trajectories of T cell differentiation and fate. In this Review, we discuss how cell metabolism influences T cell anti-tumor activity, the metabolic qualities of highly-functional T cells, and strategies to modulate metabolism for improving the immune response to tumors.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Survival ; Epigenesis, Genetic ; Humans ; Immunity, Cellular ; Immunotherapy/methods ; Metabolic Networks and Pathways ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Tumor Microenvironment
    Language English
    Publishing date 2017-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2017.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Metabolic reprograming of anti-tumor immunity.

    Sukumar, Madhusudhanan / Kishton, Rigel J / Restifo, Nicholas P

    Current opinion in immunology

    2017  Volume 46, Page(s) 14–22

    Abstract: Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response - how T ... ...

    Abstract Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response - how T cells generate energy - plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism.
    MeSH term(s) Animals ; Cell Differentiation/immunology ; Energy Metabolism ; Humans ; Immunity ; Immunotherapy/methods ; Lymphocyte Activation/immunology ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Mitochondria/metabolism ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Treatment Outcome ; Tumor Microenvironment/immunology
    Language English
    Publishing date 2017-04-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2017.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 13: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book ; Online ; Thesis: Mechanisms of rejection of high grade B cell lymphoma in mice

    Sukumar, Madhusudhanan

    2008  

    Author's details Madhusudhanan Sukumar
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--München, 2008
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book ; Online ; Thesis: Mechanisms of rejection of high grade B cell lymphoma in mice

    Sukumar, Madhusudhanan

    2008  

    Author's details Madhusudhanan Sukumar
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--München, 2008
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Arginine Arms T Cells to Thrive and Survive.

    Kishton, Rigel J / Sukumar, Madhusudhanan / Restifo, Nicholas P

    Cell metabolism

    2016  Volume 24, Issue 5, Page(s) 647–648

    Abstract: A clear role for cellular metabolism in regulating immune cell function has recently been established. In a recent issue of Cell, Geiger et al. (2016) demonstrate a role for intracellular arginine abundance in T cells for the promotion of oxidative ... ...

    Abstract A clear role for cellular metabolism in regulating immune cell function has recently been established. In a recent issue of Cell, Geiger et al. (2016) demonstrate a role for intracellular arginine abundance in T cells for the promotion of oxidative metabolism, increased cell viability, persistence, and in vivo antitumor response.
    MeSH term(s) Arginine ; Cell Survival ; T-Lymphocytes/immunology
    Chemical Substances Arginine (94ZLA3W45F)
    Language English
    Publishing date 2016-11-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2016.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Nutrient Competition: A New Axis of Tumor Immunosuppression

    Sukumar, Madhusudhanan / Roychoudhuri, Rahul / Restifo, Nicholas P

    Cell. 2015 Sept. 10, v. 162

    2015  

    Abstract: It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose ... ...

    Abstract It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
    Keywords T-lymphocytes ; cell growth ; glucose ; immunosuppression ; metabolism ; neoplasm cells ; neoplasms
    Language English
    Dates of publication 2015-0910
    Size p. 1206-1208.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2015.08.064
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 75/702: Show issues
    Z 93: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Targeting Akt in cell transfer immunotherapy for cancer.

    Crompton, Joseph G / Sukumar, Madhusudhanan / Restifo, Nicholas P

    Oncoimmunology

    2015  Volume 5, Issue 9, Page(s) e1014776

    Abstract: Pharmacologic inhibitors of the serine/threonine kinase Akt, initially aimed at deranged oncogenic pathways in tumors, have recently been shown to act as immunomodulators that markedly enhance the antitumor properties of T cells. Repurposing Akt ... ...

    Abstract Pharmacologic inhibitors of the serine/threonine kinase Akt, initially aimed at deranged oncogenic pathways in tumors, have recently been shown to act as immunomodulators that markedly enhance the antitumor properties of T cells. Repurposing Akt inhibitors to improve antitumor immunity may be viewed as a manifestation of a larger paradigmatic shift in which hallmark characteristics of cancer (e.g., immune evasion), rather than merely causal features (e.g., somatic mutations) can be exploited for therapeutic benefit.
    Language English
    Publishing date 2015-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2015.1014776
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Nutrient Competition: A New Axis of Tumor Immunosuppression.

    Sukumar, Madhusudhanan / Roychoudhuri, Rahul / Restifo, Nicholas P

    Cell

    2015  Volume 162, Issue 6, Page(s) 1206–1208

    Abstract: It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose ... ...

    Abstract It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Glycolysis ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Melanoma/immunology ; Melanoma/therapy ; Monitoring, Immunologic ; Neoplasms/metabolism ; Phosphoenolpyruvate/metabolism ; Tumor Microenvironment
    Chemical Substances Phosphoenolpyruvate (73-89-2)
    Language English
    Publishing date 2015-09-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2015.08.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book ; Online ; Thesis: Mechanisms of rejection of high grade B cell lymphoma in mice

    Sukumar, Madhusudhanan [Verfasser]

    2008  

    Author's details Madhusudhanan Sukumar
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top